Search Results - "Gaetani, Silvana"

Cannabinoid Receptor 2 Signaling in Neurodegenerative Disorders: From Pathogenesis to a Promising Therapeutic Target by Cassano, Tommaso, Calcagnini, Silvio, Pace, Lorenzo, De Marco, Federico, Romano, Adele, Gaetani, Silvana

“…As a consequence of an increasingly aging population, the number of people affected by neurodegenerative disorders, such as Alzheimer's disease, Parkinson's…”
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Oleoylethanolamide decreases frustration stress-induced binge-like eating in female rats: a novel potential treatment for binge eating disorder by Romano, Adele, Micioni Di Bonaventura, Maria Vittoria, Gallelli, Cristina Anna, Koczwara, Justyna Barbara, Smeets, Dorien, Giusepponi, Maria Elena, De Ceglia, Marialuisa, Friuli, Marzia, Micioni Di Bonaventura, Emanuela, Scuderi, Caterina, Vitalone, Annabella, Tramutola, Antonella, Altieri, Fabio, Lutz, Thomas A, Giudetti, Anna Maria, Cassano, Tommaso, Cifani, Carlo, Gaetani, Silvana

“…Binge eating disorder (BED) is the most frequent eating disorder, for which current pharmacotherapies show poor response rates and safety concerns, thus…”
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Characterization and evaluation of chitosan nanoparticles for dopamine brain delivery by Trapani, Adriana, De Giglio, Elvira, Cafagna, Damiana, Denora, Nunzio, Agrimi, Gennaro, Cassano, Tommaso, Gaetani, Silvana, Cuomo, Vincenzo, Trapani, Giuseppe

“…The aim of this study was to characterize nanoparticles (NPs) composed of chitosan (CS) and evaluate their potential for brain delivery of the neurotransmitter…”
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Biliverdin Reductase-A Mediates the Beneficial Effects of Intranasal Insulin in Alzheimer Disease by Barone, Eugenio, Tramutola, Antonella, Triani, Francesca, Calcagnini, Silvio, Di Domenico, Fabio, Ripoli, Cristian, Gaetani, Silvana, Grassi, Claudio, Butterfield, D Allan, Cassano, Tommaso, Perluigi, Marzia

“…Impairment of biliverdin reductase-A (BVR-A) is an early event leading to brain insulin resistance in AD. Intranasal insulin (INI) administration is under…”
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Recent Advances in the Neuroprotective Properties of Ferulic Acid in Alzheimer's Disease: A Narrative Review by Di Giacomo, Silvia, Percaccio, Ester, Gullì, Marco, Romano, Adele, Vitalone, Annabella, Mazzanti, Gabriela, Gaetani, Silvana, Di Sotto, Antonella

“…Alzheimer's disease (AD) is a progressive degenerative disorder of the central nervous system, characterized by neuroinflammation, neurotransmitter deficits,…”
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The role of endocannabinoid signaling in the molecular mechanisms of neurodegeneration in Alzheimer's disease by Bedse, Gaurav, Romano, Adele, Lavecchia, Angelo M, Cassano, Tommaso, Gaetani, Silvana

“…Alzheimer's disease (AD) is the most common form of progressive neurodegenerative disease characterized by cognitive impairment and mental disorders. The…”
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Ultramicronized palmitoylethanolamide rescues learning and memory impairments in a triple transgenic mouse model of Alzheimer’s disease by exerting anti-inflammatory and neuroprotective effects by Scuderi, Caterina, Bronzuoli, Maria Rosanna, Facchinetti, Roberta, Pace, Lorenzo, Ferraro, Luca, Broad, Kevin Donald, Serviddio, Gaetano, Bellanti, Francesco, Palombelli, Gianmauro, Carpinelli, Giulia, Canese, Rossella, Gaetani, Silvana, Steardo, Luca, Steardo, Luca, Cassano, Tommaso

“…In an aging society, Alzheimer’s disease (AD) exerts an increasingly serious health and economic burden. Current treatments provide inadequate symptomatic…”
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Editorial: Alzheimer's Disease: Original Mechanisms and Translational Impact by Mancuso, Cesare, Gaetani, Silvana

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Glutamate and Mitochondria: Two Prominent Players in the Oxidative Stress-Induced Neurodegeneration by Cassano, Tommaso, Pace, Lorenzo, Bedse, Gaurav, Lavecchia, Angelo Michele, De Marco, Federico, Gaetani, Silvana, Serviddio, Gaetano

“…The aetiology of major neurodegenerative diseases such as Alzheimer's disease (AD) and Parkinson's disease (PD) is still unknown, but increasing evidences…”
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Satiety factor oleoylethanolamide recruits the brain histaminergic system to inhibit food intake by Provensi, Gustavo, Coccurello, Roberto, Umehara, Hayato, Munari, Leonardo, Giacovazzo, Giacomo, Galeotti, Nicoletta, Nosi, Daniele, Gaetani, Silvana, Romano, Adele, Moles, Anna, Blandina, Patrizio, Passani, Maria Beatrice

“…Key factors driving eating behavior are hunger and satiety, which are controlled by a complex interplay of central neurotransmitter systems and peripheral…”
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From Autism to Eating Disorders and More: The Role of Oxytocin in Neuropsychiatric Disorders by Romano, Adele, Tempesta, Bianca, Micioni Di Bonaventura, Maria Vittoria, Gaetani, Silvana

“…Oxytocin (oxy) is a pituitary neuropeptide hormone synthesized from the paraventricular and supraoptic nuclei within the hypothalamus. Like other…”
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PDIA3 Expression Is Altered in the Limbic Brain Regions of Triple-Transgenic Mouse Model of Alzheimer's Disease by Cassano, Tommaso, Giamogante, Flavia, Calcagnini, Silvio, Romano, Adele, Lavecchia, Angelo Michele, Inglese, Francesca, Paglia, Giuliano, Bukke, Vidyasagar Naik, Romano, Antonino Davide, Friuli, Marzia, Altieri, Fabio, Gaetani, Silvana

“…In the present study, we used a mouse model of Alzheimer's disease (AD) (3×Tg-AD mice) to longitudinally analyse the expression level of PDIA3, a protein…”
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Pharmacological Treatment of Depression in Alzheimer’s Disease: A Challenging Task by Cassano, Tommaso, Calcagnini, Silvio, Carbone, Antonio, Bukke, Vidyasagar Naik, Orkisz, Stanislaw, Villani, Rosanna, Romano, Adele, Avolio, Carlo, Gaetani, Silvana

“…Besides the memory impairment, Alzheimer’s disease (AD) is often complicated by neuropsychiatric symptoms also known as behavioral and psychological symptoms…”
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Proteomic identification of altered protein O-GlcNAcylation in a triple transgenic mouse model of Alzheimer's disease by Tramutola, Antonella, Sharma, Nidhi, Barone, Eugenio, Lanzillotta, Chiara, Castellani, Andrea, Iavarone, Federica, Vincenzoni, Federica, Castagnola, Massimo, Butterfield, D. Allan, Gaetani, Silvana, Cassano, Tommaso, Perluigi, Marzia, Di Domenico, Fabio

“…PET scan analysis demonstrated the early reduction of cerebral glucose metabolism in Alzheimer disease (AD) patients that can make neurons vulnerable to damage…”
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Food Intake Regulates Oleoylethanolamide Formation and Degradation in the Proximal Small Intestine by Fu, Jin, Astarita, Giuseppe, Gaetani, Silvana, Kim, Janet, Cravatt, Benjamin F., Mackie, Ken, Piomelli, Daniele

“…Oleoylethanolamide (OEA) is a lipid mediator that inhibits food intake by activating the nuclear receptor peroxisome proliferator-activated receptor-α. In the…”
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Alterations of Clock Gene RNA Expression in Brain Regions of a Triple Transgenic Model of Alzheimer's Disease by Bellanti, Francesco, Iannelli, Giuseppina, Blonda, Maria, Tamborra, Rosanna, Villani, Rosanna, Romano, Adele, Calcagnini, Silvio, Mazzoccoli, Gianluigi, Vinciguerra, Manlio, Gaetani, Silvana, Giudetti, Anna Maria, Vendemiale, Gianluigi, Cassano, Tommaso, Serviddio, Gaetano

“…A disruption to circadian rhythmicity and the sleep/wake cycle constitutes a major feature of Alzheimer's disease (AD). The maintenance of circadian…”
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The Role of Brain Cholesterol and its Oxidized Products in Alzheimer's Disease by Giudetti, Anna Maria, Romano, Adele, Lavecchia, Angelo Michele, Gaetani, Silvana

“…The human brain is the most cholesterol-rich organ harboring 25% of the total cholesterol pool of the whole body. Cholesterol present in the central nervous…”
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Regulation of adenosine A2A receptor gene expression in a model of binge eating in the amygdaloid complex of female rats by Micioni Di Bonaventura, Maria Vittoria, Pucci, Mariangela, Giusepponi, Maria Elena, Romano, Adele, Lambertucci, Catia, Volpini, Rosaria, Micioni Di Bonaventura, Emanuela, Gaetani, Silvana, Maccarrone, Mauro, D’Addario, Claudio, Cifani, Carlo

“…Background: Pharmacological treatment approaches for eating disorders, such as binge eating disorder and bulimia nervosa, are currently limited. Methods and…”
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Glutamatergic alterations and mitochondrial impairment in a murine model of Alzheimer disease by Cassano, Tommaso, Serviddio, Gaetano, Gaetani, Silvana, Romano, Adele, Dipasquale, Pasqua, Cianci, Silvia, Bellanti, Francesco, Laconca, Leonardo, Romano, Antonino Davide, Padalino, Iolanda, LaFerla, Frank M, Nicoletti, Ferdinando, Cuomo, Vincenzo, Vendemiale, Gianluigi

“…Abstract Deficits in glutamate neurotransmission and mitochondrial functions were detected in the frontal cortex (FC) and hippopcampus (HIPP) of aged…”
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Modulation of the Oxidative Stress and Lipid Peroxidation by Endocannabinoids and Their Lipid Analogues by Gallelli, Cristina Anna, Calcagnini, Silvio, Romano, Adele, Koczwara, Justyna Barbara, de Ceglia, Marialuisa, Dante, Donatella, Villani, Rosanna, Giudetti, Anna Maria, Cassano, Tommaso, Gaetani, Silvana

“…Growing evidence supports the pivotal role played by oxidative stress in tissue injury development, thus resulting in several pathologies including…”
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