Search Results - "Gaken, J"

The JAK2 V617F mutation identifies a subgroup of MDS patients with isolated deletion 5q and a proliferative bone marrow by Ingram, W, Lea, N C, Cervera, J, Germing, U, Fenaux, P, Cassinat, B, Kiladjian, J J, Varkonyi, J, Antunovic, P, Westwood, N B, Arno, M J, Mohamedali, A, Gaken, J, Kontou, T, Czepulkowski, B H, Twine, N A, Tamaska, J, Csomer, J, Benedek, S, Gattermann, N, Zipperer, E, Giagounidis, A, Garcia-Casado, Z, Sanz, G, Mufti, G J

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Presence of JAK2 V617F tyrosine kinase mutation as a myeloid-lineage-specific mutation in chronic neutrophilic leukaemia by LEA, N. C, LIM, Z, WESTWOOD, N. B, ARNO, M. J, GÄKEN, J, MOHAMEDALI, A, MUFTI, G. J

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High concordance of genomic and cytogenetic aberrations between peripheral blood and bone marrow in myelodysplastic syndrome (MDS) by Mohamedali, A M, Gäken, J, Ahmed, M, Malik, F, Smith, A E, Best, S, Mian, S, Gaymes, T, Ireland, R, Kulasekararaj, A G, Mufti, G J

“…Bone marrow (BM) genetic abnormalities in myelodysplastic syndrome (MDS) have provided important biological and prognostic information; however, frequent BM…”
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P054 MicroRNA expression profiling of high and low risk MDS by Gaken, J, Mohamedali, A, Twine, N, Westwood, N, Czepulkowski, B, Chehade, S, Lea, N, Quek, L, Mufti, G

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P072 Genomic profiling of CD34+ and CD61+ cells in 5q-syndrome by Lea, N.C, Mohamedali, A, Twine, N, Gaken, J, Westwood, N, Ingram, W, Mufti, G

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The JAK2 V617F mutation is rare in RARS but common in RARS-T by Ceesay, M M, Lea, N C, Ingram, W, Westwood, N B, Gäken, J, Mohamedali, A, Cervera, J, Germing, U, Gattermann, N, Giagounidis, A, Garcia-Casado, Z, Sanz, G, Mufti, G J

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Modulation of Fos-mediated AP-1 transcription by the promyelocytic leukemia protein by VALLIAN, S, GÄKEN, J. A, GINGOLD, E. B, KOUZARIDES, T, CHANG, K.-S, FARZANEH, F

“…The growth and transformation suppressor function of promyelocytic leukemia (PML) protein are disrupted in acute promyelocytic leukemia (APL) as a result of…”
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Apoptin induces apoptosis by changing the equilibrium between the stability of TAp73 and ΔNp73 isoforms through ubiquitin ligase PIR2 by Taebunpakul, P., Sayan, B. S., Flinterman, M., Klanrit, P., Gäken, J., Odell, E. W., Melino, G., Tavassoli, M.

“…Apoptin, a protein derived from the chicken anaemia virus, induces cell death in various cancer cells but shows little or no cytotoxicity in normal cells. The…”
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C012 Prevalence and prognostic significance of allelic imbalance by single nucleotide polymorphism analysis in low risk myelodysplastic syndromes by Mohamedali, A, Gaken, J, Twine, N, Ingram, W, Westwood, N, Lea, N, Hayden, J, Carlo, A, Gattermann, N, Giagounidis, A, Germing, U, List, A, Mufti, G.J

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Human Gyrovirus Apoptin shows a similar subcellular distribution pattern and apoptosis induction as the chicken anaemia virus derived VP3/Apoptin by Bullenkamp, J, Cole, D, Malik, F, Alkhatabi, H, Kulasekararaj, A, Odell, E W, Farzaneh, F, Gäken, J, Tavassoli, M

“…The chicken anaemia virus-derived protein Apoptin/VP3 (CAV-Apoptin) has the important ability to induce tumour-selective apoptosis in a variety of human cancer…”
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Apoptin: specific killer of tumor cells? by Tavassoli, M, Guelen, L, Luxon, B A, Gäken, J

“…In the early 1990s it was discovered that the VP3/Apoptin protein encoded by the Chicken Anemia virus (CAV) possesses an inherent ability to specifically kill…”
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p400 function is required for the adenovirus E1A-mediated suppression of EGFR and tumour cell killing by FLINTERMAN, M. B, MYMRYK, J. S, KLANRIT, P, YOUSEF, A. F, LOWE, S. W, CALDAS, C, GÄKEN, J, FARZANEH, F, TAVASSOLI, M

“…We have recently shown that E1A protein of human adenovirus downregulates epidermal growth factor receptor (EGFR) expression and induces apoptosis in head and…”
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Novel costimulators in the immune gene therapy of cancer by Galea-Lauri, J, Farzaneh, F, Gäken, J

“…One of the major goals of cancer immunotherapy is the induction of tumour-specific T-lymphocyte responses that will be effective in the rejection of…”
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PML involvement in the p73-mediated E1A-induced suppression of EGFR and induction of apoptosis in head and neck cancers by Klanrit, P, Taebunpakul, P, Flinterman, M B, Odell, E W, Riaz, M A, Melino, G, Salomoni, P, Mymryk, J S, Gäken, J, Farzaneh, F, Tavassoli, M

“…Epidermal growth factor receptor (EGFR) tyrosine kinase is commonly overexpressed in human cancers; however, the cellular mechanisms regulating EGFR expression…”
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Cloning and characterization of a retroviral plasmid, pCC1, for combination suicide gene therapy by Kuiper, M, Sanches, R, Gäken, J A, Bignon, Y J

“…Introduction of the herpes simplex virus thymidine kinase (HSV-TK) gene into mammalian cells confers specific sensitivity to killing by the anti-herpes drug…”
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Role of p16/MTS1, cyclin D1 and RB in primary oral cancer and oral cancer cell lines by SARTOR, M, STEINGRIMSDOTTIR, H, ELAMIN, F, GÄKEN, J, WARNAKULASURIYA, S, PARTRIDGE, M, THAKKER, N, JOHNSON, N. W, TAVASSOLI, M

“…One of the most important components of G1 checkpoint is the retinoblastoma protein (pRB110). The activity of pRB is regulated by its phosphorylation, which is…”
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112 Microangiography: An Alternative Tool for Assessing Severe Frostbite Injury by Lacey, A, Masters, T, Punjabi, G, Moore, J, Whitley, A, Schmitz, K, Gaken, J, Fey, R, Endorf, F, Nygaard, R M

“…Abstract Introduction Assessment of frostbite injury typically relies on angiography or nuclear medicine to detect perfusion deficits prior to thrombolytic…”
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Construction of a versatile set of retroviral vectors conferring hygromycin resistance by Gäken, J, Farzaneh, F, Stocking, C, Ostertag, W

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Effect of Costimulation and the Microenvironment on Antigen Presentation by Leukemic Cells by Buggins, A.G.S., Lea, N., Ga¨ken, J., Darling, D., Farzaneh, F., Mufti, G.J., Hirst, W.J.R.

“…Costimulatory signals supplied by genetically modified tumor cells can enable T-cell recognition of tumor-associated antigens that were previously silent when…”
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TAT-apoptin is efficiently delivered and induces apoptosis in cancer cells by GUELEN, Lars, PATERSON, Hugh, GÄKEN, Joop, MEYERS, Michelle, FARZANEH, Farzin, TAVASSOLI, Mahvash

“…Apoptin has been described to induce apoptosis in various human cancer cell lines, but not in normal cells, thus making it an interesting candidate for the…”
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