Search Results - "Gaelzer Silva Torres, Bruna"

Population Pharmacokinetic Modeling of Etoposide Free Concentrations in Solid Tumor by Pigatto, Maiara Cássia, de Araujo, Bibiana Verlindo, Torres, Bruna Gaelzer Silva, Schmidt, Stephan, Magni, Paolo, Dalla Costa, Teresa

“…ABSTRACT Purpose This study aimed to determine free etoposide (ETO) concentrations in two regions of Walker-256 (W256) solid tumor using microdialysis and to…”
Get full text

Validation of a sensitive HPLC/fluorescence method for assessment of ciprofloxacin levels in plasma and prostate microdialysate samples from rats by Zimmermann, Estevan Sonego, Torres, Bruna Gaelzer Silva, Dalla Costa, Teresa

“…Chronic bacterial prostatitis treatment consists of broad‐spectrum antibiotic therapy for long periods of time. Drug penetration into the prostate makes the…”
Get full text

Semimechanistic Pharmacodynamic Modeling of Aztreonam‐Avibactam Combination to Understand Its Antimicrobial Activity Against Multidrug‐Resistant Gram‐Negative Bacteria by Chauzy, Alexia, Gaelzer Silva Torres, Bruna, Buyck, Julien, Jonge, Boudewijn, Adier, Christophe, Marchand, Sandrine, Couet, William, Grégoire, Nicolas

“…Aztreonam‐avibactam (ATM‐AVI) is a promising combination to treat serious infections caused by multidrug‐resistant (MDR) pathogens. Three distinct mechanisms…”
Get full text

Population pharmacokinetic modeling to establish the role of P-glycoprotein on ciprofloxacin distribution to lung and prostate following intravenous and intratracheal administration to Wistar rats by Zimmermann, Estevan Sonego, de Miranda Silva, Carolina, Neris, Camila, Torres, Bruna Gaelzer da Silva, Schmidt, Stephan, Dalla Costa, Teresa

“…Ciprofloxacin (CIP) is indicated for clinical treatment of urinary and respiratory tract infections. Poor infection site penetration and consequent…”
Get full text

In vitro evaluation of Pseudomonas aeruginosa chronic lung infection models: Are agar and calcium-alginate beads interchangeable? by Torres, Bruna Gaelzer Silva, Awad, Rana, Marchand, Sandrine, Couet, William, Tewes, Frederic

“…[Display omitted] Animal models of chronic lung infection with P. aeruginosa (PA) are useful tools to improve antibiotic (ATB) treatment. Two main models based…”
Get full text

HIGHLY SENSITIVE LC-MS/MS METHOD FOR THE DETERMINATION OF CLOZAPINE IN RAT PLASMA: APPLICATION TO A PRECLINICAL PHARMACOKINETIC STUDY by Haas, Sandra Elisa, Brum, Liberato, de Andrade, Cristiane, Azeredo, Francine Johansson, Pigatto, Maiara, Silva Torres, Bruna Gaelzer, Guterres, Silvia Staniçuaski, Costa, Teresa Dalla

“…A highly sensitive, rapid assay method has been developed and validated for the quantification of clozapine in rat plasma using LC-MS/MS. The extraction…”
Get full text

Population pharmacokinetic modeling of the influence of chronic and acute biofilm-forming Pseudomonas aeruginosa lung infection on ciprofloxacin free pulmonary and epithelial lining fluid concentrations by Lock, Graziela De Araujo, Helfer, Victória Etges, Dias, Bruna Bernar, Torres, Bruna Gaelzer Silva, De Araújo, Bibiana Verlindo, Dalla Costa, Teresa

“…We previously reported that ciprofloxacin (CIP) free lung interstitial concentrations are decreased by biofilm-forming Pseudomonas aeruginosa pulmonary chronic…”
Get full text

Reassessing the dosing of cefoxitin prophylaxis during major abdominal surgery: insights from microdialysis and population pharmacokinetic modelling by Boisson, Matthieu, Torres, Bruna Gaelzer Silva, Yani, Sabrina, Couet, William, Mimoz, Olivier, Dahyot-Fizelier, Claire, Marchand, Sandrine, Grégoire, Nicolas

“…Abstract Objectives Cefoxitin is frequently used for surgical antibiotic prophylaxis (SAP). Using microdialysis, we evaluated whether the currently recommended…”
Get full text