Search Results - "Gagnol, J P"

Effect of a high dose of simvastatin on muscle mitochondrial metabolism and calcium signaling in healthy volunteers by Galtier, F., Mura, T., Raynaud de Mauverger, E., Chevassus, H., Farret, A., Gagnol, J.-P., Costa, F., Dupuy, A., Petit, P., Cristol, J.P., Mercier, J., Lacampagne, A.

“…Statin use may be limited by muscle side effects. Although incompletely understood to date, their pathophysiology may involve oxidative stress and impairments…”
Get full text

Can we identify response markers to antihypertensive drugs? First results from the IDEAL Trial by Gueyffier, F, Subtil, F, Bejan-Angoulvant, T, Zerbib, Y, Baguet, J P, Boivin, J M, Mercier, A, Leftheriotis, G, Gagnol, J P, Fauvel, J P, Giraud, C, Bricca, G, Maucort-Boulch, D, Erpeldinger, S

“…Current antihypertensive strategies do not take into account that individual characteristics may influence the magnitude of blood pressure (BP) reduction…”
Get full text

Pharmacological profile of the novel inotropic agent (E,Z)-3-((2-aminoethoxy)imino)androstane-6,17-dione hydrochloride (PST2744) by Micheletti, R, Mattera, G G, Rocchetti, M, Schiavone, A, Loi, M F, Zaza, A, Gagnol, R J P, De Munari, S, Melloni, P, Carminati, P, Bianchi, G, Ferrari, P

“…The novel Na(+)/K(+)-ATPase inhibitor (E,Z)-3-((2-aminoethoxy)imino)androstane-6,17-dione hydrochloride (PST2744) was characterized for its inotropic and toxic…”
Get more information

Autonomic Nervous System Activity Imbalance in Cardiomyopathic Hamster by Giudice, Pietro Lo, Gagnol, Jean Pierre, Bellucci, Augusta, Buffone, Giovanna, Careddu, Antonia, Magni, Giuseppina, Quagliata, Teresa, Pacifici, Licia, Carminati, Paolo

“…There is strong evidence that autonomic imbalance plays an important role in progression of heart failure. Analysis of heart rate variability (HRV) has…”
Get full text

Reversal of Electrophysiologic and Hemodynamic Effects Induced by High Dose of Bupivacaine by the Combination of Clonidine and Dobutamine in Anesthetized Dogs by de La Coussaye, Jean E., Bassoul, Bruno, Brugada, Josep, Albat, Bernard, Peray, Pascale A., Gagnol, Jean P., Desch, Gérard, Eledjam, Jean J., Sassine, Antoine

“…The ability of clonidine and dobutamine to correct bupivacaine-induced cardiac electrophysiologic and hemodynamic impairment was evaluated in an experimental…”
Get full text

In vitro study on mechanisms of bupivacaine-induced depression of myocardial contractility by ELEDJAM, J. J, DE LA COUSSAYE, J. E, BRUGADA, J, BASSOUL, B, GAGNOL, J. P, FABREGAT, J. R, MASSE, C, SASSINE, A

“…Although several mechanisms have been proposed to explain bupivacaine cardiotoxicity, the predominant effect remains to be determined. In this study, we used…”
Get full text

Lemakalim, a potassium channel agonist, reverses electrophysiological impairments induced by a large dose of bupivacaine in anaesthetized dogs by de La Coussaye, J E, Eledjam, J J, Peray, P, Bruelle, P, Lefrant, J Y, Bassoul, B, Desch, G, Gagnol, J P, Sassine, A

“…We have examined the ability of lemakalim to correct bupivacaine-induced cardiac electrophysiological impairment in an experimental electrophysiological model…”
Get more information

Experimental Evidence in Favor of Role of Intracellular Actions of Bupivacaine in Myocardial Depression by de La Coussaye, Jean E., Bassoul, Bruno, Albat, Bernard, Peray, Pascale A., Gagnol, Jean P., Eledjam, Jean J., Sassine, Antoine

“…Bupivacaine is more cardiodepressant than lidocaine. Nevertheless, the marked depression of contractility induced by bupivacaine cannot be completely explained…”
Get full text

Successful conservative surgery of acute ascending aortic dissection occurring during coronary angiography by Leclercq, F, Albat, B, Messner-Pellenc, P, Hager, F X, Mariottini, C J, Macia, J C, Gagnol, J P, Grolleau-Raoux, R

“…We reported the case of an acute aortic dissection complicating right guiding catheter manipulation during engagement in the right coronary ostium. Despite…”
Get full text

Cardiac response to submaximal exercise in dogs susceptible to sudden cardiac death by Billman, G E, Schwartz, P J, Gagnol, J P, Stone, H L

“…The hemodynamic response to submaximal exercise was investigated in 38 mongrel dogs with healed anterior wall myocardial infarctions. The dogs were chronically…”
Get more information

Succinylcholine does not worsen bupivacaine-induced cardiotoxicity in pentobarbital-anaesthetized dogs by DE LA COUSSAYE, J. E, BASSOUL, B. P, ALBAT, B, PERAY, P. A, GAGNOL, J.-P, ELEDJAM, J.-J, SASSINE, A

“…The intravascular injection of a large dose of bupivacaine induces electrophysiological cardiac impairment, mainly by slowing ventricular conduction velocity,…”
Get full text

Electrophysiologic and arrhythmogenic effects of the potassium channel agonist BRL 38227 in anesthetized dogs by de La Coussaye, J E, Eledjam, J J, Bruelle, P, Peray, P A, Bassoul, B P, Gagnol, J P, Sassine, A

“…Although potassium channel openers have been demonstrated to induce arterial vasodilation and shortening of the QT interval, the complete in vivo hemodynamic…”
Get more information

Bupivacaine-induced slow-inward current inhibition : a voltage clamp study on frog atrial fibres by DE LA COUSSAYE, J. E, MASSE, C, BASSOUL, B. P, ELEDJAM, J.-J, GAGNOL, J.-P, SASSINE, A

“…The effects of various concentrations of bupivacaine on the characteristics of the slow-inward current (isi) were studied over a ten-minute period on isolated…”
Get full text

A potent radiolabeled human renin inhibitor [3H]SR42128: enzymatic, kinetic, and binding studies to renin and other aspartic proteases by Cumin, Frederic, Nisato, Dino, Gagnol, Jean Pierre, Corvol, Pierre

“…The in vitro binding of [3H]SR42128 (Iva-Phe-Nle-Sta-Ala-Sta-Arg), a potent inhibitor of human renin activity, to purified human renin and a number of other…”
Get full text

Electrophysiologic effects and pharmacokinetics of intravenous penticainide (CM 7857) by Aliot, E, Munoz, A, Khalife, K, Necciari, J, Gagnol, J P, Gilgenkrantz, J M

“…Penticainide is a new class I antiarrhythmic agent. Its electrophysiological effects and pharmacokinetic properties were studied in 28 patients undergoing…”
Get more information

Electrophysiological studies of penticainide (CM 7857), a new antiarrhythmic agent, in mammalian myocardium by Gautier, P, Guiraudou, P, Pezziardi, F, Bertrand, J P, Gagnol, J P

“…The intracellular electrophysiologic properties of a new antiarrhythmic substance, penticainide, were studied in isolated rabbit, dog, and guinea pig…”
Get more information

Effect of amiodarone on myosin isoenzymic distribution in rat ventricular myocardium by Nokin, P, Mercadier, J J, Nahum, D, Bouveret, P, Wisnewsky, C, Jungbluth, L, Gagnol, J P, Schwartz, K

“…Rats were given amiodarone (50 mg X kg-1 X day-1, orally) for 4 weeks and the distribution of ventricular isomyosins, a sensitive index of the effects of…”
Get more information

Histamine release during an experimental coronary thrombosis in awake dog by Masini, E, Phanchenault, J, Pezziardi, F, Gautier, P, Gagnol, J P

“…Histamine is released into the systemic circulation during anaphylaxis, by drugs and surgical procedures. Studies in animal models have shown that released…”
Get full text

Effects of somatostatin added to insulin in a glucose-controlled insulin infusion system by Selam, J L, Chenon, D, Pham, T C, Gagnol, J P, Sany, C, Thomas, N, Gravagne, G, Orsetti, A, Mirouze, J

“…Five insulin treated diabetics were studied on three consecutive days. Overnight variable intravenous insulin infusions were used before each study to maintain…”
Get full text

Reduction by carbachol of ventricular conduction impairments induced by various class I antiarrhythmic drugs in anesthetized dogs by de la Coussaye, J E, Bassoul, B, Bruelle, P, Peray, P A, Albat, B, Gagnol, J P, Daures, J P, Eledjam, J J, Sassine, A

“…A common property of all Class I antiarrhythmic agents is the inhibition of the fast inward current INa. Consequently, ventricular conduction velocities are…”
Get more information