Search Results - "Gademann, K"

Peptide Folding Induces High and Selective Affinity of a Linear and Small β-Peptide to the Human Somatostatin Receptor 4 by Gademann, Karl, Kimmerlin, Thierry, Hoyer, Daniel, Seebach, Dieter

“…β-Peptides with side chains in the 2- and 3-positions on neighboring residues (of (S) configuration) are known to fold and form a turn (similar to an…”
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The beta-peptide hairpin in solution: conformational study of a beta-hexapeptide in methanol by NMR spectroscopy and MD simulation by Daura, X, Gademann, K, Schäfer, H, Jaun, B, Seebach, D, van Gunsteren, W F

“…The structural and thermodynamic properties of a 6-residue beta-peptide that was designed to form a hairpin conformation have been studied by NMR spectroscopy…”
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Mechanistic Studies on the Tyrosinase-Catalyzed Formation of the Anachelin Chromophore by Gademann, Karl

“…The complex secondary metabolite anachelin, isolated from the freshwater cyanobacterium Anabaena cylindrica, is believed to act as siderophore, facilitating…”
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Peptide Folding: When Simulation Meets Experiment by Daura, Xavier, Gademann, Karl, Jaun, Bernhard, Seebach, Dieter, van Gunsteren, Wilfred F., Mark, Alan E.

“…Accurate reproduction of the mechanism of peptide folding in solution and conformational preferences as a function of amino acid sequence is possible with…”
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Aerucyclamides A and B: Isolation and Synthesis of Toxic Ribosomal Heterocyclic Peptides from the Cyanobacterium Microcystis aeruginosa PCC 7806 by Portmann, Cyril, Blom, Judith F, Gademann, Karl, Jüttner, Friedrich

“…Two new modified hexacyclopeptides, aerucyclamides A and B, were isolated from the toxic freshwater cyanobacterium Microcystis aeruginosa PCC 7806. The…”
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Highly Enantioselective Inverse-Electron-Demand Hetero-Diels-Alder Reactions of α,β-Unsaturated Aldehydes by Gademann, Karl, Chavez, David E., Jacobsen, Eric N.

“…Straightforward access to useful synthetic intermediates is provided by this new method. Simple, α,β‐unsaturated aldehydes are excellent substrates in the…”
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Nostocarboline:  Isolation and Synthesis of a New Cholinesterase Inhibitor from Nostoc 78-12A by Becher, Paul G, Beuchat, Julien, Gademann, Karl, Jüttner, Friedrich

“…A new quaternary β-carboline alkaloid, nostocarboline (1), was isolated from the freshwater cyanobacterium Nostoc 78-12A, and its constitution was assigned by…”
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Synthesis and Biological Evaluation of a Cyclo-β-tetrapeptide as a Somatostatin Analogue by Gademann, Karl, Ernst, Martin, Hoyer, Daniel, Seebach, Dieter

“…Short β‐peptides can mimic natural peptide hormones, as has been shown with a cyclo‐β‐tetrapeptide (1) that displays micromolar affinity to human somatostatin…”
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Biomimetic Surface Modifications Based on the Cyanobacterial Iron Chelator Anachelin by Zürcher, Stefan, Wäckerlin, David, Bethuel, Yann, Malisova, Barbora, Textor, Marcus, Tosatti, Samuele, Gademann, Karl

“…Siderophores are natural iron chelators that have been evolutionarily selected to bind to Fe ions with very high binding constants. We utilize these unique…”
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Beta-peptides: twisting and turning by Gademann, K, Hintermann, T, Schreiber, J V

“…Oligomers of beta-amino acids (beta-peptides), which are readily available by standard meth ods either in solution or on solid support, adopt a large variety…”
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Total Synthesis of Anachelin H by Gademann, Karl, Bethuel, Yann

“…The first total synthesis of anachelin H is reported. Starting from l-Ser, a stereodivergent synthesis of the polyketide fragment resulting in all possible…”
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A Biomimetic Route to the Peptide Alkaloid Anachelin by Gademann, Karl, Bethuel, Yann

“…A postulated biogenesis forms the basis for a synthetic route to the natural product anachelin H (1). Key steps include a tellurium‐mediated, oxidative aza…”
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Potent Algicides Based on the Cyanobacterial Alkaloid Nostocarboline by Blom, Judith F, Brütsch, Tobias, Barbaras, Damien, Bethuel, Yann, Locher, Hans H, Hubschwerlen, Christian, Gademann, Karl

“…Nostocarboline and seven derivatives were prepared and displayed minimal inhibitory concentration (MIC) values ≥100 nM against the growth of Microcystis…”
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Synthesis and Evaluation of the Bis-Nor-Anachelin Chromophore as Potential Cyanobacterial Ligand by Bethuel, Yann, Gademann, Karl

“…The cyanobacterial metabolite anachelin, postulated to serve as a biological ligand to Fe (siderophore), is composed of a fascinating blend of polyketide,…”
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The Cyclo-β-Tetrapeptide (β-HPhe-β-HThr-β-HLys-β-HTrp): Synthesis, NMR Structure in Methanol Solution, and Affinity for Human Somatostatin Receptors by Gademann, Karl, Ernst, Martin, Seebach, Dieter, Hoyer, Daniel

“…The known solid‐state structure (Fig. 1, top) of cyclo(β‐HAla)4 was used to model the structure of the title compound 1 as a prospective somatostatin mimic…”
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Nostocarboline: Isolation and Synthesis of a New Cholinesterase Inhibitor from Nostoc 78-12A by Becher, P G, Beuchat, J, Gademann, K, Juttner, F

“…A new quaternary beta -carboline alkaloid, nostocarboline (1), was isolated from the freshwater cyanobacterium Nostoc 78- 12 A, and its constitution was…”
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Design of a high-throughput device for screening surface modification protocols by Saxer, Sina, Pieles, Uwe, Elsener, Martin, Horisberger, Michael, Tosatti, Samuele, Textor, Marcus, Gademann, Karl, Zürcher, Stefan

“…The development of new high performance, ultra-thin organic coatings requires a strategy that has to consider a large number of surface treatment variables…”
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β-Thiopeptides: Synthesis, NMR Solution Structure, CD Spectra, and Photochemistry by Sifferlen, Thierry, Rueping, Magnus, Gademann, Karl, Jaun, Bernhard, Seebach, Dieter

“…To test the effect of NH−C=S groups (Scheme 1) on the stability of β‐peptide secondary structures, we have synthesized three β‐thiohexapeptide analogues of…”
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Temperature-Dependent NMR and CD Spectra of β-Peptides: On the Thermal Stability of β-Peptide Helices - Is the Folding Process of β-Peptides Non-cooperative? by Gademann, Karl, Jaun, Bernhard, Seebach, Dieter, Perozzo, Remo, Scapozza, Leonardo, Folkers, Gerd

“…Temperature‐dependent NMR and CD spectra of methanol solutions of a β‐hexapeptide and of a β‐heptapeptide at temperatures between 298 and 393 K are reported…”
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