Search Results - "Gala, Manish"

S930 Colonic Insufflation Management Using a Custom Flexible Rectal Seal by Ding, Julia, Shalabi, Nabil, Tracey, Colin, Gala, Manish, Traverso, Giovanni

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Molecular pathways: aspirin and Wnt signaling-a molecularly targeted approach to cancer prevention and treatment by Gala, Manish K, Chan, Andrew T

“…The anti-inflammatory properties of aspirin have resulted in its widespread use as an analgesic, antipyretic, and cardioprotective agent. Beyond these…”
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Development of a clinical polygenic risk score assay and reporting workflow by Hao, Limin, Kraft, Peter, Berriz, Gabriel F., Hynes, Elizabeth D., Koch, Christopher, Korategere V Kumar, Prathik, Parpattedar, Shruti S., Steeves, Marcie, Yu, Wanfeng, Antwi, Ashley A., Brunette, Charles A., Danowski, Morgan, Gala, Manish K., Green, Robert C., Jones, Natalie E., Lewis, Anna C. F., Lubitz, Steven A., Natarajan, Pradeep, Vassy, Jason L., Lebo, Matthew S.

“…Implementation of polygenic risk scores (PRS) may improve disease prevention and management but poses several challenges: the construction of clinically valid…”
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Hepatic gap junctions amplify alcohol liver injury by propagating cGAS-mediated IRF3 activation by Luther, Jay, Khan, Sanjoy, Gala, Manish K., Kedrin, Dmitry, Sridharan, Gautham, Goodman, Russell P., Garber, John J., Masia, Ricard, Diagacomo, Erik, Adams, Daniel, King, Kevin R., Piaker, Samuel, Reinecker, Hans-Christian, Yarmush, Martin L., Argemi, Josepmaria, Bataller, Ramon, Dienstag, Jules L., Chung, Raymond T., Patel, Suraj J.

“…Alcohol-related liver disease (ALD) accounts for the majority of cirrhosis and liver-related deaths worldwide. Activation of IFN-regulatory factor (IRF3)…”
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Germline Mutations in Oncogene-Induced Senescence Pathways Are Associated With Multiple Sessile Serrated Adenomas by Gala, Manish K, Mizukami, Yusuke, Le, Long P, Moriichi, Kentaro, Austin, Thomas, Yamamoto, Masayoshi, Lauwers, Gregory Y, Bardeesy, Nabeel, Chung, Daniel C

“…Background & Aims Little is known about the genetic factors that contribute to the development of sessile serrated adenomas (SSAs). SSAs contain somatic…”
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Germline Determinants of Esophageal Adenocarcinoma by Lee, Minyi, Eng, George, Handte-Reinecker, Anna, Jeon, Alvin, Stratulat, Eugeniu, Zagani, Rachid, Taylor, Martin S., Rickelt, Steffen, Kedrin, Dmitriy, Batra, Anupam, Hashmi, Ardeshir, Nishioka, Norman S., Hur, Chin, Goyal, Lipika, Bazerbachi, Fateh, Zukerberg, Lawrence, Deshpande, Vikram S., Yilmaz, Omer H., Gala, Manish K.

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Verrucous esophageal carcinoma is a unique indolent subtype of squamous cell carcinoma: a systematic review and individual patient regression analysis by Li, Darrick K., Haffar, Samir, Horibe, Masayasu, Homsi, Haya A., Zukerberg, Lawrence, Murad, Mohammad H., Visrodia, Kavel H., Gala, Manish, Katzka, David A., Bazerbachi, Fateh

“…Background and aims Verrucous esophageal carcinoma (VEC) is a rare malignancy that presents a diagnostic challenge. We aim to characterize the clinical and…”
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Continuity of transcriptomes among colorectal cancer subtypes based on meta-analysis by Ma, Siyuan, Ogino, Shuji, Parsana, Princy, Nishihara, Reiko, Qian, Zhirong, Shen, Jeanne, Mima, Kosuke, Masugi, Yohei, Cao, Yin, Nowak, Jonathan A, Shima, Kaori, Hoshida, Yujin, Giovannucci, Edward L, Gala, Manish K, Chan, Andrew T, Fuchs, Charles S, Parmigiani, Giovanni, Huttenhower, Curtis, Waldron, Levi

“…Previous approaches to defining subtypes of colorectal carcinoma (CRC) and other cancers based on transcriptomes have assumed the existence of discrete…”
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Colorectal cancer susceptibility variants and risk of conventional adenomas and serrated polyps: results from three cohort studies by Hang, Dong, Joshi, Amit D, He, Xiaosheng, Chan, Andrew T, Jovani, Manol, Gala, Manish K, Ogino, Shuji, Kraft, Peter, Turman, Constance, Peters, Ulrike, Bien, Stephanie A, Lin, Yi, Hu, Zhibin, Shen, Hongbing, Wu, Kana, Giovannucci, Edward L, Song, Mingyang

“…Abstract Background Increasing evidence suggests that conventional adenomas (CAs) and serrated polyps (SPs) represent two distinct groups of precursor lesions…”
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S280 Incident Cancer Risk and Mutation Signatures Among Elderly MUTYH Carriers: Analysis of Population-Based and Genomic Cohorts by Downie, Jonathan M., Riaz, Moeen, Xie, Sophia, Lee, Minyi, Chan, Andrew T., Gibbs, Peter, Orchard, Suzanne, Mahady, Suzanne, Sebra, Robert, Murray, Anne, Macrae, Finlay, Schadt, Eric, Woods, Robyn, McNeil, John, Lacaze, Paul, Gala, Manish

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Genetics of the serrated pathway to colorectal cancer by Kedrin, Dmitriy, Gala, Manish K

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Recurrences are common after endoscopic ampullectomy for adenoma in the familial adenomatous polyposis (FAP) syndrome by Ma, Tianle, Jang, Eun Jeong, Zukerberg, Lawrence R., Odze, Robert, Gala, Manish K., Kelsey, Peter B., Forcione, David G., Brugge, William R., Casey, Brenna W., Syngal, Sapna, Chung, Daniel C.

“…Background Endoscopic ampullectomy is increasingly performed in patients with familial adenomatous polyposis (FAP)-associated ampullary adenomas. We sought to…”
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TFF2-CXCR4 Axis Is Associated with BRAF V600E Colon Cancer by Gala, Manish K, Austin, Thomas, Ogino, Shuji, Chan, Andrew T

“…Oncogene-induced senescence (OIS), a tumor-suppressive mechanism that is induced by the replicative and metabolic stress of oncogene activation, is a key…”
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Effect of Low-dose and Standard-dose Aspirin on PGE2 Biosynthesis Among Individuals with Colorectal Adenomas: A Randomized Clinical Trial by Drew, David A., Schuck, Madeline M., Magicheva-Gupta, Marina V., Stewart, Kathleen O., Gilpin, Katherine K., Miller, Patrick, Parziale, Melanie P., Pond, Emily N., Takacsi-Nagy, Oliver, Zerjav, Dylan C., Chin, Samantha M., Mackinnon Krems, Jennifer, Meixell, Dana, Joshi, Amit D., Ma, Wenjie, Colizzo, Francis P., Carolan, Peter J., Nishioka, Norman S., Staller, Kyle, Richter, James M., Khalili, Hamed, Gala, Manish K., Garber, John J., Chung, Daniel C., Yarze, Joseph C., Zukerberg, Lawrence, Petrucci, Giovanna, Rocca, Bianca, Patrono, Carlo, Milne, Ginger L., Wang, Molin, Chan, Andrew T.

“…Abstract Low-dose aspirin is recommended by the U.S. Preventive Services Task Force for primary prevention of colorectal cancer in certain individuals…”
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Homologous Recombination Repair Truncations Predict Hypermutation in Microsatellite Stable Colorectal and Endometrial Tumors by Lee, Minyi, Eng, George, Barbari, Stephanie R., Deshpande, Vikram, Shcherbakova, Polina V., Gala, Manish K.

“…Somatic mutations in BRCA1/2 and other homologous recombination repair (HRR) genes have been associated with sensitivity to PARP inhibitors and/or platinum…”
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ASPirin Intervention for the REDuction of colorectal cancer risk (ASPIRED): a study protocol for a randomized controlled trial by Drew, David A, Chin, Samantha M, Gilpin, Katherine K, Parziale, Melanie, Pond, Emily, Schuck, Madeline M, Stewart, Kathleen, Flagg, Meaghan, Rawlings, Crystal A, Backman, Vadim, Carolan, Peter J, Chung, Daniel C, Colizzo, 3rd, Francis P, Freedman, Matthew, Gala, Manish, Garber, John J, Huttenhower, Curtis, Kedrin, Dmitriy, Khalili, Hamed, Kwon, Douglas S, Markowitz, Sanford D, Milne, Ginger L, Nishioka, Norman S, Richter, James M, Roy, Hemant K, Staller, Kyle, Wang, Molin, Chan, Andrew T

“…Although aspirin is recommended for the prevention of colorectal cancer, the specific individuals for whom the benefits outweigh the risks are not clearly…”
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Hypoxic Regulation of Vascular Endothelial Growth Factor through the Induction of Phosphatidylinositol 3-Kinase/Rho/ROCK and c-Myc by Mizukami, Yusuke, Fujiki, Kotoyo, Duerr, Eva-Maria, Gala, Manish, Jo, Won-Seok, Zhang, Xiaobo, Chung, Daniel C.

“…The induction of vascular endothelial growth factor (VEGF) is an essential feature of tumor angiogenesis. Hypoxia is a potent stimulator of VEGF expression,…”
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Health Care Infrastructure for Financially Sustainable Clinical Genomics by Lennerz, Jochen K, McLaughlin, Heather M, Baron, Jason M, Rasmussen, David, Shin, Meini Sumbada, Berners-Lee, Nancy, Batten, Julie Miller, Swoboda, Kathryn J, Gala, Manish K, Winter, Harland S, Schmahmann, Jeremy D, Sweetser, David A, Boswell, Marianne, Pacula, Maciej, Stenzinger, Albrecht, Le, Long P, Hynes, William, Rehm, Heidi, Klibanski, Anne, Black-Schaffer, Stephen W, Golden, Jeffrey A, Louis, David N, Weiss, Scott T, Iafrate, A. John

“…Next-generation sequencing has evolved technically and economically into the method of choice for interrogating the genome in cancer and inherited disorders…”
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Case 23-2012: A 59-Year-Old Man with Abdominal Pain and Weight Loss by Xavier, Ramnik J, Gala, Manish K, Bronzo, Brian K, Kelly, Paul J

“…A 59-year-old man was admitted to the hospital because of 9 months of abdominal pain, vomiting, and weight loss. He was born in a Caribbean country and had…”
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Hepatic connexin 32 associates with nonalcoholic fatty liver disease severity by Luther, Jay, Gala, Manish K., Borren, Nynke, Masia, Ricard, Goodman, Russell P., Moeller, Ida Hatoum, DiGiacomo, Erik, Ehrlich, Alyssa, Warren, Andrew, Yarmush, Martin L., Ananthakrishnan, Ashwin, Corey, Kathleen, Kaplan, Lee M., Bhatia, Sangeeta, Chung, Raymond T., Patel, Suraj J.

“…Emerging data highlight the critical role for the innate immune system in the progression of nonalcoholic fatty liver disease (NAFLD). Connexin 32 (Cx32), the…”
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