Search Results - "Galasko, Douglas"

Lewy Body Disorders by Galasko, Douglas, MD

“…Dementia syndromes associated with Lewy bodies are subdivided into dementia with Lewy bodies (DLB), an underdiagnosed cause of dementia in the elderly, and…”
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Alzheimer's disease: The right drug, the right time by Golde, Todd E, DeKosky, Steven T, Galasko, Douglas

“…Lessons from failed clinical trials can improve the development of Alzheimer's disease–modifying therapies Alzheimer's disease (AD) is an age-associated…”
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Clonally expanded CD8 T cells patrol the cerebrospinal fluid in Alzheimer’s disease by Gate, David, Saligrama, Naresha, Leventhal, Olivia, Yang, Andrew C., Unger, Michael S., Middeldorp, Jinte, Chen, Kelly, Lehallier, Benoit, Channappa, Divya, De Los Santos, Mark B., McBride, Alisha, Pluvinage, John, Elahi, Fanny, Tam, Grace Kyin-Ye, Kim, Yongha, Greicius, Michael, Wagner, Anthony D., Aigner, Ludwig, Galasko, Douglas R., Davis, Mark M., Wyss-Coray, Tony

“…Alzheimer’s disease is an incurable neurodegenerative disorder in which neuroinflammation has a critical function 1 . However, little is known about the…”
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CD4 + T cells contribute to neurodegeneration in Lewy body dementia by Gate, David, Tapp, Emma, Leventhal, Olivia, Shahid, Marian, Nonninger, Tim J, Yang, Andrew C, Strempfl, Katharina, Unger, Michael S, Fehlmann, Tobias, Oh, Hamilton, Channappa, Divya, Henderson, Victor W, Keller, Andreas, Aigner, Ludwig, Galasko, Douglas R, Davis, Mark M, Poston, Kathleen L, Wyss-Coray, Tony

“…Recent studies indicate that the adaptive immune system plays a role in Lewy body dementia (LBD). However, the mechanism regulating T cell brain homing in LBD…”
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α-Synuclein oligomers induce early axonal dysfunction in human iPSC-based models of synucleinopathies by Prots, Iryna, Grosch, Janina, Brazdis, Razvan-Marius, Simmnacher, Katrin, Veber, Vanesa, Havlicek, Steven, Hannappel, Christian, Krach, Florian, Krumbiegel, Mandy, Schütz, Oliver, Reis, André, Wrasidlo, Wolfgang, Galasko, Douglas R., Groemer, Teja W., Masliah, Eliezer, Schlötzer-Schrehardt, Ursula, Xiang, Wei, Winkler, Jürgen, Winner, Beate

“…α-Synuclein (α-Syn) aggregation, proceeding fromoligomers to fibrils, is one central hallmark of neurodegeneration in synucleinopathies. α-Syn oligomers are…”
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Cerebrospinal fluid immune dysregulation during healthy brain aging and cognitive impairment by Piehl, Natalie, van Olst, Lynn, Ramakrishnan, Abhirami, Teregulova, Victoria, Simonton, Brooke, Zhang, Ziyang, Tapp, Emma, Channappa, Divya, Oh, Hamilton, Losada, Patricia M., Rutledge, Jarod, Trelle, Alexandra N., Mormino, Elizabeth C., Elahi, Fanny, Galasko, Douglas R., Henderson, Victor W., Wagner, Anthony D., Wyss-Coray, Tony, Gate, David

“…Cerebrospinal fluid (CSF) contains a tightly regulated immune system. However, knowledge is lacking about how CSF immunity is altered with aging or…”
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Subjective cognitive complaints contribute to misdiagnosis of mild cognitive impairment by Edmonds, Emily C, Delano-Wood, Lisa, Galasko, Douglas R, Salmon, David P, Bondi, Mark W

“…Subjective cognitive complaints are a criterion for the diagnosis of mild cognitive impairment (MCI), despite their uncertain relationship to objective memory…”
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Subtle Cognitive Decline and Biomarker Staging in Preclinical Alzheimer's Disease by Edmonds, Emily C, Delano-Wood, Lisa, Galasko, Douglas R, Salmon, David P, Bondi, Mark W

“…The NIA-AA criteria for "preclinical" Alzheimer's disease (AD) propose a staging method in which AD biomarkers follow an invariable temporal sequence in…”
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Early versus late MCI: Improved MCI staging using a neuropsychological approach by Edmonds, Emily C., McDonald, Carrie R., Marshall, Anisa, Thomas, Kelsey R., Eppig, Joel, Weigand, Alexandra J., Delano-Wood, Lisa, Galasko, Douglas R., Salmon, David P., Bondi, Mark W.

“…The Alzheimer's Disease Neuroimaging Initiative (ADNI) separates “early” and “late” mild cognitive impairment (MCI) based on a single memory test. We compared…”
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Plasma exosomal α-synuclein is likely CNS-derived and increased in Parkinson’s disease by Shi, Min, Liu, Changqin, Cook, Travis J., Bullock, Kristin M., Zhao, Yanchun, Ginghina, Carmen, Li, Yanfei, Aro, Patrick, Dator, Romel, He, Chunmei, Hipp, Michael J., Zabetian, Cyrus P., Peskind, Elaine R., Hu, Shu-Ching, Quinn, Joseph F., Galasko, Douglas R., Banks, William A., Zhang, Jing

“…Extracellular α-synuclein is important in the pathogenesis of Parkinson’s disease (PD) and also as a potential biomarker when tested in the cerebrospinal fluid…”
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Plasma biomarkers for Alzheimer’s Disease in relation to neuropathology and cognitive change by Smirnov, Denis S., Ashton, Nicholas J., Blennow, Kaj, Zetterberg, Henrik, Simrén, Joel, Lantero-Rodriguez, Juan, Karikari, Thomas K., Hiniker, Annie, Rissman, Robert A., Salmon, David P., Galasko, Douglas

“…Plasma biomarkers related to amyloid, tau, and neurodegeneration (ATN) show great promise for identifying these pathological features of Alzheimer’s Disease…”
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miR-212 and miR-132 Are Downregulated in Neurally Derived Plasma Exosomes of Alzheimer's Patients by Cha, Diana J, Mengel, David, Mustapic, Maja, Liu, Wen, Selkoe, Dennis J, Kapogiannis, Dimitrios, Galasko, Douglas, Rissman, Robert A, Bennett, David A, Walsh, Dominic M

“…It was recently discovered that brain cells release extracellular vesicles (EV) which can pass from brain into blood. These findings raise the possibility that…”
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Hippocampal α-Synuclein in Dementia with Lewy Bodies Contributes to Memory Impairment and Is Consistent with Spread of Pathology by Adamowicz, David H, Roy, Subhojit, Salmon, David P, Galasko, Douglas R, Hansen, Lawrence A, Masliah, Eliezer, Gage, Fred H

“…Despite considerable research to uncover them, the anatomic and neuropathologic correlates of memory impairment in dementia with Lewy bodies (DLB) remain…”
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Version 3 of the National Alzheimer’s Coordinating Center’s Uniform Data Set by Besser, Lilah, Kukull, Walter, Knopman, David S, Chui, Helena, Galasko, Douglas, Weintraub, Sandra, Jicha, Gregory, Carlsson, Cynthia, Burns, Jeffrey, Quinn, Joseph, Sweet, Robert A, Rascovsky, Katya, Teylan, Merilee, Beekly, Duane, Thomas, George, Bollenbeck, Mark, Monsell, Sarah, Mock, Charles, Zhou, Xiao Hua, Thomas, Nicole, Robichaud, Elizabeth, Dean, Margaret, Hubbard, Janene, Jacka, Mary, Schwabe-Fry, Kristen, Wu, Joylee, Phelps, Creighton, Morris, John C

“…INTRODUCTION:In 2015, the US Alzheimer’s Disease Centers (ADC) implemented Version 3 of the Uniform Data Set (UDS). This paper describes the history of Version…”
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Identification and validation of novel cerebrospinal fluid biomarkers for staging early Alzheimer's disease by Perrin, Richard J, Craig-Schapiro, Rebecca, Malone, James P, Shah, Aarti R, Gilmore, Petra, Davis, Alan E, Roe, Catherine M, Peskind, Elaine R, Li, Ge, Galasko, Douglas R, Clark, Christopher M, Quinn, Joseph F, Kaye, Jeffrey A, Morris, John C, Holtzman, David M, Townsend, R Reid, Fagan, Anne M

“…Ideally, disease modifying therapies for Alzheimer disease (AD) will be applied during the 'preclinical' stage (pathology present with cognition intact) before…”
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The ageing systemic milieu negatively regulates neurogenesis and cognitive function by Villeda, Saul A., Luo, Jian, Mosher, Kira I., Zou, Bende, Britschgi, Markus, Bieri, Gregor, Stan, Trisha M., Fainberg, Nina, Ding, Zhaoqing, Eggel, Alexander, Lucin, Kurt M., Czirr, Eva, Park, Jeong-Soo, Couillard-Després, Sebastien, Aigner, Ludwig, Li, Ge, Peskind, Elaine R., Kaye, Jeffrey A., Quinn, Joseph F., Galasko, Douglas R., Xie, Xinmin S., Rando, Thomas A., Wyss-Coray, Tony

“…Blood-borne factors affect the ageing brain Regenerative capacity and cognitive function decline during ageing. A study using heterochronic parabiosis, in…”
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Degree of bilingualism predicts age of diagnosis of Alzheimer's disease in low-education but not in highly educated Hispanics by Gollan, Tamar H., Salmon, David P., Montoya, Rosa I., Galasko, Douglas R.

“…► Objectively measured degree of bilingualism predicts age-of-diagnosis of Alzheimer's disease. ► Spanish–English bilinguals with probable AD. ► Significant…”
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Research criteria for the diagnosis of Alzheimer's disease: revising the NINCDS–ADRDA criteria by Dubois, Bruno, MD, Feldman, Howard H, MD, Jacova, Claudia, PhD, DeKosky, Steven T, MD, Barberger-Gateau, Pascale, MD, Cummings, Jeffrey, MD, Delacourte, André, PhD, Galasko, Douglas, MD, Gauthier, Serge, MD, Jicha, Gregory, MD, Meguro, Kenichi, MD, O'Brien, John, MD, Pasquier, Florence, MD, Robert, Philippe, MD, Rossor, Martin, MD, Salloway, Steven, MD, Stern, Yaakov, PhD, Visser, Pieter J, MD, Scheltens, Philip, MD

“…Summary The NINCDS–ADRDA and the DSM-IV-TR criteria for Alzheimer's disease (AD) are the prevailing diagnostic standards in research; however, they have now…”
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Increasing Inaccuracy of Self-Reported Subjective Cognitive Complaints Over 24 Months in Empirically Derived Subtypes of Mild Cognitive Impairment by Edmonds, Emily C, Weigand, Alexandra J, Thomas, Kelsey R, Eppig, Joel, Delano-Wood, Lisa, Galasko, Douglas R, Salmon, David P, Bondi, Mark W

“…Although subjective cognitive complaints (SCC) are an integral component of the diagnostic criteria for mild cognitive impairment (MCI), previous findings…”
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Selective molecular alterations in the autophagy pathway in patients with Lewy body disease and in models of alpha-synucleinopathy by Crews, Leslie, Spencer, Brian, Desplats, Paula, Patrick, Christina, Paulino, Amy, Rockenstein, Edward, Hansen, Lawrence, Adame, Anthony, Galasko, Douglas, Masliah, Eliezer

“…Lewy body disease is a heterogeneous group of neurodegenerative disorders characterized by alpha-synuclein accumulation that includes dementia with Lewy bodies…”
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