Search Results - "Gaile, Daniel P."

Myd88 is required for disease development in a primary Sjögren’s syndrome mouse model by Kiripolsky, Jeremy, McCabe, Liam G., Gaile, Daniel P., Kramer, Jill M.

“…Murine model of primary Sjögren’s syndrome establishes Myd88 as a crucial mediator of local and systemic disease manifestations. Sjögren’s syndrome (SS) is an…”
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Lentivirus Live Cell Array for Quantitative Assessment of Gene and Pathway Activation during Myogenic Differentiation of Mesenchymal Stem Cells by Moharil, Janhavi, Lei, Pedro, Tian, Jun, Gaile, Daniel P, Andreadis, Stelios T

“…Stem cell differentiation involves multiple cascades of transcriptional regulation that govern the cell fate. To study the real-time dynamics of this complex…”
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Putative null distributions corresponding to tests of differential expression in the Golden Spike dataset are intensity dependent by Gaile, Daniel P, Miecznikowski, Jeffrey C

“…We provide a re-analysis of the Golden Spike dataset, a first generation "spike-in" control microarray dataset. The original analysis of the Golden Spike…”
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Arsenic responsive microRNAs in vivo and their potential involvement in arsenic-induced oxidative stress by Ren, Xuefeng, Gaile, Daniel P., Gong, Zhihong, Qiu, Wenting, Ge, Yichen, Zhang, Chuanwu, Huang, Chenping, Yan, Hongtao, Olson, James R., Kavanagh, Terrance J., Wu, Hongmei

“…Arsenic exposure is postulated to modify microRNA (miRNA) expression, leading to changes of gene expression and toxicities, but studies relating the responses…”
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Genomic profiling of myeloid sarcoma by array comparative genomic hybridization by Deeb, George, Baer, Maria R., Gaile, Daniel P., Sait, Sheila N. Jani, Barcos, Maurice, Wetzler, Meir, Conroy, Jeffrey M., Nowak, Norma J., Cowell, John K., Cheney, Richard T.

“…Myeloid sarcoma (MS) is a tumor mass of myeloblasts or immature myeloid cells occurring in an extramedullary site. In this study, seven cases of MS [stomach…”
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Long tandem repeats as a form of genomic copy number variation: structure and length polymorphism of a chromosome 5p repeat in control and schizophrenia populations by Bruce, Heather A, Sachs, Nancy, Rudnicki, Dobrila D, Lin, Stephanie G, Willour, Virginia L, Cowell, John K, Conroy, Jeffrey, McQuaid, Devin E, Rossi, Michael, Gaile, Daniel P, Nowak, Norma J, Holmes, Susan E, Sklar, Pamela, Ross, Christopher A, Delisi, Lynn E, Margolis, Russell L

“…Genomic copy number variations (CNVs) are a major form of variation in the human genome and play an etiologic role in several neuropsychiatric diseases. Tandem…”
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Systemic manifestations of primary Sjögren's syndrome in the NOD.B10Sn-H2b/J mouse model by Kiripolsky, Jeremy, Shen, Long, Liang, Yichen, Li, Alisa, Suresh, Lakshmanan, Lian, Yun, Li, Quan-Zhen, Gaile, Daniel P., Kramer, Jill M.

“…Animal models that recapitulate human disease are crucial for the study of Sjögren's Syndrome (SS). While several SS mouse models exist, there are few primary…”
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Differential copy number aberrations in novel candidate genes associated with progression from in situ to invasive ductal carcinoma of the breast by Liao, Shaoxi, Desouki, Mohamed M., Gaile, Daniel P., Shepherd, Lori, Nowak, Norma J., Conroy, Jeffrey, Barry, William T., Geradts, Joseph

“…Only a minority of intraductal carcinomas of the breast give rise to stromally invasive disease. We microdissected 206 paraffin blocks representing 116…”
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Belief propagation in genotype-phenotype networks by Moharil, Janhavi, May, Paul, Gaile, Daniel P, Blair, Rachael Hageman

“…Graphical models have proven to be a valuable tool for connecting genotypes and phenotypes. Structural learning of phenotype-genotype networks has received…”
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Analysis of IgM antibody production and repertoire in a mouse model of Sjögren's syndrome by Kramer, Jill M., Holodick, Nichol E., Vizconde, Teresa C., Raman, Indu, Yan, Mei, Li, Quan‐Zhen, Gaile, Daniel P., Rothstein, Thomas L.

“…IgM derived from salivary B cells exhibits distinct repertoire characteristics, and is enriched for specific autoantibodies in a murine model of SS. This study…”
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Identification of consistent functional genetic modules by Miecznikowski, Jeffrey C, Gaile, Daniel P, Chen, Xiwei, Tritchler, David L

“…It is often of scientific interest to find a set of genes that may represent an independent functional module or network, such as a functional gene expression…”
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From small studies to precision medicine: prioritizing candidate biomarkers by Gaile, Daniel P, Miecznikowski, Jeffrey C

“…There are still many open questions in data-analytic research pertaining to biomarker development in the era of personalized/precision medicine and big data…”
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A novel characterization of the generalized family wise error rate using empirical null distributions by Miecznikowski, Jeffrey C, Gaile, Daniel P

“…We present a novel characterization of the generalized family wise error rate: kFWER. The interpretation allows researchers to view kFWER as a function of the…”
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Identification of metastasis-associated breast cancer genes using a high-resolution whole genome profiling approach by Desouki, Mohamed M., Liao, Shaoxi, Huang, Huayi, Conroy, Jeffrey, Nowak, Norma J., Shepherd, Lori, Gaile, Daniel P., Geradts, Joseph

“…Purpose We employed a whole genome tumor profiling approach in an attempt to identify DNA copy number alterations (CNAs) and new candidate genes that are…”
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A New Normalizing Algorithm for BAC CGH Arrays with Quality Control Metrics by Miecznikowski, Jeffrey C., Gaile, Daniel P., Liu, Song, Shepherd, Lori A., Nowak, Norma

“…The main focus in pin-tip (or print-tip) microarray analysis is determining which probes, genes, or oligonucleotides are differentially expressed. Specifically…”
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The Genomic Relationship Between Primary Breast Carcinomas and Their Nodal Metastases by Desouki, Mohamed M., Liao, Shaoxi, Conroy, Jeffrey, Nowak, Norma J., Shepherd, Lori, Gaile, Daniel P., Geradts, Joseph

“…We screened the whole tumor genome to identify DNA copy number gains and losses that discriminate between primary breast carcinomas (MP) and their nodal…”
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Diabetes-altered gene expression in rat skeletal muscle corrected by oral administration of vanadyl sulfate by Willsky, Gail R, Chi, Lai-Har, Liang, Yulan, Gaile, Daniel P, Hu, Zihua, Crans, Debbie C

“…1 Department of Biochemistry, School of Medicine and Biomedical Sciences, The State University of New York (SUNY) at Buffalo, Buffalo 2 Department of…”
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Human papillomavirus and tobacco use in tongue base cancers by Stoler, Daniel L, Smaldino, Philip J, Darbary, Huferesh K, Sullivan, Maureen A, Popat, Saurin R, Hicks, Jr, Wesley L, Merzianu, Mihai, Gaile, Daniel P, Anderson, Garth R, Loree, Thom R

“…Human papillomavirus 16 (HPV-16) infection and tobacco use are associated with human oropharyngeal cancers. We conducted a study of the role of HPV and tobacco…”
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An exact bootstrap approach towards modification of the Harrell-Davis quantile function estimator for censored data by Wang, Dongliang, Hutson, Alan D., Gaile, Daniel P.

“…A new kernel quantile estimator is proposed for right-censored data, which takes the form of , where w j(u, c) is based on a beta kernel with bandwidth…”
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aCGH local copy number aberrations associated with overall copy number genomic instability in colorectal cancer: coordinate involvement of the regions including BCR and ABL by Bartos, Jeremy D, Gaile, Daniel P, McQuaid, Devin E, Conroy, Jeffrey M, Darbary, Huferesh, Nowak, Norma J, Block, Annemarie, Petrelli, Nicholas J, Mittelman, Arnold, Stoler, Daniel L, Anderson, Garth R

“…In order to identify small regions of the genome whose specific copy number alteration is associated with high genomic instability in the form of overall…”
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