Search Results - "Gainous, T Blair"
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Early Chordate Origins of the Vertebrate Second Heart Field
Published in Science (American Association for the Advancement of Science) (30-07-2010)“…The vertebrate heart is formed from diverse embryonic territories, including the first and second heart fields. The second heart field (SHF) gives rise to the…”
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2
Loss-of-function variants in myocardin cause congenital megabladder in humans and mice
Published in The Journal of clinical investigation (01-12-2019)“…Myocardin (MYOCD) is the founding member of a class of transcriptional coactivators that bind the serum-response factor to activate gene expression programs…”
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3
Cooperative activation of cardiac transcription through myocardin bridging of paired MEF2 sites
Published in Development (Cambridge) (01-04-2017)“…Enhancers frequently contain multiple binding sites for the same transcription factor. These homotypic binding sites often exhibit synergy, whereby the…”
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4
Diverse ETS transcription factors mediate FGF signaling in the Ciona anterior neural plate
Published in Developmental biology (15-03-2015)“…The ascidian Ciona intestinalis is a marine invertebrate belonging to the sister group of the vertebrates, the tunicates. Its compact genome and simple,…”
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5
The pre-vertebrate origins of neurogenic placodes
Published in Nature (London) (27-08-2015)“…A study showing that tunicates possess a proto-placodal ectoderm that produces neurons with dual neurosecretory and chemosensory function, which may represent…”
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6
Cooperative activation of cardiac transcription through myocardin bridging of paired MEF2 sites
Published in Development (Cambridge) (28-03-2017)“…Enhancers frequently contain multiple binding sites for the same transcription factor. These homotypic binding sites often exhibit synergy, whereby the…”
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Journal Article -
7
Improving few-shot learning-based protein engineering with evolutionary sampling
Published 23-05-2023“…Designing novel functional proteins remains a slow and expensive process due to a variety of protein engineering challenges; in particular, the number of…”
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