Search Results - "Galante, Pedro"

A potential role for intragenic miRNAs on their hosts' interactome by Hinske, Ludwig Christian G, Galante, Pedro A F, Kuo, Winston P, Ohno-Machado, Lucila

“…miRNAs are small, non-coding RNA molecules that mainly act as negative regulators of target gene messages. Due to their regulatory functions, they have lately…”
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Gene copy-number polymorphism caused by retrotransposition in humans by Schrider, Daniel R, Navarro, Fabio C P, Galante, Pedro A F, Parmigiani, Raphael B, Camargo, Anamaria A, Hahn, Matthew W, de Souza, Sandro J

“…The era of whole-genome sequencing has revealed that gene copy-number changes caused by duplication and deletion events have important evolutionary,…”
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Functional genomics analyses of RNA-binding proteins reveal the splicing regulator SNRPB as an oncogenic candidate in glioblastoma by Correa, Bruna R, de Araujo, Patricia Rosa, Qiao, Mei, Burns, Suzanne C, Chen, Chen, Schlegel, Richard, Agarwal, Seema, Galante, Pedro A F, Penalva, Luiz O F

“…Glioblastoma (GBM) is the most common and aggressive type of brain tumor. Currently, GBM has an extremely poor outcome and there is no effective treatment. In…”
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Monoallelic deleterious MUTYH germline variants as a driver for tumorigenesis by Barreiro, Rodrigo Araujo Sequeira, Sabbaga, Jorge, Rossi, Benedito M, Achatz, Maria Isabel W, Bettoni, Fabiana, Camargo, Anamaria A, Asprino, Paula F, Galante, Pedro

“…MUTYH encodes a glycosylase involved in the base excision repair of DNA. Biallelic pathogenic germline variants in MUTYH cause an autosomal recessive condition…”
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Suspected Germline TP53 Variants and Clonal Hematopoiesis of Indeterminate Potential: Lessons Learned From a Molecular Tumor Board by Xavier, Camila B, Link, Rudinei, Abreu, Leonília, Bettoni, Fabiana, Marson, Fabiane, Galante, Pedro A F, Masotti, Cibele, Amano, Mariane T, de Molla, Vinicius, Camargo, Anamaria A, Asprino, Paula F, Sabbaga, Jorge

“…Abstract Objective Li-Fraumeni syndrome (LFS) is a pan-cancer predisposition syndrome caused by germline pathogenic variants in the gene TP53. The…”
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Host gene constraints and genomic context impact the expression and evolution of human microRNAs by França, Gustavo S., Vibranovski, Maria D., Galante, Pedro A. F.

“…Increasing evidence has shown that recent miRNAs tend to emerge within coding genes. Here we conjecture that human miRNA evolution is tightly influenced by the…”
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Identification of a novel alternative splicing isoform of the Hippo kinase STK3/MST2 with impaired kinase and cell growth suppressing activities by Rodrigues, Ana Maria, Paula Zen Petisco Fiore, Ana, Guardia, Gabriela D. A., Tomasin, Rebeka, Azevedo Reis Teixeira, André, Giordano, Ricardo Jose, Schechtman, Deborah, Pagano, Michele, Galante, Pedro A. F., Bruni-Cardoso, Alexandre

“…Mammalian Ste-20-like Kinases 1 and 2 (MST1/2) are core serine-threonine kinases of the Hippo pathway regulating several cellular processes, including cell…”
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Impact of the thyroid hormone T3 and its nuclear receptor TRα1 on colon cancer stem cell phenotypes and response to chemotherapies by Giolito, Maria Virginia, Bodoirat, Serguei, La Rosa, Theo, Reslinger, Mathieu, Guardia, Gabriela D. A., Mourtada, Jana, Claret, Leo, Joung, Alain, Galante, Pedro A. F., Penalva, Luiz O. F., Plateroti, Michelina

“…Colorectal cancers (CRCs) are highly heterogeneous and show a hierarchical organization, with cancer stem cells (CSCs) responsible for tumor development,…”
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Alternative polyadenylation allows differential negative feedback of human miRNA miR-579 on its host gene ZFR by Hinske, Ludwig Christian, Galante, Pedro A F, Limbeck, Elisabeth, Möhnle, Patrick, Parmigiani, Raphael B, Ohno-Machado, Lucila, Camargo, Anamaria A, Kreth, Simone

“…About half of the known miRNA genes are located within protein-coding host genes, and are thus subject to co-transcription. Accumulating data indicate that…”
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Antagonism between the RNA-binding protein Musashi1 and miR-137 and its potential impact on neurogenesis and glioblastoma development by Velasco, Mitzli X, Kosti, Adam, Guardia, Gabriela D A, Santos, Marcia C, Tegge, Allison, Qiao, Mei, Correa, Bruna R S, Hernández, Greco, Kokovay, Erzsebet, Galante, Pedro A F, Penalva, Luiz O F

“…RNA-binding proteins (RBPs) and miRNAs are critical gene expression regulators that interact with one another in cooperative and antagonistic fashions. We…”
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Depletion of Ric-8B leads to reduced mTORC2 activity by Nagai, Maíra H, Xavier, Victor P S, Gutiyama, Luciana M, Machado, Cleiton F, Reis, Alice H, Donnard, Elisa R, Galante, Pedro A F, Abreu, Jose G, Festuccia, William T, Malnic, Bettina

“…mTOR, a serine/threonine protein kinase that is involved in a series of critical cellular processes, can be found in two functionally distinct complexes,…”
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Three-dimensional nuclear architecture distinguishes thyroid cancer histotypes by Rangel-Pozzo, Aline, Dos Santos, Filipe F, Dettori, Tinuccia, Giulietti, Matteo, Frau, Daniela Virginia, Galante, Pedro A F, Vanni, Roberta, Pathak, Alok, Fischer, Gabor, Gartner, John, Caria, Paola, Mai, Sabine

“…Molecular markers can serve as diagnostic tools to support pathological analysis in thyroid neoplasms. However, because the same markers can be observed in…”
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sideRETRO: a pipeline for identifying somatic and polymorphic insertions of processed pseudogenes or retrocopies by Miller, Thiago L A, Orpinelli Rego, Fernanda, Buzzo, José Leonel L, Galante, Pedro A F

“…Retrocopies or processed pseudogenes are gene copies resulting from mRNA retrotransposition. These gene duplicates can be fixed, somatically inserted or…”
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Recurrent somatic mutation in DROSHA induces microRNA profile changes in Wilms tumour by Torrezan, Giovana T., Ferreira, Elisa N., Nakahata, Adriana M., Barros, Bruna D. F., Castro, Mayra T. M., Correa, Bruna R., Krepischi, Ana C. V., Olivieri, Eloisa H. R., Cunha, Isabela W., Tabori, Uri, Grundy, Paul E., Costa, Cecilia M. L., de Camargo, Beatriz, Galante, Pedro A. F., Carraro, Dirce M.

“…Wilms tumour (WT) is an embryonal kidney neoplasia for which very few driver genes have been identified. Here we identify DROSHA mutations in 12% of WT samples…”
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Patient-derived conditionally reprogrammed cells maintain intra-tumor genetic heterogeneity by Correa, Bruna R. S., Hu, Joanna, Penalva, Luiz O. F., Schlegel, Richard, Rimm, David L., Galante, Pedro A. F., Agarwal, Seema

“…Preclinical in vitro models provide an essential tool to study cancer cell biology as well as aid in translational research, including drug target…”
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RNA processing as an alternative route to attack glioblastoma by Marcelino Meliso, Fabiana, Hubert, Christopher G., Favoretto Galante, Pedro A., Penalva, Luiz O.

“…Genomic analyses have become an important tool to identify new avenues for therapy. This is especially true for cancer types with extremely poor outcomes,…”
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A Genome-Wide Landscape of Retrocopies in Primate Genomes by Navarro, Fábio C P, Galante, Pedro A F

“…Gene duplication is a key factor contributing to phenotype diversity across and within species. Although the availability of complete genomes has led to the…”
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ELF4 is a critical component of a miRNA-transcription factor network and is a bridge regulator of glioblastoma receptor signaling and lipid dynamics by Kosti, Adam, Chiou, Jennifer, Guardia, Gabriela D A, Lei, Xiufen, Balinda, Henriette, Landry, Tesha, Lu, Xiyuan, Qiao, Mei, Gilbert, Andrea, Brenner, Andrew, Galante, Pedro A F, Tiziani, Stefano, Penalva, Luiz O F

“…Abstract Background The loss of neurogenic tumor suppressor microRNAs miR-124, miR-128, and miR-137 is associated with glioblastoma’s undifferentiated state…”
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Severe Acute Respiratory Syndrome Coronavirus 2 Variants of Concern: A Perspective for Emerging More Transmissible and Vaccine-Resistant Strains by de Souza, Anacleto Silva, de Freitas Amorim, Vitor Martins, Guardia, Gabriela D A, Dos Santos, Filipe F, Ulrich, Henning, Galante, Pedro A F, de Souza, Robson Francisco, Guzzo, Cristiane Rodrigues

“…Novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants of concern (VOC) are constantly threatening global public health. With no end date,…”
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Regulation of the THRA gene, encoding the thyroid hormone nuclear receptor TRα1, in intestinal lesions by Giolito, Maria Virginia, La Rosa, Théo, Farhat, Diana, Bodoirat, Serguei, Guardia, Gabriela D. A., Domon‐Dell, Claire, Galante, Pedro A. F., Freund, Jean‐Noel, Plateroti, Michelina

“…The THRA gene, encoding the thyroid hormone nuclear receptor TRα1, is expressed in an increasing gradient at the bottom of intestinal crypts, overlapping with…”
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