Search Results - "Galante, Raymond"

Aging in mice reduces the ability to sustain sleep/wake states by Wimmer, Mathieu E, Rising, Justin, Galante, Raymond J, Wyner, Abraham, Pack, Allan I, Abel, Ted

“…One of the most significant problems facing older individuals is difficulty staying asleep at night and awake during the day. Understanding the mechanisms by…”
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Role of Homer proteins in the maintenance of sleep-wake states by Naidoo, Nirinjini, Ferber, Megan, Galante, Raymond J, McShane, Blake, Hu, Jia Hua, Zimmerman, John, Maislin, Greg, Cater, Jacqui, Wyner, Abraham, Worley, Paul, Pack, Allan I

“…Sleep is an evolutionarily conserved process that is linked to diurnal cycles and normal daytime wakefulness. Healthy sleep and wakefulness are integral to a…”
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High-throughput visual assessment of sleep stages in mice using machine learning by Geuther, Brian, Chen, Mandy, Galante, Raymond J, Han, Owen, Lian, Jie, George, Joshy, Pack, Allan I, Kumar, Vivek

“…Abstract Study Objectives Sleep is an important biological process that is perturbed in numerous diseases, and assessment of its substages currently requires…”
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Structural Variation Shapes the Landscape of Recombination in Mouse by Morgan, Andrew P, Gatti, Daniel M, Najarian, Maya L, Keane, Thomas M, Galante, Raymond J, Pack, Allan I, Mott, Richard, Churchill, Gary A, de Villena, Fernando Pardo-Manuel

“…Meiotic recombination is an essential feature of sexual reproduction that ensures faithful segregation of chromosomes and redistributes genetic variants in…”
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Macromolecule biosynthesis: a key function of sleep by Mackiewicz, Miroslaw, Shockley, Keith R, Romer, Micah A, Galante, Raymond J, Zimmerman, John E, Naidoo, Nirinjini, Baldwin, Donald A, Jensen, Shane T, Churchill, Gary A, Pack, Allan I

“…1 Center for Sleep and Respiratory Neurobiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 2 Division of Sleep…”
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The dihydropyrimidine dehydrogenase gene contributes to heritable differences in sleep in mice by Keenan, Brendan T., Galante, Raymond J., Lian, Jie, Zhang, Lin, Guo, Xiaofeng, Veatch, Olivia J., Chesler, Elissa J., O’Brien, W. Timothy, Svenson, Karen L., Churchill, Gary A., Pack, Allan I.

“…Many aspects of sleep are heritable, but only a few sleep-regulating genes have been reported. Here, we leverage mouse models to identify and confirm a…”
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RNA-seq analysis of galaninergic neurons from ventrolateral preoptic nucleus identifies expression changes between sleep and wake by Guo, Xiaofeng, Gao, Xiaoling, Keenan, Brendan T, Zhu, Jingxu, Sarantopoulou, Dimitra, Lian, Jie, Galante, Raymond J, Grant, Gregory R, Pack, Allan I

“…Previous studies show that galanin neurons in ventrolateral preoptic nucleus (VLPO-Gal) are essential for sleep regulation. Here, we explored the…”
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High-throughput sleep phenotyping produces robust and heritable traits in Diversity Outbred mice and their founder strains by Keenan, Brendan T, Galante, Raymond J, Lian, Jie, Simecek, Petr, Gatti, Daniel M, Zhang, Lin, Lim, Diane C, Svenson, Karen L, Churchill, Gary A, Pack, Allan I

“…Abstract Study Objectives This study describes high-throughput phenotyping strategies for sleep and circadian behavior in mice, including examinations of…”
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Reduction of the molecular chaperone binding immunoglobulin protein (BiP) accentuates the effect of aging on sleep-wake behavior by Naidoo, Nirinjini, Zhu, Jingxu, Galante, Raymond J., Lian, Jie, Strus, Ewa, Lee, Amy, Keenan, Brendan T., Pack, Allan I.

“…Sleep and wake quality, quantity, and architecture become modified with aging. Sleep and wake quality decline coinciding with increased fragmentation of both…”
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Sleep deprivation induces the unfolded protein response in mouse cerebral cortex by Naidoo, Nirinjini, Giang, William, Galante, Raymond J., Pack, Allan I.

“…Little is known about the molecular mechanisms underlying sleep. We show the induction of key regulatory proteins in a cellular protective pathway, the…”
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Simulating obstructive sleep apnea patients' oxygenation characteristics into a mouse model of cyclical intermittent hypoxia by Lim, Diane C, Brady, Daniel C, Po, Pengse, Chuang, Li Pang, Marcondes, Laise, Kim, Emily Y, Keenan, Brendan T, Guo, Xiaofeng, Maislin, Greg, Galante, Raymond J, Pack, Allan I

“…Mouse models of cyclical intermittent hypoxia (CIH) are used to study the consequences of both hypoxia and oxidative stress in obstructive sleep apnea (OSA)…”
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Characterization of the bout durations of sleep and wakefulness by McShane, Blakeley B., Galante, Raymond J., Jensen, Shane T., Naidoo, Nirinjini, Pack, Allan I., Wyner, Abraham

“…▶ Distribution of bout length is described by a spike-and-slab mixture distribution. ▶ Distribution for a state depends on which state the mouse is…”
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Novel method for high-throughput phenotyping of sleep in mice by Pack, Allan I, Galante, Raymond J, Maislin, Greg, Cater, Jacqueline, Metaxas, Dimitris, Lu, Shan, Zhang, Lin, Smith, Randy Von, Kay, Timothy, Lian, Jie, Svenson, Karen, Peters, Luanne L

“…1 Center for Sleep and Respiratory Neurobiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 2 Division of Sleep Medicine,…”
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Aging and sleep deprivation induce the unfolded protein response in the pancreas: implications for metabolism by Naidoo, Nirinjini, Davis, James G., Zhu, Jingxu, Yabumoto, Maya, Singletary, Kristan, Brown, Marishka, Galante, Raymond, Agarwal, Beamon, Baur, Joseph A.

“…Summary Sleep disruption has detrimental effects on glucose metabolism through pathways that remain poorly defined. Although numerous studies have examined the…”
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Heritability of fat distributions in male mice from the founder strains of the Diversity Outbred mouse population by Keenan, Brendan T, Webster, Jeanette C, Wiemken, Andrew S, Lavi-Romer, Nir, Nguyen, Teresa, Svenson, Karen L, Galante, Raymond J, Churchill, Gary A, Pickup, Stephen, Pack, Allan I, Schwab, Richard J

“…Specific fat distributions are risk factors for complex diseases, including coronary heart disease and obstructive sleep apnea. To demonstrate the utility of…”
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Transcriptional Profiling of Cholinergic Neurons From Basal Forebrain Identifies Changes in Expression of Genes Between Sleep and Wake by Nikonova, Elena V., Gilliland, Jason DA, Tanis, Keith Q., Podtelezhnikov, Alexei A., Rigby, Alison M, Galante, Raymond J., Finney, Eva M, Stone, David J., Renger, John J., Pack, Allan I., Winrow, Christopher J.

“…Abstract Study objective: To assess differences in gene expression in cholinergic basal forebrain cells between sleeping and sleep-deprived mice sacrificed at…”
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Changes in Components of Energy Regulation in Mouse Cortex with Increases in Wakefulness by NIKONOVA, Elena V, NAIDOO, Nirinjini, LIN ZHANG, ROMER, Micah, CATER, Jacqueline R, SCHARF, Matthew T, GALANTE, Raymond J, PACK, Allan I

“…Increases in ATP production machinery have been described in brain after 3 h of sleep deprivation. Whether this is sustained with longer durations of extended…”
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Assessing REM sleep in mice using video data by McShane, Blakeley B, Galante, Raymond J, Biber, Michael, Jensen, Shane T, Wyner, Abraham J, Pack, Allan I

“…Assessment of sleep and its substages in mice currently requires implantation of chronic electrodes for measurement of electroencephalogram (EEG) and…”
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Normal sleep requires the astrocyte brain-type fatty acid binding protein FABP7 by Gerstner, Jason R, Perron, Isaac J, Riedy, Samantha M, Yoshikawa, Takeo, Kadotani, Hiroshi, Owada, Yuji, Van Dongen, Hans P A, Galante, Raymond J, Dickinson, Kaitlin, Yin, Jerry C P, Pack, Allan I, Frank, Marcos G

“…Sleep is found widely in the animal kingdom. Despite this, few conserved molecular pathways that govern sleep across phyla have been described. The mammalian…”
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Age-related changes in adenosine metabolic enzymes in sleep/wake regulatory areas of the brain by Mackiewicz, Miroslaw, Nikonova, Elena V., Zimmermann, John E., Romer, Micah A., Cater, Jacqueline, Galante, Raymond J., Pack, Allan I.

“…The impact of age on the enzymatic activities of adenosine metabolic enzymes, i.e., adenosine deaminase, adenosine kinase, cytosolic- and ecto-5′-nucleotidase…”
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