Search Results - "Gaiano, Nicholas"

Notch signaling in the mammalian central nervous system: insights from mouse mutants by Gaiano, Nicholas, Yoon, Keejung

“…The Notch pathway, although originally identified in fruit flies, is now among the most heavily studied in mammalian biology. In mice, loss-of-function and…”
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Strange Bedfellows: Reelin and Notch Signaling Interact to Regulate Cell Migration in the Developing Neocortex by Gaiano, Nicholas

“…Neuronal cell migration in the developing neocortex relies on the Reelin signaling cascade to establish the characteristic “inside out” lamination pattern. In…”
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Semaphorin 3E-Plexin-D1 signaling regulates VEGF function in developmental angiogenesis via a feedback mechanism by Kim, Jiha, Oh, Won-Jong, Gaiano, Nicholas, Yoshida, Yutaka, Gu, Chenghua

“…Blood vessel networks are typically formed by angiogenesis, a process in which new vessels form by sprouting of endothelial cells from pre-existing vessels…”
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The role of notch in promoting glial and neural stem cell fates by GAIANO, Nicholas, FISHELL, Gord

“…The Notch signaling pathway has long been known to influence cell fate in the developing nervous system. However, this pathway has generally been thought to…”
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A Dynamic Notch Injury Response Activates Epicardium and Contributes to Fibrosis Repair by Russell, Jamie L, Goetsch, Sean C, Gaiano, Nicholas R, Hill, Joseph A, Olson, Eric N, Schneider, Jay W

“…RATIONALE:Transgenic Notch reporter mice express enhanced green fluorescent protein in cells with C-promoter binding factor-1 response element transcriptional…”
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The Notch Target Hes1 Directly Modulates Gli1 Expression and Hedgehog Signaling: A Potential Mechanism of Therapeutic Resistance by SCHRECK, Karisa C, TAYLOR, Pete, MARCHIONNI, Luigi, GOPALAKRISHNAN, Vidya, BAR, Eli E, GAIANO, Nicholas, EBERHART, Charles G

“…Multiple developmental pathways including Notch, Hedgehog, and Wnt are active in malignant brain tumors such as medulloblastoma and glioblastoma (GBM). This…”
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Activity-Induced Notch Signaling in Neurons Requires Arc/Arg3.1 and Is Essential for Synaptic Plasticity in Hippocampal Networks by Alberi, Lavinia, Liu, Shuxi, Wang, Yue, Badie, Ramy, Smith-Hicks, Constance, Wu, Jing, Pierfelice, Tarran J., Abazyan, Bagrat, Mattson, Mark P., Kuhl, Dietmar, Pletnikov, Mikhail, Worley, Paul F., Gaiano, Nicholas

“…Notch signaling in the nervous system has been most studied in the context of cell fate specification. However, numerous studies have suggested that Notch also…”
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Imaging hematopoietic precursor division in real time by Wu, Mingfu, Kwon, Hyog Young, Rattis, Frederique, Blum, Jordan, Zhao, Chen, Ashkenazi, Rina, Jackson, Trachette L, Gaiano, Nicholas, Oliver, Tim, Reya, Tannishtha

“…Stem cells are thought to balance self-renewal and differentiation through asymmetric and symmetric divisions, but whether such divisions occur during…”
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Integration of Notch and Wnt signaling in hematopoietic stem cell maintenance by Pazianos, Gregory, Gaiano, Nicholas, Zhao, Chen, Willert, Karl, DiMascio, Leah N, Yoon, Keejung, Reya, Tannishtha, Rattis, Frédérique M, Congdon, Kendra L, Duncan, Andrew W, Cook, J Michael

“…A fundamental question in hematopoietic stem cell (HSC) biology is how self-renewal is controlled. Here we show that the molecular regulation of two critical…”
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Radial Glial Identity Is Promoted by Notch1 Signaling in the Murine Forebrain by Gaiano, Nicholas, Nye, Jeffrey S., Fishell, Gord

“…In vertebrates, Notch signaling is generally thought to inhibit neural differentiation. However, whether Notch can also promote specific early cell fates in…”
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The exon junction complex component Magoh controls brain size by regulating neural stem cell division by Larson, Denise M, Liaw, Hung-Jiun, Silver, Debra L, Schreck, Karisa C, Pierfelice, Tarran J, Myung, Kyungjae, Gaiano, Nicholas, Walsh, Christopher A, Pavan, William J, Burnetti, Anthony J, Watkins-Chow, Dawn E

“…Silver et al . demonstrate that Magoh, a component of the RNA-binding exon junction complex (EJC), controls mouse cerebral cortical size by regulating neural…”
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Regulation of neural progenitor cell development in the nervous system by Corbin, Joshua G., Gaiano, Nicholas, Juliano, Sharon L., Poluch, Sylvie, Stancik, Elizabeth, Haydar, Tarik F.

“…The mammalian telencephalon, which comprises the cerebral cortex, olfactory bulb, hippocampus, basal ganglia, and amygdala, is the most complex and intricate…”
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The canonical Notch pathway effector RBP-J regulates neuronal plasticity and expression of GABA transporters in hippocampal networks by Liu, Shuxi, Wang, Yue, Worley, Paul F., Mattson, Mark P., Gaiano, Nicholas

“…ABSTRACT Activation of the Notch pathway in neurons is essential for learning and memory in various species from invertebrates to mammals. However, it remains…”
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Botch Promotes Neurogenesis by Antagonizing Notch by Chi, Zhikai, Zhang, Jianmin, Tokunaga, Akinori, Harraz, Maged M., Byrne, Sean T., Dolinko, Andrew, Xu, Jing, Blackshaw, Seth, Gaiano, Nicholas, Dawson, Ted M., Dawson, Valina L.

“…Regulation of self-renewal and differentiation of neural stem cells is still poorly understood. Here we investigate the role of a developmentally expressed…”
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Dorsoventral patterning is established in the telencephalon of mutants lacking both Gli3 and Hedgehog signaling by Rallu, Murielle, Machold, Robert, Gaiano, Nicholas, Corbin, Joshua G, McMahon, Andrew P, Fishell, Gord

“…Considerable data suggest that sonic hedgehog (Shh) is both necessary and sufficient for the specification of ventral pattern throughout the nervous system,…”
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Notch3 Activation Promotes Invasive Glioma Formation in a Tissue Site-Specific Manner by PIERFELICE, Tarran J, SCHRECK, Karisa C, DANG, Louis, ASNAGHI, Laura, GAIANO, Nicholas, EBERHART, Charles G

“…Although Notch signaling has been widely implicated in neoplastic growth, direct evidence for in vivo initiation of neoplasia by the pathway in murine models…”
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Combinatorial function of the homeodomain proteins Nkx2.1 and Gsh2 in ventral telencephalic patterning by Corbin, Joshua G, Rutlin, Michael, Gaiano, Nicholas, Fishell, Gord

“…Regional patterning of the mammalian telencephalon requires the function of three homeodomain-containing transcription factors, Pax6, Gsh2 and Nkx2.1. These…”
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Spatiotemporal selectivity of response to Notch1 signals in mammalian forebrain precursors by Chambers, C B, Peng, Y, Nguyen, H, Gaiano, N, Fishell, G, Nye, J S

“…The olfactory bulb, neocortex and archicortex arise from a common pool of progenitors in the dorsal telencephalon. We studied the consequences of supplying…”
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Notch3 signaling promotes radial glial/progenitor character in the mammalian telencephalon by Dang, Louis, Yoon, Keejung, Wang, Mike, Gaiano, Nicholas

“…The Notch signaling pathway is known to influence cell fate in the developing mammalian nervous system. Previous work in the mouse telencephalon has shown that…”
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Notch in the Vertebrate Nervous System: An Old Dog with New Tricks by Pierfelice, Tarran, Alberi, Lavinia, Gaiano, Nicholas

“…The Notch pathway is prominent among those known to regulate neural development in vertebrates. Notch receptor activation can inhibit neurogenesis, maintain…”
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