Search Results - "Gadaleta, Mariana"

Regulation of DNA Replication through Natural  Impediments in the Eukaryotic Genome by Gadaleta, Mariana C, Noguchi, Eishi

“…All living organisms need to duplicate their genetic information while protecting it from unwanted mutations, which can lead to genetic disorders and cancer…”
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Lingering single-strand breaks trigger Rad51-independent homology-directed repair of collapsed replication forks in the polynucleotide kinase/phosphatase mutant of fission yeast by Sanchez, Arancha, Gadaleta, Mariana C, Limbo, Oliver, Russell, Paul

“…The DNA repair enzyme polynucleotide kinase/phosphatase (PNKP) protects genome integrity by restoring ligatable 5'-phosphate and 3'-hydroxyl termini at…”
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Brc1 Promotes the Focal Accumulation and SUMO Ligase Activity of Smc5-Smc6 during Replication Stress by Oravcová, Martina, Gadaleta, Mariana C., Nie, Minghua, Reubens, Michael C., Limbo, Oliver, Russell, Paul, Boddy, Michael N.

“…As genetic instability drives disease or loss of cell fitness, cellular safeguards have evolved to protect the genome, especially during sensitive cell cycle…”
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Timeless protection of telomeres by Gadaleta, Mariana C., González-Medina, Alberto, Noguchi, Eishi

“…The DNA replication machinery encounters problems at numerous genomic regions that are inherently difficult to replicate. These genomic regions include…”
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New vectors for epitope tagging and gene disruption in Schizosaccharomyces pombe by Gadaleta, Mariana C, Iwasaki, Osamu, Noguchi, Chiaki, Noma, Ken-ichi, Noguchi, Eishi

“…We describe a series of new vectors for PCR-based epitope tagging and gene disruption in the fission yeast Schizosaccharomyces pombe, an exceptional model…”
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Swi1 Timeless Prevents Repeat Instability at Fission Yeast Telomeres by Gadaleta, Mariana C, Das, Mukund M, Tanizawa, Hideki, Chang, Ya-Ting, Noma, Ken-ichi, Nakamura, Toru M, Noguchi, Eishi

“…Genomic instability associated with DNA replication stress is linked to cancer and genetic pathologies in humans. If not properly regulated, replication…”
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Chromatin immunoprecipitation to detect DNA replication and repair factors by Gadaleta, Mariana C, Iwasaki, Osamu, Noguchi, Chiaki, Noma, Ken-Ichi, Noguchi, Eishi

“…DNA replication is tightly coupled with DNA repair processes in order to preserve genomic integrity. During DNA replication, the replication fork encounters a…”
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Swi1Timeless Prevents Repeat Instability at Fission Yeast Telomeres by Gadaleta, Mariana C, Das, Mukund M, Tanizawa, Hideki, Chang, Ya-Ting, Noma, Ken-ichi, Nakamura, Toru M, Noguchi, Eishi

“…Genomic instability associated with DNA replication stress is linked to cancer and genetic pathologies in humans. If not properly regulated, replication…”
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TrkB Isoforms Differentially Affect AICD Production through Their Intracellular Functional Domains by Leung, Brian P., Ansaloni, Sara, Sebastian, Neeraj P., Samudralwar, Rohini, Gadaleta, Mariana, Saunders, Aleister J.

“…We report that NTRK2, the gene encoding for the TrkB receptor, can regulate APP metabolism, specifically AICD levels. Using the human neuroblastoma cell line…”
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Swi1 Timeless Prevents Repeat Instability at Fission Yeast Telomeres by Noguchi, Eishi, Gadaleta, Mariana

“…Abstract only Genomic instability associated with DNA replication stress is linked to cancer and genetic pathologies in humans. Replication stress, such as…”
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Swi1.sup.Timeless Prevents Repeat Instability at Fission Yeast Telomeres by Gadaleta, Mariana C, Das, Mukund M, Tanizawa, Hideki, Chang, Ya-Ting, Noma, Ken-ichi, Nakamura, Toru M, Noguchi, Eishi

“…Genomic instability associated with DNA replication stress is linked to cancer and genetic pathologies in humans. If not properly regulated, replication…”
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P3‐197: TrkB isoforms differentially regulate amyloid precursor protein Swedish mutant glycosylation and processing by Ansaloni, Sara, Leung, Brian, Gadaleta, Mariana, Saunders, Aleister

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TrkB isoforms differentially regulate amyloid precursor protein Swedish mutant glycosylation and processing by Ansaloni, Sara, Leung, Brian, Gadaleta, Mariana, Saunders, Aleister

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New Enzymes Involved in the Mechanism of Action of Epidermal Growth Factor in a Clonal Strain of Leydig Tumor Cells by Castilla, Rocío, Gadaleta, Mariana, Castillo, Ana Fernanda, Duarte, Alejandra, Neuman, Isabel, Paz, Cristina, Cornejo Maciel, Fabiana, Podestá, Ernesto J

“…The studies presented herein were designed to investigate the effect of mouse epidermal growth factor (mEGF) on arachidonic acid (AA) release in a clonal…”
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