Search Results - "Gaine, Marie E."

Sleep Deprivation and the Epigenome by Gaine, Marie E, Chatterjee, Snehajyoti, Abel, Ted

“…Sleep deprivation disrupts the lives of millions of people every day and has a profound impact on the molecular biology of the brain. These effects begin as…”
Get full text

Altered hippocampal transcriptome dynamics following sleep deprivation by Gaine, Marie E, Bahl, Ethan, Chatterjee, Snehajyoti, Michaelson, Jacob J, Abel, Ted, Lyons, Lisa C

“…Widespread sleep deprivation is a continuing public health problem in the United States and worldwide affecting adolescents and adults. Acute sleep deprivation…”
Get full text

Translational changes induced by acute sleep deprivation uncovered by TRAP-Seq by Lyons, Lisa C, Chatterjee, Snehajyoti, Vanrobaeys, Yann, Gaine, Marie E, Abel, Ted

“…Sleep deprivation is a global health problem adversely affecting health as well as causing decrements in learning and performance. Sleep deprivation induces…”
Get full text

Protein Kinase A in neurological disorders by Glebov-McCloud, Alexander G P, Saide, Walter S, Gaine, Marie E, Strack, Stefan

“…Cyclic adenosine 3', 5' monophosphate (cAMP)-dependent Protein Kinase A (PKA) is a multi-functional serine/threonine kinase that regulates a wide variety of…”
Get full text

The CBP KIX domain regulates long-term memory and circadian activity by Chatterjee, Snehajyoti, Angelakos, Christopher C, Bahl, Ethan, Hawk, Joshua D, Gaine, Marie E, Poplawski, Shane G, Schneider-Anthony, Anne, Yadav, Manish, Porcari, Giulia S, Cassel, Jean-Christophe, Giese, K Peter, Michaelson, Jacob J, Lyons, Lisa C, Boutillier, Anne-Laurence, Abel, Ted

“…CREB-dependent transcription necessary for long-term memory is driven by interactions with CREB-binding protein (CBP), a multi-domain protein that binds…”
Get full text

Blood epigenome-wide association studies of suicide attempt in adults with bipolar disorder by Mirza, Salahudeen, Lima, Camila N. C., Del Favero-Campbell, Alexandra, Rubinstein, Alexandre, Topolski, Natasha, Cabrera-Mendoza, Brenda, Kovács, Emese H. C., Blumberg, Hilary P., Richards, Jenny Gringer, Williams, Aislinn J., Wemmie, John A., Magnotta, Vincent A., Fiedorowicz, Jess G., Gaine, Marie E., Walss-Bass, Consuelo, Quevedo, Joao, Soares, Jair C., Fries, Gabriel R.

“…Suicide attempt (SA) risk is elevated in individuals with bipolar disorder (BD), and DNA methylation patterns may serve as possible biomarkers of SA. We…”
Get full text

A Genotype-Phenotype Analysis of Glutathione Peroxidase 4 in Human Atrial Myocardium and Its Association with Postoperative Atrial Fibrillation by Berdaweel, Islam A, Hart, Alexander A, Jatis, Andrew J, Karlan, Nathan, Akhter, Shahab A, Gaine, Marie E, Smith, Ryan M, Anderson, Ethan J

“…Heterogeneity in the incidence of postoperative atrial fibrillation (POAF) following heart surgery implies that underlying genetic and/or physiological factors…”
Get full text

Dissecting 16p11.2 hemi-deletion to study sex-specific striatal phenotypes of neurodevelopmental disorders by Kim, Jaekyoon, Vanrobaeys, Yann, Kelvington, Benjamin, Peterson, Zeru, Baldwin, Emily, Gaine, Marie E., Nickl-Jockschat, Thomas, Abel, Ted

“…Neurodevelopmental disorders (NDDs) are polygenic in nature and copy number variants (CNVs) are ideal candidates to study the nature of this polygenic risk…”
Get full text

Organophosphorus pesticide exposure from house dust and parent-reported child behavior in Latino children from an orchard community by Khan, Khalid M., Gaine, Marie E., Daniel, Alyssa R., Chilamkuri, Pavani, Rohlman, Diane S.

“…Organophosphorus pesticide (OP) exposure is known to have adverse effects on the nervous system. Children from agricultural communities are at risk of exposure…”
Get full text

A mutation in the PRKAR1B gene drives pathological mechanisms of neurodegeneration across species by Benjamin-Zukerman, Tal, Shimon, Gilat, Gaine, Marie E, Dakwar, Anwar, Peled, Netta, Aboraya, Mohammad, Masri-Ismail, Ashar, Safadi-Safa, Rania, Solomon, Meir, Lev-Ram, Varda, Rissman, Robert A, Mayrhofer, Johanna E, Raffeiner, Andrea, Mol, Merel O, Argue, Benney M R, McCool, Shaylah, Doan, Binh, van Swieten, John, Stefan, Eduard, Abel, Ted, Ilouz, Ronit

“…Protein Kinase A (PKA) neuronal function is controlled by the interaction of a regulatory (R) subunit dimer to two catalytic (C) subunits. Recently, the L50R…”
Get full text

Cerebellar morphological differences and associations with extrinsic factors in bipolar disorder type I by Harmata, Gail I.S., Barsotti, Ercole John, Casten, Lucas G., Fiedorowicz, Jess G., Williams, Aislinn, Shaffer, Joseph J., Richards, Jenny Gringer, Sathyaputri, Leela, Schmitz, Samantha L., Christensen, Gary E., Long, Jeffrey D., Gaine, Marie E., Xu, Jia, Michaelson, Jake J., Wemmie, John A., Magnotta, Vincent A.

“…The neural underpinnings of bipolar disorder (BD) remain poorly understood. The cerebellum is ideally positioned to modulate emotional regulation circuitry yet…”
Get full text

Association between the epigenetic lifespan predictor GrimAge and history of suicide attempt in bipolar disorder by Lima, Camila N C, Kovács, Emese H C, Mirza, Salahudeen, Del Favero-Campbell, Alexandra, Diaz, Alexandre Paim, Quevedo, Joao, Argue, Benney M R, Richards, Jenny Gringer, Williams, Aislinn, Wemmie, John A, Magnotta, Vincent A, Fiedorowicz, Jess G, Soares, Jair C, Gaine, Marie E, Fries, Gabriel R

“…Bipolar disorder (BD) has been previously associated with premature mortality and aging, including acceleration of epigenetic aging. Suicide attempts (SA) are…”
Get full text

Differentially methylated regions in bipolar disorder and suicide by Gaine, Marie E., Seifuddin, Fayaz, Sabunciyan, Sarven, Lee, Richard S., Benke, Kelly S., Monson, Eric T., Zandi, Peter P., Potash, James B., Willour, Virginia L.

“…The addition of a methyl group to, typically, a cytosine‐guanine dinucleotide (CpG) creates distinct DNA methylation patterns across the genome that can…”
Get full text

Targeted sequencing of the LRRTM gene family in suicide attempters with bipolar disorder by Reichman, Rachel D., Gaynor, Sophia C., Monson, Eric T., Gaine, Marie E., Parsons, Meredith G., Zandi, Peter P., Potash, James B., Willour, Virginia L.

“…Glutamatergic signaling is the primary excitatory neurotransmission pathway in the brain, and its relationship to neuropsychiatric disorders is of considerable…”
Get full text

Male-specific association of the 2p25 region with suicide attempt in bipolar disorder by Gaynor, Sophia C., Monson, Eric T., Gaine, Marie E., Chimenti, Michael S., Reichman, Rachel D., Parsons, Meredith, Oonthonpan, Lalita, Zandi, Peter P., Potash, James B., Willour, Virginia L.

“…We previously conducted a genome-wide association study (GWAS) of attempted suicide within bipolar disorder, which implicated common variation in the 2p25…”
Get full text

GATA2 regulates the erythropoietin receptor in t(12;21) ALL by Gaine, Marie E, Sharpe, Daniel J, Smith, James S, Colyer, Hilary A A, Hodges, Vivien M, Lappin, Terry R, Mills, Ken I

“…The t(12;21) (p13;q22) chromosomal translocation resulting in the fusion gene is the most frequent structural cytogenetic abnormality in children with acute…”
Get full text

Assessment of Whole-Exome Sequence Data in Attempted Suicide within a Bipolar Disorder Cohort by Monson, Eric T, Pirooznia, Mehdi, Parla, Jennifer, Kramer, Melissa, Goes, Fernando S, Gaine, Marie E, Gaynor, Sophia C, de Klerk, Kelly, Jancic, Dubravka, Karchin, Rachel, McCombie, W Richard, Zandi, Peter P, Potash, James B, Willour, Virginia L

“…Suicidal behavior is a complex and devastating phenotype with a heritable component that has not been fully explained by existing common genetic variant…”
Get full text