Search Results - "Gailhouste, Luc"

Mesenchymal stem cell-derived extracellular vesicles: a glimmer of hope in treating Alzheimer's disease by Liew, Lee Chuen, Katsuda, Takeshi, Gailhouste, Luc, Nakagama, Hitoshi, Ochiya, Takahiro

“…One of the pathological hallmarks of Alzheimer's disease (AD) is the presence of extracellular plaques resulting from the accumulation of beta-amyloid peptide…”
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Epigenetic reprogramming using 5-azacytidine promotes an anti-cancer response in pancreatic adenocarcinoma cells by Gailhouste, Luc, Liew, Lee Chuen, Hatada, Izuho, Nakagama, Hitoshi, Ochiya, Takahiro

“…Curative management of pancreatic adenocarcinoma is limited because this malignancy remains resistant to most chemotherapeutic drugs. Strategies that reverse…”
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Isolation and purification method of mouse fetal hepatoblasts by Gailhouste, Luc

“…During development, liver precursors constitute a valuable source of pluripotent stem cells that present the ability to differentiate into both a hepatic and…”
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Differentiation Therapy by Epigenetic Reconditioning Exerts Antitumor Effects on Liver Cancer Cells by Gailhouste, Luc, Liew, Lee Chuen, Yasukawa, Ken, Hatada, Izuho, Tanaka, Yasuhito, Nakagama, Hitoshi, Ochiya, Takahiro

“…Primary liver tumors are mainly represented by hepatocellular carcinoma (HCC), one of the most aggressive and resistant forms of cancer. Liver tumorigenesis is…”
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MicroRNA‐493‐5p‐mediated repression of the MYCN oncogene inhibits hepatic cancer cell growth and invasion by Yasukawa, Ken, Liew, Lee Chuen, Hagiwara, Keitaro, Hironaka‐Mitsuhashi, Ai, Qin, Xian‐Yang, Furutani, Yutaka, Tanaka, Yasuhito, Nakagama, Hitoshi, Kojima, Soichi, Kato, Takashi, Ochiya, Takahiro, Gailhouste, Luc

“…Primary hepatic tumors mainly include hepatocellular carcinoma (HCC), which is one of the most frequent causes of cancer‐related deaths worldwide. Thus far,…”
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miR‐148a plays a pivotal role in the liver by promoting the hepatospecific phenotype and suppressing the invasiveness of transformed cells by Gailhouste, Luc, Gomez‐Santos, Laura, Hagiwara, Keitaro, Hatada, Izuho, Kitagawa, Noriyuki, Kawaharada, Kazushi, Thirion, Muriel, Kosaka, Nobuyoshi, Takahashi, Ryou‐u, Shibata, Tatsuhiro, Miyajima, Atsushi, Ochiya, Takahiro

“…MicroRNAs (miRNAs) are evolutionary conserved small RNAs that post‐transcriptionally regulate the expression of target genes. To date, the role of miRNAs in…”
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Non-Genomic Control of Dynamic MYCN Gene Expression in Liver Cancer by Qin, Xian-Yang, Gailhouste, Luc

“…Upregulated gene expression is restricted to specialized cell populations such as EpCAM cancer stem cells in liver cancer, regardless of DNA amplification and…”
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MEG3-derived miR-493-5p overcomes the oncogenic feature of IGF2-miR-483 loss of imprinting in hepatic cancer cells by Gailhouste, Luc, Liew, Lee Chuen, Yasukawa, Ken, Hatada, Izuho, Tanaka, Yasuhito, Kato, Takashi, Nakagama, Hitoshi, Ochiya, Takahiro

“…Numerous studies have described the critical role played by microRNAs (miRNAs) in cancer progression and the potential of these small non-coding RNAs for…”
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MicroRNA‐124a inhibits endoderm lineage commitment by targeting Sox17 and Gata6 in mouse embryonic stem cells by Liew, Lee Chuen, Gailhouste, Luc, Tan, Geok Chin, Yamamoto, Yusuke, Takeshita, Fumitaka, Nakagama, Hitoshi, Ochiya, Takahiro

“…The role of microRNAs (miRNAs) during mouse early development, especially in endoderm germ layer formation, is largely unknown. Here, via miRNA profiling…”
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MiR‐1285‐5p/TMEM194A axis affects cell proliferation in breast cancer by Hironaka‐Mitsuhashi, Ai, Otsuka, Kurataka, Gailhouste, Luc, Sanchez Calle, Anna, Kumazaki, Minami, Yamamoto, Yusuke, Fujiwara, Yasuhiro, Ochiya, Takahiro

“…The onset of breast cancer among young patients is a major issue in cancer etiology. Our previous study has shown that poor prognosis in young women with…”
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Fibrillar collagen scoring by second harmonic microscopy: A new tool in the assessment of liver fibrosis by Gailhouste, Luc, Grand, Yann Le, Odin, Christophe, Guyader, Dominique, Turlin, Bruno, Ezan, Frédéric, Désille, Yoann, Guilbert, Thomas, Bessard, Anne, Frémin, Christophe, Theret, Nathalie, Baffet, Georges

“…Background & Aims Imaging of supramolecular structures by multiphoton microscopy offers significant advantages for studying specific fibrillar compounds in…”
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Establishment of a Rapid Detection System for ISG20-Dependent SARS-CoV-2 Subreplicon RNA Degradation Induced by Interferon-α by Furutani, Yutaka, Toguchi, Mariko, Higuchi, Shoko, Yanaka, Kaori, Gailhouste, Luc, Qin, Xian-Yang, Masaki, Takahiro, Ochi, Sae, Matsuura, Tomokazu

“…Inhaled nebulized interferon (IFN)-α and IFN-β have been shown to be effective in the management of coronavirus disease 2019 (COVID-19). We aimed to construct…”
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Targeting transglutaminase 2 mediated exostosin glycosyltransferase 1 signaling in liver cancer stem cells with acyclic retinoid by Qin, Xian-Yang, Furutani, Yutaka, Yonezawa, Kento, Shimizu, Nobutaka, Kato-Murayama, Miyuki, Shirouzu, Mikako, Xu, Yali, Yamano, Yumiko, Wada, Akimori, Gailhouste, Luc, Shrestha, Rajan, Takahashi, Masataka, Keillor, Jeffrey W., Su, Ting, Yu, Wenkui, Fujii, Shinya, Kagechika, Hiroyuki, Dohmae, Naoshi, Shirakami, Yohei, Shimizu, Masahito, Masaki, Takahiro, Matsuura, Tomokazu, Suzuki, Harukazu, Kojima, Soichi

“…Transglutaminase 2 (TG2) is a multifunctional protein that promotes or suppresses tumorigenesis, depending on intracellular location and conformational…”
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Epigenetic reprogramming promotes the antiviral action of IFNα in HBV-infected cells by Gailhouste, Luc, Sudoh, Masayuki, Qin, Xian-Yang, Watashi, Koichi, Wakita, Takaji, Ochiya, Takahiro, Matsuura, Tomokazu, Kojima, Soichi, Furutani, Yutaka

“…Chronic hepatitis B virus (HBV) infections remain a health burden affecting ~250 million people worldwide. Thus far, available interferon-alpha (IFNα)-based…”
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MEK1/2 Overactivation Can Promote Growth Arrest by Mediating ERK1/2-Dependent Phosphorylation of p70S6K by Guégan, Jean-Philippe, Ezan, Frédéric, Gailhouste, Luc, Langouët, Sophie, Baffet, Georges

“…The extracellular signal‐regulated kinase (ERK)1/2 mitogen‐activated protein (MAP) kinase pathway has been involved in the positive and negative regulation of…”
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RNAi‐mediated MEK1 knock‐down prevents ERK1/2 activation and abolishes human hepatocarcinoma growth in vitro and in vivo by Gailhouste, Luc, Ezan, Frédéric, Bessard, Anne, Frémin, Christophe, Rageul, Julie, Langouët, Sophie, Baffet, Georges

“…The mitogen‐activated protein kinases MEK/ERK pathway regulates fundamental processes in malignant cells and represents an attractive target in the development…”
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A robust collagen scoring method for human liver fibrosis by second harmonic microscopy by Guilbert, Thomas, Odin, Christophe, Le Grand, Yann, Gailhouste, Luc, Turlin, Bruno, Ezan, Frédérick, Désille, Yoann, Baffet, Georges, Guyader, Dominique

“…Second Harmonic Generation (SHG) microscopy offers the opportunity to image collagen of type I without staining. We recently showed that a simple scoring…”
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Epigenetic Reprogramming of Human Hepatoma Cells: A Low-Cost Option for Drug Metabolism Assessment by Gailhouste, Luc, Liew, Lee Chuen, Yasukawa, Ken, Hagiwara, Keitaro, Iwazaki, Norihiko, Yamada, Yasuhiro, Hatada, Izuho, Ochiya, Takahiro

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Multiple division cycles and long‐term survival of hepatocytes are distinctly regulated by extracellular signal‐regulated kinases ERK1 and ERK2 by Frémin, Christophe, Bessard, Anne, Ezan, Frédéric, Gailhouste, Luc, Régeard, Morgane, Le Seyec, Jacques, Gilot, David, Pagès, Gilles, Pouysségur, Jacques, Langouët, Sophie, Baffet, Georges

“…We investigated the specific role of the mitogen‐activated protein kinase (MAPK) extracellular signal‐regulated kinase 1 (ERK1)/ERK2 pathway in the regulation…”
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The complexity of ERK1 and ERK2 MAPKs in multiple hepatocyte fate responses by Frémin, Christophe, Ezan, Frédéric, Guegan, Jean-Philippe, Gailhouste, Luc, Trotard, Maud, Le Seyec, Jacques, Rageul, Julie, Theret, Nathalie, Langouët, Sophie, Baffet, Georges

“…Recent reports suggest that extracellular signal‐regulated kinase (ERK1) and ERK2 mitogen‐activated protein kinases (MAPK) may direct specific biological…”
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