Search Results - "Gaebler, Christian"

Plasma Neutralization of the SARS-CoV-2 Omicron Variant by Schmidt, Fabian, Muecksch, Frauke, Weisblum, Yiska, Da Silva, Justin, Bednarski, Eva, Cho, Alice, Wang, Zijun, Gaebler, Christian, Caskey, Marina, Nussenzweig, Michel C, Hatziioannou, Theodora, Bieniasz, Paul D

“…Neutralization assays of SARS-CoV-2 pseudoviruses expressing wild-type, omicron, or a synthetic resistant spike protein in plasma drawn from 47 people over…”
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Measuring SARS-CoV-2 neutralizing antibody activity using pseudotyped and chimeric viruses by Schmidt, Fabian, Weisblum, Yiska, Muecksch, Frauke, Hoffmann, Hans-Heinrich, Michailidis, Eleftherios, Lorenzi, Julio C C, Mendoza, Pilar, Rutkowska, Magdalena, Bednarski, Eva, Gaebler, Christian, Agudelo, Marianna, Cho, Alice, Wang, Zijun, Gazumyan, Anna, Cipolla, Melissa, Caskey, Marina, Robbiani, Davide F, Nussenzweig, Michel C, Rice, Charles M, Hatziioannou, Theodora, Bieniasz, Paul D

“…The emergence of SARS-CoV-2 and the ensuing explosive epidemic of COVID-19 disease has generated a need for assays to rapidly and conveniently measure the…”
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High genetic barrier to SARS-CoV-2 polyclonal neutralizing antibody escape by Schmidt, Fabian, Weisblum, Yiska, Rutkowska, Magdalena, Poston, Daniel, DaSilva, Justin, Zhang, Fengwen, Bednarski, Eva, Cho, Alice, Schaefer-Babajew, Dennis J., Gaebler, Christian, Caskey, Marina, Nussenzweig, Michel C., Hatziioannou, Theodora, Bieniasz, Paul D.

“…The number and variability of the neutralizing epitopes targeted by polyclonal antibodies in individuals who are SARS-CoV-2 convalescent and vaccinated are key…”
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Naturally enhanced neutralizing breadth against SARS-CoV-2 one year after infection by Wang, Zijun, Muecksch, Frauke, Schaefer-Babajew, Dennis, Finkin, Shlomo, Viant, Charlotte, Gaebler, Christian, Hoffmann, Hans- Heinrich, Barnes, Christopher O., Cipolla, Melissa, Ramos, Victor, Oliveira, Thiago Y., Cho, Alice, Schmidt, Fabian, Da Silva, Justin, Bednarski, Eva, Aguado, Lauren, Yee, Jim, Daga, Mridushi, Turroja, Martina, Millard, Katrina G., Jankovic, Mila, Gazumyan, Anna, Zhao, Zhen, Rice, Charles M., Bieniasz, Paul D., Caskey, Marina, Hatziioannou, Theodora, Nussenzweig, Michel C.

“…More than one year after its inception, the coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)…”
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Structures of Human Antibodies Bound to SARS-CoV-2 Spike Reveal Common Epitopes and Recurrent Features of Antibodies by Barnes, Christopher O., West, Anthony P., Huey-Tubman, Kathryn E., Hoffmann, Magnus A.G., Sharaf, Naima G., Hoffman, Pauline R., Koranda, Nicholas, Gristick, Harry B., Gaebler, Christian, Muecksch, Frauke, Lorenzi, Julio C. Cetrulo, Finkin, Shlomo, Hägglöf, Thomas, Hurley, Arlene, Millard, Katrina G., Weisblum, Yiska, Schmidt, Fabian, Hatziioannou, Theodora, Bieniasz, Paul D., Caskey, Marina, Robbiani, Davide F., Nussenzweig, Michel C., Bjorkman, Pamela J.

“…Neutralizing antibody responses to coronaviruses mainly target the receptor-binding domain (RBD) of the trimeric spike. Here, we characterized polyclonal…”
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Mapping mutations to the SARS-CoV-2 RBD that escape binding by different classes of antibodies by Greaney, Allison J., Starr, Tyler N., Barnes, Christopher O., Weisblum, Yiska, Schmidt, Fabian, Caskey, Marina, Gaebler, Christian, Cho, Alice, Agudelo, Marianna, Finkin, Shlomo, Wang, Zijun, Poston, Daniel, Muecksch, Frauke, Hatziioannou, Theodora, Bieniasz, Paul D., Robbiani, Davide F., Nussenzweig, Michel C., Bjorkman, Pamela J., Bloom, Jesse D.

“…Monoclonal antibodies targeting a variety of epitopes have been isolated from individuals previously infected with SARS-CoV-2, but the relative contributions…”
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Enhanced SARS-CoV-2 neutralization by dimeric IgA by Wang, Zijun, Lorenzi, Julio C C, Muecksch, Frauke, Finkin, Shlomo, Viant, Charlotte, Gaebler, Christian, Cipolla, Melissa, Hoffmann, Hans-Heinrich, Oliveira, Thiago Y, Oren, Deena A, Ramos, Victor, Nogueira, Lilian, Michailidis, Eleftherios, Robbiani, Davide F, Gazumyan, Anna, Rice, Charles M, Hatziioannou, Theodora, Bieniasz, Paul D, Caskey, Marina, Nussenzweig, Michel C

“…Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus that causes coronavirus disease 2019 (COVID-19), primarily infects cells at mucosal…”
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Escape from neutralizing antibodies by SARS-CoV-2 spike protein variants by Weisblum, Yiska, Schmidt, Fabian, Zhang, Fengwen, DaSilva, Justin, Poston, Daniel, Lorenzi, Julio Cc, Muecksch, Frauke, Rutkowska, Magdalena, Hoffmann, Hans-Heinrich, Michailidis, Eleftherios, Gaebler, Christian, Agudelo, Marianna, Cho, Alice, Wang, Zijun, Gazumyan, Anna, Cipolla, Melissa, Luchsinger, Larry, Hillyer, Christopher D, Caskey, Marina, Robbiani, Davide F, Rice, Charles M, Nussenzweig, Michel C, Hatziioannou, Theodora, Bieniasz, Paul D

“…Neutralizing antibodies elicited by prior infection or vaccination are likely to be key for future protection of individuals and populations against…”
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Increased memory B cell potency and breadth after a SARS-CoV-2 mRNA boost by Muecksch, Frauke, Wang, Zijun, Cho, Alice, Gaebler, Christian, Ben Tanfous, Tarek, DaSilva, Justin, Bednarski, Eva, Ramos, Victor, Zong, Shuai, Johnson, Brianna, Raspe, Raphael, Schaefer-Babajew, Dennis, Shimeliovich, Irina, Daga, Mridushi, Yao, Kai-Hui, Schmidt, Fabian, Millard, Katrina G., Turroja, Martina, Jankovic, Mila, Oliveira, Thiago Y., Gazumyan, Anna, Caskey, Marina, Hatziioannou, Theodora, Bieniasz, Paul D., Nussenzweig, Michel C.

“…The Omicron variant of SARS-CoV-2 infected many vaccinated and convalescent individuals 1 – 3 . Despite the reduced protection from infection, individuals who…”
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Anti-SARS-CoV-2 receptor-binding domain antibody evolution after mRNA vaccination by Cho, Alice, Muecksch, Frauke, Schaefer-Babajew, Dennis, Wang, Zijun, Finkin, Shlomo, Gaebler, Christian, Ramos, Victor, Cipolla, Melissa, Mendoza, Pilar, Agudelo, Marianna, Bednarski, Eva, DaSilva, Justin, Shimeliovich, Irina, Dizon, Juan, Daga, Mridushi, Millard, Katrina G., Turroja, Martina, Schmidt, Fabian, Zhang, Fengwen, Tanfous, Tarek Ben, Jankovic, Mila, Oliveria, Thiago Y., Gazumyan, Anna, Caskey, Marina, Bieniasz, Paul D., Hatziioannou, Theodora, Nussenzweig, Michel C.

“…Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection produces B cell responses that continue to evolve for at least a year. During that time,…”
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Persistent cellular immunity to SARS-CoV-2 infection by Breton, Gaëlle, Mendoza, Pilar, Hägglöf, Thomas, Oliveira, Thiago Y, Schaefer-Babajew, Dennis, Gaebler, Christian, Turroja, Martina, Hurley, Arlene, Caskey, Marina, Nussenzweig, Michel C

“…SARS-CoV-2 is responsible for an ongoing pandemic that has affected millions of individuals around the globe. To gain further understanding of the immune…”
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Affinity maturation of SARS-CoV-2 neutralizing antibodies confers potency, breadth, and resilience to viral escape mutations by Muecksch, Frauke, Weisblum, Yiska, Barnes, Christopher O., Schmidt, Fabian, Schaefer-Babajew, Dennis, Wang, Zijun, C. Lorenzi, Julio C., Flyak, Andrew I., DeLaitsch, Andrew T., Huey-Tubman, Kathryn E., Hou, Shurong, Schiffer, Celia A., Gaebler, Christian, Da Silva, Justin, Poston, Daniel, Finkin, Shlomo, Cho, Alice, Cipolla, Melissa, Oliveira, Thiago Y., Millard, Katrina G., Ramos, Victor, Gazumyan, Anna, Rutkowska, Magdalena, Caskey, Marina, Nussenzweig, Michel C., Bjorkman, Pamela J., Hatziioannou, Theodora, Bieniasz, Paul D.

“…Antibodies elicited by infection accumulate somatic mutations in germinal centers that can increase affinity for cognate antigens. We analyzed 6 independent…”
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Antibody feedback regulates immune memory after SARS-CoV-2 mRNA vaccination by Schaefer-Babajew, Dennis, Wang, Zijun, Muecksch, Frauke, Cho, Alice, Loewe, Maximilian, Cipolla, Melissa, Raspe, Raphael, Johnson, Brianna, Canis, Marie, DaSilva, Justin, Ramos, Victor, Turroja, Martina, Millard, Katrina G., Schmidt, Fabian, Witte, Leander, Dizon, Juan, Shimeliovich, Irina, Yao, Kai-Hui, Oliveira, Thiago Y., Gazumyan, Anna, Gaebler, Christian, Bieniasz, Paul D., Hatziioannou, Theodora, Caskey, Marina, Nussenzweig, Michel C.

“…Feedback inhibition of humoral immunity by antibodies was first documented in 1909 1 . Subsequent studies showed that, depending on the context, antibodies can…”
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Somatic Mutations of the Immunoglobulin Framework Are Generally Required for Broad and Potent HIV-1 Neutralization by Klein, Florian, Diskin, Ron, Scheid, Johannes F., Gaebler, Christian, Mouquet, Hugo, Georgiev, Ivelin S., Pancera, Marie, Zhou, Tongqing, Incesu, Reha-Baris, Fu, Brooks Zhongzheng, Gnanapragasam, Priyanthi N.P., Oliveira, Thiago Y., Seaman, Michael S., Kwong, Peter D., Bjorkman, Pamela J., Nussenzweig, Michel C.

“…Broadly neutralizing antibodies (bNAbs) to HIV-1 can prevent infection and are therefore of great importance for HIV-1 vaccine design. Notably, bNAbs…”
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HIV therapy by a combination of broadly neutralizing antibodies in humanized mice by Klein, Florian, Halper-Stromberg, Ariel, Horwitz, Joshua A., Gruell, Henning, Scheid, Johannes F., Bournazos, Stylianos, Mouquet, Hugo, Spatz, Linda A., Diskin, Ron, Abadir, Alexander, Zang, Trinity, Dorner, Marcus, Billerbeck, Eva, Labitt, Rachael N., Gaebler, Christian, Marcovecchio, Paola M., Incesu, Reha-Baris, Eisenreich, Thomas R., Bieniasz, Paul D., Seaman, Michael S., Bjorkman, Pamela J., Ravetch, Jeffrey V., Ploss, Alexander, Nussenzweig, Michel C.

“…Passive immunotherapy with a combination of neutralizing monoclonal antibodies is shown to be effective in suppressing HIV replication in a humanized mouse…”
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Detection and characterization of the SARS-CoV-2 lineage B.1.526 in New York by West, Anthony P., Wertheim, Joel O., Wang, Jade C., Vasylyeva, Tetyana I., Havens, Jennifer L., Chowdhury, Moinuddin A., Gonzalez, Edimarlyn, Fang, Courtney E., Di Lonardo, Steve S., Hughes, Scott, Rakeman, Jennifer L., Lee, Henry H., Barnes, Christopher O., Gnanapragasam, Priyanthi N. P., Yang, Zhi, Gaebler, Christian, Caskey, Marina, Nussenzweig, Michel C., Keeffe, Jennifer R., Bjorkman, Pamela J.

“…Wide-scale SARS-CoV-2 genome sequencing is critical to tracking viral evolution during the ongoing pandemic. We develop the software tool, Variant Database…”
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Epistasis lowers the genetic barrier to SARS-CoV-2 neutralizing antibody escape by Witte, Leander, Baharani, Viren A., Schmidt, Fabian, Wang, Zijun, Cho, Alice, Raspe, Raphael, Guzman-Cardozo, Camila, Muecksch, Frauke, Canis, Marie, Park, Debby J., Gaebler, Christian, Caskey, Marina, Nussenzweig, Michel C., Hatziioannou, Theodora, Bieniasz, Paul D.

“…Waves of SARS-CoV-2 infection have resulted from the emergence of viral variants with neutralizing antibody resistance mutations. Simultaneously, repeated…”
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Impact of misclassified defective proviruses on HIV reservoir measurements by Reeves, Daniel B., Gaebler, Christian, Oliveira, Thiago Y., Peluso, Michael J., Schiffer, Joshua T., Cohn, Lillian B., Deeks, Steven G., Nussenzweig, Michel C.

“…Most proviruses persisting in people living with HIV (PWH) on antiretroviral therapy (ART) are defective. However, rarer intact proviruses almost always…”
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Memory B cell responses to Omicron subvariants after SARS-CoV-2 mRNA breakthrough infection in humans by Wang, Zijun, Zhou, Pengcheng, Muecksch, Frauke, Cho, Alice, Ben Tanfous, Tarek, Canis, Marie, Witte, Leander, Johnson, Brianna, Raspe, Raphael, Schmidt, Fabian, Bednarski, Eva, Da Silva, Justin, Ramos, Victor, Zong, Shuai, Turroja, Martina, Millard, Katrina G, Yao, Kai-Hui, Shimeliovich, Irina, Dizon, Juan, Kaczynska, Anna, Jankovic, Mila, Gazumyan, Anna, Oliveira, Thiago Y, Caskey, Marina, Gaebler, Christian, Bieniasz, Paul D, Hatziioannou, Theodora, Nussenzweig, Michel C

“…Individuals who receive a third mRNA vaccine dose show enhanced protection against severe COVID-19, but little is known about the impact of breakthrough…”
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SARS CoV-2 mRNA vaccination exposes latent HIV to Nef-specific CD8+ T-cells by Stevenson, Eva M., Terry, Sandra, Copertino, Dennis, Leyre, Louise, Danesh, Ali, Weiler, Jared, Ward, Adam R., Khadka, Pragya, McNeil, Evan, Bernard, Kevin, Miller, Itzayana G., Ellsworth, Grant B., Johnston, Carrie D., Finkelsztein, Eli J., Zumbo, Paul, Betel, Doron, Dündar, Friederike, Duncan, Maggie C., Lapointe, Hope R., Speckmaier, Sarah, Moran-Garcia, Nadia, Papa, Michelle Premazzi, Nicholes, Samuel, Stover, Carissa J., Lynch, Rebecca M., Caskey, Marina, Gaebler, Christian, Chun, Tae-Wook, Bosque, Alberto, Wilkin, Timothy J., Lee, Guinevere Q., Brumme, Zabrina L., Jones, R. Brad

“…Efforts to cure HIV have focused on reactivating latent proviruses to enable elimination by CD8 + cytotoxic T-cells. Clinical studies of latency reversing…”
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