Search Results - "Gaillard, Pieter J"

Pharmacokinetics, brain delivery, and efficacy in brain tumor-bearing mice of glutathione pegylated liposomal doxorubicin (2B3-101) by Gaillard, Pieter J, Appeldoorn, Chantal C M, Dorland, Rick, van Kregten, Joan, Manca, Francesca, Vugts, Danielle J, Windhorst, Bert, van Dongen, Guus A M S, de Vries, Helga E, Maussang, David, van Tellingen, Olaf

“…Brain cancer is a devastating disease affecting many people worldwide. Effective treatment with chemotherapeutics is limited due to the presence of the…”
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Enhanced brain delivery of liposomal methylprednisolone improved therapeutic efficacy in a model of neuroinflammation by Gaillard, Pieter J., Appeldoorn, Chantal C.M., Rip, Jaap, Dorland, Rick, van der Pol, Susanne M.A., Kooij, Gijs, de Vries, Helga E., Reijerkerk, Arie

“…Neuroinflammation contributes to a wide range of disorders of the central nervous system (CNS). Of the available anti-inflammatory drugs, only glucocorticoids…”
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Glutathione PEGylated liposomes: pharmacokinetics and delivery of cargo across the blood-brain barrier in rats by Rip, Jaap, Chen, Linda, Hartman, Robin, van den Heuvel, Angelique, Reijerkerk, Arie, van Kregten, Joan, van der Boom, Burt, Appeldoorn, Chantal, de Boer, Marco, Maussang, David, de Lange, Elizabeth C. M., Gaillard, Pieter J.

“…Abstract Partly due to poor blood-brain barrier drug penetration the treatment options for many brain diseases are limited. To safely enhance drug delivery to…”
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A novel co-culture model of the blood-retinal barrier based on primary retinal endothelial cells, pericytes and astrocytes by Wisniewska-Kruk, Joanna, Hoeben, Kees A., Vogels, Ilse M.C., Gaillard, Pieter J., Van Noorden, Cornelis J.F., Schlingemann, Reinier O., Klaassen, Ingeborg

“…Loss of blood-retinal barrier (BRB) properties is an important feature in the pathology of diabetic macular edema (DME), but cellular mechanisms underlying BRB…”
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Targeted blood-to-brain drug delivery --10 key development criteria by Gaillard, Pieter J, Visser, Corine C, Appeldoorn, Chantal C M, Rip, Jaap

“…Drug delivery to the brain remains challenging due to the presence of the blood-brain barrier. In this review, 10 key development criteria are presented that…”
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Imaged-guided focused ultrasound in combination with various formulations of doxorubicin for the treatment of diffuse intrinsic pontine glioma by Haumann, Rianne, Bianco, John I., Waranecki, Piotr M., Gaillard, Pieter J., Storm, Gert, Ries, Mario, van Vuurden, Dannis G., Kaspers, Gertjan J. L., Hulleman, Esther

“…Abstract Background Diffuse intrinsic pontine glioma (DIPG) is a notoriously difficult tumor to treat, with an overall survival of DIPG patients being only…”
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Current research into brain barriers and the delivery of therapeutics for neurological diseases: a report on CNS barrier congress London, UK, 2017 by Greenwood, John, Hammarlund-Udenaes, Margareta, Jones, Hazel C, Stitt, Alan W, Vandenbrouke, Roosmarijn E, Romero, Ignacio A, Campbell, Matthew, Fricker, Gert, Brodin, Birger, Manninga, Heiko, Gaillard, Pieter J, Schwaninger, Markus, Webster, Carl, Wicher, Krzysztof B, Khrestchatisky, Michel

“…This is a report on the CNS barrier congress held in London, UK, March 22-23rd 2017 and sponsored by Kisaco Research Ltd. The two 1-day sessions were chaired…”
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Treatment with penicillin G and hydrocortisone reduces ALS-associated symptoms: a case series of three patients by Tuk, Bert, Jousma, Harmen, Gaillard, Pieter J

“…Three male Caucasian patients with ALS were admitted to the hospital due to progressive dysphagia and dysarthria. During two 21-day courses of penicillin G and…”
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Correction to: Current research into brain barriers and the delivery of therapeutics for neurological diseases: a report on CNS barrier congress London, UK, 2017 by Greenwood, John, Hammarlund-Udenaes, Margareta, Jones, Hazel C, Stitt, Alan W, Vandenbroucke, Roosmarijn E, Romero, Ignacio A, Campbell, Matthew, Fricker, Gert, Brodin, Birger, Manninga, Heiko, Gaillard, Pieter J, Schwaninger, Markus, Webster, Carl, Wicher, Krzysztof B, Khrestchatisky, Michel

“…After publication of the article [1], it has been brought to our attention that there are some errors in the formatting of names in the final version of the…”
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Targeted brain delivery of methotrexate by glutathione PEGylated liposomes: How can the formulation make a difference? by Hu, Yang, Gaillard, Pieter J., de Lange, Elizabeth C.M., Hammarlund-Udenaes, Margareta

“…[Display omitted] The purpose of this study was to quantitatively investigate how conjugation of GSH to different liposomal formulations influence the brain…”
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Enhanced doxorubicin delivery to the brain administered through glutathione PEGylated liposomal doxorubicin (2B3-101) as compared with generic Caelyx,(®)/Doxil(®)--a cerebral open flow microperfusion pilot study by Birngruber, Thomas, Raml, Reingard, Gladdines, Werner, Gatschelhofer, Christina, Gander, Edgar, Ghosh, Arijit, Kroath, Thomas, Gaillard, Pieter J, Pieber, Thomas R, Sinner, Frank

“…The neuroprotective blood-brain barrier (BBB) keeps many drug candidates below therapeutic levels in the central nervous system. Glutathione PEGylated…”
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In vivo Functional Evaluation of Increased Brain Delivery of the Opioid Peptide DAMGO by Glutathione-PEGylated Liposomes by Lindqvist, Annika, Rip, Jaap, van Kregten, Joan, Gaillard, Pieter J, Hammarlund-Udenaes, Margareta

“…Purpose The purpose of this study was to evaluate formulation factors causing improvement in brain delivery of a small peptide after encapsulation into a…”
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Targeted CRM197-PEG-PEI/siRNA Complexes for Therapeutic RNAi in Glioblastoma by Höbel, Sabrina, Appeldoorn, Chantal C M, Gaillard, Pieter J, Aigner, Achim

“…RNA interference (RNAi) allows the specific knockdown of tumor relevant genes. To induce RNAi, the delivery of small interfering RNAs (siRNAs) is of crucial…”
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The Impact of Liposomal Formulations on the Release and Brain Delivery of Methotrexate: An In Vivo Microdialysis Study by Hu, Yang, Rip, Jaap, Gaillard, Pieter J, de Lange, Elizabeth C M, Hammarlund-Udenaes, Margareta

“…The impact of liposomal formulations on the in vivo release and brain delivery of methotrexate (MTX) was quantitatively assessed in rats. Two PEGylated…”
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Enhanced glutathione PEGylated liposomal brain delivery of an anti-amyloid single domain antibody fragment in a mouse model for Alzheimer's disease by Rotman, Maarten, Welling, Mick M, Bunschoten, Anton, de Backer, Maaike E, Rip, Jaap, Nabuurs, Rob J A, Gaillard, Pieter J, van Buchem, Mark A, van der Maarel, Silvère M, van der Weerd, Louise

“…Treatment of neurodegenerative disorders such as Alzheimer's disease is hampered by the blood-brain barrier (BBB). This tight cerebral vascular endothelium…”
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Enhanced Brain Delivery of the Opioid Peptide DAMGO in Glutathione PEGylated Liposomes: A Microdialysis Study by Lindqvist, Annika, Rip, Jaap, Gaillard, Pieter J, Björkman, Sven, Hammarlund-Udenaes, Margareta

“…Glutathione PEGylated (GSH-PEG) liposomes were evaluated for their ability to enhance and prolong blood-to-brain drug delivery of the opioid peptide DAMGO…”
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In Vivo Quantitative Understanding of PEGylated Liposome’s Influence on Brain Delivery of Diphenhydramine by Hu, Yang, Gaillard, Pieter J., Rip, Jaap, de Lange, Elizabeth C.M., Hammarlund-Udenaes, Margareta

“…Despite the promising features of liposomes as brain drug delivery vehicles, it remains uncertain how they influence the brain uptake in vivo. In order to gain…”
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BBB crossing assessment and BBB crossing technologies in CNS Drug Discovery by Gaillard, Pieter J.

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Glutathione PEGylated liposomal methylprednisolone (2B3-201) attenuates CNS inflammation and degeneration in murine myelin oligodendrocyte glycoprotein induced experimental autoimmune encephalomyelitis by Lee, De-Hyung, Rötger, Caroline, Appeldoorn, Chantal C.M, Reijerkerk, Arie, Gladdines, Werner, Gaillard, Pieter J, Linker, Ralf A

“…Abstract Methylprednisolone (MP) pulses are the mainstay for relapse therapy in multiple sclerosis (MS). To improve the efficacy of treatment and reduce the…”
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Strategies to improve drug delivery across the blood-brain barrier by DE BOER, Albertus G, GAILLARD, Pieter J

“…The blood-brain barrier (BBB), together with the blood-cerebrospinal-fluid barrier, protects and regulates the homeostasis of the brain. However, these…”
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