Search Results - "Gajula, Rajendra P"

Separation of circadian- and behavior-driven metabolite rhythms in humans provides a window on peripheral oscillators and metabolism by Skene, Debra J., Skornyakov, Elena, Chowdhury, Namrata R., Gajula, Rajendra P., Middleton, Benita, Satterfield, Brieann C., Porter, Kenneth I., Van Dongen, Hans P. A., Gaddameedhi, Shobhan

“…Misalignment between internal circadian rhythmicity and externally imposed behavioral schedules, such as occurs in shift workers, has been implicated in…”
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TWIST1-WDR5- Hottip Regulates Hoxa9 Chromatin to Facilitate Prostate Cancer Metastasis by Malek, Reem, Gajula, Rajendra P, Williams, Russell D, Nghiem, Belinda, Simons, Brian W, Nugent, Katriana, Wang, Hailun, Taparra, Kekoa, Lemtiri-Chlieh, Ghali, Yoon, Arum R, True, Lawrence, An, Steven S, DeWeese, Theodore L, Ross, Ashley E, Schaeffer, Edward M, Pienta, Kenneth J, Hurley, Paula J, Morrissey, Colm, Tran, Phuoc T

“…TWIST1 is a transcription factor critical for development that can promote prostate cancer metastasis. During embryonic development, TWIST1 and HOXA9 are…”
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MORC2 Signaling Integrates Phosphorylation-Dependent, ATPase-Coupled Chromatin Remodeling during the DNA Damage Response by Li, Da-Qiang, Nair, Sujit S., Ohshiro, Kazufumi, Kumar, Anupam, Nair, Vasudha S., Pakala, Suresh B., Reddy, Sirigiri Divijendra Natha, Gajula, Rajendra P., Eswaran, Jeyanthy, Aravind, L., Kumar, Rakesh

“…Chromatin dynamics play a central role in maintaining genome integrity, but how this is achieved remains largely unknown. Here, we report that microrchidia…”
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Corrigendum to “Structure-function studies of the bHLH phosphorylation domain of TWIST1 in prostate cancer cells” [Neoplasia 17 (2014) 85] by Gajula, Rajendra P., Chettiar, Sivarajan T., Williams, Russell D., Nugent, Katriana, Kato, Yoshinori, Wang, Hailun, Malek, Reem, Taparra, Kekoa, Cades, Jessica, Annadanam, Anvesh, Yoon, A-Rum, Fertig, Elana, Firulli, Beth A., Mazzacurati, Lucia, Burns, Timothy F., Firulli, Anthony B., An, Steven S., Tran, Phuoc T.

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Concurrent versus sequential sorafenib therapy in combination with radiation for hepatocellular carcinoma by Wild, Aaron T, Gandhi, Nishant, Chettiar, Sivarajan T, Aziz, Khaled, Gajula, Rajendra P, Williams, Russell D, Kumar, Rachit, Taparra, Kekoa, Zeng, Jing, Cades, Jessica A, Velarde, Esteban, Menon, Siddharth, Geschwind, Jean F, Cosgrove, David, Pawlik, Timothy M, Maitra, Anirban, Wong, John, Hales, Russell K, Torbenson, Michael S, Herman, Joseph M, Tran, Phuoc T

“…Sorafenib (SOR) is the only systemic agent known to improve survival for hepatocellular carcinoma (HCC). However, SOR prolongs survival by less than 3 months…”
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Structure-Function Studies of the bHLH Phosphorylation Domain of TWIST1 in Prostate Cancer Cells by Gajula, Rajendra P, Chettiar, Sivarajan T, Williams, Russell D, Nugent, Katriana, Kato, Yoshinori, Wang, Hailun, Malek, Reem, Taparra, Kekoa, Cades, Jessica, Annadanam, Anvesh, Yoon, A-Rum, Fertig, Elana, Firulli, Beth A, Mazzacurati, Lucia, Burns, Timothy F, Firulli, Anthony B, An, Steven S, Tran, Phuoc T

“…Abstract The TWIST1 gene has diverse roles in development and pathologic diseases such as cancer. TWIST1 is a dimeric basic helix-loop-helix (bHLH)…”
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Nelfinavir induces radiation sensitization in pituitary adenoma cells by Zeng, Jing, See, Alfred P., Aziz, Khaled, Thiyagarajan, Saravanan, Salih, Tarek, Gajula, Rajendra P., Armour, Michael, Phallen, Jillian, Terezakis, Stephanie, Kleinberg, Lawrence, Redmond, Kristen, Hales, Russell K., Salvatori, Roberto, Quinones-Hinojosa, Alfredo, Tran, Phuoc T., Lim, Michael

“…Pituitary adenomas with local invasion and high secretory activity remain a therapeutic challenge. The HIV protease inhibitor nelfinavir is a radiosensitizer…”
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Night shift schedule causes circadian dysregulation of DNA repair genes and elevated DNA damage in humans by Koritala, Bala S. C., Porter, Kenneth I., Arshad, Osama A., Gajula, Rajendra P., Mitchell, Hugh D., Arman, Tarana, Manjanatha, Mugimane G., Teeguarden, Justin, Van Dongen, Hans P. A., McDermott, Jason E., Gaddameedhi, Shobhan

“…Circadian disruption has been identified as a risk factor for health disorders such as obesity, cardiovascular disease, and cancer. Although epidemiological…”
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The circadian clock protects against ionizing radiation‐induced cardiotoxicity by Dakup, Panshak P., Porter, Kenneth I., Gajula, Rajendra P., Goel, Peeyush N., Cheng, Zhaokang, Gaddameedhi, Shobhan

“…ABSTRACT Radiation therapy (RT) is commonly used to treat solid tumors of the breast, lung, and esophagus; however, the heart is an unintentional target of…”
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The circadian clock regulates cisplatin-induced toxicity and tumor regression in melanoma mouse and human models by Dakup, Panshak P, Porter, Kenneth I, Little, Alexander A, Gajula, Rajendra P, Zhang, Hui, Skornyakov, Elena, Kemp, Michael G, Van Dongen, Hans P A, Gaddameedhi, Shobhan

“…Cisplatin is one of the most commonly used chemotherapeutic drugs; however, toxicity and tumor resistance limit its use. Studies using murine models and human…”
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Molecular-Level Dysregulation of Insulin Pathways and Inflammatory Processes in Peripheral Blood Mononuclear Cells by Circadian Misalignment by McDermott, Jason E., Jacobs, Jon M., Merrill, Nathaniel J., Mitchell, Hugh D., Arshad, Osama A., McClure, Ryan, Teeguarden, Justin, Gajula, Rajendra P., Porter, Kenneth I., Satterfield, Brieann C., Lundholm, Kirsie R., Skene, Debra J., Gaddameedhi, Shobhan, Dongen, Hans P. A. Van

“…Circadian misalignment due to night work has been associated with an elevated risk for chronic diseases. We investigated the effects of circadian misalignment…”
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Circadian clock protein BMAL1 regulates melanogenesis through MITF in melanoma cells by Sarkar, Soumyadeep, Porter, Kenneth I., Dakup, Panshak P., Gajula, Rajendra P., Koritala, Bala S. C., Hylton, Ryan, Kemp, Michael G., Wakamatsu, Kazumasa, Gaddameedhi, Shobhan

“…Solar ultraviolet B radiation (UVB) is one of the leading causes of various skin conditions, including photoaging, sunburn erythema, and melanoma. As a…”
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Commentary: Chemiexcitation of melanin derivatives induces DNA photoproducts long after UV exposure by Gajula, Rajendra P, Gaddameedhi, Shobhan

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Inhibition of TWIST1 leads to activation of oncogene-induced senescence in oncogene-driven non-small cell lung cancer by Burns, Timothy F, Dobromilskaya, Irina, Murphy, Sara C, Gajula, Rajendra P, Thiyagarajan, Saravanan, Chatley, Sarah N H, Aziz, Khaled, Cho, Yoon-Jae, Tran, Phuoc T, Rudin, Charles M

“…A large fraction of non-small cell lung cancers (NSCLC) are dependent on defined oncogenic driver mutations. Although targeted agents exist for EGFR- and…”
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The twist box domain is required for Twist1-induced prostate cancer metastasis by Gajula, Rajendra P, Chettiar, Sivarajan T, Williams, Russell D, Thiyagarajan, Saravanan, Kato, Yoshinori, Aziz, Khaled, Wang, Ruoqi, Gandhi, Nishant, Wild, Aaron T, Vesuna, Farhad, Ma, Jinfang, Salih, Tarek, Cades, Jessica, Fertig, Elana, Biswal, Shyam, Burns, Timothy F, Chung, Christine H, Rudin, Charles M, Herman, Joseph M, Hales, Russell K, Raman, Venu, An, Steven S, Tran, Phuoc T

“…Twist1, a basic helix-loop-helix transcription factor, plays a key role during development and is a master regulator of the epithelial-mesenchymal transition…”
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Novel Hsp90 inhibitor NVP-AUY922 radiosensitizes prostate cancer cells by Gandhi, Nishant, Wild, Aaron T., Chettiar, Sivarajan T., Aziz, Khaled, Kato, Yoshinori, Gajula, Rajendra P., Williams, Russell D., Cades, Jessica A., Annadanam, Anvesh, Song, Danny, Zhang, Yonggang, Hales, Russell K., Herman, Joseph M., Armour, Elwood, DeWeese, Theodore L., Schaeffer, Edward M., Tran, Phuoc T.

“…Outcomes for poor-risk localized prostate cancers treated with radiation are still insufficient. Targeting the "non-oncogene" addiction or stress response…”
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MicroRNAs and cancer therapy: The next wave or here to stay? by Reddy, Sirigiri Divijendra Natha, Gajula, Rajendra P., Pakala, Suresh B., Kumar, Rakesh

“…MicroRNAs are small, non-coding RNAs that regulate gene expression by degrading and/or suppressing the translation of target mRNA by Watson-Crick base pairing…”
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Abstract 6060: The transactivation domain of TWIST1 is required for TWIST1-induced aggressiveness in non-small cell lung cancer by Lafargue, Audrey, Wang, Hailun, Chettiar, Sivarajan T., Gajula, Rajendra P., Taparra, Kekoa, Nugent, Katriana, Tran, Phuoc T.

“…Abstract Lung cancer is the most common cause of mortality by cancer. Non-small cell lung carcinoma (NSCLC) accounts for 80% of lung cancers. Although…”
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Abstract PO-067: The transactivation domain of TWIST1 is required for TWIST1-induced aggressiveness in non-small cell lung cancer by Lafargue, Audrey, Wang, Hailun, Chettiar, Sivarajan T., Gajula, Rajendra P., Smack, Caleb, Siddiqui, Ismaeel, Taparra, Kekoa, Lam, Christine, Carrieri, Francesca, Nugent, Katriana, Zachara, Natasha, Tran, Phuoc T.

“…Abstract Non-small cell lung carcinoma (NSCLC) is the most common cause of cancer mortality. Although therapeutic advances have been made, resistance to…”
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Corrigendum to "Structure-function studies of the bHLH phosphorylation domain of TWIST1 in prostate cancer cells" Neoplasia 17 (2014) 85 by Gajula, Rajendra P, Chettiar, Sivarajan T, Williams, Russell D, Nugent, Katriana, Kato, Yoshinori, Wang, Hailun, Malek, Reem, Taparra, Kekoa, Cades, Jessica, Annadanam, Anvesh, Yoon, A-Rum, Fertig, Elana, Firulli, Beth A, Mazzacurati, Lucia, Burns, Timothy F, Firulli, Anthony B, An, Steven S, Tran, Phuoc T

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