Hepatoprotective Effect of C-Phycocyanin: Protection for Carbon Tetrachloride andR-(+)-Pulegone-Mediated Hepatotoxicty in Rats

Effect of C-phycocyanin (fromSpirulina platensis) pretreatment on carbontetrachloride andR-(+)-pulegone-induced hepatotoxicity in rats was studied. Intraperitoneal (i.p.) administration (200 mg/kg) of a single dose of phycocyanin to rats, one or three hours prior toR-(+)-pulegone (250 mg/kg) or carb...

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Published in:	Biochemical and biophysical research communications Vol. 249; no. 2; pp. 428 - 431
Main Authors:	Vadiraja, Bhat.B., Gaikwad, Nilesh.W., Madyastha, K.M.
Format:	Journal Article
Language:	English
Published:	Elsevier Inc 19-08-1998
Subjects:	C-phycocyanin carbon tetrachloride hepatoprotective effect hepatotoxicity R-(+)-pulegone, a monoterpene ketone Spirulina platensis R-(+)-pulegone, a monoterpene ketone C-phycocyanin carbon tetrachloride hepatotoxicity hepatoprotective effect Spirulina platensis
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Summary:	Effect of C-phycocyanin (fromSpirulina platensis) pretreatment on carbontetrachloride andR-(+)-pulegone-induced hepatotoxicity in rats was studied. Intraperitoneal (i.p.) administration (200 mg/kg) of a single dose of phycocyanin to rats, one or three hours prior toR-(+)-pulegone (250 mg/kg) or carbontetrachloride (0.6 ml/kg) challenge, significantly reduced the hepatotoxicity caused by these chemicals. For instance, serum glutamate pyruvate transaminase (SGPT) activity was almost equal to control values. The losses of microsomal cytochrome P450, glucose-6-phosphatase and aminopyrine-N-demethylase were significantly reduced, suggesting that phycocyanin provides protection to liver enzymes. It was noticed that the level of menthofuran, the proximate toxin ofR-(+)-pulegone was nearly 70% more in the urine samples collected from rats treated withR-(+)-pulegone alone than rats treated with the combination of phycocyanin andR-(+)-pulegone. The possible mechanism involved in the hepatoprotection is discussed.
ISSN:	0006-291X 1090-2104
DOI:	10.1006/bbrc.1998.9149