Search Results - "Gagea, Mihai"

Rapid acceleration of KRAS-mutant pancreatic carcinogenesis via remodeling of tumor immune microenvironment by PPARδ by Liu, Yi, Deguchi, Yasunori, Wei, Daoyan, Liu, Fuyao, Moussalli, Micheline J., Deguchi, Eriko, Li, Donghui, Wang, Huamin, Valentin, Lovie Ann, Colby, Jennifer K., Wang, Jing, Zheng, Xiaofeng, Ying, Haoqiang, Gagea, Mihai, Ji, Baoan, Shi, Jiaqi, Yao, James C., Zuo, Xiangsheng, Shureiqi, Imad

“…Pancreatic intraepithelial neoplasia (PanIN) is a precursor of pancreatic ductal adenocarcinoma (PDAC), which commonly occurs in the general populations with…”
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KLF4 Is Essential for Induction of Cellular Identity Change and Acinar-to-Ductal Reprogramming during Early Pancreatic Carcinogenesis by Wei, Daoyan, Wang, Liang, Yan, Yongmin, Jia, Zhiliang, Gagea, Mihai, Li, Zhiwei, Zuo, Xiangsheng, Kong, Xiangyu, Huang, Suyun, Xie, Keping

“…Understanding the molecular mechanisms of tumor initiation has significant impact on early cancer detection and intervention. To define the role of KLF4 in…”
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YAP/TAZ-Mediated Upregulation of GAB2 Leads to Increased Sensitivity to Growth Factor-Induced Activation of the PI3K Pathway by Wang, Chao, Gu, Chao, Jeong, Kang Jin, Zhang, Dong, Guo, Wei, Lu, Yiling, Ju, Zhenlin, Panupinthu, Nattapon, Yang, Ji Yeon, Gagea, Mihai Mike, Ng, Patrick Kwok Shing, Zhang, Fan, Mills, Gordon B

“…The transcription regulators YAP and TAZ function as effectors of the HIPPO signaling cascade, critical for organismal development, cell growth, and cellular…”
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Multifunctional Effects of a Small-Molecule STAT3 Inhibitor on NASH and Hepatocellular Carcinoma in Mice by Jung, Kwang Hwa, Yoo, Wonbeak, Stevenson, Heather L, Deshpande, Dipti, Shen, Hong, Gagea, Mihai, Yoo, Suk-Young, Wang, Jing, Eckols, T Kris, Bharadwaj, Uddalak, Tweardy, David J, Beretta, Laura

“…The incidence of hepatocellular carcinoma is increasing in the United States, and liver cancer is the second leading cause of cancer-related mortality…”
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Generation and testing of clinical-grade exosomes for pancreatic cancer by Mendt, Mayela, Kamerkar, Sushrut, Sugimoto, Hikaru, McAndrews, Kathleen M, Wu, Chia-Chin, Gagea, Mihai, Yang, Sujuan, Blanko, Elena V Rodriges, Peng, Qian, Ma, Xiaoyan, Marszalek, Joseph R, Maitra, Anirban, Yee, Cassian, Rezvani, Katayoun, Shpall, Elizabeth, LeBleu, Valerie S, Kalluri, Raghu

“…Exosomes are extracellular vesicles produced by all cells with a remarkable ability to efficiently transfer genetic material, including exogenously loaded…”
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Mammary-specific expression of Trim24 establishes a mouse model of human metaplastic breast cancer by Shah, Vrutant V., Duncan, Aundrietta D., Jiang, Shiming, Stratton, Sabrina A., Allton, Kendra L., Yam, Clinton, Jain, Abhinav, Krause, Patrick M., Lu, Yue, Cai, Shirong, Tu, Yizheng, Zhou, Xinhui, Zhang, Xiaomei, Jiang, Yan, Carroll, Christopher L., Kang, Zhijun, Liu, Bin, Shen, Jianjun, Gagea, Mihai, Manu, Sebastian M., Huo, Lei, Gilcrease, Michael, Powell, Reid T., Guo, Lei, Stephan, Clifford, Davies, Peter J., Parker-Thornburg, Jan, Lozano, Guillermina, Behringer, Richard R., Piwnica-Worms, Helen, Chang, Jeffrey T., Moulder, Stacy L., Barton, Michelle Craig

“…Conditional overexpression of histone reader Tri partite m otif containing protein 24 (TRIM24) in mouse mammary epithelia ( Trim24 COE ) drives spontaneous…”
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IL‐30 (IL27p28) attenuates liver fibrosis through inducing NKG2D‐rae1 interaction between NKT and activated hepatic stellate cells in mice by Mitra, Abhisek, Satelli, Arun, Yan, Jun, Xueqing, Xia, Gagea, Mihai, Hunter, Christopher A., Mishra, Lopa, Li, Shulin

“…Chronic hepatic diseases, such as cirrhosis, hepatocellular carcinoma, and virus‐mediated immunopathogenic infections, affect billions of people worldwide…”
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The Long Noncoding RNA CCAT2 Induces Chromosomal Instability Through BOP1-AURKB Signaling by Chen, Baoqing, Dragomir, Mihnea P., Fabris, Linda, Bayraktar, Recep, Knutsen, Erik, Liu, Xu, Tang, Changyan, Li, Yongfeng, Shimura, Tadanobu, Ivkovic, Tina Catela, Cruz De los Santos, Mireia, Anfossi, Simone, Shimizu, Masayoshi, Shah, Maitri Y., Ling, Hui, Shen, Peng, Multani, Asha S., Pardini, Barbara, Burks, Jared K., Katayama, Hiroyuki, Reineke, Lucas C., Huo, Longfei, Syed, Muddassir, Song, Shumei, Ferracin, Manuela, Oki, Eiji, Fromm, Bastian, Ivan, Cristina, Bhuvaneshwar, Krithika, Gusev, Yuriy, Mimori, Koshi, Menter, David, Sen, Subrata, Matsuyama, Takatoshi, Uetake, Hiroyuki, Vasilescu, Catalin, Kopetz, Scott, Parker-Thornburg, Jan, Taguchi, Ayumu, Hanash, Samir M., Girnita, Leonard, Slaby, Ondrej, Goel, Ajay, Varani, Gabriele, Gagea, Mihai, Li, Chunlai, Ajani, Jaffer A., Calin, George A.

“…Chromosomal instability (CIN) is a carcinogenesis event that promotes metastasis and resistance to therapy by unclear mechanisms. Expression of the colon…”
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YEATS2 links histone acetylation to tumorigenesis of non-small cell lung cancer by Mi, Wenyi, Guan, Haipeng, Lyu, Jie, Zhao, Dan, Xi, Yuanxin, Jiang, Shiming, Andrews, Forest H., Wang, Xiaolu, Gagea, Mihai, Wen, Hong, Tora, Laszlo, Dent, Sharon Y. R., Kutateladze, Tatiana G., Li, Wei, Li, Haitao, Shi, Xiaobing

“…Recognition of modified histones by “reader” proteins constitutes a key mechanism regulating diverse chromatin-associated processes important for normal and…”
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Differentiation therapy for hepatocellular carcinoma: Multifaceted effects of miR‐148a on tumor growth and phenotype and liver fibrosis by Jung, Kwang Hwa, Zhang, Jing, Zhou, Chong, Shen, Hong, Gagea, Mihai, Rodriguez‐Aguayo, Cristian, Lopez‐Berestein, Gabriel, Sood, Anil K., Beretta, Laura

“…The death rate from hepatocellular carcinoma (HCC) is increasing, and liver cancer is the second leading cause of cancer‐related mortality worldwide. Most…”
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miR-21 Inhibition Reduces Liver Fibrosis and Prevents Tumor Development by Inducing Apoptosis of CD24+ Progenitor Cells by Zhang, Jing, Jiao, Jingjing, Cermelli, Silvia, Muir, Kyle, Jung, Kwang Hwa, Zou, Ruhai, Rashid, Asif, Gagea, Mihai, Zabludoff, Sonya, Kalluri, Raghu, Beretta, Laura

“…miR-21 is upregulated in hepatocellular carcinoma and intrahepatic cholangiocarcinoma, where it is associated with poor prognosis. Here, we offer preclinical…”
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A spontaneous model of spondyloarthropathies that develops bone loss and pathological bone formation: A process regulated by IL27RA-/- and mutant-p53 by Dibra, Denada, Xia, Xueqing, Gagea, Mihai, Lozano, Guillermina, Li, Shulin

“…Spondyloarthropathies, the second most frequently occurring form of chronic inflammatory arthritis, affects young adults in particular. However, a proper model…”
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Inhibition of mitochondrial complex I reverses NOTCH1-driven metabolic reprogramming in T-cell acute lymphoblastic leukemia by Baran, Natalia, Lodi, Alessia, Dhungana, Yogesh, Herbrich, Shelley, Collins, Meghan, Sweeney, Shannon, Pandey, Renu, Skwarska, Anna, Patel, Shraddha, Tremblay, Mathieu, Kuruvilla, Vinitha Mary, Cavazos, Antonio, Kaplan, Mecit, Warmoes, Marc O., Veiga, Diogo Troggian, Furudate, Ken, Rojas-Sutterin, Shanti, Haman, Andre, Gareau, Yves, Marinier, Anne, Ma, Helen, Harutyunyan, Karine, Daher, May, Garcia, Luciana Melo, Al-Atrash, Gheath, Piya, Sujan, Ruvolo, Vivian, Yang, Wentao, Shanmugavelandy, Sriram Saravanan, Feng, Ningping, Gay, Jason, Du, Di, Yang, Jun J., Hoff, Fieke W., Kaminski, Marcin, Tomczak, Katarzyna, Eric Davis, R., Herranz, Daniel, Ferrando, Adolfo, Jabbour, Elias J., Emilia Di Francesco, M., Teachey, David T., Horton, Terzah M., Kornblau, Steven, Rezvani, Katayoun, Sauvageau, Guy, Gagea, Mihai, Andreeff, Michael, Takahashi, Koichi, Marszalek, Joseph R., Lorenzi, Philip L., Yu, Jiyang, Tiziani, Stefano, Hoang, Trang, Konopleva, Marina

“…T-cell acute lymphoblastic leukemia (T-ALL) is commonly driven by activating mutations in NOTCH1 that facilitate glutamine oxidation. Here we identify…”
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Pirtobrutinib inhibits wild-type and mutant Bruton’s tyrosine kinase-mediated signaling in chronic lymphocytic leukemia by Aslan, Burcu, Kismali, Gorkem, Iles, Lakesla R., Manyam, Ganiraju C., Ayres, Mary L., Chen, Lisa S., Gagea, Mihai, Bertilaccio, Maria Teresa Sabrina, Wierda, William G., Gandhi, Varsha

“…Pirtobrutinib (LOXO-305), a reversible inhibitor of Bruton’s tyrosine kinase (BTK), was designed as an alternative strategy to treat ibrutinib-resistant…”
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NHERF1/EBP50 Suppresses Wnt-β-Catenin Pathway–Driven Intestinal Neoplasia by Georgescu, Maria-Magdalena, Gagea, Mihai, Cote, Gilbert

“…Abstract NHERF1/EBP50, an adaptor molecule that interacts with β-catenin, YAP, and PTEN, has been recently implicated in the progression of various human…”
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Targeting CXCR4 abrogates resistance to trastuzumab by blocking cell cycle progression and synergizes with docetaxel in breast cancer treatment by Liu, Shuying, Xie, Shelly M, Liu, Wenbin, Gagea, Mihai, Hanker, Ariella B, Nguyen, Nguyen, Singareeka Raghavendra, Akshara, Yang-Kolodji, Gloria, Chu, Fuliang, Neelapu, Sattva S, Marchese, Adriano, Hanash, Samir, Zimmermann, Johann, Arteaga, Carlos L, Tripathy, Debasish

“…Although trastuzumab and other HER2-targeted therapies have significantly improved survival in patients with HER2 overexpressed or amplified (HER2+) breast…”
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Grb2 monomer–dimer equilibrium determines normal versus oncogenic function by Ahmed, Zamal, Timsah, Zahra, Suen, Kin M., Cook, Nathan P., Lee, Gilbert R., Lin, Chi-Chuan, Gagea, Mihai, Marti, Angel A., Ladbury, John E.

“…The adaptor protein growth factor receptor-bound protein 2 (Grb2) is ubiquitously expressed in eukaryotic cells and involved in a multitude of intracellular…”
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TRPA1–FGFR2 binding event is a regulatory oncogenic driver modulated by miRNA-142-3p by Berrout, Jonathan, Kyriakopoulou, Eleni, Moparthi, Lavanya, Hogea, Alexandra S., Berrout, Liza, Ivan, Cristina, Lorger, Mihaela, Boyle, John, Peers, Chris, Muench, Stephen, Gomez, Jacobo Elies, Hu, Xin, Hurst, Carolyn, Hall, Thomas, Umamaheswaran, Sujanitha, Wesley, Laura, Gagea, Mihai, Shires, Michael, Manfield, Iain, Knowles, Margaret A., Davies, Simon, Suhling, Klaus, Gonzalez, Yurema Teijeiro, Carragher, Neil, Macleod, Kenneth, Abbott, N. Joan, Calin, George A., Gamper, Nikita, Zygmunt, Peter M., Timsah, Zahra

“…Recent evidence suggests that the ion channel TRPA1 is implicated in lung adenocarcinoma (LUAD), where its role and mechanism of action remain unknown. We have…”
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Sulindac plus a phospholipid is effective for polyp reduction and safer than sulindac alone in a mouse model of colorectal cancer development by Davis, Jennifer S, Kanikarla-Marie, Preeti, Gagea, Mihai, Yu, Patrick L, Fang, Dexing, Sebastian, Manu, Yang, Peiying, Hawk, Ernest, Dashwood, Roderick, Lichtenberger, Lenard M, Menter, David, Kopetz, Scott

“…Non-steroidal anti-inflammatory drugs (NSAIDs) such as aspirin and sulindac are effective for colorectal cancer prevention in humans and some animal models,…”
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Human Biofield Therapy and the Growth of Mouse Lung Carcinoma by Yang, Peiying, Jiang, Yan, Rhea, Patrea R., Conway, Tara L., Chen, Dongmei, Gagea, Mihai, Harribance, Sean L., Cohen, Lorenzo

“…Biofield therapies have gained popularity and are being explored as possible treatments for cancer. In some cases, devices have been developed that mimic the…”
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