Search Results - "Gaffin, Robert"

Inwardly rectifying K+ channels are major contributors to flow‐induced vasodilatation in resistance arteries by Ahn, Sang Joon, Fancher, Ibra S., Bian, Jing‐Tan, Zhang, Chong Xu, Schwab, Sarah, Gaffin, Robert, Phillips, Shane A., Levitan, Irena

“…Key points Endothelial inwardly rectifying K+ (Kir2.1) channels regulate flow‐induced vasodilatation via nitric oxide (NO) in mouse mesenteric resistance…”
Get full text

Early sensitization of myofilaments to Ca2+ prevents genetically linked dilated cardiomyopathy in mice by Alves, Marco L, Warren, Chad M, Simon, Jillian N, Gaffin, Robert D, Montminy, Eric M, Wieczorek, David F, Solaro, R John, Wolska, Beata M

“…Dilated cardiomoypathies (DCM) are a heterogeneous group of inherited and acquired diseases characterized by decreased contractility and enlargement of cardiac…”
Get full text

Desensitization of myofilaments to Ca2+ as a therapeutic target for hypertrophic cardiomyopathy with mutations in thin filament proteins by Alves, Marco L, Dias, Fernando A L, Gaffin, Robert D, Simon, Jillian N, Montminy, Eric M, Biesiadecki, Brandon J, Hinken, Aaron C, Warren, Chad M, Utter, Megan S, Davis, Rd, Robert T, Sakthivel, Sadayappan, Robbins, Jeffrey, Wieczorek, David F, Solaro, R John, Wolska, Beata M

“…Hypertrophic cardiomyopathy (HCM) is a common genetic disorder caused mainly by mutations in sarcomeric proteins and is characterized by maladaptive myocardial…”
Get full text

Rescue of familial cardiomyopathies by modifications at the level of sarcomere and Ca2+ fluxes by Alves, Marco L, Gaffin, Robert D, Wolska, Beata M

“…Abstract Cardiomyopathies are a heterogeneous group of diseases of the myocardium associated with mechanical and/or electrical dysfunction that frequently show…”
Get full text

Neonatal gene transfer of Serca2a delays onset of hypertrophic remodeling and improves function in familial hypertrophic cardiomyopathy by Peña, James R, Szkudlarek, Ariani C, Warren, Chad M, Heinrich, Lynley S, Gaffin, Robert D, Jagatheesan, Ganapathy, del Monte, Federica, Hajjar, Roger J, Goldspink, Paul H, Solaro, R. John, Wieczorek, David F, Wolska, Beata M

“…Abstract Familial hypertrophic cardiomyopathy (FHC) is an autosomal dominant genetic disorder linked to numerous mutations in the sarcomeric proteins. The…”
Get full text

Roles of phosphorylation of myosin binding protein-C and troponin I in mouse cardiac muscle twitch dynamics by Tong, Carl W., Gaffin, Robert D., Zawieja, David C., Muthuchamy, Mariappan

“…A normal heart increases its contractile force with increasing heart rate. Although calcium handling and myofibrillar proteins have been implicated in…”
Get full text

Long-term rescue of a familial hypertrophic cardiomyopathy caused by a mutation in the thin filament protein, tropomyosin, via modulation of a calcium cycling protein by Gaffin, Robert D, Peña, James R, Alves, Marco S.L, Dias, Fernando A.L, Chowdhury, Shamim A.K, Heinrich, Lynley S, Goldspink, Paul H, Kranias, Evangelia G, Wieczorek, David F, Wolska, Beata M

“…Abstract We have recently shown that a temporary increase in sarcoplasmic reticulum (SR) cycling via adenovirus-mediated overexpression of sarcoplasmic…”
Get full text

Effects of nicotine administration in a mouse model of familial hypertrophic cardiomyopathy, α-tropomyosin D175N by Gaffin, Robert D, Chowdhury, Shamim A K, Alves, Marco S L, Dias, Fernando A L, Ribeiro, Cibele T D, Fogaca, Rosalvo T H, Wieczorek, David F, Wolska, Beata M

“…The effects of nicotine (NIC) on normal hearts are fairly well established, yet its effects on hearts displaying familial hypertrophic cardiomyopathy have not…”
Get more information

Arginine-glycine-aspartic acid (RGD)-containing peptides inhibit the force production of mouse papillary muscle bundles via alpha 5 beta 1 integrin by Sarin, Vandana, Gaffin, Robert D, Meininger, Gerald A, Muthuchamy, Mariappan

“…Integrins are considered to be an important mechanosensor in cardiac myocytes. To test whether integrins can influence cardiac contractile function, the…”
Get full text

Arginine–glycine–aspartic acid (RGD)‐containing peptides inhibit the force production of mouse papillary muscle bundles via α5β1 integrin by Sarin, Vandana, Gaffin, Robert D., Meininger, Gerald A., Muthuchamy, Mariappan

“…Integrins are considered to be an important mechanosensor in cardiac myocytes. To test whether integrins can influence cardiac contractile function, the…”
Get full text

Changes in end-to-end interactions of tropomyosin affect mouse cardiac muscle dynamics by Gaffin, Robert D, Gokulan, Kuppan, Sacchettini, James C, Hewett, Timothy E, Klevitsky, Raisa, Robbins, Jeffrey, Sarin, Vandana, Zawieja, David C, Meininger, Gerald A, Muthuchamy, Mariappan

“…The ends of striated muscle tropomyosin (TM) are integral for thin filament cooperativity, determining the cooperative unit size and regulating the affinity of…”
Get more information

Charged residue changes in the carboxy‐terminus of α‐tropomyosin alter mouse cardiac muscle contractility by Gaffin, Robert D., Gokulan, Kuppan, Sacchettini, James C., Hewett, Timothy, Klevitsky, Raisa, Robbins, Jeffrey, Muthuchamy, Mariappan

“…Striated muscle tropomyosin (TM) is an essential thin filament protein that is sterically and allosterically involved in calcium‐mediated cardiac contraction…”
Get full text

Enhancing natriuretic peptide signaling in adipose tissue, but not in muscle, protects against diet-induced obesity and insulin resistance by Wu, Wei, Shi, Fubiao, Liu, Dianxin, Ceddia, Ryan P, Gaffin, Robert, Wei, Wan, Fang, Huafeng, Lewandowski, E Douglas, Collins, Sheila

“…In addition to controlling blood pressure, cardiac natriuretic peptides (NPs) can stimulate lipolysis in adipocytes and promote the "browning" of white adipose…”
Get more information

Charged residue alterations in the inner‐core domain and carboxy‐terminus of α‐tropomyosin differentially affect mouse cardiac muscle contractility by Gaffin, Robert D., Tong, Carl W., Zawieja, David C., Hewett, Timothy E., Klevitsky, Raisa, Robbins, Jeffrey, Muthuchamy, Mariappan

“…Two important charge differences between the α‐ and β‐tropomyosin (TM) isoforms are the exchange of a serine residue in the inner‐core region at position 229,…”
Get full text

Shear‐stress sensitive endothelial K channels play major role in flow‐induced vasodilation by Ahn, Sang Joon, Fancher, Ibra S, Bian, Jing‐tan, Zhang, Chong Xu, Gaffin, Robert, Phillips, Shane A, Levitan, Irena

“…Abstract only Inwardly rectifying K + (Kir) channels are known to be a putative flow sensor of endothelial cells but their role in the sensitivity of vascular…”
Get full text

Inwardly rectifying K super(+) channels are major contributors to flow-induced vasodilatation in resistance arteries by Ahn, Sang Joon, Fancher, Ibra S, Bian, Jing-Tan, Zhang, Chong Xu, Schwab, Sarah, Gaffin, Robert, Phillips, Shane A, Levitan, Irena

“…Key points * Endothelial inwardly rectifying K super(+) (Kir2.1) channels regulate flow-induced vasodilatation via nitric oxide (NO) in mouse mesenteric…”
Get full text

Rescue of a Dilated Cardiomyopathy Mouse Model Caused by a Mutation in Tropomyosin (E54K) by Expression of Slow Skeletal Troponin I by Warren, Chad M., Alves, Marco S.L., Montminy, Eric M., Simon, Jillian N., Gaffin, Robert D., Rajan, Sudarsan, Wieczorek, David F., Solaro, R. John, Wolska, Beata M.

Get full text

Desensitization of Myofilaments to Ca 2+ as a Therapeutic Target for Hypertrophic Cardiomyopathy With Mutations in Thin Filament Proteins by Alves, Marco L., Dias, Fernando A.L., Gaffin, Robert D., Simon, Jillian N., Montminy, Eric M., Biesiadecki, Brandon J., Hinken, Aaron C., Warren, Chad M., Utter, Megan S., Davis, Robert T., Sadayappan, Sakthivel, Robbins, Jeffrey, Wieczorek, David F., Solaro, R. John, Wolska, Beata M.

Get full text

VS-501: A NOVEL, NON-ABSORBED, CALCIUM- AND ALUMINUM-FREE, HIGHLY EFFECTIVE PHOSPHATE BINDER DERIVED FROM NATURAL PLANT POLYMER by Wu-Wong, J Ruth, Chen, Yung-Wu, Gaffin, Robert, Hall, Andy, Wong, Jonathan T, Xiong, Joseph, Wessale, Jerry L

“…Inadequate control of serum phosphate in chronic kidney disease can lead to pathologies of clinical importance. Effectiveness of on-market phosphate binders is…”
Get full text

Arginine-glycine-aspartic acid (RGD)-containing peptides inhibit the force production of mouse papillary muscle bundles via alpha sub(5) beta sub(1) integrin by Sarin, Vandana, Gaffin, Robert D, Meininger, Gerald A, Muthuchamy, Mariappan

“…Integrins are considered to be an important mechanosensor in cardiac myocytes. To test whether integrins can influence cardiac contractile function, the…”
Get full text