Search Results - "Gaisano, Herbert Y."

Here come the newcomer granules, better late than never by Gaisano, Herbert Y

“…Highlights • Different Munc18/SNARE complexes mediate distinct insulin exocytotic events in β-cells. • The Syntaxin-3/VAMP8/SNAP25 SNARE complex mediates…”
Get full text

Plasma membrane flipping of Syntaxin-2 regulates its inhibitory action on insulin granule exocytosis by Kang, Fei, Xie, Li, Qin, Tairan, Miao, Yifan, Kang, Youhou, Takahashi, Toshimasa, Liang, Tao, Xie, Huanli, Gaisano, Herbert Y.

“…Enhancing pancreatic β-cell secretion is a primary therapeutic target for type-2 diabetes (T2D). Syntaxin-2 (Stx2) has just been identified to be an inhibitory…”
Get full text

Cell polarity defines three distinct domains in pancreatic β-cells by Gan, Wan J, Zavortink, Michael, Ludick, Christine, Templin, Rachel, Webb, Robyn, Webb, Richard, Ma, Wei, Poronnik, Philip, Parton, Robert G, Gaisano, Herbert Y, Shewan, Annette M, Thorn, Peter

“…The structural organisation of pancreatic β-cells in the islets of Langerhans is relatively unknown. Here, using three-dimensional (3D) two-photon, 3D confocal…”
Get full text

Elevated triglyceride-glucose (TyG) index predicts incidence of Prediabetes: a prospective cohort study in China by Wen, Jing, Wang, Anping, Liu, Guangxu, Wang, Meiping, Zuo, Yingting, Li, Wei, Zhai, Qi, Mu, Yiming, Gaisano, Herbert Y., He, Yan, Dou, Jingtao

“…Abstract Background Prediabetes has become a pandemic. This study aimed to identify a better predictor for the incidence of prediabetes, which we hypothesize…”
Get full text

Pancreatitis-Induced Depletion of Syntaxin 2 Promotes Autophagy and Increases Basolateral Exocytosis by Dolai, Subhankar, Liang, Tao, Orabi, Abrahim I., Holmyard, Douglas, Xie, Li, Greitzer-Antes, Dafna, Kang, Youhou, Xie, Huanli, Javed, Tanveer A., Lam, Patrick P., Rubin, Deborah C., Thorn, Peter, Gaisano, Herbert Y.

“…Pancreatic acinar cells are polarized epithelial cells that store enzymes required for digestion as inactive zymogens, tightly packed at the cell apex…”
Get full text

Ex vivo human pancreatic slice preparations offer a valuable model for studying pancreatic exocrine biology by Liang, Tao, Dolai, Subhankar, Xie, Li, Winter, Erin, Orabi, Abrahim I., Karimian, Negar, Cosen-Binker, Laura I., Huang, Ya-Chi, Thorn, Peter, Cattral, Mark S., Gaisano, Herbert Y.

“…A genuine understanding of human exocrine pancreas biology and pathobiology has been hampered by a lack of suitable preparations and reliance on rodent models…”
Get full text

Insulin secretion from beta cells in intact mouse islets is targeted towards the vasculature by Low, Jiun T., Zavortink, Michael, Mitchell, Justin M., Gan, Wan J., Do, Oanh Hoang, Schwiening, Christof J., Gaisano, Herbert Y., Thorn, Peter

“…Aims/hypothesis We set out to test the hypothesis that insulin secretion from beta cells is targeted towards the vasculature. Methods The spatial location of…”
Get full text

Vesicle-associated Membrane Protein 8 (VAMP8) Is a SNARE (Soluble N-Ethylmaleimide-sensitive Factor Attachment Protein Receptor) Selectively Required for Sequential Granule-to-granule Fusion by Behrendorff, Natasha, Dolai, Subhankar, Hong, Wanjin, Gaisano, Herbert Y., Thorn, Peter

“…Compound exocytosis is found in many cell types and is the major form of regulated secretion in acinar and mast cells. Its key characteristic is the homotypic…”
Get full text

Higher systolic blood pressure is specifically associated with better islet beta-cell function in T2DM patients with high glycemic level by Xia, Zhang, Song, Lijuan, Fang, Dongdong, You, Wenjun, Li, Feng, Zheng, Deqiang, Li, Yuhao, Lin, Lu, Dou, Jingtao, Su, Xin, Zhai, Qi, Zuo, Yingting, Zhang, Yibo, Gaisano, Herbert Y, Jiang, Jiajia, He, Yan

“…Patients with type 2 diabetes mellitus (T2DM) usually have higher blood viscosity attributed to high blood glucose that can decrease blood supply to the…”
Get full text

Entamoeba histolytica -Induced Mucin Exocytosis Is Mediated by VAMP8 and Is Critical in Mucosal Innate Host Defense by Cornick, Steve, Moreau, France, Gaisano, Herbert Y, Chadee, Kris

“…Intestinal mucus secretion is critical in maintaining mucosal host defense against a myriad of pathogens by preventing direct association with the epithelium…”
Get full text

New Roles of Syntaxin-1A in Insulin Granule Exocytosis and Replenishment by Liang, Tao, Qin, Tairan, Xie, Li, Dolai, Subhankar, Zhu, Dan, Prentice, Kacey J., Wheeler, Michael, Kang, Youhou, Osborne, Lucy, Gaisano, Herbert Y.

“…In type-2 diabetes (T2D), severely reduced islet syntaxin-1A (Syn-1A) levels contribute to insulin secretory deficiency. We generated β-cell-specific Syn-1A-KO…”
Get full text

Association of Diabetes and Prognosis of Minor Stroke and Its Subtypes: A Prospective Observational Study by Pan, Yuesong, Wang, Yongjun, Li, Hao, Gaisano, Herbert Y, Wang, Yilong, He, Yan

“…The association between diabetes mellitus (DM) and prognosis of minor stroke is unclear. The aim of this study is to investigate whether DM contributes to the…”
Get full text

The secretory deficit in islets from db/db mice is mainly due to a loss of responding beta cells by Do, Oanh H., Low, Jiun T., Gaisano, Herbert Y., Thorn, Peter

“…Aims/hypothesis We used the db / db mouse to determine the nature of the secretory defect in intact islets. Methods Glucose tolerance was compared in db / db…”
Get full text

Exocyst sec5 regulates exocytosis of newcomer insulin granules underlying biphasic insulin secretion by Xie, Li, Zhu, Dan, Kang, Youhou, Liang, Tao, He, Yu, Gaisano, Herbert Y

“…The exocyst complex subunit Sec5 is a downstream effector of RalA-GTPase which promotes RalA-exocyst interactions and exocyst assembly, serving to tether…”
Get full text

The SNARE Protein Syntaxin-1a Plays an Essential Role in Biphasic Exocytosis of the Incretin Hormone Glucagon-Like Peptide 1 by Wheeler, Sarah E, Stacey, Holly M, Nahaei, Yasaman, Hale, Stephen J, Hardy, Alexandre B, Reimann, Frank, Gribble, Fiona M, Larraufie, Pierre, Gaisano, Herbert Y, Brubaker, Patricia L

“…Exocytosis of the hormone glucagon-like peptide 1 (GLP-1) by the intestinal L cell is essential for the incretin effect after nutrient ingestion and is…”
Get full text

Syntaxin-4 mediates exocytosis of pre-docked and newcomer insulin granules underlying biphasic glucose-stimulated insulin secretion in human pancreatic beta cells by Xie, Li, Zhu, Dan, Dolai, Subhankar, Liang, Tao, Qin, Tairan, Kang, Youhou, Xie, Huanli, Huang, Ya-Chi, Gaisano, Herbert Y.

“…Aims/hypothesis Of the four exocytotic syntaxins (Syns), much is now known about the role of Syn-1A (pre-docked secretory granules [SGs]) and Syn-3 (newcomer…”
Get full text

Spatial and temporal coordination of insulin granule exocytosis in intact human pancreatic islets by Almaça, Joana, Liang, Tao, Gaisano, Herbert Y., Nam, Hong Gil, Berggren, Per-Olof, Caicedo, Alejandro

“…Aims/hypothesis Insulin secretion is widely studied because it plays a central role in glucose homeostasis and diabetes. Processes from insulin granule fusion…”
Get full text

SUMOylation Regulates Insulin Exocytosis Downstream of Secretory Granule Docking in Rodents and Humans by DAI, Xiao-Qing, PLUMMER, Greg, CASIMIR, Marina, YOUHOU KANG, HAJMRLE, Catherine, GAISANO, Herbert Y, MANNING FOX, Jocelyn E, MACDONALD, Patrick E

“…The reversible attachment of small ubiquitin-like modifier (SUMO) proteins controls target localization and function. We examined an acute role for the…”
Get full text

Mediating effect of adiponectin between free fatty acid and tumor necrosis factor-α in patients with diabetes by Xia, Zhang, Shi, Shulong, Ma, Xiaoqing, Li, Feng, Li, Xinya, Gaisano, Herbert Y., Zhao, Mingyang, Li, Yuhao, He, Yan, Jiang, Jiajia

“…Background/Objectives Increased free fatty acid (FFA) promotes adiponectin secretion in healthy subjects and induces inflammation in diabetes. Given the…”
Get full text

Cell-to-Cell Communication and the Regulation of Pancreatic Function by Thorn, Peter, Gaisano, Herbert Y

Get full text