Search Results - "Gaeta, F C"

ELAM-1 mediates cell adhesion by recognition of a carbohydrate ligand, sialyl-Lex by PHILLIPS, M. L, NUDELMAN, E, GAETA, F. C. A, PEREZ, M, SINGHAL, A. K, HAKOMORI, S.-I, PAULSON, J. C

“…Recruitment of neutrophils to sites of inflammation is mediated in part by endothelial leukocyte adhesion molecule-1 (ELAM-1), which is expressed on activated…”
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HLA DR4w4-binding motifs illustrate the biochemical basis of degeneracy and specificity in peptide-DR interactions by Sette, A, Sidney, J, Oseroff, C, del Guercio, MF, Southwood, S, Arrhenius, T, Powell, MF, Colon, SM, Gaeta, FC, Grey, HM

“…In the present study, we describe the definition of a DRB1*0401 (DR4w4)-specific motif. The strategy used entailed a three-step process: 1) screening a large…”
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Expression and functional significance of alternatively spliced CS1 fibronectin in rheumatoid arthritis microvasculature by ELICES, M. J, TSAI, V, STRAHL, D, GOEL, A. S, TOLLEFSON, V, ARRHENIUS, T, WAYNER, E. A, GAETA, F. C. A, FIKES, J. D, FIRESTEIN, G. S

“…Expression of fibronectin (FN) isoforms containing CS1, a 25-amino acid sequence present within the alternatively spliced IIICS region of FN, has been analyzed…”
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On the interaction of promiscuous antigenic peptides with different DR alleles. Identification of common structural motifs by O'Sullivan, D, Arrhenius, T, Sidney, J, Del Guercio, MF, Albertson, M, Wall, M, Oseroff, C, Southwood, S, Colon, SM, Gaeta, FC

“…We have investigated the interaction between DR1 molecules and the two antigenic peptides, tetanus toxoid 830-843 and hemagglutinin 307-319, previously known…”
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MHC interaction and T cell recognition of carbohydrates and glycopeptides by Ishioka, GY, Lamont, AG, Thomson, D, Bulbow, N, Gaeta, FC, Sette, A, Grey, HM

“…The T cell independence of complex polysaccharide Ag has suggested the possibility that carbohydrates may be incapable of T cell recognition because of a…”
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Cross-species comparisons of the pharmacokinetics of ibudilast by Sanftner, L. M., Gibbons, J. A., Gross, M. I., Suzuki, B. M., Gaeta, F. C. A., Johnson, K. W.

“…To enable clinical development of ibudilast for new indications, its pharmacokinetics were characterized in mice, rats, rabbits, dogs, cynomolgus monkeys, and…”
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Functional consequences of engagement of the T cell receptor by low affinity ligands by Alexander, J, Snoke, K, Ruppert, J, Sidney, J, Wall, M, Southwood, S, Oseroff, C, Arrhenius, T, Gaeta, FC, Colon, SM

“…The mechanisms involved in TCR antagonism by Ag analog/MHC have been analyzed. A detailed structure-activity relationship study indicated that modification of…”
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Effect of pH on MHC class II-peptide interactions by Sette, A, Southwood, S, O'Sullivan, D, Gaeta, FC, Sidney, J, Grey, HM

“…The effect of pH on class II-peptide interactions has been analyzed using several mouse (IAd, IAk, IEd, IEk) and human (DR1, DR5, DR7) MHC specificities, and…”
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Thrombin receptor peptide-mediated leukocyte rolling in rat mesenteric venules: roles of P-selectin and sialyl Lewis X by Zimmerman, B J, Paulson, J C, Arrhenius, T S, Gaeta, F C, Granger, D N

“…Neutrophil adhesion to monolayers of cultured endothelial cells is enhanced, via a P-selectin-mediated mechanism, by a 14-amino acid peptide fragment (TRP-14)…”
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Single amino acid changes in DR and antigen define residues critical for peptide-MHC binding and T cell recognition by Krieger, JI, Karr, RW, Grey, HM, Yu, WY, O'Sullivan, D, Batovsky, L, Zheng, ZL, Colon, SM, Gaeta, FC, Sidney, J

“…Single amino acid substitutions of Ag and MHC were used to analyze the fine structure of the influenza hemagglutinin (HA)-derived epitope (HA 307-319)…”
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Mechanism of Cholesteryl Ester Transfer Protein Inhibition by a Neutralizing Monoclonal Antibody and Mapping of the Monoclonal Antibody Epitope by Swenson, T L, Hesler, C B, Brown, M L, Quinet, E, Trotta, P P, Haslanger, M F, Gaeta, F C, Marcel, Y L, Milne, R W, Tall, A R

“…The plasma cholesteryl ester transfer protein (CETP, Mr 74,000) has a binding site for neutral lipid which can readily equilibrate with lipoprotein cholesteryl…”
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Failure to demonstrate long-lived MHC saturation both in vitro and in vivo. Implications for therapeutic potential of MHC-blocking peptides by Ishioka, GY, Adorini, L, Guery, JC, Gaeta, FC, LaFond, R, Alexander, J, Powell, MF, Sette, A, Grey, HM

“…Peptides that bind with high affinity to class II MHC molecules can inhibit T cell activation both in vitro and in vivo. Thus, they have been suggested as…”
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Peptide stability in drug development. II: Effect of single amino acid substitution and glycosylation on peptide reactivity in human serum by POWELL, M. F, STEWART, T, OTVOS, L. JR, URGE, L, GAETA, F. C. A, SETTE, A, ARRHENIUS, T, THOMSON, D, SODA, K, COLON, S. M

“…The determination of peptide stability in human serum (HS) or plasma constitutes a powerful screening assay for eliminating unstable peptides from further…”
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Freezing adhesion molecules in a state of high-avidity binding blocks eosinophil migration by KUIJPERS, T. W, MUL, E. P. J, BLOM, M, KOVACH, N. L, GAETA, F. C. A, TOLLEFSON, V, ELICES, M. J, HARLAN, J. M

“…Leukocyte extravasation is mediated by multiple interactions of adhesive surface structures with ligands on endothelial cells and matrix components. The…”
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Ligand Interactions with E-Selectin. Identification of a New Binding Site for Recognition of N-Acyl Aromatic Glucosamine Substituents of Sialyl Lewis X by Ramphal, John Y, Hiroshige, Mariann, Lou, Boliang, Gaudino, John J, Hayashi, Masaji, Chen, Shiow Meei, Chiang, Lin C, Gaeta, Federico C. A, DeFrees, Shawn A

“…Several N-acylglucosamine derivatives of sialyl Lewis X (1−3) were prepared using a combined chemical enzymatic approach and evaluated as an inhibitor of…”
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High affinity for class II molecules as a necessary but not sufficient characteristic of encephalitogenic determinants by Wall, M, Southwood, S, Sidney, J, Oseroff, C, del Guericio, M F, Lamont, A G, Colón, S M, Arrhenius, T, Gaeta, F C, Sette, A

“…A direct binding assay specific for IAs molecules has been developed and its immunological relevance validated by examining, for a panel of nine different…”
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Sialyl lewisx-containing oligosaccharide attenuates myocardial reperfusion injury in cats by BUERKE, M, WYERICH, A. S, ZHONGLI ZHENG, GAETA, F. C. A, FORREST, M. J, LEFER, A. M

“…Neutrophil (PMN) adhesion to the vascular endothelium is an important mechanism of myocardial reperfusion injury. The adhesion process is initially mediated by…”
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Potent peptide inhibitors of smooth muscle myosin light chain kinase: mapping of the pseudosubstrate and calmodulin binding domains by Foster, C J, Johnston, S A, Sunday, B, Gaeta, F C

“…Smooth muscle myosin light chain kinase (MLCK) is activated by calcium-calmodulin and, in turn, phosphorylates and activates the smooth muscle actomyosin…”
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MHC class II molecules bind indiscriminately self and non-self peptide homologs: effect on the immunogenicity of non-self peptides by Sette, A, Sidney, J, Gaeta, F C, Appella, E, Colón, S M, del Guercio, M F, Guéry, J C, Adorini, L

“…Synthetic peptides spanning the entire sequence of both human and mouse beta 2-microglobulin (beta 2M) have been tested for their capacity to bind to three…”
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Small peptide inhibitors of smooth muscle myosin light chain kinase by Gaeta, Federico C. A, Lehman de Gaeta, Laura S, Kogan, Timothy P, Or, Yat Sun, Foster, Carolyn, Czarniecki, Michael

“…The pentapeptide Ser-Asn-Val-Phe-Ala-OBzl has been identified as the smallest inhibitory peptide of myosin light chain kinase (MLCK) derived from the primary…”
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