Search Results - "Gaisa, Nadine"

Mechanisms of organ fibrosis: Emerging concepts and implications for novel treatment strategies by Lurje, Isabella, Gaisa, Nadine T., Weiskirchen, Ralf, Tacke, Frank

“…Fibrosis, or tissue scarring, develops as a pathological deviation from the physiological wound healing response and can occur in various organs such as the…”
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Benchmarking weakly-supervised deep learning pipelines for whole slide classification in computational pathology by Ghaffari Laleh, Narmin, Muti, Hannah Sophie, Loeffler, Chiara Maria Lavinia, Echle, Amelie, Saldanha, Oliver Lester, Mahmood, Faisal, Lu, Ming Y., Trautwein, Christian, Langer, Rupert, Dislich, Bastian, Buelow, Roman D., Grabsch, Heike Irmgard, Brenner, Hermann, Chang-Claude, Jenny, Alwers, Elizabeth, Brinker, Titus J., Khader, Firas, Truhn, Daniel, Gaisa, Nadine T., Boor, Peter, Hoffmeister, Michael, Schulz, Volkmar, Kather, Jakob Nikolas

“…•We provide a large-scale benchmarking comparison of multiple Deep Learning approaches for analysis of pathology slides in multiple large patient cohorts.•HIA,…”
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ARID1A-deficiency in urothelial bladder cancer: No predictive biomarker for EZH2-inhibitor treatment response? by Garczyk, Stefan, Schneider, Ursula, Lurje, Isabella, Becker, Katharina, Vögeli, Thomas A, Gaisa, Nadine T, Knüchel, Ruth

“…Bladder cancer therapy relies on aggressive treatments highlighting the need for new, targeted therapies with reduced side effects. SWI/SNF complexes are…”
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TERT promoter mutation analysis as a surrogate to morphology and immunohistochemistry in problematic spindle cell lesions of the urinary bladder by Bertz, Simone, Stöhr, Robert, Gaisa, Nadine T, Wullich, Bernd, Hartmann, Arndt, Agaimy, Abbas

“…Aims Pseudosarcomatous myofibroblastic proliferations (PSMPs) of the urinary bladder are diagnostically challenging. Diagnostic difficulties are mainly due to…”
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Nerve fibers in the tumor microenvironment in neurotropic cancer—pancreatic cancer and cholangiocarcinoma by Tan, Xiuxiang, Sivakumar, Shivan, Bednarsch, Jan, Wiltberger, Georg, Kather, Jakob Nikolas, Niehues, Jan, de Vos-Geelen, Judith, Valkenburg-van Iersel, Liselot, Kintsler, Svetlana, Roeth, Anjali, Hao, Guangshan, Lang, Sven, Coolsen, Mariëlle E., den Dulk, Marcel, Aberle, Merel R., Koolen, Jarne, Gaisa, Nadine T., Olde Damink, Steven W. M., Neumann, Ulf P., Heij, Lara R.

“…Pancreatic ductal adenocarcinoma (PDAC) and cholangiocarcinoma (CCA) are both deadly cancers and they share many biological features besides their close…”
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Scoring Systems for Immunohistochemistry in Urothelial Carcinoma by Bösherz, Mark-Sebastian, Samarska, Iryna V, Gaisa, Nadine T

“…Immunohistochemistry is widely used in diagnostic and scientific analysis of urothelial carcinoma. Objective interpretation of staining results is mandatory…”
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Epigenetic inactivation of ST6GAL1 in human bladder cancer by Antony, Pia, Rose, Michael, Heidenreich, Axel, Knüchel, Ruth, Gaisa, Nadine T, Dahl, Edgar

“…Posttranslational protein modifications are known to modulate key biological processes like proliferation and apoptosis. Accumulating evidence shows that…”
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Next-Generation Sequencing Reveals Potential Predictive Biomarkers and Targets of Therapy for Urothelial Carcinoma in Situ of the Urinary Bladder by Garczyk, Stefan, Ortiz-Brüchle, Nadina, Schneider, Ursula, Lurje, Isabella, Guricova, Karolina, Gaisa, Nadine T., Lorsy, Eva, Lindemann-Docter, Katharina, Heidenreich, Axel, Knüchel, Ruth

“…Bacillus Calmette-Guérin instillation after removal of the tumor is the first line of treatment for urothelial carcinoma in situ (CIS), the precursor lesion of…”
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Progression of urothelial carcinoma in situ of the urinary bladder: a switch from luminal to basal phenotype and related therapeutic implications by Barth, Isabella, Schneider, Ursula, Grimm, Tobias, Karl, Alexander, Horst, David, Gaisa, Nadine T., Knüchel, Ruth, Garczyk, Stefan

“…The stratification of bladder cancer into luminal and basal tumors has recently been introduced as a novel prognostic system in patient cohorts of…”
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EGFR activity addiction facilitates anti-ERBB based combination treatment of squamous bladder cancer by Rose, Michael, Maurer, Angela, Wirtz, Julia, Bleilevens, Andreas, Waldmann, Tanja, Wenz, Maximilian, Eyll, Marie, Geelvink, Mirja, Gereitzig, Melanie, Rüchel, Nadine, Denecke, Bernd, Eltze, Elke, Herrmann, Edwin, Toma, Marieta, Horst, David, Grimm, Tobias, Denzinger, Stefan, Ecke, Thorsten, Vögeli, Thomas Alexander, Knuechel, Ruth, Maurer, Jochen, Gaisa, Nadine T.

“…Recent findings suggested a benefit of anti-EGFR therapy for basal-like muscle-invasive bladder cancer (MIBC). However, the impact on bladder cancer with…”
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Immunohistochemical Analysis of Urothelial Carcinoma Tissues for Proliferation and Differentiation Markers by Rose, Michael, Gaisa, Nadine T

“…Immunohistochemistry is a standard method in histopathology and enables the localized detection of proteins in histological tissue sections. Specific…”
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The detection of isochromosome i(12p) in malignant germ cell tumours and tumours with somatic malignant transformation by the use of quantitative real‐time polymerase chain reaction by Fichtner, Alexander, Richter, Annika, Filmar, Simon, Gaisa, Nadine T, Schweyer, Stefan, Reis, Henning, Nettersheim, Daniel, Oing, Christoph, Gayer, Fabian A, Leha, Andreas, Küffer, Stefan, Ströbel, Philipp, Kaulfuß, Silke, Bremmer, Felix

“…Aims Malignant germ cell tumours (GCTs) of the testis are rare neoplasms, but the most common solid malignancies in young men. World Health Organization…”
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Characterisation of tumour-immune phenotypes and PD-L1 positivity in squamous bladder cancer by Jung, Max, Rose, Michael, Knuechel, Ruth, Loeffler, Chiara, Muti, Hannah, Kather, Jakob Nikolas, Gaisa, Nadine T

“…Immune checkpoint inhibitor (ICI) therapy has become a viable treatment strategy in bladder cancer. However, treatment responses vary, and improved biomarkers…”
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Not all false positive diagnoses are equal: On the prognostic implications of false-positive diagnoses made in breast MRI versus in mammography / digital tomosynthesis screening by Kuhl, Christiane K, Keulers, Annika, Strobel, Kevin, Schneider, Hannah, Gaisa, Nadine, Schrading, Simone

“…Breast magnetic resonance imaging (MRI) has been reported to frequently result in false-positive diagnoses, limiting its positive predictive value (PPV)…”
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Liver Phenotypes of European Adults Heterozygous or Homozygous for Pi∗Z Variant of AAT (Pi∗MZ vs Pi∗ZZ genotype) and Noncarriers by Schneider, Carolin V., Hamesch, Karim, Gross, Annika, Mandorfer, Mattias, Moeller, Linda S., Pereira, Vitor, Pons, Monica, Kuca, Pawel, Reichert, Matthias C., Benini, Federica, Burbaum, Barbara, Voss, Jessica, Gutberlet, Marla, Woditsch, Vivien, Lindhauer, Cecilia, Fromme, Malin, Kümpers, Julia, Bewersdorf, Lisa, Schaefer, Benedikt, Eslam, Mohammed, Bals, Robert, Janciauskiene, Sabina, Carvão, Joana, Neureiter, Daniel, Zhou, Biaohuan, Wöran, Katharina, Bantel, Heike, Geier, Andreas, Dirrichs, Timm, Stickel, Felix, Teumer, Alexander, Verbeek, Jef, Nevens, Frederik, Govaere, Olivier, Krawczyk, Marcin, Roskams, Tania, Haybaeck, Johannes, Lurje, Georg, Chorostowska-Wynimko, Joanna, Genesca, Joan, Reiberger, Thomas, Lammert, Frank, Krag, Aleksander, George, Jacob, Anstee, Quentin M., Trauner, Michael, Datz, Christian, Gaisa, Nadine T., Denk, Helmut, Trautwein, Christian, Aigner, Elmar, Strnad, Pavel

“…Homozygosity for the Pi∗Z variant of the gene that encodes the alpha-1 antitrypsin peptide (AAT), called the Pi∗ZZ genotype, causes a liver and lung disease…”
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Evaluation of Therapeutic Targets in Histological Subtypes of Bladder Cancer by Wucherpfennig, Sophie, Rose, Michael, Maurer, Angela, Cassataro, Maria Angela, Seillier, Lancelot, Morsch, Ronja, Hammad, Ehab, Baldia, Philipp Heinrich, Ecke, Thorsten H, Vögeli, Thomas-Alexander, Knüchel, Ruth, Gaisa, Nadine T

“…Histologically, bladder cancer is a heterogeneous group comprising urothelial carcinoma (UC), squamous cell carcinoma, adenocarcinomas (ACs), urachal…”
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Upregulation of the long non-coding RNA CASC9 as a biomarker for squamous cell carcinoma by Sassenberg, Madeleine, Droop, Johanna, Schulz, Wolfgang A, Dietrich, Dimo, Loick, Sophia Marie, Wiek, Constanze, Scheckenbach, Kathrin, Gaisa, Nadine T, Hoffmann, Michèle J

“…Few diagnostic and prognostic biomarkers are available for head-and-neck squamous cell carcinoma (HNSCC). Long non-coding RNAs (lncRNAs) have shown promise as…”
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Diagnostic and Prognostic Implications of FGFR3high/Ki67high Papillary Bladder Cancers by Geelvink, Mirja, Babmorad, Armin, Maurer, Angela, Stöhr, Robert, Grimm, Tobias, Bach, Christian, Knuechel, Ruth, Rose, Michael, Gaisa, Nadine

“…Prognostic/therapeutic stratification of papillary urothelial cancers is solely based upon histology, despite activated FGFR3-signaling was found to be…”
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Multiregion human bladder cancer sequencing reveals tumour evolution, bladder cancer phenotypes and implications for targeted therapy by Heide, Timon, Maurer, Angela, Eipel, Monika, Knoll, Katrin, Geelvink, Mirja, Veeck, Juergen, Knuechel, Ruth, van Essen, Julius, Stoehr, Robert, Hartmann, Arndt, Altmueller, Janine, Graham, Trevor A, Gaisa, Nadine T

“…We present an evolutionary analysis of the relative time of genetic events underlying tumorigenesis in human bladder cancers from 10 whole cystectomy specimens…”
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Hepatobiliary phenotypes of adults with alpha-1 antitrypsin deficiency by Fromme, Malin, Schneider, Carolin V, Pereira, Vitor, Hamesch, Karim, Pons, Monica, Reichert, Matthias C, Benini, Federica, Ellis, Paul, H Thorhauge, Katrine, Mandorfer, Mattias, Burbaum, Barbara, Woditsch, Vivien, Chorostowska-Wynimko, Joanna, Verbeek, Jef, Nevens, Frederik, Genesca, Joan, Miravitlles, Marc, Nuñez, Alexa, Schaefer, Benedikt, Zoller, Heinz, Janciauskiene, Sabina, Abreu, Nélia, Jasmins, Luís, Gaspar, Rui, Liberal, Rodrigo, Macedo, Guilherme, Mahadeva, Ravi, Gomes, Catarina, Schneider, Kai Markus, Trauner, Michael, Krag, Aleksander, Gooptu, Bibek, Thorburn, Douglas, Marshall, Aileen, Hurst, John R, Lomas, David A, Lammert, Frank, Gaisa, Nadine T, Clark, Virginia, Griffiths, William, Trautwein, Christian, Turner, Alice M, McElvaney, Noel G, Strnad, Pavel

“…Alpha-1 antitrypsin deficiency (AATD) is a common, potentially lethal inborn disorder caused by mutations in alpha-1 antitrypsin (AAT). Homozygosity for the…”
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