Search Results - "Gaida, Matthias"

Neutrophil-Derived Proteases in the Microenvironment of Pancreatic Cancer -Active Players in Tumor Progression by Felix, Klaus, Gaida, Matthias M

“…A hallmark of pancreatic ductal adenocarcinoma (PDAC) is the fibro-inflammatory microenvironment, consisting of activated pancreatic stellate cells,…”
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Prognostic Factors of Survival After Neoadjuvant Treatment and Resection for Initially Unresectable Pancreatic Cancer by Klaiber, Ulla, Schnaidt, Eva S., Hinz, Ulf, Gaida, Matthias M., Heger, Ulrike, Hank, Thomas, Strobel, Oliver, Neoptolemos, John P., Mihaljevic, André L., Büchler, Markus W., Hackert, Thilo

“…MINIWe analyzed prognostic factors after neoadjuvant therapy and resection in 280 patients with initially unresectable pancreatic cancer—the largest…”
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CXCL10 and CCL21 Promote Migration of Pancreatic Cancer Cells Toward Sensory Neurons and Neural Remodeling in Tumors in Mice, Associated With Pain in Patients by Hirth, Michael, Gandla, Jagadeesh, Höper, Christiane, Gaida, Matthias M., Agarwal, Nitin, Simonetti, Manuela, Demir, Aykut, Xie, Yong, Weiss, Cleo, Michalski, Christoph W., Hackert, Thilo, Ebert, Matthias P., Kuner, Rohini

“…Pancreatic ductal adenocarcinoma (PDAC) is frequently accompanied by excruciating pain, which has been associated with attraction of cancer cells and their…”
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TNF plays a crucial role in inflammation by signaling via T cell TNFR2 by Alam, Muhammad S., Otsuka, Shizuka, Wong, Nathan, Abbasi, Aamna, Gaida, Matthias M., Fan, Yu, Meerzaman, Daoud, Ashwell, Jonathan D.

“…TNF, produced largely by T and innate immune cells, is potently proinflammatory, as are cytokines such as IFN-γ and IL-17 produced by Th1 and Th17 cells,…”
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A Novel MIF Signaling Pathway Drives the Malignant Character of Pancreatic Cancer by Targeting NR3C2 by Yang, Shouhui, He, Peijun, Wang, Jian, Schetter, Aaron, Tang, Wei, Funamizu, Naotake, Yanaga, Katsuhiko, Uwagawa, Tadashi, Satoskar, Abhay R, Gaedcke, Jochen, Bernhardt, Markus, Ghadimi, B Michael, Gaida, Matthias M, Bergmann, Frank, Werner, Jens, Ried, Thomas, Hanna, Nader, Alexander, H Richard, Hussain, S Perwez

“…Pancreatic cancers with aberrant expression of macrophage migration inhibitory factor (MIF) are particularly aggressive. To identify key signaling pathways…”
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Calcineurin inhibitors suppress acute graft-versus-host disease via NFAT-independent inhibition of T cell receptor signaling by Otsuka, Shizuka, Melis, Nicolas, Gaida, Matthias M, Dutta, Debjani, Weigert, Roberto, Ashwell, Jonathan D

“…Inhibitors of calcineurin phosphatase activity (CNIs) such as cyclosporin A (CsA) are widely used to treat tissue transplant rejection and acute…”
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Why is pancreatic cancer so deadly? The pathologist's view by Hruban, Ralph H, Gaida, Matthias M, Thompson, Elizabeth, Hong, Seung‐Mo, Noë, Michaël, Brosens, Lodewijk AA, Jongepier, Martine, Offerhaus, G Johan A, Wood, Laura D

“…The remarkable aggressiveness of pancreatic cancer has never been fully explained. Although clearly multifactorial, we postulate that venous invasion, a…”
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Stress Granules Determine the Development of Obesity-Associated Pancreatic Cancer by Fonteneau, Guillaume, Redding, Alexandra, Hoag-Lee, Hannah, Sim, Edward S, Heinrich, Stefan, Gaida, Matthias M, Grabocka, Elda

“…Obesity is a global epidemic and a major predisposing factor for cancer. Increasing evidence shows that obesity-associated stress is a key driver of cancer…”
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Deep Learning in Pancreatic Tissue: Identification of Anatomical Structures, Pancreatic Intraepithelial Neoplasia, and Ductal Adenocarcinoma by Kriegsmann, Mark, Kriegsmann, Katharina, Steinbuss, Georg, Zgorzelski, Christiane, Kraft, Anne, Gaida, Matthias M

“…Identification of pancreatic ductal adenocarcinoma (PDAC) and precursor lesions in histological tissue slides can be challenging and elaborate, especially due…”
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Inhibition of the Cyclin K‐CDK12 complex induces DNA damage and increases the effect of androgen deprivation therapy in prostate cancer by Frei, Katharina, Schecher, Sabrina, Daher, Tamas, Hörner, Nina, Richter, Jutta, Hildebrand, Ute, Schindeldecker, Mario, Witzel, Hagen R., Tsaur, Igor, Porubsky, Stefan, Gaida, Matthias M., Roth, Wilfried, Tagscherer, Katrin E.

“…Androgen deprivation therapy (ADT) is the mainstay of the current first‐line treatment concepts for patients with advanced prostate carcinoma (PCa). However,…”
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Spatially Resolved Multi-Omics Single-Cell Analyses Inform Mechanisms of Immune Dysfunction in Pancreatic Cancer by Yousuf, Suhail, Qiu, Mengjie, Voith von Voithenberg, Lena, Hulkkonen, Johannes, Macinkovic, Igor, Schulz, Axel R., Hartmann, Domenic, Mueller, Florian, Mijatovic, Margarete, Ibberson, David, AlHalabi, Karam T., Hetzer, Jenny, Anders, Simon, Brüne, Bernhard, Mei, Henrik E., Imbusch, Charles D., Brors, Benedikt, Heikenwälder, Mathias, Gaida, Matthias M., Büchler, Markus W., Weigert, Andreas, Hackert, Thilo, Roth, Susanne

“…As pancreatic ductal adenocarcinoma (PDAC) continues to be recalcitrant to therapeutic interventions, including poor response to immunotherapy, albeit…”
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Potential role of the bitter taste receptor T2R14 in the prolonged survival and enhanced chemoresponsiveness induced by apigenin by Stern, Louisa, Boehme, Lukas Fabian, Goetz, Mara Rebecca, Nitschke, Christine, Giannou, Anastasios, Zhang, Tao, Güngör, Cenap, Reeh, Matthias, Izbicki, Jakob Robert, Fliegert, Ralf, Hausen, Anne, Giese, Nathalia, Hackert, Thilo, Niv, Masha Y, Heinrich, Stefan, Gaida, Matthias Martin, Ghadban, Tarik

“…Bitter taste receptors (T2Rs) are G protein‑coupled receptors originally detected in the gustatory system. More recently, T2Rs have been shown to be expressed…”
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Performance of different CT enhancement quantification methods as predictors of pancreatic cancer recurrence after upfront surgery by Mohamed, Sherif A., Barlemann, Alina, Steinle, Verena, Nonnenmacher, Tobias, Güttlein, Michelle, Hackert, Thilo, Loos, Martin, Gaida, Matthias M., Kauczor, Hans-Ulrich, Klauss, Miriam, Mayer, Philipp

“…The prognosis of pancreatic cancer (PDAC) after tumor resection remains poor, mostly due to a high but variable risk of recurrence. A promising tool for…”
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Imaging features of intraductal tubulopapillary neoplasm of the pancreas and its differentiation from conventional pancreatic ductal adenocarcinoma by Khristenko, Ekaterina, Hank, Thomas, Gaida, Matthias M., Kauczor, Hans-Ulrich, Hackert, Thilo, Klauß, Miriam, Mayer, Philipp

“…Intraductal tubulopapillary neoplasms (ITPN) are rare pancreatic tumors (< 1% of exocrine neoplasms) and are considered to have better prognosis than classical…”
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Risk of the Watch-and-Wait Concept in Surgical Treatment of Intraductal Papillary Mucinous Neoplasm by Tjaden, Christine, Sandini, Marta, Mihaljevic, André L, Kaiser, Jörg, Khristenko, Ekaterina, Mayer, Philipp, Hinz, Ulf, Gaida, Matthias M, Berchtold, Christoph, Diener, Markus K, Schneider, Martin, Mehrabi, Arianeb, Müller-Stich, Beat P, Strobel, Oliver, Hackert, Thilo, Büchler, Markus W

“…The natural history of intraductal papillary mucinous neoplasms (IPMNs) remains uncertain. The inconsistencies among published guidelines preclude accurate…”
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Lymphoepithelial cyst of the pancreas: can common imaging features help to avoid resection? by Khristenko, Ekaterina, Garcia, Elena Esteban, Gaida, Matthias M., Hackert, Thilo, Mayer, Philipp, Kauczor, Hans-Ulrich, Klauss, Miriam

“…Background Differentiation of cystic pancreatic neoplasms remains a challenging task for radiologists regarding the main aim of identifying malignant and…”
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Phase 2 Trial of Oncolytic H-1 Parvovirus Therapy Shows Safety and Signs of Immune System Activation in Patients With Metastatic Pancreatic Ductal Adenocarcinoma by Hajda, Jacek, Leuchs, Barbara, Angelova, Assia L, Frehtman, Veronika, Rommelaere, Jean, Mertens, Mieke, Pilz, Maximilian, Kieser, Meinhard, Krebs, Ottheinz, Dahm, Michael, Huber, Bernard, Engeland, Christine E, Mavratzas, Athanasios, Hohmann, Nicolas, Schreiber, Jutta, Jäger, Dirk, Halama, Niels, Sedlaczek, Oliver, Gaida, Matthias M, Daniel, Volker, Springfeld, Christoph, Ungerechts, Guy

“…To investigate the safety, clinical efficacy, virus pharmacokinetics, shedding, and immune response after administration of an oncolytic parvovirus (H-1PV,…”
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The radiomorphological appearance of the invasive margin in pancreatic cancer is associated with tumor budding by Mayer, Philipp, Hausen, Anne, Steinle, Verena, Bergmann, Frank, Kauczor, Hans-Ulrich, Loos, Martin, Roth, Wilfried, Klauss, Miriam, Gaida, Matthias M

“…Purpose Pancreatic cancer (PDAC) is characterized by infiltrative, spiculated tumor growth into the surrounding non-neoplastic tissue. Clinically, its…”
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Noninvasive risk stratification of intraductal papillary mucinous neoplasia with malignant potential by serum apolipoprotein‐A2‐isoforms by Felix, Klaus, Honda, Kazufumi, Nagashima, Kengo, Kashiro, Ayumi, Takeuchi, Keiko, Kobayashi, Takashi, Hinterkopf, Sascha, Gaida, Matthias M., Dang, Hien, Brindl, Niall, Kaiser, Jörg, Büchler, Markus W., Strobel, Oliver

“…Intraductal papillary mucinous neoplasms (IPMNs) are premalignant lesions of pancreatic cancer. An accurate serum biomarker, which allows earlier…”
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Assessment of glomerular morphological patterns by deep learning algorithms by Weis, Cleo-Aron, Bindzus, Jan Niklas, Voigt, Jonas, Runz, Marlen, Hertjens, Svetlana, Gaida, Matthias M., Popovic, Zoran V., Porubsky, Stefan

“…Background Compilation of different morphological lesion signatures is characteristic of renal pathology. Previous studies have documented the potential value…”
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