Search Results - "Gagné, Rémi"

Transgenerational hypocortisolism and behavioral disruption are induced by the antidepressant fluoxetine in male zebrafish Danio rerio by Vera-Chang, Marilyn N., St-Jacques, Antony D., Gagné, Rémi, Martyniuk, Chris J., Yauk, Carole L., Moon, Thomas W., Trudeau, Vance L.

“…The global prevalence of depression is high during childbearing. Due to the associated risks to the mother and baby, the selective serotonin reuptake inhibitor…”
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Bisphenol A and Bisphenol S Induce Distinct Transcriptional Profiles in Differentiating Human Primary Preadipocytes by Boucher, Jonathan G, Gagné, Rémi, Rowan-Carroll, Andrea, Boudreau, Adèle, Yauk, Carole L, Atlas, Ella

“…Bisphenol S (BPS) is increasingly used as a replacement plasticizer for bisphenol A (BPA) but its effects on human health have not been thoroughly examined…”
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Depot-Specific Analysis of Human Adipose Cells and Their Responses to Bisphenol S by Peshdary, Vian, Styles, George, Gagné, Rémi, Yauk, Carole L, Sorisky, Alexander, Atlas, Ella

“…Abstract Exposure to endocrine-disrupting chemicals (EDCs) is associated with adverse health outcomes including obesity and diabetes. Obesity, and more…”
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Hepatic transcriptional dose-response analysis of male and female Fischer rats exposed to hexabromocyclododecane by Farmahin, Reza, Gannon, Anne Marie, Gagné, Rémi, Rowan-Carroll, Andrea, Kuo, Byron, Williams, Andrew, Curran, Ivan, Yauk, Carole L.

“…Hexabromocyclododecane (HBCD) is a brominated flame retardant found in the environment and human tissues. The toxicological effects of HBCD exposure are not…”
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Impact of Genomics Platform and Statistical Filtering on Transcriptional Benchmark Doses (BMD) and Multiple Approaches for Selection of Chemical Point of Departure (PoD) by Webster, A Francina, Chepelev, Nikolai, Gagné, Rémi, Kuo, Byron, Recio, Leslie, Williams, Andrew, Yauk, Carole L

“…Many regulatory agencies are exploring ways to integrate toxicogenomic data into their chemical risk assessments. The major challenge lies in determining how…”
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Genetic Toxicity of Complex Mixtures of Polycyclic Aromatic Hydrocarbons: Evaluating Dose-Additivity in a Transgenic Mouse Model by Long, Alexandra S, Lemieux, Christine L, Gagné, Rémi, Lambert, Iain B, White, Paul A

“…This study evaluates the risk assessment approach currently employed for polycyclic aromatic hydrocarbon (PAH)-contaminated media, wherein carcinogenic hazards…”
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Characterizing Benzo[a]pyrene-induced lacZ mutation spectrum in transgenic mice using next-generation sequencing by Beal, Marc A, Gagné, Rémi, Williams, Andrew, Marchetti, Francesco, Yauk, Carole L

“…The transgenic rodent mutation reporter assay provides an efficient approach to identify mutagenic agents in vivo. A major advantage of this assay is that…”
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The use of in vitro transcriptional data to identify thresholds of effects in a human lens epithelial cell-line exposed to ionizing radiation by Chauhan, Vinita, Rowan-Carroll, Andrea, Gagné, Rémi, Kuo, Byron, Williams, Andrew, Yauk, Carole L.

“…Purpose: The International Commission on Radiological Protection (ICRP) recently recommended reducing the occupational equivalent dose limit for the lens of…”
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Prolonged Low-Dose Dioxin Exposure Impairs Metabolic Adaptability to High-Fat Diet Feeding in Female but Not Male Mice by Matteo, Geronimo, Hoyeck, Myriam P, Blair, Hannah L, Zebarth, Julia, Rick, Kayleigh R C, Williams, Andrew, Gagné, Rémi, Buick, Julie K, Yauk, Carole L, Bruin, Jennifer E

“…Context Human studies consistently show an association between exposure to persistent organic pollutants, including 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD,…”
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Transcriptional profiling of male F344 rats suggests the involvement of calcium signaling in the mode of action of acrylamide-induced thyroid cancer by Chepelev, Nikolai L., Gagné, Rémi, Maynor, Timothy, Kuo, Byron, Hobbs, Cheryl A., Recio, Leslie, Yauk, Carole L.

“…Acrylamide (AA) exposure in 2-year cancer bioassays leads to thyroid, but not liver, adenomas and adenocarcinomas in rats. Hypothesized modes of action (MOAs)…”
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Transcriptional profiling of male CD-1 mouse lungs and Harderian glands supports the involvement of calcium signaling in acrylamide-induced tumors by Chepelev, Nikolai L., Gagné, Rémi, Maynor, Timothy, Kuo, Byron, Hobbs, Cheryl A., Recio, Leslie, Yauk, Carole L.

“…Acrylamide (AA) exposure causes increased incidence of forestomach, lung, and Harderian gland tumors in male mice. One hypothesized mode of action (MOA) for…”
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A Modern Genotoxicity Testing Paradigm: Integration of the High-Throughput CometChip® and the TGx-DDI Transcriptomic Biomarker in Human HepaRG™ Cell Cultures by Buick, Julie K., Williams, Andrew, Meier, Matthew J., Swartz, Carol D., Recio, Leslie, Gagné, Rémi, Ferguson, Stephen S., Engelward, Bevin P., Yauk, Carole L.

“…Higher-throughput, mode-of-action-based assays provide a valuable approach to expedite chemical evaluation for human health risk assessment. In this study, we…”
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Paternal exposure to benzo(a)pyrene induces genome-wide mutations in mouse offspring by Beal, Marc A., Meier, Matthew J., Williams, Andrew, Rowan-Carroll, Andrea, Gagné, Rémi, Lindsay, Sarah J., Fitzgerald, Tomas, Hurles, Matthew E., Marchetti, Francesco, Yauk, Carole L.

“…Understanding the effects of environmental exposures on germline mutation rates has been a decades-long pursuit in genetics. We used next-generation sequencing…”
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Integrated Genotoxicity Testing of three anti-infective drugs using the TGx-DDI transcriptomic biomarker and high-throughput CometChip ® assay in TK6 cells by Buick, Julie K, Rowan-Carroll, Andrea, Gagné, Rémi, Williams, Andrew, Chen, Renxiang, Li, Heng-Hong, Fornace, Jr, Albert J, Chao, Christy, Engelward, Bevin P, Frötschl, Roland, Ellinger-Ziegelbauer, Heidrun, Pettit, Syril D, Aubrecht, Jiri, Yauk, Carole L

“…Genotoxicity testing relies on the detection of gene mutations and chromosome damage and has been used in the genetic safety assessment of drugs and chemicals…”
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Transcriptional Profiling of Dibenzo[def,p]chrysene-induced Spleen Atrophy Provides Mechanistic Insights into its Immunotoxicity in MutaMouse by Chepelev, Nikolai L, Long, Alexandra S, Williams, Andrew, Kuo, Byron, Gagné, Rémi, Kennedy, Dean A, Phillips, David H, Arlt, Volker M, White, Paul A, Yauk, Carole L

“…Dibenzo[def,p]chrysene (DBC) is the most carcinogenic polycyclic aromatic hydrocarbon (PAH) examined to date. We investigated the immunotoxicity of DBC,…”
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Thyroid hormone-regulated gene expression in juvenile mouse liver: identification of thyroid response elements using microarray profiling and in silico analyses by Paquette, Martin A, Dong, Hongyan, Gagné, Rémi, Williams, Andrew, Malowany, Morie, Wade, Mike G, Yauk, Carole L

“…Disruption of thyroid hormone signalling can alter growth, development and energy metabolism. Thyroid hormones exert their effects through interactions with…”
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Adipogenic Effects and Gene Expression Profiling of Firemaster® 550 Components in Human Primary Preadipocytes by Tung, Emily W Y, Peshdary, Vian, Gagné, Remi, Rowan-Carroll, Andrea, Yauk, Carole L, Boudreau, Adéle, Atlas, Ella

“…Exposure to flame retardants has been associated with negative health outcomes including metabolic effects. As polybrominated diphenyl ether flame retardants…”
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Brief Developmental Exposure to Fluoxetine Causes Life-Long Alteration of the Brain Transcriptome in Zebrafish by Nozari, Amin, Gagné, Remi, Lu, Chunyu, Yauk, Carole, Trudeau, Vance L

“…Fluoxetine (FLX) and other selective serotonin reuptake inhibitors are widely used to treat depressive disorders during pregnancy. Early-life exposure to FLX…”
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Transcriptional profiling of the mouse hippocampus supports an NMDAR-mediated neurotoxic mode of action for benzo[a]pyrene by Chepelev, Nikolai L., Long, Alexandra S., Bowers, Wayne J., Gagné, Rémi, Williams, Andrew, Kuo, Byron, Phillips, David H., Arlt, Volker M., White, Paul A., Yauk, Carole L.

“…Benzo[a]pyrene (BaP) is a genotoxic carcinogen and a neurotoxicant. The neurotoxicity of BaP is proposed to arise from either genotoxicity leading to neuronal…”
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Adipogenic Mesenchymal Stromal Cells from Bone Marrow and Their Hematopoietic Supportive Role: Towards Understanding the Permissive Marrow Microenvironment in Acute Myeloid Leukemia by Le, Yevgeniya, Fraineau, Sylvain, Chandran, Priya, Sabloff, Mitchell, Brand, Marjorie, Lavoie, Jessie R., Gagne, Rémi, Rosu-Myles, Michael, Yauk, Carole L., Richardson, Richard B., Allan, David S.

“…Purpose The role of bone marrow-derived mesenchymal stem/stromal cells (MSCs) in creating a permissive microenvironment that supports the emergence and…”
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