Search Results - "Gaggi, Giulia"
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The Effects of Combined Exposure to Bisphenols and Perfluoroalkyls on Human Perinatal Stem Cells and the Potential Implications for Health Outcomes
Published in International journal of molecular sciences (01-10-2023)“…The present study investigates the impact of two endocrine disruptors, namely Bisphenols (BPs) and Perfluoroalkyls (PFs), on human stem cells. These chemicals…”
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Machine learning identifies phenotypic profile alterations of human dopaminergic neurons exposed to bisphenols and perfluoroalkyls
Published in Scientific reports (11-12-2023)“…Parkinson’s disease (PD) is the second most common neurodegenerative disease and is characterized by the loss of midbrain dopaminergic neurons. Endocrine…”
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Metoprolol disrupts inflammatory response of human cardiomyocytes via β-arrestin2 biased agonism and NF-κB signaling modulation
Published in Biomedicine & pharmacotherapy (01-12-2023)“…Recent evidence supports non-class cardioprotective effects of metoprolol against neutrophil-mediated ischemia-reperfusion injury during exacerbated…”
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Spare Parts from Discarded Materials: Fetal Annexes in Regenerative Medicine
Published in International journal of molecular sciences (29-03-2019)“…One of the main aims in regenerative medicine is to find stem cells that are easy to obtain and are safe and efficient in either an autologous or allogenic…”
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Targeted systematic evolution of an RNA platform neutralizing DNMT1 function and controlling DNA methylation
Published in Nature communications (06-01-2023)“…DNA methylation is a fundamental epigenetic modification regulating gene expression. Aberrant DNA methylation is the most common molecular lesion in cancer…”
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Human Mesenchymal Stromal Cells Unveil an Unexpected Differentiation Potential toward the Dopaminergic Neuronal Lineage
Published in International journal of molecular sciences (09-09-2020)“…Degeneration of dopaminergic neurons represents the cause of many neurodegenerative diseases, with increasing incidence worldwide. The replacement of dead…”
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Antenatal Exposure to Plastic Pollutants: Study of the Bisphenols and Perfluoroalkyls Effects on Human Stem Cell Models
Published in Exposure and health (01-06-2024)“…Endocrine disruptors (EDs), such as Bisphenols (BPs) and Perfluoroalkyls (PFs), are a class of plastic pollutants widely used in industrial applications. Human…”
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Editorial: Endocrine disruptors: mechanism of action and implications for human health
Published in Frontiers in cell and developmental biology (2024)Get full text
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Human-Induced Pluripotent Stem Cell Technology and Cardiomyocyte Generation: Progress and Clinical Applications
Published in Cells (Basel, Switzerland) (25-05-2018)“…Human-induced pluripotent stem cells (hiPSCs) are reprogrammed cells that have hallmarks similar to embryonic stem cells including the capacity of self-renewal…”
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Decellularized Extracellular Matrices and Cardiac Differentiation: Study on Human Amniotic Fluid-Stem Cells
Published in International journal of molecular sciences (31-08-2020)“…Cell therapy with a variety of stem populations is increasingly being investigated as a promising regenerative strategy for cardiovascular (CV) diseases. Their…”
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Gingival Response to Dental Implant: Comparison Study on the Effects of New Nanopored Laser-Treated vs. Traditional Healing Abutments
Published in International journal of molecular sciences (22-08-2020)“…The health of peri-implant soft tissues is important for the long-term success rate of dental implants and the surface topography is pivotal in influencing it…”
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Impact on peri-implant connective tissue of laser treated versus traditional healing abutments: a human clinical trials
Published in BMC oral health (27-06-2023)“…Dental implant is the principal treatment for edentulism and the healthiness of the peri-implant tissue has a pivotal role for its longterm success. In…”
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Chemical and Biological Molecules Involved in Differentiation, Maturation, and Survival of Dopaminergic Neurons in Health and Parkinson’s Disease: Physiological Aspects and Clinical Implications
Published in Biomedicines (29-06-2021)“…Parkinson’s disease (PD) is one of the most common neurodegenerative disease characterized by a specific and progressive loss of dopaminergic (DA) neurons and…”
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Effect of Physical Exercise on the Release of Microparticles with Angiogenic Potential
Published in Applied sciences (01-07-2020)“…Cellular communication has a fundamental role in both human physiological and pathological states and various mechanisms are involved in the crosstalk between…”
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Human Ubiquitin-Specific Peptidase 18 Is Regulated by microRNAs via the 3'Untranslated Region, A Sequence Duplicated in Long Intergenic Non-coding RNA Genes Residing in chr22q11.21
Published in Frontiers in genetics (03-02-2021)“…Ubiquitin-specific peptidase 18 (USP18) acts as gatekeeper of type I interferon (IFN) responses by binding to the IFN receptor subunit IFNAR2 and preventing…”
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Human mesenchymal amniotic fluid stem cells reveal an unexpected neuronal potential differentiating into functional spinal motor neurons
Published in Frontiers in cell and developmental biology (22-07-2022)“…Human amniotic fluids stem cells (hAFSCs) can be easily isolated from the amniotic fluid during routinely scheduled amniocentesis. Unlike hiPSCs or hESC, they…”
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Unraveling the Epigenetic Landscape: Insights into Parkinson's Disease, Amyotrophic Lateral Sclerosis, and Multiple Sclerosis
Published in Brain sciences (29-05-2024)“…Parkinson's disease (PD), multiple sclerosis (MS), and amyotrophic lateral sclerosis (ALS) are examples of neurodegenerative movement disorders (NMDs), which…”
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Real-Time Monitoring of Levetiracetam Effect on the Electrophysiology of an Heterogenous Human iPSC-Derived Neuronal Cell Culture Using Microelectrode Array Technology
Published in Biosensors (Basel) (12-11-2021)“…Levetiracetam (LEV) is a broad-spectrum and widely used antiepileptic drug that also has neuroprotective effects in different neurological conditions. Given…”
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Human fetal membrane-mesenchymal stromal cells generate functional spinal motor neurons in vitro
Published in iScience (21-10-2022)“…Human fetal membrane mesenchymal stromal cells (hFM-MSCs) are a cell population easily isolable from the amniochorionic membrane of term placentas, without…”
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Resveratrol Enhances the Cytotoxic Activity of Lymphocytes from Menopausal Women
Published in Antioxidants (29-11-2021)“…Nutraceuticals and functional foods are the main sources of antioxidants and have positive effects on health through regulation of the redox balance…”
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