Search Results - "Gadhe, Laxmikant"

α-Synuclein aggregation nucleates through liquid–liquid phase separation by Ray, Soumik, Singh, Nitu, Kumar, Rakesh, Patel, Komal, Pandey, Satyaprakash, Datta, Debalina, Mahato, Jaladhar, Panigrahi, Rajlaxmi, Navalkar, Ambuja, Mehra, Surabhi, Gadhe, Laxmikant, Chatterjee, Debdeep, Sawner, Ajay Singh, Maiti, Siddhartha, Bhatia, Sandhya, Gerez, Juan Atilio, Chowdhury, Arindam, Kumar, Ashutosh, Padinhateeri, Ranjith, Riek, Roland, Krishnamoorthy, G., Maji, Samir K.

“…α-Synuclein (α-Syn) aggregation and amyloid formation is directly linked with Parkinson’s disease pathogenesis. However, the early events involved in this…”
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Intermolecular interactions underlie protein/peptide phase separation irrespective of sequence and structure at crowded milieu by Poudyal, Manisha, Patel, Komal, Gadhe, Laxmikant, Sawner, Ajay Singh, Kadu, Pradeep, Datta, Debalina, Mukherjee, Semanti, Ray, Soumik, Navalkar, Ambuja, Maiti, Siddhartha, Chatterjee, Debdeep, Devi, Jyoti, Bera, Riya, Gahlot, Nitisha, Joseph, Jennifer, Padinhateeri, Ranjith, Maji, Samir K.

“…Liquid-liquid phase separation (LLPS) has emerged as a crucial biological phenomenon underlying the sequestration of macromolecules (such as proteins and…”
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Structural and Functional Insights into α-Synuclein Fibril Polymorphism by Mehra, Surabhi, Gadhe, Laxmikant, Bera, Riya, Sawner, Ajay Singh, Maji, Samir K

“…Abnormal accumulation of aggregated α-synuclein (α-Syn) is seen in a variety of neurodegenerative diseases, including Parkinson's disease (PD), multiple system…”
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Glycosaminoglycans have variable effects on α-synuclein aggregation and differentially affect the activities of the resulting amyloid fibrils by Mehra, Surabhi, Ghosh, Dhiman, Kumar, Rakesh, Mondal, Mrityunjoy, Gadhe, Laxmikant G., Das, Subhadeep, Anoop, Arunagiri, Jha, Narendra N., Jacob, Reeba S., Chatterjee, Debdeep, Ray, Soumik, Singh, Nitu, Kumar, Ashutosh, Maji, Samir K.

“…Parkinson's disease is mainly a sporadic disorder in which both environmental and cellular factors play a major role in the initiation of this disease…”
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Comparison of Kinetics, Toxicity, Oligomer Formation, and Membrane Binding Capacity of α‑Synuclein Familial Mutations at the A53 Site, Including the Newly Discovered A53V Mutation by Mohite, Ganesh M, Kumar, Rakesh, Panigrahi, Rajlaxmi, Navalkar, Ambuja, Singh, Nitu, Datta, Debalina, Mehra, Surabhi, Ray, Soumik, Gadhe, Laxmikant G, Das, Subhadeep, Singh, Namrata, Chatterjee, Debdeep, Kumar, Ashutosh, Maji, Samir K

“…The involvement of α-synuclein (α-Syn) amyloid formation in Parkinson’s disease (PD) pathogenesis is supported by the discovery of α-Syn gene (SNCA) mutations…”
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The Familial α‑Synuclein A53E Mutation Enhances Cell Death in Response to Environmental Toxins Due to a Larger Population of Oligomers by Mohite, Ganesh M, Navalkar, Ambuja, Kumar, Rakesh, Mehra, Surabhi, Das, Subhadeep, Gadhe, Laxmikant G, Ghosh, Dhiman, Alias, Basil, Chandrawanshi, Vikas, Ramakrishnan, Aishwarya, Mehra, Sarika, Maji, Samir K

“…Amyloid formation of α-synuclein (α-Syn) and its familial mutations are directly linked with Parkinson’s disease (PD) pathogenesis. Recently, a new familial…”
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Benzimidazole‐based fluorophores for the detection of amyloid fibrils with higher sensitivity than Thioflavin‐T by Pravin, Narayanaperumal, Kumar, Rakesh, Tripathi, Shalini, Kumar, Pardeep, Mohite, Ganesh M, Navalkar, Ambuja, Panigrahi, Rajlaxmi, Singh, Namrata, Gadhe, Laxmikant G., Manchanda, Shaffi, Shimozawa, Makoto, Nilsson, Per, Johansson, Jan, Kumar, Ashutosh, Maji, Samir K., Shanmugam, Maheswaran

“…Protein aggregation into amyloid fibrils is a key feature of a multitude of neurodegenerative diseases such as Alzheimer's, Parkinson's, and Prion disease. To…”
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Co-aggregation and secondary nucleation in the life cycle of human prolactin/galanin functional amyloids by Chatterjee, Debdeep, Jacob, Reeba S, Ray, Soumik, Navalkar, Ambuja, Singh, Namrata, Sengupta, Shinjinee, Gadhe, Laxmikant, Kadu, Pradeep, Datta, Debalina, Paul, Ajoy, Arunima, Sakunthala, Mehra, Surabhi, Pindi, Chinmai, Kumar, Santosh, Singru, Praful, Senapati, Sanjib, Maji, Samir K

“…Synergistic-aggregation and cross-seeding by two different proteins/peptides in the amyloid aggregation are well evident in various neurological disorders…”
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Liquid-liquid Phase Separation of α-Synuclein: A New Mechanistic Insight for α-Synuclein Aggregation Associated with Parkinson's Disease Pathogenesis by Mukherjee, Semanti, Sakunthala, Arunima, Gadhe, Laxmikant, Poudyal, Manisha, Sawner, Ajay Singh, Kadu, Pradeep, Maji, Samir K.

“…[Display omitted] •The aberrant amyloid aggregation of α-Syn is a key pathological event in PD.•LLPS of α-Syn drives the nucleation for amyloid aggregation and…”
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Biocompatible Fluorescent Probe for Selective Detection of Amyloid Fibrils by Das, Anirban, Dutta, Tanoy, Gadhe, Laxmikant, Koner, Apurba Lal, Saraogi, Ishu

“…The misfolding and aggregation of proteins leading to amyloid formation has been linked to numerous diseases, necessitating the development of tools to monitor…”
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p53 amyloid pathology is correlated with higher cancer grade irrespective of the mutant or wild-type form by Sengupta, Shinjinee, Singh, Namrata, Paul, Ajoy, Datta, Debalina, Chatterjee, Debdeep, Mukherjee, Semanti, Gadhe, Laxmikant, Devi, Jyoti, Mahesh, Yeshwanth, Jolly, Mohit Kumar, Maji, Samir K.

“…ABSTRACT p53 (also known as TP53) mutation and amyloid formation are long associated with cancer pathogenesis; however, the direct demonstration of the link…”
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Intermediates of α-synuclein aggregation: Implications in Parkinson's disease pathogenesis by Gadhe, Laxmikant, Sakunthala, Arunima, Mukherjee, Semanti, Gahlot, Nitisha, Bera, Riya, Sawner, Ajay Singh, Kadu, Pradeep, Maji, Samir K.

“…Cytoplasmic deposition of aberrantly misfolded α-synuclein (α-Syn) is a common feature of synucleinopathies, including Parkinson’s disease (PD). However, the…”
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Machine-Free Polymerase Chain Reaction with Triangular Gold and Silver Nanoparticles by Kadu, Pradeep, Pandey, Satyaprakash, Neekhra, Suditi, Kumar, Rakesh, Gadhe, Laxmikant, Srivastava, Rohit, Sastry, Murali, Maji, Samir K

“…Photothermal effects of metal nanoparticles (NPs) are used for various biotechnological applications. Although NPs have been used in a polymerase chain…”
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Phase separation and other forms of α-Synuclein self-assemblies by Poudyal, Manisha, Sakunthala, Arunima, Mukherjee, Semanti, Gadhe, Laxmikant, Maji, Samir K

“…α-Synuclein (α-Syn) is a natively unstructured protein, which self-assembles into higher-order aggregates possessing serious pathophysiological implications…”
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Sensitized Emission Imaging Allows Nanoscale Surface Polarity Mapping of α‑Synuclein Amyloid Fibrils by Mahato, Jaladhar, Mukherjee, Rajat, Bose, Abhik, Mehra, Surabhi, Gadhe, Laxmikant, Maji, Samir K., Chowdhury, Arindam

“…When misfolded, α-Synuclein (α-Syn), a natively disordered protein, aggregates to form amyloid fibrils responsible for the neurodegeneration observed in…”
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Direct Demonstration of Seed Size-Dependent α‑Synuclein Amyloid Amplification by Sakunthala, Arunima, Datta, Debalina, Navalkar, Ambuja, Gadhe, Laxmikant, Kadu, Pradeep, Patel, Komal, Mehra, Surabhi, Kumar, Rakesh, Chatterjee, Debdeep, Devi, Jyoti, Sengupta, Kundan, Padinhateeri, Ranjith, Maji, Samir K.

“…The size of amyloid seeds is known to modulate their autocatalytic amplification and cellular toxicity. However, the seed size-dependent secondary nucleation…”
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α-Synuclein Aggregation Intermediates form Fibril Polymorphs with Distinct Prion-like Properties by Mehra, Surabhi, Ahlawat, Sahil, Kumar, Harish, Datta, Debalina, Navalkar, Ambuja, Singh, Nitu, Patel, Komal, Gadhe, Laxmikant, Kadu, Pradeep, Kumar, Rakesh, Jha, Narendra N., Sakunthala, Arunima, Sawner, Ajay S., Padinhateeri, Ranjith, Udgaonkar, Jayant B., Agarwal, Vipin, Maji, Samir K.

“…[Display omitted] •Amyloid polymorphism is associated with distinct disease phenotypes in proteopathies.•Conformational heterogeneity during α-Syn aggregation…”
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