Sex differences in stroke: Challenges and opportunities
Biologic sex influences many variables that are important to brain health in general, and to stroke or cerebral ischemia in particular, such as general health status, cerebrovascular anatomy and function, unique risk factors such as pregnancy and preeclampsia, symptomatology, and therapeutic respons...
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| Published in: | Journal of Cerebral Blood Flow & Metabolism Vol. 38; no. 12; pp. 2179 - 2191 |
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| Main Authors: | , , , , , , , , , , , |
| Format: | Book Review Journal Article |
| Language: | English |
| Published: |
London, England
SAGE Publications
01-12-2018
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| Subjects: | |
| Online Access: | Get full text |
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| Summary: | Biologic sex influences many variables that are important to brain health in general, and to stroke or cerebral ischemia in particular, such as general health status, cerebrovascular anatomy and function, unique risk factors such as pregnancy and preeclampsia, symptomatology, and therapeutic response. A more complete understanding of the scale and depth of sexual dimorphism in the brain and the role of more general sex-based factors is crucial to reducing the burden of stroke in women and men. This focused review highlights recent findings in stroke, including sex differences in epidemiology, risk factor reduction, comparative use of stroke therapeutics in both sexes, the importance of frailty in women, and the biologic basis for sex differences in stroke. Such findings show tremendous promise for the future of personalized medicine in stroke prevention and treatment. |
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| Bibliography: | ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-3 content type line 23 ObjectType-Review-1 |
| ISSN: | 0271-678X 1559-7016 |
| DOI: | 10.1177/0271678X18793324 |