Search Results - "Gakovic, Milica"

Synthekines are surrogate cytokine and growth factor agonists that compel signaling through non-natural receptor dimers by Moraga, Ignacio, Spangler, Jamie B, Mendoza, Juan L, Gakovic, Milica, Wehrman, Tom S, Krutzik, Peter, Garcia, K Christopher

“…Cytokine and growth-factor ligands typically signal through homo- or hetero-dimeric cell surface receptors via Janus Kinase (JAK/TYK), or Receptor Tyrosine…”
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Tuning MPL signaling to influence hematopoietic stem cell differentiation and inhibit essential thrombocythemia progenitors by Cui, Lu, Moraga, Ignacio, Lerbs, Tristan, Van Neste, Camille, Wilmes, Stephan, Tsutsumi, Naotaka, Trotman-Grant, Aaron Claudius, Gakovic, Milica, Andrews, Sarah, Gotlib, Jason, Darmanis, Spyros, Enge, Martin, Quake, Stephen, Hitchcock, Ian S., Piehler, Jacob, Garcia, K. Christopher, Wernig, Gerlinde

“…Thrombopoietin (TPO) and the TPO-receptor (TPO-R, or c-MPL) are essential for hematopoietic stem cell (HSC) maintenance and megakaryocyte differentiation…”
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Decoupling the Functional Pleiotropy of Stem Cell Factor by Tuning c-Kit Signaling by Ho, Chia Chi M., Chhabra, Akanksha, Starkl, Philipp, Schnorr, Peter-John, Wilmes, Stephan, Moraga, Ignacio, Kwon, Hye-Sook, Gaudenzio, Nicolas, Sibilano, Riccardo, Wehrman, Tom S., Gakovic, Milica, Sockolosky, Jonathan T., Tiffany, Matthew R., Ring, Aaron M., Piehler, Jacob, Weissman, Irving L., Galli, Stephen J., Shizuru, Judith A., Garcia, K. Christopher

“…Most secreted growth factors and cytokines are functionally pleiotropic because their receptors are expressed on diverse cell types. While important for normal…”
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Two rare disease-associated Tyk2 variants are catalytically impaired but signaling competent by Li, Zhi, Gakovic, Milica, Ragimbeau, Josiane, Eloranta, Maija-Leena, Rönnblom, Lars, Michel, Frédérique, Pellegrini, Sandra

“…Tyk2 belongs to the Janus protein tyrosine kinase family and is involved in signaling of immunoregulatory cytokines (type I and III IFNs, IL-6, IL-10, and…”
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Pleiotropic effects of Sox2 during the development of the zebrafish epithalamus by Pavlou, Sofia, Astell, Katy, Kasioulis, Ioannis, Gakovic, Milica, Baldock, Richard, van Heyningen, Veronica, Coutinho, Pedro

“…The zebrafish epithalamus is part of the diencephalon and encompasses three major components: the pineal, the parapineal and the habenular nuclei. Using sox2…”
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The Stat3-activating Tyk2 V678F Mutant Does Not Up-regulate Signaling through the Type I Interferon Receptor but Confers Ligand Hypersensitivity to a Homodimeric Receptor by Gakovic, Milica, Ragimbeau, Josiane, Francois, Véronique, Constantinescu, Stefan N., Pellegrini, Sandra

“…Tyk2 is a Jak family member involved in cytokine signaling through heterodimeric-type receptors. Here, we analyzed the impact of the Val678-to-Phe substitution…”
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Concomitant deletion of Ptpn6 and Ptpn11 in T cells fails to improve anticancer responses by Ventura, Pedro M O, Gakovic, Milica, Fischer, Berenice A, Spinelli, Laura, Rota, Giorgia, Pathak, Shalini, Khameneh, Hanif J, Zenobi, Alessandro, Thomson, Sarah, Birchmeier, Walter, Cantrell, Doreen A, Guarda, Greta

“…Anticancer T cells acquire a dysfunctional state characterized by poor effector function and expression of inhibitory receptors, such as PD‐1. Blockade of PD‐1…”
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The role of RPGR in cilia formation and actin stability by Gakovic, Milica, Shu, Xinhua, Kasioulis, Ioannis, Carpanini, Sarah, Moraga, Ignacio, Wright, Alan F.

“…Mutations in the retinitis pigmentosa GTPase regulator (RPGR) protein cause one of the most common and severe forms of inherited retinal dystrophy. In spite of…”
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Zebrafish Rpgr is required for normal retinal development and plays a role in dynein-based retrograde transport processes by Shu, Xinhua, Zeng, Zhiqiang, Gautier, Philippe, Lennon, Alan, Gakovic, Milica, Patton, E. Elizabeth, Wright, Alan F.

“…Mutations in the human RPGR gene cause one of the most common and severe forms of inherited retinal dystrophy, but the function of its protein product remains…”
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Knockdown of the zebrafish ortholog of the retinitis pigmentosa 2 (RP2) gene results in retinal degeneration by Shu, Xinhua, Zeng, Zhiqiang, Gautier, Philippe, Lennon, Alan, Gakovic, Milica, Cheetham, Michael E, Patton, E Elizabeth, Wright, Alan F

“…The authors investigated the expression and function of the zebrafish ortholog of the retinitis pigmentosa 2 (RP2) gene. Zebrafish RP2 (ZFRP2) cDNA was…”
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21 Functional analyses of three human TYK2 variants by Ragimbeau, Josiane, Gakovic, Milica, Eloranta, Maija L., Pellegrini, Sandra

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