Search Results - "Galante, F."

Gene copy-number polymorphism caused by retrotransposition in humans by Schrider, Daniel R, Navarro, Fabio C P, Galante, Pedro A F, Parmigiani, Raphael B, Camargo, Anamaria A, Hahn, Matthew W, de Souza, Sandro J

“…The era of whole-genome sequencing has revealed that gene copy-number changes caused by duplication and deletion events have important evolutionary,…”
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Monoallelic deleterious MUTYH germline variants as a driver for tumorigenesis by Barreiro, Rodrigo Araujo Sequeira, Sabbaga, Jorge, Rossi, Benedito M, Achatz, Maria Isabel W, Bettoni, Fabiana, Camargo, Anamaria A, Asprino, Paula F, Galante, Pedro

“…MUTYH encodes a glycosylase involved in the base excision repair of DNA. Biallelic pathogenic germline variants in MUTYH cause an autosomal recessive condition…”
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Host gene constraints and genomic context impact the expression and evolution of human microRNAs by França, Gustavo S., Vibranovski, Maria D., Galante, Pedro A. F.

“…Increasing evidence has shown that recent miRNAs tend to emerge within coding genes. Here we conjecture that human miRNA evolution is tightly influenced by the…”
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Impact of the thyroid hormone T3 and its nuclear receptor TRα1 on colon cancer stem cell phenotypes and response to chemotherapies by Giolito, Maria Virginia, Bodoirat, Serguei, La Rosa, Theo, Reslinger, Mathieu, Guardia, Gabriela D. A., Mourtada, Jana, Claret, Leo, Joung, Alain, Galante, Pedro A. F., Penalva, Luiz O. F., Plateroti, Michelina

“…Colorectal cancers (CRCs) are highly heterogeneous and show a hierarchical organization, with cancer stem cells (CSCs) responsible for tumor development,…”
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Patient-derived conditionally reprogrammed cells maintain intra-tumor genetic heterogeneity by Correa, Bruna R. S., Hu, Joanna, Penalva, Luiz O. F., Schlegel, Richard, Rimm, David L., Galante, Pedro A. F., Agarwal, Seema

“…Preclinical in vitro models provide an essential tool to study cancer cell biology as well as aid in translational research, including drug target…”
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Severe Acute Respiratory Syndrome Coronavirus 2 Variants of Concern: A Perspective for Emerging More Transmissible and Vaccine-Resistant Strains by de Souza, Anacleto Silva, de Freitas Amorim, Vitor Martins, Guardia, Gabriela D A, Dos Santos, Filipe F, Ulrich, Henning, Galante, Pedro A F, de Souza, Robson Francisco, Guzzo, Cristiane Rodrigues

“…Novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants of concern (VOC) are constantly threatening global public health. With no end date,…”
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The Clinical and Molecular Profile of Lung Cancer Patients Harboring the TP53 R337H Germline Variant in a Brazilian Cancer Center: The Possible Mechanism of Carcinogenesis by Lopes, Carlos D. H., Antonacio, Fernanda F., Moraes, Priscila M. G., Asprino, Paula F., Galante, Pedro A. F., Jardim, Denis L., de Macedo, Mariana P., Sandoval, Renata L., Katz, Artur, de Castro, Gilberto, Achatz, Maria Isabel

“…In southern and southeastern Brazil, the TP53 founder variant c.1010G>A (R337H) has been previously documented with a prevalence of 0.3% within the general…”
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Alternative polyadenylation allows differential negative feedback of human miRNA miR-579 on its host gene ZFR by Hinske, Ludwig Christian, Galante, Pedro A F, Limbeck, Elisabeth, Möhnle, Patrick, Parmigiani, Raphael B, Ohno-Machado, Lucila, Camargo, Anamaria A, Kreth, Simone

“…About half of the known miRNA genes are located within protein-coding host genes, and are thus subject to co-transcription. Accumulating data indicate that…”
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Inter-fractional monitoring of 12C ions treatments: results from a clinical trial at the CNAO facility by Fischetti, M., Baroni, G., Battistoni, G., Bisogni, G., Cerello, P., Ciocca, M., De Maria, P., De Simoni, M., Di Lullo, B., Donetti, M., Dong, Y., Embriaco, A., Ferrero, V., Fiorina, E., Franciosini, G., Galante, F., Kraan, A., Luongo, C., Magi, M., Mancini-Terracciano, C., Marafini, M., Malekzadeh, E., Mattei, I., Mazzoni, E., Mirabelli, R., Mirandola, A., Morrocchi, M., Muraro, S., Patera, V., Pennazio, F., Schiavi, A., Sciubba, A., Solfaroli Camillocci, E., Sportelli, G., Tampellini, S., Toppi, M., Traini, G., Valle, S. M., Vischioni, B., Vitolo, V., Sarti, A.

“…The high dose conformity and healthy tissue sparing achievable in Particle Therapy when using C ions calls for safety factors in treatment planning, to prevent…”
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Compact S -band linear accelerator system for ultrafast, ultrahigh dose-rate radiotherapy by Faillace, L., Barone, S., Battistoni, G., Di Francesco, M., Felici, G., Ficcadenti, L., Franciosini, G., Galante, F., Giuliano, L., Grasso, L., Mostacci, A., Muraro, S., Pacitti, M., Palumbo, L., Patera, V., Migliorati, M.

“…Radiation therapy is currently the most utilized technique for the treatment of tumors by means of ionizing radiation, such as electrons, protons and x/gamma…”
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Identification of agonists for a group of human odorant receptors by Gonzalez-Kristeller, Daniela C, do Nascimento, João B P, Galante, Pedro A F, Malnic, Bettina

“…Olfaction plays a critical role in several aspects of the human life. Odorants are detected by hundreds of odorant receptors (ORs) which belong to the…”
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The paralogues MAGOH and MAGOHB are oncogenic factors in high-grade gliomas and safeguard the splicing of cell division and cell cycle genes by Barreiro, Rodrigo A. S., Guardia, Gabriela D. A., Meliso, Fabiana M., Lei, Xiufen, Li, Wei-Qing, Savio, Andre, Fellermeyer, Martin, Conceição, Helena B., Mercuri, Rafael L. V., Landry, Tesha, Qiao, Mei, Blazquez, Lorea, Ule, Jernej, Penalva, Luiz O.F., Galante, Pedro A. F.

“…The exon junction complex (EJC) plays key roles throughout the lifespan of RNA and is particularly relevant in the nervous system. We investigated the roles of…”
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Retro-miRs: novel and functional miRNAs originating from mRNA retrotransposition by Mercuri, Rafael L. V, Conceição, Helena B, Guardia, Gabriela D. A, Goldstein, Gabriel, Vibranovski, Maria D, Hinske, Ludwig C, Galante, Pedro A. F

“…Abstract Background Reverse-transcribed gene copies (retrocopies) have emerged as major sources of evolutionary novelty. MicroRNAs (miRNAs) are small and…”
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Open chromatin analysis in Trypanosoma cruzi life forms highlights critical differences in genomic compartments and developmental regulation at tDNA loci by Lima, Alex Ranieri Jerônimo, Silva, Herbert Guimarães de Sousa, Poubel, Saloe, Rosón, Juliana Nunes, de Lima, Loyze Paola Oliveira, Costa-Silva, Héllida Marina, Gonçalves, Camila Silva, Galante, Pedro A F, Holetz, Fabiola, Motta, Maria Cristina Machado, Silber, Ariel M, Elias, M Carolina, da Cunha, Julia Pinheiro Chagas

“…Genomic organization and gene expression regulation in trypanosomes are remarkable because protein-coding genes are organized into codirectional gene clusters…”
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Regulation of the THRA gene, encoding the thyroid hormone nuclear receptor TRα1, in intestinal lesions by Giolito, Maria Virginia, La Rosa, Théo, Farhat, Diana, Bodoirat, Serguei, Guardia, Gabriela D. A., Domon‐Dell, Claire, Galante, Pedro A. F., Freund, Jean‐Noel, Plateroti, Michelina

“…The THRA gene, encoding the thyroid hormone nuclear receptor TRα1, is expressed in an increasing gradient at the bottom of intestinal crypts, overlapping with…”
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Inter-fractional monitoring of [Formula: see text]C ions treatments: results from a clinical trial at the CNAO facility by Fischetti, M, Baroni, G, Battistoni, G, Bisogni, G, Cerello, P, Ciocca, M, De Maria, P, De Simoni, M, Di Lullo, B, Donetti, M, Dong, Y, Embriaco, A, Ferrero, V, Fiorina, E, Franciosini, G, Galante, F, Kraan, A, Luongo, C, Magi, M, Mancini-Terracciano, C, Marafini, M, Malekzadeh, E, Mattei, I, Mazzoni, E, Mirabelli, R, Mirandola, A, Morrocchi, M, Muraro, S, Patera, V, Pennazio, F, Schiavi, A, Sciubba, A, Solfaroli Camillocci, E, Sportelli, G, Tampellini, S, Toppi, M, Traini, G, Valle, S M, Vischioni, B, Vitolo, V, Sarti, A

“…The high dose conformity and healthy tissue sparing achievable in Particle Therapy when using C ions calls for safety factors in treatment planning, to prevent…”
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RCPedia: a database of retrocopied genes by Navarro, Fábio C P, Galante, Pedro A F

“…Retrocopies are copies of mature RNAs that are usually devoid of regulatory sequences and introns. They have routinely been classified as processed…”
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Correction to: Open chromatin analysis in Trypanosoma cruzi life forms highlights critical differences in genomic compartments and developmental regulation at tDNA loci by Lima, Alex Ranieri Jerônimo, de Sousa Silva, Herbert Guimarães, Poubel, Saloe Bispo, Rosón, Juliana Nunes, de Lima, Loyze Paola Oliveira, Costa-Silva, Héllida Marina, Gonçalves, Camila Silva, Galante, Pedro A. F, Holetz, Fabiola, Motta, Maria Cristina Machado, Silber, Ariel M, Elias, M. Carolina, da Cunha, Julia Pinheiro Chagas

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The Effects of Neoadjuvant Chemoradiation in Locally Advanced Rectal Cancer—The Impact in Intratumoral Heterogeneity by Bettoni, Fabiana, Masotti, Cibele, Corrêa, Bruna R., Donnard, Elisa, dos Santos, Filipe F., São Julião, Guilherme P., Vailati, Bruna B., Habr-Gama, Angelita, Galante, Pedro A. F., Perez, Rodrigo O., Camargo, Anamaria A.

“…Purpose: Intratumoral genetic heterogeneity (ITGH) is a common feature of solid tumors. However, little is known about the effect of neoadjuvant chemoradiation…”
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Transposon insertion profiling by sequencing (TIPseq) for mapping LINE-1 insertions in the human genome by Steranka, Jared P, Tang, Zuojian, Grivainis, Mark, Huang, Cheng Ran Lisa, Payer, Lindsay M, Rego, Fernanda O R, Miller, Thiago Luiz Araujo, Galante, Pedro A F, Ramaswami, Sitharam, Heguy, Adriana, Fenyö, David, Boeke, Jef D, Burns, Kathleen H

“…Transposable elements make up a significant portion of the human genome. Accurately locating these mobile DNAs is vital to understand their role as a source of…”
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