Search Results - "Gajewska, B. U."

GM-CSF transgene expression in the airway allows aerosolized ovalbumin to induce allergic sensitization in mice by Stämpfli, M R, Wiley, R E, Neigh, G S, Gajewska, B U, Lei, X F, Snider, D P, Xing, Z, Jordana, M

“…The purpose of this study was to explore whether repeated exposure to aerosolized ovalbumin (OVA) in the context of local expression of GM-CSF can initiate a…”
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The lung cytokine microenvironment influences molecular events in the lymph nodes during Th1 and Th2 respiratory mucosal sensitization to antigen in vivo by RITZ, S. A., CUNDALL, M. J., GAJEWSKA, B. U., SWIRSKI, F. K., WILEY, R. E., ALVAREZ, D., COYLE, A. J., STAMPFLI, M. R., JORDANA, M.

“…SUMMARY Originally defined by their patterns of cytokine production, Th1 and Th2 cells have been described more recently to express other genes differentially…”
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Inhalation of a harmless antigen (ovalbumin) elicits immune activation but divergent immunoglobulin and cytokine activities in mice by Swirski, F. K., Gajewska, B. U., Alvarez, D., Ritz, S. A., Cundall, M. J., Cates, E. C., Coyle, A. J., Gutierrez-Ramos, J.-C., Inman, M. D., Jordana, M., Stämpfli, M. R.

“…Background Exposure to aerosolized harmless antigen such as ovalbumin (OVA) has previously been shown to induce inhalation tolerance, a state characterized by…”
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Temporal-Spatial Analysis of the Immune Response in a Murine Model of Ovalbumin-Induced Airways Inflammation by Gajewska, Beata U, Swirski, Filip K, Alvarez, David, Ritz, Stacey A, Goncharova, Susanna, Cundall, Meghan, Snider, Denis P, Coyle, Anthony J, Gutierrez-Ramos, Jose-Carlos, Stampfli, Martin R, Jordana, Manel

“…The objective of this study was to define phenotypic changes of antigen-presenting cells (APCs) and T cells in a murine model of antigen-induced airways…”
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Interleukin-10 Gene Transfer to the Airway Regulates Allergic Mucosal Sensitization in Mice by Stampfli, Martin R, Cwiartka, Monika, Gajewska, Beata U, Alvarez, David, Ritz, Stacey A, Inman, Mark D, Xing, Zhou, Jordana, Manel

“…The objective of this study was to investigate the effect of airway gene transfer of interleukin (IL)-10, a cytokine with potent anti-inflammatory and…”
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Generation of experimental allergic airways inflammation in the absence of draining lymph nodes by Gajewska, B U, Alvarez, D, Vidric, M, Goncharova, S, Stämpfli, M R, Coyle, A J, Gutierrez-Ramos, J C, Jordana, M

“…The objective of this study was to investigate the contribution of secondary lymphoid organs in the generation and maintenance of experimental allergic airway…”
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Expression of the Th1 chemokine IFN-gamma-inducible protein 10 in the airway alters mucosal allergic sensitization in mice by Wiley, R, Palmer, K, Gajewska, B, Stämpfli, M, Alvarez, D, Coyle, A, Gutierrez-Ramos, J, Jordana, M

“…Although the preliminary characterization of chemokines and their receptors has been prolific, comparatively little is known about the role of chemokines in…”
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Determinants of the immune-inflammatory response in allergic airway inflammation: Overview of antigen presentation and cellular activation by Ritz, Stacey A., Gajewska, Beata U., Stämpfli, Martin R., Jordana, Manel

“…Under normal circumstances the lung is in a state of immunologic homeostasis, a condition in which exposure to innocuous antigens does not lead to…”
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Continuous Exposure to House Dust Mite Elicits Chronic Airway Inflammation and Structural Remodeling by Johnson, Jill R, Wiley, Ryan E, Fattouh, Ramzi, Swirski, Filip K, Gajewska, Beata U, Coyle, Anthony J, Gutierrez-Ramos, Jose-Carlos, Ellis, Russ, Inman, Mark D, Jordana, Manel

“…It is now fully appreciated that asthma is a disease of a chronic nature resulting from intermittent or continued aeroallergen exposure leading to airway…”
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The B7 family member B7-H3 preferentially down-regulates T helper type 1-mediated immune responses by Suh, Woong-Kyung, Mak, Tak W, Gajewska, Beata U, Okada, Hitoshi, Gronski, Matthew A, Bertram, Edward M, Dawicki, Wojciech, Duncan, Gordon S, Bukczynski, Jacob, Plyte, Suzanne, Elia, Andrew, Wakeham, Andrew, Itie, Annick, Chung, Stephen, Da Costa, Joan, Arya, Sudha, Horan, Tom, Campbell, Pauline, Gaida, Kevin, Ohashi, Pamela S, Watts, Tania H, Yoshinaga, Steven K, Bray, Mark R, Jordana, Manel

“…We investigated the in vivo function of the B7 family member B7-H3 (also known as B7RP-2) by gene targeting. B7-H3 inhibited T cell proliferation mediated by…”
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Costimulation through the inducible costimulator ligand is essential for both T helper and B cell functions in T cell-dependent B cell responses by Mak, Tak W, Tafuri, Anna, Shahinian, Arda, Yoshinaga, Steve K, Wakeham, Andrew, Boucher, Louis-Martin, Pintilie, Melania, Duncan, Gordon, Gajewska, Beata U, Gronski, Matthew, Eriksson, Urs, Odermatt, Bernhard, Ho, Alexandra, Bouchard, Denis, Whorisky, John S, Jordana, Manel, Ohashi, Pamela S, Pawson, Tony, Bladt, Friedhelm

“…Costimulation through the inducible costimulator (ICOS) and its ligand (ICOSL) is essential for T cell-dependent B cell responses, but the cellular and…”
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Chronic Exposure to Innocuous Antigen in Sensitized Mice Leads to Suppressed Airway Eosinophilia That Is Reversed by Granulocyte Macrophage Colony-Stimulating Factor by Swirski, Filip K, Sajic, Dusan, Robbins, Clinton S, Gajewska, Beata U, Jordana, Manel, Stampfli, Martin R

“…In this study we investigated the impact of chronic allergen exposure on airway inflammation and humoral responses in sensitized mice. We observed marked…”
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Effect of GM-CSF on immune, inflammatory, and clinical responses to ragweed in a novel mouse model of mucosal sensitization by Cates, Elizabeth C., Gajewska, Beata U., Goncharova, Susanna, Alvarez, David, Fattouh, Ramzi, Coyle, Anthony J., Gutierrez-Ramos, José-Carlos, Jordana, Manel

“…Background: Conventional models of allergic airway inflammation involve intraperitoneal administration of ovalbumin in conjunction with a chemical adjuvant…”
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B7RP-1 Is Not Required for the Generation of Th2 Responses in a Model of Allergic Airway Inflammation but Is Essential for the Induction of Inhalation Tolerance by Gajewska, Beata U, Tafuri, Anna, Swirski, Filip K, Walker, Tina, Johnson, Jill R, Shea, Theresa, Shahinian, Arda, Goncharova, Susanna, Mak, Tak W, Stampfli, Martin R, Jordana, Manel

“…The recently described ICOS-B7RP-1 costimulatory pathway has been implicated in the generation of effector Th2 responses and, hence, has become an attractive…”
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Granulocyte Macrophage Colony-Stimulating Factor-Driven Respiratory Mucosal Sensitization Induces Th2 Differentiation and Function Independently of Interleukin-4 by Ritz, Stacey A, Cundall, Meghan J, Gajewska, Beata U, Alvarez, David, Gutierrez-Ramos, Jose-Carlos, Coyle, Anthony J, McKenzie, Andrew N. J, Stampfli, Martin R, Jordana, Manel

“…The development of T helper (Th)2 responses is a key step in the pathogenesis of asthma. Interleukin (IL)-4 is thought to be important, although not strictly…”
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GM-CSF and dendritic cells in allergic airway inflammation: basic mechanisms and prospects for therapeutic intervention by Gajewska, Beata U, Wiley, Ryan E, Jordana, Manel

“…The interaction between dendritic cells (DC) and naïve T cells is the first step in the evolution of an immune response, either tolerogenic or inflammatory…”
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