Search Results - "Gagestein, Berend"

Anandamide and other N-acylethanolamines: A class of signaling lipids with therapeutic opportunities by Mock, Elliot D., Gagestein, Berend, van der Stelt, Mario

“…N-acylethanolamines (NAEs), including N-palmitoylethanolamine (PEA), N-oleoylethanolamine (OEA), N-arachidonoylethanolamine (AEA, anandamide),…”
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Live‐Cell Imaging of Sterculic Acid—a Naturally Occurring 1,2‐Cyclopropene Fatty Acid—by Bioorthogonal Reaction with Turn‐On Tetrazine‐Fluorophore Conjugates by Bertheussen, Kristine, Plassche, Merel, Bakkum, Thomas, Gagestein, Berend, Ttofi, Iakovia, Sarris, Alexi J. C., Overkleeft, Herman S., Stelt, Mario, Kasteren, Sander I.

“…In the field of lipid research, bioorthogonal chemistry has made the study of lipid uptake and processing in living systems possible, whilst minimising…”
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Comparative Photoaffinity Profiling of Omega‑3 Signaling Lipid Probes Reveals Prostaglandin Reductase 1 as a Metabolic Hub in Human Macrophages by Gagestein, Berend, von Hegedus, Johannes H., Kwekkeboom, Joanneke C., Heijink, Marieke, Blomberg, Niek, van der Wel, Tom, Florea, Bogdan I., van den Elst, Hans, Wals, Kim, Overkleeft, Herman S., Giera, Martin, Toes, René E. M., Ioan-Facsinay, Andreea, van der Stelt, Mario

“…The fish oil constituent docosahexaenoic acid (DHA, 22:6 n-3) is a signaling lipid with anti-inflammatory properties. The molecular mechanisms underlying the…”
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Discovery of isoquinoline sulfonamides as allosteric gyrase inhibitors with activity against fluoroquinolone-resistant bacteria by Bakker, Alexander T., Kotsogianni, Ioli, Avalos, Mariana, Punt, Jeroen M., Liu, Bing, Piermarini, Diana, Gagestein, Berend, Slingerland, Cornelis J., Zhang, Le, Willemse, Joost J., Ghimire, Leela B., van den Berg, Richard J. H. B. N., Janssen, Antonius P. A., Ottenhoff, Tom H. M., van Boeckel, Constant A. A., van Wezel, Gilles P., Ghilarov, Dmitry, Martin, Nathaniel I., van der Stelt, Mario

“…Bacteria have evolved resistance to nearly all known antibacterials, emphasizing the need to identify antibiotics that operate via novel mechanisms. Here we…”
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Previously Published Phosphatase Probes have Limited Utility Due to their Unspecific Reactivity by ter Brake, F. H. G., Luttikhuizen, S. A. F. M., Wel, T., Gagestein, B., Florea, B. I., Stelt, M., Janssen, A. P. A.

“…This study explores the use of activity‐based protein profiling to study protein tyrosine phosphatases. With the discovery of allosteric SHP2 inhibitors, this…”
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Chemical Proteomics Reveals Off-Targets of the Anandamide Reuptake Inhibitor WOBE437 by Gagestein, Berend, Stevens, Anna F., Fazio, Domenico, Florea, Bogdan I., van der Wel, Tom, Bakker, Alexander T., Fezza, Filomena, Dulk, Hans den, Overkleeft, Herman S., Maccarrone, Mauro, van der Stelt, Mario

“…Anandamide or N-arachidonoylethanolamine (AEA) is a signaling lipid that modulates neurotransmitter release via activation of the type 1 cannabinoid receptor…”
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Olaparib‐Based Photoaffinity Probes for PARP‐1 Detection in Living Cells by Voorneveld, Jim, Florea, Bogdan I., Bakkum, Thomas, Mendowicz, Rafal J., Veer, Miriam S., Gagestein, Berend, Kasteren, Sander I., Stelt, Mario, Overkleeft, Herman S., Filippov, Dmitri V.

“…The poly‐ADP‐ribose polymerase (PARP) is a protein from the family of ADP‐ribosyltransferases that catalyzes polyadenosine diphosphate ribose (ADPR) formation…”
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Comprehensive structure-activity-relationship of azaindoles as highly potent FLT3 inhibitors by Grimm, Sebastian H., Gagestein, Berend, Keijzer, Jordi F., Liu, Nora, Wijdeven, Ruud H., Lenselink, Eelke B., Tuin, Adriaan W., van den Nieuwendijk, Adrianus M.C.H., van Westen, Gerard J.P., van Boeckel, Constant A.A., Overkleeft, Herman S., Neefjes, Jacques, van der Stelt, Mario

“…[Display omitted] Acute myeloid leukemia (AML) is characterized by fast progression and low survival rates, in which Fms-like tyrosine kinase 3 (FLT3) receptor…”
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Opportunities for Lipid-Based Probes in the Field of Immunology by Koenders, Sebastiaan T A, Gagestein, Berend, van der Stelt, Mario

“…Lipids perform a wide range of functions inside the cell, ranging from structural building block of membranes and energy storage to cell signaling. The mode of…”
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Synthesis of α- and β-Galactopyranose-Configured Isomers of Cyclophellitol and Cyclophellitol Aziridine by Willems, Lianne I., Beenakker, Thomas J. M., Murray, Benjamin, Gagestein, Berend, van den Elst, Hans, van Rijssel, Erwin R., Codée, Jeroen D. C., Kallemeijn, Wouter W., Aerts, Johannes M. F. G., van der Marel, Gijsbert A., Overkleeft, Herman S.

“…Cyclophellitol and cyclophellitol aziridine are potent and irreversible mechanism‐based inhibitors of retaining β‐glucosidases. Alterations in the…”
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Live‐Cell Imaging of Sterculic Acid—a Naturally Occurring 1,2‐Cyclopropene Fatty Acid—by Bioorthogonal Reaction with Turn‐On Tetrazine‐Fluorophore Conjugates by Bertheussen, Kristine, Plassche, Merel, Bakkum, Thomas, Gagestein, Berend, Ttofi, Iakovia, Sarris, Alexi J. C., Overkleeft, Herman S., Stelt, Mario, Kasteren, Sander I.

“…In the field of lipid research, bioorthogonal chemistry has made the study of lipid uptake and processing in living systems possible, whilst minimising…”
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Synthesis of [alpha]- and [beta]-Galactopyranose-Configured Isomers of Cyclophellitol and Cyclophellitol Aziridine by Willems, Lianne I, Beenakker, Thomas J M, Murray, Benjamin, Gagestein, Berend, van den Elst, Hans, van Rijssel, Erwin R, Codee, Jeroen D C, Kallemeijn, Wouter W, Aerts, Johannes M F G, van der Marel, Gijsbert A, Overkleeft, Herman S

“…Cyclophellitol and cyclophellitol aziridine are potent and irreversible mechanism-based inhibitors of retaining [beta]-glucosidases. Alterations in the…”
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