Search Results - "Gajewski, Ewa"

Substrate specificity of the Escherichia coli Fpg protein formamidopyrimidine-DNA glycosylase: excision of purine lesions in DNA produced by ionizing radiation or photosensitization by Boiteux, Serge, Gajewski, Ewa, Laval, Jacques, Dizdaroglu, Miral

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Mechanistic studies of ionizing radiation and oxidative mutagenesis: genetic effects of a single 8-hydroxyguanine (7-hydro-8-oxoguanine) residue inserted at a unique site in a viral genome by Wood, Michael L, Dizdaroglu, Miral, Gajewski, Ewa, Essigmann, John M

“…T4 RNA ligase was used to construct a deoxypentanucleotide containing a single 8-hydroxyguanine (7-hydro-8-oxoguanine; G8-OH) residue, which is one of the…”
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Damage to the DNA bases in mammalian chromatin by hydrogen peroxide in the presence of ferric and cupric ions by Dizdaroglu, M, Rao, G, Halliwell, B, Gajewski, E

“…Modification of DNA bases in mammalian chromatin upon treatment with hydrogen peroxide in the presence of ferric and cupric ions was studied. Ten DNA base…”
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Modification of DNA bases in mammalian chromatin by radiation-generated free radicals by Gajewski, Ewa, Rao, Govind, Nackerdien, Zeena, Dizdaroglu, Miral

“…Modification of DNA bases in mammalian chromatin in aqueous suspension by ionizing radiation generated free radicals was investigated. Argon, air, N2O, and…”
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Chemical nature of in vivo DNA base damage in hydrogen peroxide-treated mammalian cells by Dizdaroglu, M, Nackerdien, Z, Chao, B C, Gajewski, E, Rao, G

“…Hydrogen peroxide is generated in mammalian cells by normal metabolism or by treatment with external agents. Treatment of mammalian cells with this oxidizing…”
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Chemical nature of DNA-protein cross-links produced in mammalian chromatin by hydrogen peroxide in the presence of iron or copper ions by Nackerdien, Zeena, Rao, Govind, Cacciuttolo, Marco A, Gajewski, Ewa, Dizdaroglu, Miral

“…We report on the elucidation of DNA-protein cross-links formed in isolated mammalian chromatin upon treatment with H2O2 in the presence of iron or copper ions…”
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Quantitative Measurement of Radiation-Induced Base Products in DNA Using Gas Chromatography-Mass Spectrometry by Fuciarelli, Alfred F., Wegher, Brent J., Gajewski, Ewa, Dizdaroglu, Miral, Blakely, William F.

“…Gas chromatography-mass spectrometry with selected-ion monitoring was used to study radiation-induced damage to DNA. Quantitative analysis of modified purine…”
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Structure of a hydroxyl radical induced cross-link of thymine and tyrosine by Margolis, Sam A, Coxon, Bruce, Gajewski, Ewa, Dizdaroglu, Miral

“…DNA-protein cross-links are formed when living cells or isolated chromatin is exposed to ionizing radiation. Little is known about the actual cross-linked…”
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Oxidative DNA base damage in MCF-10A breast epithelial cells at clinically achievable concentrations of doxorubicin by Gajewski, Ewa, Gaur, Shikha, Akman, Steven A., Matsumoto, Linda, van Balgooy, Josephus N.A., Doroshow, James H.

“…The cellular metabolism of doxorubicin generates reactive oxygen species with significant potential to damage DNA. Such DNA damage can result in mutations if…”
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Structure of a hydroxyl radical-induced DNA-protein crosslink involving thymine and tyrosine in nucleohistone by Dizdaroglu, Miral, Gajewski, Ewa, Reddy, Prasad, Margolis, Sam A

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Oxidative DNA base modifications in peripheral blood mononuclear cells of patients treated with high-dose infusional doxorubicin by Doroshow, James H., Synold, Timothy W., Somlo, George, Akman, Steven A., Gajewski, Ewa

“…In prior studies, it was demonstrated that the redox metabolism of doxorubicin leads to the formation of promutagenic oxidized DNA bases in human chromatin,…”
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Hydroxyl radical induced cross-linking of cytosine and tyrosine in nucleohistone by Gajewski, Ewa, Dizdaroglu, Miral

“…Hydroxyl radical induced formation of a DNA-protein cross-link involving cytosine and tyrosine in nucleohistone in buffered aqueous solution is reported. The…”
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Selected-ion mass spectrometry: assays of oxidative DNA damage by Dizdaroglu, M, Gajewski, E

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Structure and mechanism of hydroxyl radical-induced formation of a DNA-protein cross-link involving thymine and lysine in nucleohistone by DIZDAROGLU, M, GAJEWSKI, E

“…Hydroxyl radical-induced formation of a DNA-protein cross-link involving thymine and lysine in calf thymus nucleohistone in vitro is reported. Basic amino…”
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Structure of a hydroxyl radical induced DNA-protein cross-link involving thymine and tyrosine in nucleohistone by Dizdaroglu, M, Gajewski, E, Reddy, P, Margolis, S A

“…Hydroxyl radical induced formation of a DNA-protein cross-link involving thymine and tyrosine in nucleohistone is described. Hydroxyl radicals were generated…”
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Bleomycin-dependent damage to the bases in DNA is a minor side reaction by Gajewski, Ewa, Aruoma, Okezie I, Dizdaroglu, Miral, Halliwell, Barry

“…The antitumor antibiotic bleomycin degrades DNA in the presence of ferric ions and H2O2 or in the presence of ferric ions, oxygen, and ascorbic acid. When DNA…”
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Structure of hydroxyl radical-induced DNA-protein crosslinks in calf thymus nucleohistone in vitro by Gajewski, E, Fuciarelli, A F, Dizdaroglu, M

“…Hydroxyl radicals are known to produce DNA-protein crosslinks in chromatin in vivo and in vitro. Here we investigated DNA-protein crosslinks formed between…”
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RADIATION-INDUCED PRODUCTS OF PEPTIDES AND THEIR ENZYMATIC DIGESTIBILITY by GAJEWSKI, EWA

“…Chemical characterization of radiation-induced products of peptides and proteins is essential for understanding the effect of ionizing radiation on peptides…”
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Identification of some OH radical-induced products of lysozyme by Dizdaroglu, M, Gajewski, E, Simic, M G, Krutzsch, H C

“…OH radical reactions with lysozyme in gamma-irradiated N2O saturated aqueous solutions caused formation of allo-threonine, alpha-amino-n-butyric acid, o- and…”
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Enzymatic digestibility of peptides cross-linked by ionizing radiation by Dizdaroglu, M, Gajewski, E, Simic, M G

“…p6gestibility by proteolytic enzymes of peptides cross-linked by ionizing radiation was investigated. Small peptides of alanine and phenylalanine were chosen…”
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