Search Results - "Gajendrarao, Poornima"

Genomic Studies in a Large Cohort of Hearing Impaired Italian Patients Revealed Several New Alleles, a Rare Case of Uniparental Disomy (UPD) and the Importance to Search for Copy Number Variations by Morgan, Anna, Lenarduzzi, Stefania, Cappellani, Stefania, Pecile, Vanna, Morgutti, Marcello, Orzan, Eva, Ghiselli, Sara, Ambrosetti, Umberto, Brumat, Marco, Gajendrarao, Poornima, La Bianca, Martina, Faletra, Flavio, Grosso, Enrico, Sirchia, Fabio, Sensi, Alberto, Graziano, Claudio, Seri, Marco, Gasparini, Paolo, Girotto, Giorgia

“…Hereditary hearing loss (HHL) is a common disorder characterized by a huge genetic heterogeneity. The definition of a correct molecular diagnosis is essential…”
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Molecular modeling of disease causing mutations in domain C1 of cMyBP-C by Gajendrarao, Poornima, Krishnamoorthy, Navaneethakrishnan, Kassem, Heba Sh, Moharem-Elgamal, Sarah, Cecchi, Franco, Olivotto, Iacopo, Yacoub, Magdi H

“…Cardiac myosin binding protein-C (cMyBP-C) is a multi-domain (C0-C10) protein that regulates heart muscle contraction through interaction with myosin, actin…”
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Impact of disease-causing mutations on inter-domain interactions in cMyBP-C: a steered molecular dynamics study by Krishnamoorthy, Navaneethakrishnan, Gajendrarao, Poornima, Olivotto, Iacopo, Yacoub, Magdi

“…The molecular interactions of the sarcomeric proteins are essential in the regulation of various cardiac functions. Mutations in the gene MYBPC3 coding for…”
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A Strategy to Enhance Secretion of Extracellular Matrix Components by Stem Cells: Relevance to Tissue Engineering by Krishnamoorthy, Navaneethakrishnan, Tseng, Yuan-Tsan, Gajendrarao, Poornima, Sarathchandra, Padmini, McCormack, Ann, Carubelli, Ivan, Sohier, Jerome, Latif, Najma, Chester, Adrian H, Yacoub, Magdi H

“…The ability of cells to secrete extracellular matrix proteins is an important property in the repair, replacement, and regeneration of living tissue. Cells…”
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An Investigation of the Molecular Mechanism of Double cMyBP-C Mutation in a Patient with End-Stage Hypertrophic Cardiomyopathy by Gajendrarao, Poornima, Krishnamoorthy, Navaneethakrishnan, Selvaraj, Senthil, Girolami, Francesca, Cecchi, Franco, Olivotto, Iacopo, Yacoub, Magdi

“…Mutations in the gene coding for cardiac myosin binding protein-C (cMyBP-C), a multi-domain (C0-C10) protein, are a major causative factor for inherited…”
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Probing possible egress channels for multiple ligands in human CYP3A4: A molecular modeling study by Krishnamoorthy, Navaneethakrishnan, Gajendrarao, Poornima, Thangapandian, Sundarapandian, Lee, Yuno, Lee, Keun Woo

“…Human cytochrome P450 (CYP) 3A4 extensively contributes to metabolize 50% of the marketed drugs. Recently, a CYP3A4 structure with two molecules of…”
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Molecular modeling study on orphan human protein CYP4A22 for identification of potential ligand binding site by Gajendrarao, Poornima, Krishnamoorthy, Navaneethakrishnan, Sakkiah, Sugunadevi, Lazar, Prettina, Lee, Keun Woo

“…A molecular structure is an essential source to identify ligand binding sites in orphan human cytochrome P450 4A22 (CYP4A22) that belongs to family 4, which is…”
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Molecular modeling study of CodX reveals importance of N-terminal and C-terminal domain in the CodWX complex structure of Bacillus subtilis by Krishnamoorthy, Navaneethakrishnan, Gajendrarao, Poornima, Eom, Soo Hyun, Kwon, Yong Jung, Cheong, Gang-Won, Lee, Keun Woo

“…In Bacillus subtilis, CodW peptidase and CodX ATPase function together as a distinctive ATP-dependent protease called CodWX, which participates in protein…”
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