Search Results - "Gajula, Kiran S"

A Portable Hot Spot Recognition Loop Transfers Sequence Preferences from APOBEC Family Members to Activation-induced Cytidine Deaminase by Kohli, Rahul M., Abrams, Shaun R., Gajula, Kiran S., Maul, Robert W., Gearhart, Patricia J., Stivers, James T.

“…Enzymes of the AID/APOBEC family, characterized by the targeted deamination of cytosine to generate uracil within DNA, mediate numerous critical immune…”
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Local Sequence Targeting in the AID/APOBEC Family Differentially Impacts Retroviral Restriction and Antibody Diversification by Kohli, Rahul M., Maul, Robert W., Guminski, Amy F., McClure, Rhonda L., Gajula, Kiran S., Saribasak, Huseyin, McMahon, Moira A., Siliciano, Robert F., Gearhart, Patricia J., Stivers, James T.

“…Nucleic acid cytidine deaminases of the activation-induced deaminase (AID)/APOBEC family are critical players in active and innate immune responses, playing…”
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Designing an Elusive C•G→G•C CRISPR Base Editor by Gajula, Kiran S.

“…Protein engineering advances, including DNA repair manipulation of CRISPR (Clustered Regularly Interspaced Short Palindromic Repeat) machinery, have paved the…”
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Cooperativity between Cas9 and hyperactive AID establishes broad and diversifying mutational footprints in base editors by Berríos, Kiara N, Barka, Aleksia, Gill, Jasleen, Serrano, Juan C, Bailer, Peter F, Parker, Jared B, Evitt, Niklaus H, Gajula, Kiran S, Shi, Junwei, Kohli, Rahul M

“…Abstract The partnership of DNA deaminase enzymes with CRISPR-Cas nucleases is now a well-established method to enable targeted genomic base editing. However,…”
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High-throughput mutagenesis reveals functional determinants for DNA targeting by activation-induced deaminase by Gajula, Kiran S, Huwe, Peter J, Mo, Charlie Y, Crawford, Daniel J, Stivers, James T, Radhakrishnan, Ravi, Kohli, Rahul M

“…Antibody maturation is a critical immune process governed by the enzyme activation-induced deaminase (AID), a member of the AID/APOBEC DNA deaminase family…”
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