Search Results - "Gafson, Arie"

Neurofilaments: neurobiological foundations for biomarker applications by Gafson, Arie R, Barthélemy, Nicolas R, Bomont, Pascale, Carare, Roxana O, Durham, Heather D, Julien, Jean-Pierre, Kuhle, Jens, Leppert, David, Nixon, Ralph A, Weller, Roy O, Zetterberg, Henrik, Matthews, Paul M

“…Interest in neurofilaments has risen sharply in recent years with recognition of their potential as biomarkers of brain injury or neurodegeneration in CSF and…”
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Lesion-level correspondence and longitudinal properties of paramagnetic rim and slowly expanding lesions in multiple sclerosis by Elliott, Colm, Rudko, David A, Arnold, Douglas L, Fetco, Dumitru, Elkady, Ahmed M, Araujo, David, Zhu, Bing, Gafson, Arie, Tian, Zhe, Belachew, Shibeshih, Bradley, Daniel P, Fisher, Elizabeth

“…Background: Paramagnetic rim lesions (PRLs) and slowly expanding lesions (SELs) have been posited as markers of chronic active lesions (CALs). Objective: To…”
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A randomized study of natalizumab dosing regimens for relapsing–remitting multiple sclerosis by Trojano, Maria, Ramió-Torrentà, Lluís, Grimaldi, Luigi ME, Lubetzki, Catherine, Schippling, Sven, Evans, Karleyton C, Ren, Zheng, Muralidharan, Kumar Kandadi, Licata, Stephanie, Gafson, Arie R

“…Background: REFINE was an exploratory, dose- and frequency-blinded, prospective, randomized, dose-ranging study in relapsing–remitting multiple sclerosis…”
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Slowly expanding lesions are a marker of progressive MS – No by Arnold, Douglas L, Belachew, Shibeshih, Gafson, Arie R, Gaetano, Laura, Bernasconi, Corrado, Elliott, Colm

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Genome-wide study of longitudinal brain imaging measures of multiple sclerosis progression across six clinical trials by Loomis, Stephanie J., Sadhu, Nilanjana, Fisher, Elizabeth, Gafson, Arie R., Huang, Yunfeng, Yang, Chengran, Hughes, Emily E., Marshall, Eric, Herman, Ann, John, Sally, Runz, Heiko, Jia, Xiaoming, Bhangale, Tushar, Bronson, Paola G.

“…While the genetics of MS risk susceptibility are well-described, and recent progress has been made on the genetics of disease severity, the genetics of disease…”
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Effect of reduction in brain amyloid levels on change in cognitive and functional decline in randomized clinical trials: An instrumental variable meta‐analysis by Pang, Menglan, Zhu, Ling, Gabelle, Audrey, Gafson, Arie R., Platt, Robert W, Galvin, James E, Krolak‐Salmon, Pierre, Rubino, Ivana, de Moor, Carl, Belachew, Shibeshih, Shen, Changyu

“…Introduction Whether the reduction in brain amyloid beta (Aβ) plaque alone may substantially slow cognitive and functional decline in patients with dementia or…”
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Single-timepoint low-dimensional characterization and classification of acute versus chronic multiple sclerosis lesions using machine learning by Caba, Bastien, Cafaro, Alexandre, Lombard, Aurélien, Arnold, Douglas L., Elliott, Colm, Liu, Dawei, Jiang, Xiaotong, Gafson, Arie, Fisher, Elizabeth, Belachew, Shibeshih Mitiku, Paragios, Nikos

“…•Machine learning model classifies acute vs chronic multiple sclerosis (MS) lesions.•Used single timepoint non-contrast conventional T1- and T2-weighted MRI…”
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Inflammatory Activity on Natalizumab Predicts Short-Term but Not Long-Term Disability in Multiple Sclerosis by Raffel, Joel, Gafson, Arie R, Dahdaleh, Samer, Malik, Omar, Jones, Brynmor, Nicholas, Richard

“…In people with multiple sclerosis treated with interferon-beta or glatiramer acetate, new MRI lesions and relapses during the first year of treatment predict a…”
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New views on the complex interplay between degeneration and autoimmunity in multiple sclerosis by Stys, Peter K, Tsutsui, Shigeki, Gafson, Arie R, 't Hart, Bert A, Belachew, Shibeshih, Geurts, Jeroen J G

“…Multiple sclerosis (MS) is a frequently disabling neurological disorder characterized by symptoms, clinical signs and imaging abnormalities that typically…”
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Glial fibrillary acidic protein and multiple sclerosis progression independent of acute inflammation by Jiang, Xiaotong, Shen, Changyu, Teunissen, Charlotte E, Wessels, Mark, Zetterberg, Henrik, Giovannoni, Gavin, Singh, Carol M, Caba, Bastien, Elliott, Colm, Fisher, Elizabeth, de Moor, Carl, Belachew, Shibeshih, Gafson, Arie R

“…Background: The clinical relevance of serum glial fibrillary acidic protein (sGFAP) concentration as a biomarker of MS disability progression independent of…”
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Toward the end of a controversy on the effect of reduction in brain amyloid levels on change in cognitive and functional decline in Alzheimer's disease—Reply to a letter by Pang, Menglan, Zhu, Ling, Gabelle, Audrey, Gafson, Arie R., Platt, Robert W., Galvin, James E., Krolak‐Salmon, Pierre, Rubino, Ivana, Moor, Carl, Belachew, Shibeshih, Shen, Changyu

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Serum Neurofilament Light and Multiple Sclerosis Progression Independent of Acute Inflammation by Gafson, Arie R, Jiang, Xiaotong, Shen, Changyu, Kapoor, Raj, Zetterberg, Henrik, Fox, Robert J, Belachew, Shibeshih

“…This cohort study investigates serum neurofilament light concentration as a biomarker associated with disability progression in multiple sclerosis in the…”
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Safety, Patient-Reported Well-Being, and Physician-Reported Assessment of Walking Ability in Patients with Multiple Sclerosis for Prolonged-Release Fampridine Treatment in Routine Clinical Practice: Results of the LIBERATE Study by Castelnovo, Giovanni, Gerlach, Oliver, Freedman, Mark S., Bergmann, Arnfin, Sinay, Vladimiro, Castillo-Triviño, Tamara, Kong, George, Koster, Thijs, Williams, Heather, Gafson, Arie R., Killestein, Joep

“…Background Prolonged-release fampridine (PR-FAM) 10-mg tablet twice daily is the only approved pharmacological treatment for improvement of walking ability in…”
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Remote Monitoring in the Home Validates Clinical Gait Measures for Multiple Sclerosis by Supratak, Akara, Datta, Gourab, Gafson, Arie R, Nicholas, Richard, Guo, Yike, Matthews, Paul M

“…The timed 25-foot walk (T25FW) is widely used as a clinic performance measure, but has yet to be directly validated against gait speed in the home environment…”
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Assessing the utility of magnetic resonance imaging-based “SuStaIn” disease subtyping for precision medicine in relapsing-remitting and secondary progressive multiple sclerosis by Jiang, Xiaotong, Shen, Changyu, Caba, Bastien, Arnold, Douglas L, Elliott, Colm, Zhu, Bing, Fisher, Elizabeth, Belachew, Shibeshih, Gafson, Arie R

“…•SuStaIn is a first-in-class machine-learning algorithm defining MS disease subtypes based on MRI characteristics.•SuStaIn subtypes were evaluated for clinical…”
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Chronic lesion activity and disability progression in secondary progressive multiple sclerosis by Beynon, Vanessa, George, Ilena C, Elliott, Colm, Arnold, Douglas L, Ke, Jun, Chen, Huaihou, Zhu, Li, Ke, Chunlei, Giovannoni, Gavin, Scaramozza, Matthew, Campbell, Nolan, Bradley, Daniel P, Franchimont, Nathalie, Gafson, Arie, Belachew, Shibeshih

“…ObjectiveSlowly expanding lesions (SELs), a subgroup of chronic white matter lesions that gradually expand over time, have been shown to predict disability…”
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Towards the incorporation of lumbar puncture into clinical trials for multiple sclerosis by Gafson, Arie R, Giovannoni, Gavin

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CCSVI-A. A call to clinicans and scientists to vocalise in an Internet age by Gafson, Arie R, Giovannoni, Gavin

“…Abstract In 2008, Paulo Zamboni pioneered the ‘liberation procedure’ for treating multiple sclerosis (MS), claiming that MS is caused by an abnormality of…”
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Breaking the cycle: Reversal of flux in the tricarboxylic acid cycle by dimethyl fumarate by Gafson, Arie R, Savva, Constantinos, Thorne, Tom, David, Mark, Gomez-Romero, Maria, Lewis, Matthew R, Nicholas, Richard, Heslegrave, Amanda, Zetterberg, Henrik, Matthews, Paul M

“…OBJECTIVETo infer molecular effectors of therapeutic effects and adverse events for dimethyl fumarate (DMF) in patients with relapsing-remitting MS (RRMS)…”
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Mononuclear cell transcriptome changes associated with dimethyl fumarate in MS by Gafson, Arie R, Kim, Kicheol, Cencioni, Maria T, van Hecke, Wim, Nicholas, Richard, Baranzini, Sergio E, Matthews, Paul M

“…OBJECTIVETo identify short-term changes in gene expression in peripheral blood mononuclear cells (PBMCs) associated with treatment response to dimethyl…”
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