Search Results - "Gal, Joseph"

ab Initio DFT and MD Simulations Serving as an Anchor for Correcting Melting Curves Reported by DAC and SW Experiments—Some Transition Metals as Illustrative Examples by Gal, Joseph

“…The pressure–temperature scales in DAC and shock wave (SW) experiments should be corrected by taking into account the thermal pressure shifts. In the present…”
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The Discovery of Stereoselectivity at Biological Receptors: Arnaldo Piutti and the Taste of the Asparagine Enantiomers-History and Analysis on the 125th Anniversary by Gal, Joseph

“…ABSTRACT In 1886, Italian chemist Arnaldo Piutti isolated, for the first time, d‐asparagine, the enantiomer of the known l‐asparagine. He obtained 100 g of…”
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Molecular Chirality in Chemistry and Biology: Historical Milestones by Gal, Joseph

“…Beginning early in the 19th century, developments in crystallography, optics, and chemistry in France set the stage for the discovery of molecular chirality by…”
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The discovery of biological enantioselectivity: Louis Pasteur and the fermentation of tartaric acid, 1857-A review and analysis 150 yr later by Gal, Joseph

“…Nearly a decade after discovering molecular chirality in 1848, Louis Pasteur changed research direction and began investigating fermentations. Conflicting…”
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Pasteur and the art of chirality by Gal, Joseph

“…Louis Pasteur was a scientific giant of the nineteenth century, but, as Joseph Gal asks, was his most famous contribution to the understanding of chemistry —…”
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Computational discovery of novel low micromolar human pregnane X receptor antagonists by Ekins, Sean, Kholodovych, Vladyslav, Ai, Ni, Sinz, Michael, Gal, Joseph, Gera, Lajos, Welsh, William J, Bachmann, Kenneth, Mani, Sridhar

“…Very few antagonists have been identified for the human pregnane X receptor (PXR). These molecules may be of use for modulating the effects of therapeutic…”
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Stereoselective metabolism of methadone N-demethylation by cytochrome P4502B6 and 2C19 by Gerber, John G., Rhodes, Robert J., Gal, Joseph

“…Methadone is a clinically used opioid agonist that is oxidatively metabolized by cytochrome P450 (CYP) isoforms to a stable metabolite, EDDP. Methadone is a…”
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Cascading crystallographic transitions α → ω → β → β’→ β" and melting curve of elemental zirconium by Gal, Joseph

“…Precise fitting of the experimental data analyzed separately for each identified crystallographic phase (α, ω, β, β′and β") yield different bulk moduli Bo and…”
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The Influence of liquid-liquid phase transition in molten argon on the controversial melting results of Mo, Ta and W by Gal, Joseph

“…The long standing controversy between the melting of the bcc Mo,Ta,W and vanadium (V) metals, measured by dynamic shock experiments compared to the melting…”
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Louis Pasteur, Chemical Linguist: Founding the Language of Stereochemistry by Gal, Joseph

“…Pasteur’s major discovery in chemistry was the recognition of molecular chirality, in 1848. He understood that his new science needed its own language, and…”
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In defense of Louis Pasteur: Critique of Gerald Geison's deconstruction of Pasteur's discovery of molecular chirality by Gal, Joseph

“…Louis Pasteur discovered the phenomenon of molecular chirality, based on his studies of tartrate crystals. His finding remains one of the most important…”
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Louis Pasteur, Chemist: An Account of His Studies of Cinchona Alkaloids by Gal, Joseph

“…Pasteur carried out pioneering work on cinchona alkaloids and their derivatives and his studies led to important discoveries. He examined crystals of cinchona…”
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Melting curves and bulk moduli of the solid noble gasses He, Ne, Ar, Kr and Xe by Gal, Joseph, Friedlander, Lonia

“…Alternative bulk moduli for He, Ne, Ar, Xe and Kr, which differ from those reported in the literature, are presented. These alternative bulk moduli are based…”
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Proposal for a New Stereochemically Informative Nonproprietary Drug Naming System by Gal, Joseph

“…Background The stereochemical aspects of drugs are generally recognized as fundamentally important influencers of drug action and disposition. Nevertheless,…”
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Louis Pasteur, language, and molecular chirality. I. Background and Dissymmetry by Gal, Joseph

“…Louis Pasteur resolved sodium ammonium (±)‐tartrate in 1848, thereby discovering molecular chirality. Although hindered by the primitive state of organic…”
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Enantioselectivity of inhibition of cytochrome P450 3A4 (CYP3A4) by ketoconazole: Testosterone and methadone as substrates by Dilmaghanian, Shahrzad, Gerber, John G., Filler, Scott G., Sanchez, Angela, Gal, Joseph

“…Racemic ketoconazole (KTZ) was the first orally active azole antifungal agent used in clinical practice and has become widely used in the treatment of mucosal…”
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Stereochemical vocabulary for structures that are chiral but not asymmetric: History, analysis, and proposal for a rational terminology by Gal, Joseph

“…Asymmetric objects are necessarily chiral, but a structure may be chiral and not asymmetric if it possesses one or more proper rotation axes. Chiral but not…”
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Molecular chirality: language, history, and significance by Gal, Joseph

“…In this chapter some background material concerning molecular chirality and enantiomerism is presented. First some basic chemical-molecular aspects of…”
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Carl Friedrich Naumann and the introduction of enantio terminology: A review and analysis on the 150th anniversary by Gal, Joseph

“…Enantiomorphism and enantiomorphous were the first enantio‐based terms, introduced 150 years ago, by Carl Friedrich Naumann, a German crystallographer, to…”
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Early history of the recognition of molecular biochirality by Gal, Joseph, Cintas, Pedro

“…This opening chapter recalls the history of the discoveries that led to the appreciation of the nature and importance of molecular chirality in biology, as…”
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