Search Results - "Gagnon, A."

CHOPCHOP v2: a web tool for the next generation of CRISPR genome engineering by Labun, Kornel, Montague, Tessa G, Gagnon, James A, Thyme, Summer B, Valen, Eivind

“…In just 3 years CRISPR genome editing has transformed biology, and its popularity and potency continue to grow. New CRISPR effectors and rules for locating…”
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Efficient mutagenesis by Cas9 protein-mediated oligonucleotide insertion and large-scale assessment of single-guide RNAs by Gagnon, James A, Valen, Eivind, Thyme, Summer B, Huang, Peng, Akhmetova, Laila, Ahkmetova, Laila, Pauli, Andrea, Montague, Tessa G, Zimmerman, Steven, Richter, Constance, Schier, Alexander F

“…The CRISPR/Cas9 system has been implemented in a variety of model organisms to mediate site-directed mutagenesis. A wide range of mutation rates has been…”
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Simultaneous single-cell profiling of lineages and cell types in the vertebrate brain by Raj, Bushra, Wagner, Daniel E, McKenna, Aaron, Pandey, Shristi, Klein, Allon M, Shendure, Jay, Gagnon, James A, Schier, Alexander F

“…scGESTALT enables large-scale characterization of cell types and lineage relationships during vertebrate brain development. The lineage relationships among the…”
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Whole-organism lineage tracing by combinatorial and cumulative genome editing by McKenna, Aaron, Findlay, Gregory M., Gagnon, James A., Horwitz, Marshall S., Schier, Alexander F., Shendure, Jay

“…Multicellular systems develop from single cells through distinct lineages. However, current lineage-tracing approaches scale poorly to whole, complex…”
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Twinkle, twinkle little star: Photoswitchable fluorophores for super-resolution imaging by Chozinski, Tyler J., Gagnon, Lauren A., Vaughan, Joshua C.

“…Photoswitchable fluorescent probes are key elements of newly developed super-resolution fluorescence microscopy techniques that enable far-field interrogation…”
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Comparison of advanced oxidation processes for the removal of natural organic matter by Lamsal, Rupa, Walsh, Margaret E., Gagnon, Graham A.

“…This study examined the impact of UV, ozone (O 3), advanced oxidation processes (AOPs) including O 3/UV, H 2O 2/UV H 2O 2/O 3 in the change of molecular weight…”
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Prey DNA detection success following digestion by intraguild predators: influence of prey and predator species by GAGNON, A.-È., DOYON, J., HEIMPEL, G. E., BRODEUR, J.

“…Intraguild predation (IGP) has been increasingly recognized as an important interaction in ecological systems over the past two decades, and remarkable…”
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Efficient CRISPR-Cas9-Mediated Generation of Knockin Human Pluripotent Stem Cells Lacking Undesired Mutations at the Targeted Locus by Merkle, Florian T., Neuhausser, Werner M., Santos, David, Valen, Eivind, Gagnon, James A., Maas, Kristi, Sandoe, Jackson, Schier, Alexander F., Eggan, Kevin

“…The CRISPR-Cas9 system has the potential to revolutionize genome editing in human pluripotent stem cells (hPSCs), but its advantages and pitfalls are still…”
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Coinfections and their molecular consequences in the porcine respiratory tract by Saade, Georges, Deblanc, Céline, Bougon, Juliette, Marois-Créhan, Corinne, Fablet, Christelle, Auray, Gaël, Belloc, Catherine, Leblanc-Maridor, Mily, Gagnon, Carl A, Zhu, Jianzhong, Gottschalk, Marcelo, Summerfield, Artur, Simon, Gaëlle, Bertho, Nicolas, Meurens, François

“…Understudied, coinfections are more frequent in pig farms than single infections. In pigs, the term "Porcine Respiratory Disease Complex" (PRDC) is often used…”
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Conserved regulation of Nodal-mediated left-right patterning in zebrafish and mouse by Montague, Tessa G, Gagnon, James A, Schier, Alexander F

“…Nodal is the major effector of left-right axis development. In mice, Nodal forms heterodimers with Gdf1 and is inhibited by Cerl2/Dand5 at the node, and by…”
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Comprehensive evaluation of deconvolution methods for human brain gene expression by Sutton, Gavin J., Poppe, Daniel, Simmons, Rebecca K., Walsh, Kieran, Nawaz, Urwah, Lister, Ryan, Gagnon-Bartsch, Johann A., Voineagu, Irina

“…Transcriptome deconvolution aims to estimate the cellular composition of an RNA sample from its gene expression data, which in turn can be used to correct for…”
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Folding and misfolding of potassium channel monomers during assembly and tetramerization by Song, Kevin C., Molina, Andrew V., Chen, Ruofan, Gagnon, Isabelle A., Koh, Young Hoon, Roux, Benoît, Sosnick, Tobin R.

“…The dynamics and folding of potassium channel pore domain monomers are connected to the kinetics of tetramer assembly. In all-atom molecular dynamics…”
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Raw water biofiltration for surface water manganese control by Earle, Martin R., Stoddart, Amina K., Gagnon, Graham A.

“…Manganese (Mn) control in surface water systems is a challenge for the drinking water industry, especially through a sustainability framework. Current methods…”
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scMerge leverages factor analysis, stable expression, and pseudoreplication to merge multiple single-cell RNA-seq datasets by Lin, Yingxin, Ghazanfar, Shila, Wang, Kevin Y. X., Gagnon-Bartsch, Johann A., Lo, Kitty K., Su, Xianbin, Han, Ze-Guang, Ormerod, John T., Speed, Terence P., Yang, Pengyi, Yang, Jean Yee Hwa

“…Concerted examination of multiple collections of single-cell RNA sequencing (RNA-seq) data promises further biological insights that cannot be uncovered with…”
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Impurity-induced magnetic moments on the graphene-lattice Hubbard model: An inhomogeneous cluster dynamical mean-field theory study by Charlebois, M., Sénéchal, D., Gagnon, A.-M., Tremblay, A.-M. S.

“…Defect-induced magnetic moments are at the center of the research effort on spintronic applications of graphene. Here, we study the problem of a nonmagnetic…”
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Transcriptional Analysis of PRRSV-Infected Porcine Dendritic Cell Response to Streptococcus suis Infection Reveals Up-Regulation of Inflammatory-Related Genes Expression by Auray, Gaël, Lachance, Claude, Wang, Yingchao, Gagnon, Carl A, Segura, Mariela, Gottschalk, Marcelo

“…The porcine reproductive and respiratory syndrome virus (PRRSV) is one of the most important swine pathogens and often serves as an entry door for other viral…”
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Integrating Traditional Ecological Knowledge and Ecological Science: a Question of Scale by Gagnon, Catherine A., Berteaux, Dominique

“…The benefits and challenges of integrating traditional ecological knowledge and scientific knowledge have led to extensive discussions over the past decades,…”
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Enhanced detection of viruses for improved water safety by Hayes, Emalie K., Gouthro, Madison T., Fuller, Megan, Redden, David J., Gagnon, Graham A.

“…Human viruses pose a significant health risk in freshwater environments, but current monitoring methods are inadequate for detecting viral presence…”
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Microbe transmission from pet shop to lab-reared zebrafish reveals a pathogenic birnavirus by Rice, Marlen C, Janik, Andrew J, Elde, Nels C, Gagnon, James A, Balla, Keir M

“…Zebrafish are popular research organisms selected for laboratory use due in part to widespread availability from the pet trade. Many contemporary colonies of…”
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Expansion microscopy of zebrafish for neuroscience and developmental biology studies by Freifeld, Limor, Odstrcil, Iris, Förster, Dominique, Ramirez, Alyson, Gagnon, James A., Randlett, Owen, Costa, Emma K., Asano, Shoh, Celiker, Orhan T., Gao, Ruixuan, Martin-Alarcon, Daniel A., Reginato, Paul, Dick, Cortni, Chen, Linlin, Schoppik, David, Engert, Florian, Baier, Herwig, Boyden, Edward S.

“…Expansion microscopy (ExM) allows scalable imaging of preserved 3D biological specimens with nanoscale resolution on fast diffraction-limited microscopes…”
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