Search Results - "Gai, Marta"

Citron kinase controls abscission through RhoA and anillin by Gai, Marta, Camera, Paola, Dema, Alessandro, Bianchi, Federico, Berto, Gaia, Scarpa, Elena, Germena, Giulia, Di Cunto, Ferdinando

“…The small GTPase RhoA plays a crucial role in the different stages of cytokinesis, including contractile ring formation, cleavage furrow ingression, and…”
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Lestaurtinib inhibits Citron kinase activity and medulloblastoma growth through induction of DNA damage, apoptosis and cytokinesis failure by Pallavicini, Gianmarco, Iegiani, Giorgia, Parolisi, Roberta, Ferraro, Alessia, Garello, Francesca, Bitonto, Valeria, Terreno, Enzo, Gai, Marta, Di Cunto, Ferdinando

“…Medulloblastoma (MB), the most common malignant pediatric brain tumor, is currently treated with surgery followed by radiation and chemotherapy, which is…”
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ZIKA virus elicits P53 activation and genotoxic stress in human neural progenitors similar to mutations involved in severe forms of genetic microcephaly and p53 by Ghouzzi, Vincent El, Bianchi, Federico T, Molineris, Ivan, Mounce, Bryan C, Berto, Gaia E, Rak, Malgorzata, Lebon, Sophie, Aubry, Laetitia, Tocco, Chiara, Gai, Marta, Chiotto, Alessandra MA, Sgrò, Francesco, Pallavicini, Gianmarco, Simon-Loriere, Etienne, Passemard, Sandrine, Vignuzzi, Marco, Gressens, Pierre, Di Cunto, Ferdinando

“…Epidemiological evidence from the current outbreak of Zika virus (ZIKV) and recent studies in animal models indicate a strong causal link between ZIKV and…”
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HSP27 is required for invasion and metastasis triggered by hepatocyte growth factor by Pavan, Simona, Musiani, Daniele, Torchiaro, Erica, Migliardi, Giorgia, Gai, Marta, Cunto, Ferdinando, Erriquez, Jessica, Olivero, Martina, Renzo, Maria Flavia

“…The hepatocyte growth factor (HGF) also known as scatter factor activates cancer cell invasion and metastasis. We show that in ovarian cancer cells HGF induced…”
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Citron Kinase Deficiency Leads to Chromosomal Instability and TP53-Sensitive Microcephaly by Bianchi, Federico Tommaso, Tocco, Chiara, Pallavicini, Gianmarco, Liu, Yifan, Vernì, Fiammetta, Merigliano, Chiara, Bonaccorsi, Silvia, El-Assawy, Nadia, Priano, Lorenzo, Gai, Marta, Berto, Gaia Elena, Chiotto, Alessandra Maria Adelaide, Sgrò, Francesco, Caramello, Alessia, Tasca, Laura, Ala, Ugo, Neri, Francesco, Oliviero, Salvatore, Mauro, Alessandro, Geley, Stephan, Gatti, Maurizio, Di Cunto, Ferdinando

“…Mutations in citron (CIT), leading to loss or inactivation of the citron kinase protein (CITK), cause primary microcephaly in humans and rodents, associated…”
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Dihydroorotate dehydrogenase inhibition reveals metabolic vulnerability in chronic myeloid leukemia by Houshmand, Mohammad, Vitale, Nicoletta, Orso, Francesca, Cignetti, Alessandro, Molineris, Ivan, Gaidano, Valentina, Sainas, Stefano, Giorgis, Marta, Boschi, Donatella, Fava, Carmen, Passoni, Alice, Gai, Marta, Geuna, Massimo, Sora, Federica, Iurlo, Alessandra, Abruzzese, Elisabetta, Breccia, Massimo, Mulas, Olga, Caocci, Giovanni, Castagnetti, Fausto, Taverna, Daniela, Oliviero, Salvatore, Pane, Fabrizio, Lolli, Marco Lucio, Circosta, Paola, Saglio, Giuseppe

“…The development of different generations of BCR-ABL1 tyrosine kinase inhibitors (TKIs) has led to the high overall survival of chronic myeloid leukemia (CML)…”
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Neuronal Cell-Intrinsic Defects in Mouse Models of Down Syndrome by Chiotto, Alessandra Maria Adelaide, Migliorero, Martina, Pallavicini, Gianmarco, Bianchi, Federico Tommaso, Gai, Marta, Di Cunto, Ferdinando, Berto, Gaia Elena

“…Down Syndrome (DS) is the most common genetic disorder associated with intellectual disability (ID). Excitatory neurons of DS patients and mouse models show…”
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The DCR protein TTC3 affects differentiation and Golgi compactness in neurons through specific actin-regulating pathways by Berto, Gaia Elena, Iobbi, Cristina, Camera, Paola, Scarpa, Elena, Iampietro, Corinne, Bianchi, Federico, Gai, Marta, Sgrò, Francesco, Cristofani, Flavio, Gärtner, Annette, Dotti, Carlos G, Di Cunto, Ferdinando

“…In neuronal cells, actin remodeling plays a well known role in neurite extension but is also deeply involved in the organization of intracellular structures,…”
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Tissue RNA Integrity in Visium Spatial Protocol (Fresh Frozen Samples) by Antico, Federica, Gai, Marta, Arigoni, Maddalena

“…The transcriptome of a tissue can be acquired both by single-cell RNAseq (scRNA-seq) and by spatial transcriptomics (ST). The dissociation step, which is…”
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Citron kinase in spindle orientation and primary microcephaly by Gai, Marta, Di Cunto, Ferdinando

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CENPE Inhibition Leads to Mitotic Catastrophe and DNA Damage in Medulloblastoma Cells by Iegiani, Giorgia, Gai, Marta, Di Cunto, Ferdinando, Pallavicini, Gianmarco

“…Medulloblastoma (MB) is the most frequent brain tumor in children. The standard treatment consists in surgery, followed by radiotherapy and chemotherapy. These…”
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MicroRNAs-143 and -145 induce epithelial to mesenchymal transition and modulate the expression of junction proteins by Avalle, Lidia, Incarnato, Danny, Savino, Aurora, Gai, Marta, Marino, Francesca, Pensa, Sara, Barbieri, Isaia, Stadler, Michael B, Provero, Paolo, Oliviero, Salvatore, Poli, Valeria

“…Transforming growth factor (TGF)- β is one of the major inducers of epithelial to mesenchymal transition (EMT), a crucial program that has a critical role in…”
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Goldberg–Shprintzen syndrome protein KIF1BP is a CITK interactor implicated in cytokinesis by Pallavicini, Gianmarco, Gai, Marta, Iegiani, Giorgia, Berto, Gaia Elena, Adrait, Annie, Couté, Yohann, Di Cunto, Ferdinando

“…ABSTRACT Goldberg–Shprintzen disease (GOSHS) is a rare microcephaly syndrome accompanied by intellectual disability, dysmorphic facial features, peripheral…”
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ASPM and CITK regulate spindle orientation by affecting the dynamics of astral microtubules by Gai, Marta, Bianchi, Federico T, Vagnoni, Cristiana, Vernì, Fiammetta, Bonaccorsi, Silvia, Pasquero, Selina, Berto, Gaia E, Sgrò, Francesco, Chiotto, Alessandra MA, Annaratone, Laura, Sapino, Anna, Bergo, Anna, Landsberger, Nicoletta, Bond, Jacqueline, Huttner, Wieland B, Di Cunto, Ferdinando

“…Correct orientation of cell division is considered an important factor for the achievement of normal brain size, as mutations in genes that affect this process…”
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Methyl-CpG Binding Protein 2 (MeCP2) Localizes at the Centrosome and Is Required for Proper Mitotic Spindle Organization by Bergo, Anna, Strollo, Marta, Gai, Marta, Barbiero, Isabella, Stefanelli, Gilda, Sertic, Sarah, Cobolli Gigli, Clementina, Di Cunto, Ferdinando, Kilstrup-Nielsen, Charlotte, Landsberger, Nicoletta

“…Mutations in MECP2 cause a broad spectrum of neuropsychiatric disorders of which Rett syndrome represents the best defined condition. Both neuronal and…”
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Inactivation of Citron Kinase Inhibits Medulloblastoma Progression by Inducing Apoptosis and Cell Senescence by Pallavicini, Gianmarco, Sgrò, Francesco, Garello, Francesca, Falcone, Mattia, Bitonto, Valeria, Berto, Gaia E, Bianchi, Federico T, Gai, Marta, Chiotto, Alessandra M A, Filippi, Miriam, Cutrin, Juan C, Ala, Ugo, Terreno, Enzo, Turco, Emilia, Cunto, Ferdinando Di

“…Medulloblastoma is the most common malignant brain tumor in children. Current treatment for medulloblastoma consists of surgery followed by irradiation of the…”
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Citron kinase-dependent F-actin maintenance at midbody secondary ingression sites mediates abscission by Dema, Alessandro, Macaluso, Francesca, Sgrò, Francesco, Berto, Gaia E, Bianchi, Federico T, Chiotto, Alessandra A, Pallavicini, Gianmarco, Di Cunto, Ferdinando, Gai, Marta

“…Abscission is the final step of cytokinesis whereby the intercellular bridge (ICB) linking the two daughter cells is cut. The ICB contains a structure called…”
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p140Cap inhibits β-Catenin in the breast cancer stem cell compartment instructing a protective anti-tumor immune response by Salemme, Vincenzo, Vedelago, Mauro, Sarcinella, Alessandro, Moietta, Federico, Piccolantonio, Alessio, Moiso, Enrico, Centonze, Giorgia, Manco, Marta, Guala, Andrea, Lamolinara, Alessia, Angelini, Costanza, Morellato, Alessandro, Natalini, Dora, Calogero, Raffaele, Incarnato, Danny, Oliviero, Salvatore, Conti, Laura, Iezzi, Manuela, Tosoni, Daniela, Bertalot, Giovanni, Freddi, Stefano, Tucci, Francesco A., De Sanctis, Francesco, Frusteri, Cristina, Ugel, Stefano, Bronte, Vincenzo, Cavallo, Federica, Provero, Paolo, Gai, Marta, Taverna, Daniela, Turco, Emilia, Pece, Salvatore, Defilippi, Paola

“…The p140Cap adaptor protein is a tumor suppressor in breast cancer associated with a favorable prognosis. Here we highlight a function of p140Cap in…”
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Human liver stem cells express UGT1A1 and improve phenotype of immunocompromised Crigler Najjar syndrome type I mice by Famulari, Elvira Smeralda, Navarro-Tableros, Victor, Herrera Sanchez, Maria Beatriz, Bortolussi, Giulia, Gai, Marta, Conti, Laura, Silengo, Lorenzo, Tolosano, Emanuela, Tetta, Ciro, Muro, Andrés Fernando, Camussi, Giovanni, Fagoonee, Sharmila, Altruda, Fiorella

“…Crigler Najjar Syndrome type I (CNSI) is a rare recessive disorder caused by mutations in the Ugt1a1 gene. There is no permanent cure except for liver…”
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Of rings and spines: The multiple facets of Citron proteins in neural development by Bianchi, Federico T., Gai, Marta, Berto, Gaia E., Di Cunto, Ferdinando

“…The Citron protein was originally identified for its capability to specifically bind the active form of RhoA small GTPase, leading to the simplistic hypothesis…”
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