Search Results - "Gadina, Massimo"

JAK–STAT Signaling as a Target for Inflammatory and Autoimmune Diseases: Current and Future Prospects by Banerjee, Shubhasree, Biehl, Ann, Gadina, Massimo, Hasni, Sarfaraz, Schwartz, Daniella M.

“…The Janus kinase/signal transduction and activator of transcription (JAK–STAT) signaling pathway is implicated in the pathogenesis of inflammatory and…”
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JAK inhibition as a therapeutic strategy for immune and inflammatory diseases by Schwartz, Daniella M., Kanno, Yuka, Villarino, Alejandro, Ward, Michael, Gadina, Massimo, O'Shea, John J.

“…Key Points Despite their success, conventional and biologic disease-modifying antirheumatic drugs are not effective in all patients. First-generation Janus…”
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Selective Janus kinase inhibitors come of age by O’Shea, John J., Gadina, Massimo

“…Janus kinase (JAK) inhibitors (jakinibs) that target downstream signalling by a large range of cytokines are effective in treating autoimmune and rheumatic…”
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Type 2 immunity in the skin and lungs by Akdis, Cezmi A., Arkwright, Peter D., Brüggen, Marie-Charlotte, Busse, William, Gadina, Massimo, Guttman‐Yassky, Emma, Kabashima, Kenji, Mitamura, Yasutaka, Vian, Laura, Wu, Jianni, Palomares, Oscar

“…There has been extensive progress in understanding the cellular and molecular mechanisms of inflammation and immune regulation in allergic diseases of the skin…”
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The JAK-STAT pathway at 30: Much learned, much more to do by Philips, Rachael L., Wang, Yuxin, Cheon, HyeonJoo, Kanno, Yuka, Gadina, Massimo, Sartorelli, Vittorio, Horvath, Curt M., Darnell, James E., Stark, George R., O’Shea, John J.

“…The discovery of the Janus kinase (JAK)-signal transducer and activator of transcription (STAT) pathway arose from investigations of how cells respond to…”
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JAK inhibitors: Ten years after by Spinelli, Francesca Romana, Meylan, Françoise, O'Shea, John J., Gadina, Massimo

“…The European Journal of Immunology was launched 50 years ago, coinciding with the discovery of many cytokines and growth factors and the emergence of an…”
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The JAK-STAT Pathway: Impact on Human Disease and Therapeutic Intervention by O'Shea, John J, Schwartz, Daniella M, Villarino, Alejandro V, Gadina, Massimo, McInnes, Iain B, Laurence, Arian

“…The Janus kinase (JAK)-signal transducer of activators of transcription (STAT) pathway is now recognized as an evolutionarily conserved signaling pathway…”
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Translational and clinical advances in JAK‐STAT biology: The present and future of jakinibs by Gadina, Massimo, Johnson, Catrina, Schwartz, Daniella, Bonelli, Michael, Hasni, Sarfaraz, Kanno, Yuka, Changelian, Paul, Laurence, Arian, O'Shea, John J.

“…In this era, it is axiomatic that cytokines have critical roles in cellular development and differentiation, immune homeostasis, and host defense. Equally,…”
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Janus kinases to jakinibs: from basic insights to clinical practice by Gadina, Massimo, Le, Mimi T, Schwartz, Daniella M, Silvennoinen, Olli, Nakayamada, Shingo, Yamaoka, Kunihiro, O'Shea, John J

“…Abstract Cytokines are critical mediators of diverse immune and inflammatory diseases. Targeting cytokines and cytokine receptors with biologics has…”
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Tofacitinib Ameliorates Murine Lupus and Its Associated Vascular Dysfunction by Furumoto, Yasuko, Smith, Carolyne K., Blanco, Luz, Zhao, Wenpu, Brooks, Stephen R., Thacker, Seth G., Zarzour, Abdalrahman, Sciumè, Giuseppe, Tsai, Wanxia L., Trier, Anna M., Nunez, Leti, Mast, Laurel, Hoffmann, Victoria, Remaley, Alan T., O'Shea, John J., Kaplan, Mariana J., Gadina, Massimo

“…Objective Dysregulation of innate and adaptive immune responses contributes to the pathogenesis of systemic lupus erythematosus (SLE) and its associated…”
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JAK/STAT signaling in regulation of innate lymphoid cells: The gods before the guardians by Stabile, Helena, Scarno, Gianluca, Fionda, Cinzia, Gismondi, Angela, Santoni, Angela, Gadina, Massimo, Sciumè, Giuseppe

“…Summary Immunity to pathogens is ensured through integration of early responses mediated by innate cells and late effector functions taking place after…”
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Biallelic hypomorphic mutations in a linear deubiquitinase define otulipenia, an early-onset autoinflammatory disease by Zhou, Qing, Yu, Xiaomin, Demirkaya, Erkan, Deuitch, Natalie, Stone, Deborah, Tsai, Wanxia Li, Kuehn, Hye Sun, Wang, Hongying, Yang, Dan, Park, Yong Hwan, Ombrello, Amanda K., Blake, Mary, Romeo, Tina, Remmers, Elaine F., Chae, Jae Jin, Mullikin, James C., Güzel, Ferhat, Milner, Joshua D., Boehm, Manfred, Rosenzweig, Sergio D., Gadina, Massimo, Welch, Steven B., Özen, Seza, Topaloglu, Rezan, Abinun, Mario, Kastner, Daniel L., Aksentijevich, Ivona

“…Systemic autoinflammatory diseases are caused by mutations in genes that function in innate immunity. Here, we report an autoinflammatory disease caused by…”
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Type I/II cytokines, JAKs, and new strategies for treating autoimmune diseases by Schwartz, Daniella M., Bonelli, Michael, Gadina, Massimo, O'Shea, John J.

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Whole Chromosome Instability induces senescence and promotes SASP by Andriani, Grasiella Angelina, Almeida, Vinnycius Pereira, Faggioli, Francesca, Mauro, Maurizio, Tsai, Wanxia Li, Santambrogio, Laura, Maslov, Alexander, Gadina, Massimo, Campisi, Judith, Vijg, Jan, Montagna, Cristina

“…Age-related accumulation of ploidy changes is associated with decreased expression of genes controlling chromosome segregation and cohesin functions. To…”
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Pharmacokinetics, Pharmacodynamics, and Proposed Dosing of the Oral JAK1 and JAK2 Inhibitor Baricitinib in Pediatric and Young Adult CANDLE and SAVI Patients by Kim, Hanna, Brooks, Kristina M., Tang, Cheng Cai, Wakim, Paul, Blake, Mary, Brooks, Stephen R., Montealegre Sanchez, Gina A., de Jesus, Adriana A., Huang, Yan, Tsai, Wanxia Li, Gadina, Massimo, Prakash, Apurva, Janes, Jonathan Marcus, Zhang, Xin, Macias, William L., Kumar, Parag, Goldbach‐Mansky, Raphaela

“…Population pharmacokinetic (popPK) modeling was used to characterize the PK profile of the oral Janus kinase (JAK)1/JAK2 inhibitor, baricitinib, in 18 patients…”
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Modulation of innate and adaptive immune responses by tofacitinib (CP-690,550) by Ghoreschi, Kamran, Jesson, Michael I, Li, Xiong, Lee, Jamie L, Ghosh, Sarbani, Alsup, Jason W, Warner, James D, Tanaka, Masao, Steward-Tharp, Scott M, Gadina, Massimo, Thomas, Craig J, Minnerly, John C, Storer, Chad E, LaBranche, Timothy P, Radi, Zaher A, Dowty, Martin E, Head, Richard D, Meyer, Debra M, Kishore, Nandini, O'Shea, John J

“…Inhibitors of the JAK family of nonreceptor tyrosine kinases have demonstrated clinical efficacy in rheumatoid arthritis and other inflammatory disorders;…”
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Expression of interferon-regulated genes in juvenile dermatomyositis versus Mendelian autoinflammatory interferonopathies by Kim, Hanna, Gunter-Rahman, Fatima, McGrath, John A, Lee, Esther, de Jesus, Adriana A, Targoff, Ira N, Huang, Yan, O'Hanlon, Terrance P, Tsai, Wanxia L, Gadina, Massimo, Miller, Frederick W, Goldbach-Mansky, Raphaela, Rider, Lisa G

“…Juvenile dermatomyositis (JDM) is a systemic autoimmune disease with a prominent interferon (IFN) signature, but the pathogenesis of JDM and the etiology of…”
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3-hydroxy-L-kynurenamine is an immunomodulatory biogenic amine by Clement, Cristina C., D’Alessandro, Angelo, Thangaswamy, Sangeetha, Chalmers, Samantha, Furtado, Raquel, Spada, Sheila, Mondanelli, Giada, Ianni, Federica, Gehrke, Sarah, Gargaro, Marco, Manni, Giorgia, Cara, Luisa Carlota Lopez, Runge, Peter, Tsai, Wanxia Li, Karaman, Sinem, Arasa, Jorge, Fernandez-Rodriguez, Ruben, Beck, Amanda, Macchiarulo, Antonio, Gadina, Massimo, Halin, Cornelia, Fallarino, Francesca, Skobe, Mihaela, Veldhoen, Marc, Moretti, Simone, Formenti, Silvia, Demaria, Sandra, Soni, Rajesh K., Galarini, Roberta, Sardella, Roccaldo, Lauvau, Gregoire, Putterman, Chaim, Alitalo, Kari, Grohmann, Ursula, Santambrogio, Laura

“…© The Author(s) 2021. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing,…”
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Editorial: JAK inhibition in autoimmune and inflammatory diseases by Telliez, Jean-Baptiste, Gadina, Massimo, Ghoreschi, Kamran, Silvennoinen, Olli, Spinelli, Francesca Romana

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Jakinibs of All Trades: Inhibiting Cytokine Signaling in Immune-Mediated Pathologies by Alexander, Madison, Luo, Yiming, Raimondi, Giorgio, O'Shea, John J, Gadina, Massimo

“…Over the last 25 years, inhibition of Janus kinases (JAKs) has been pursued as a modality for treating various immune and inflammatory disorders. While the…”
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