Search Results - "Gajbhiye, Asmita"

Ameliorative effect of Sida cordifolia in rotenone induced oxidative stress model of Parkinson's disease by Khurana, Navneet, Gajbhiye, Asmita

“…•Rotenone produced PD-like behavioral and neurochemical alterations.•Rotenone causes increased oxidative stress and histopathological changes.•AESC and AFSC…”
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Convenient Novel Method to Access N‑Benzylated Isatoic Anhydride: Reaction Behavior of Isatoic Anhydride with 4‑Chlorobenzyl Chloride in the Presence of Bases by Verma, Ekta, Patil, Shailendra, Gajbhiye, Asmita

“…Sodium hydride, potassium carbonate, and other bases are commonly used for N-alkylation of heterocyclic compounds. This report reveals the problems associated…”
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Exploration of quinazoline-tethered hydroxamic acid derivatives as HDAC inhibitors for anticancer activity: Design, synthesis, molecular docking, and biological evaluation by Mishra, Shweta, Verma, Ekta, Patil, Shailendra, Rajani, Dhanji P., Gajbhiye, Asmita

“…A novel series of quinazoline-tethered hydroxamic acids were designed, synthesized, and evaluated for in vitro HDAC inhibition, in vitro cytotoxicity, and in…”
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Floating microspheres encapsulating carvedilol for the effective management of hypertension by Patel, Sapna, Dubey, Naina, Gajbhiye, Asmita, Patil, Shailendra

“…Carvedilol (CVD) is an antihypertensive agent with a short half-life, pH-dependent solubility, and narrow absorption window. The purpose of this research was…”
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Sequential analysis for identification of byproduct from N -benzylation reaction: wound healing and anti-inflammatory potential of the byproduct 4-chlorobenzyl 2-((4-chlorobenzyl)amino)benzoate by Verma, Ekta, Patil, Shailendra, Gajbhiye, Asmita

“…A very common reaction, N -benzylation of isatoic anhydride in the presence of sodium hydride base, produces byproducts. The yield of one of the byproducts was…”
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Synthesis and Pharmacological Evaluation of (6-Substituted 4-Oxo-4H-chromene-3 yl) methyl N-substituted Aminoacetates by Gajbhiye, Asmita, Mallareddy, V, Achaiah, G

“…A series of the title compounds were synthesized and characterized by spectral data. All the compounds were evaluated for in vitro antihistaminic activity by…”
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Discovery of novel series of 4-quinolone hybrids as multi-targeting agent: Design, synthesis and H1-antihistaminic activity to treat allergic asthma by Verma, Ekta, Mishra, Shweta, Patil, Shailendra, Gajbhiye, Asmita

“…•The multi-targeted 4-quinolone hybrids are designed, synthesized and characterized for the treatment of allergic asthma.•Asthma-associated antihistaminic…”
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Bio-isosteric replacement of amide group with 1,2,3-triazole in phenacetin improves the toxicology and efficacy of phenacetin-triazole conjugates (PhTCs) by Sahu, Adarsh, Das, Debashree, Agrawal, Ram Kishore, Gajbhiye, Asmita

“…Inflammatory algesia and pyresia are common pathological consequences of physiological defense. Phenacetin introduced as effective analgesic anti-pyretic…”
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Heme-mimetic potential of iron conjugated pheophytin-I in attenuating oxidative stress-induced cellular and vascular toxicity by Das, Debashree, Patil, Shailendra, Gajbhiye, Asmita

“…Purpose of the Study: Heme is the cardinal porphyrin in systemic physiology, apart from hemoglobin it forms structural skeleton of physiological antioxidants…”
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Sequential analysis for identification of byproduct from -benzylation reaction: wound healing and anti-inflammatory potential of the byproduct 4-chlorobenzyl 2-((4-chlorobenzyl)amino)benzoate by Verma, Ekta, Patil, Shailendra, Gajbhiye, Asmita

“…A very common reaction, N -benzylation of isatoic anhydride in the presence of sodium hydride base, produces byproducts. The yield of one of the byproducts was…”
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Bioisosteric Replacement of Amide Group with 1,2,3-Triazoles in Acetaminophen Addresses Reactive Oxygen Species-Mediated Hepatotoxic Insult in Wistar Albino Rats by Sahu, Adarsh, Das, Debashree, Sahu, Preeti, Mishra, Shweta, Sakthivel, Ayyamperumal, Gajbhiye, Asmita, Agrawal, Ramkishore

“…Acetaminophen (AP) is a popularly recommended over-the-counter analgesic–antipyretic in clinical use. However, the drug is handicapped by the occurrence of…”
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Exploring sodium glucose cotransporter (SGLT2) inhibitors with machine learning approach: A novel hope in anti-diabetes drug discovery by Moinul, Md, Amin, Sk Abdul, Kumar, Prabhat, Patil, Umesh Kumar, Gajbhiye, Asmita, Jha, Tarun, Gayen, Shovanlal

“…Conventional anti-diabetes agents exhibit some undesirable side effects. Recently, lactic acidosis and/or bladder cancer were also reported with the use of…”
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Pharmacological evaluation of mangiferin herbosomes for antioxidant and hepatoprotection potential against ethanol induced hepatic damage by Jain, Pushpendra Kumar, Kharya, Murlidhar, Gajbhiye, Asmita

“…Context: Fatty liver is the first stage of alcoholic damage which is reversible with abstinence from alcohol. Mangiferin (MF) showed potent scavenging activity…”
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Design, Synthesis, and Molecular Docking Analysis of 4‐Quinolone‐2‐Carboxylic Acid Derivatives as Antimicrobial Agents by Verma, Ekta, Mishra, Shweta, Pal, Mahendra Kumar, Patil, Shailendra, Gajbhiye, Asmita

“…Quinolones represent a class of potent antibacterial agents that primarily function by inhibiting bacterial topoisomerases and DNA gyrase. A crucial feature of…”
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PASS assisted prediction and pharmacological evaluation of novel nicotinic analogs for nootropic activity in mice by Khurana, Navneet, Ishar, Mohan Pal Singh, Gajbhiye, Asmita, Goel, Rajesh Kumar

“…The aim of present study is to predict the probable nootropic activity of novel nicotine analogues with the help of computer program, PASS (prediction of…”
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Synthesis, Characterization and Pharmacological Evaluation of Ultra Short Dipeptides as Antimicrobial and Anticancer Agents by Rai, Neha, Rathore, Swati, Tiwari, Richa Tripathy, Patil, Shailendra, Gajbhiye, Asmita

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Design and in silico Prediction of New Methylenedioxyphenyl Derivatives as DNA Topoisomerase II Inhibitors by Rathore, Swati, Reddemma, Maadhu, Rai, Neha, Tiwari, Richa Tripathy, Begum, Shaheen, Patil, Shailendra, Patil, Asmita Gajbhiye

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AMELIORATIVE EFFECT OF SIDA CORDIFOLIA L. AGAINST SCOPOLAMINE-INDUCED COGNITIVE DEFICIT MICE MODEL by Khurana, Navneet, Sharma, Neha, Patil, Shailendra, Gajbhiye, Asmita

“…  Objective: In this study, ameliorative effect of aqueous extracts of Sida cordifolia and hydroethanolic extracts of S. cordifolia L. (AESC and EESC,…”
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Enhancement of absorption and hepatoprotective potential through soya-phosphatidylcholine-andrographolide vesicular system by Jain, Pushpendra Kumar, Khurana, Navneet, Pounikar, Yogesh, Gajbhiye, Asmita, Kharya, Murli Dhar

“…Abstract Andrographis paniculata is a medicinal herb used extensively for various ailments and contains therapeutically active phytoconstituent,…”
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Development of mesophasic microreservoir-based transdermal drug delivery system of propranolol by Omray, L K, Kohli, S, Khopade, A J, Patil, S, Gajbhiye, Asmita, Agrawal, G P

“…The mesophasic microreservoir comprises lyotrophic liquid crystals. The liquid crystals were prepared of Brij-35, cetosteryl alcohol and propranolol and…”
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