Search Results - "Gadad, Andanappa K."

Synthesis and anticancer evaluation of novel 2-cyclopropylimidazo[2,1- b][1,3,4]-thiadiazole derivatives by Noolvi, Malleshappa N., Patel, Harun M., Singh, Navjot, Gadad, Andanappa K., Cameotra, Swaranjit Singh, Badiger, Arvind

“…A series of 2,5,6-trisubstituted imidazo[2,1- b][1,3,4]-thiadiazole derivatives 4( a– k) have been prepared by reaction of…”
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Synthesis and biological evaluation of 2-trifluoromethyl/sulfonamido-5,6-diaryl substituted imidazo[2,1- b]-1,3,4-thiadiazoles: A novel class of cyclooxygenase-2 inhibitors by Gadad, Andanappa K., Palkar, Mahesh B., Anand, K., Noolvi, Malleshappa N., Boreddy, Thippeswamy S., Wagwade, J.

“…A series of 2-trifluoromethyl/sulfonamido-5,6-diarylsubstituted imidazo[2,1- b]-1,3,4-thiadiazole derivatives 15a– j have been synthesized by the reaction of…”
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Enoyl ACP reductase as effective target for the synthesized novel antitubercular drugs: a-state-of-the-art by Joshi, Shrinivas D, Dixit, Sheshagiri R, More, Uttam A, Aminabhavi, Tejraj M, Kulkarni, Venkatrao H, Gadad, Andanappa K

“…The emergence of drug resistant strains of important human pathogens has created an urgent necessity to find new targets and novel antitubercular agents…”
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Design, synthesis and evaluation of small molecule imidazo[2,1-b][1,3,4]thiadiazoles as inhibitors of transforming growth factor-β type-I receptor kinase (ALK5) by Patel, Harun M., Sing, Baljeet, Bhardwaj, Varun, Palkar, Mahesh, Shaikh, Mahamadhanif S., Rane, Rajesh, Alwan, Wesam S., Gadad, Andanappa K., Noolvi, Malleshappa N., Karpoormath, Rajshekhar

“…A new series of imidazo[2,1-b][1,3,4]thiadiazoles 5(a–g), 6(a–g), 9(a–i) and 12(a–h) were synthesized as transforming growth factor-β (TGF-β) type I receptor…”
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Biological activities of imidazo[2,1-b][1,3,4]thiadiazole derivatives: A review by Bhongade, Bhoomendra A., Talath, Sirajunisa, Gadad, Ravikiran A., Gadad, Andanappa K.

“…Imidazo[2,1-b][1,3,4]thiadiazole heterocycle was discovered during the 1950s. Since then, many newer derivatives are being developed and evaluated for their…”
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Chemistry of imidazo[2,1- b][1,3,4]thiadiazoles by Khazi, Imtiyaz Ahmed M., Gadad, Andanappa K., Lamani, Ravi S., Bhongade, Bhoomendra A.

“…Research work on Imidazo[2,1 -b][1,3,4]thiadiazole ring system extending over a period of 55 years led to some drug candidates and promising lead molecules…”
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Synthesis and antitubercular evaluation of imidazo[2,1-b][1,3,4]thiadiazole derivatives by Patel, Harun M., Noolvi, Malleshappa N., Sethi, Navdeep Singh, Gadad, Andanappa K., Cameotra, Swaranjit Singh

“…In the present study, a series of imidazo[2,1-b][1,3,4]thiadiazole derivatives 5(a–j) were synthesized and characterized by IR, 1H NMR, 13C NMR and mass…”
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Design, synthesis, molecular docking and 3D-QSAR studies of potent inhibitors of enoyl-acyl carrier protein reductase as potential antimycobacterial agents by More, Uttam A., Joshi, Shrinivas D., Aminabhavi, Tejraj M., Gadad, Andanappa K., Nadagouda, Mallikarjuna N., Kulkarni, Venkatrao H.

“…In order to develop a lead antimycobacterium tuberculosis compound, a series of 52, novel pyrrole hydrazine derivatives have been synthesized and screened…”
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Synthesis and antitumor activity of optically active thiourea and their 2-aminobenzothiazole derivatives: A novel class of anticancer agents by Manjula, S.N., Malleshappa Noolvi, N., Vipan Parihar, K., Manohara Reddy, S.A., Ramani, Vijay, Gadad, Andanappa K., Singh, Gurdial, Gopalan Kutty, N., Mallikarjuna Rao, C.

“…A novel series of optically active 2-aminobenzothiazole derivatives were synthesized by reaction of optically active amine ( I) with thiophosgene to obtain…”
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Design, synthesis of quinolinyl Schiff bases and azetidinones as enoyl ACP-reductase inhibitors by Joshi, Shrinivas D., More, Uttam A., Parkale, Deepak, Aminabhavi, Tejraj M., Gadad, Andanappa K., Nadagouda, Mallikarjuna N., Jawarkar, Rahul

“…New series of quinoline derivatives were synthesized from 2-chloroquinoline-3-carbaldehydes. In the reaction sequence, substituted acetanilides were cyclized…”
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Synthesis and anti-tubercular activity of a series of 2-sulfonamido/trifluoromethyl-6-substituted imidazo[2,1- b]-1,3,4-thiadiazole derivatives by Gadad, Andanappa K., Noolvi, Malleshappa N., Karpoormath, Rajshekhar V.

“…[Display omitted] A series of 2-sulfonamido/trifluoromethyl-6-(4′-substituted aryl/heteroaryl)imidazo[2,1- b]-1,3,4-thiadiazole derivatives ( II) have been…”
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Synthesis of 5-Fluoroaminobenzothiazoles by Sharma, Pooja, Singh, Gurdial, Bhongade, Bhoomendra A., Noolvi, Malleshappa N., Gadad, Andanappa K.

“…A series of 5-fluoro-2-(N-substituted)aminobenzothiazoles were synthesized by intramolecular cyclisation of the corresponding thioureas, which were prepared by…”
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Insight into the Structural Requirements of Urokinase-Type Plasminogen Activator Inhibitors Based on 3D QSAR CoMFA/CoMSIA Models by Bhongade, Bhoomendra A, Gadad, Andanappa K

“…Urokinase-type plasminogen activator (uPA), a trypsin-like serine protease, has been implicated in large number of malignancies, tumor cell invasion,…”
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3D-QSAR CoMFA studies on trypsin-like serine protease inhibitors: a comparative selectivity analysis by Bhongade, Bhoomendra A., Gouripur, Veerappa V., Gadad, Andanappa K.

“…3D-QSAR/CoMFA models have been generated for a series of indole/benzoimidazole-5-carboxamidines as trypsin-like serine protease inhibitors viz. tPA, factor Xa,…”
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Synthesis, stability studies, anti-inflammatory activity and ulcerogenicity of morpholinoalkyl ester prodrugs of niflumic acid by TALATH, Sirajunisa, GADADL, Andanappa K

“…In search for potential prodrugs for anti-inflammatory drug candidates in the niflumate series, novel morpholinoalkyl ester prodrugs of niflumic acid (CAS…”
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Synthesis and molecular modeling studies of novel pyrrole analogs as antimycobacterial agents by Joshi, Shrinivas D., More, Uttam A., Pansuriya, Ketan, Aminabhavi, Tejraj M., Gadad, Andanappa K.

“…In the present investigation, a series of 4-(4-pyrrol-1-yl/2,5-dimethyl-4-pyrrol-1-yl) benzoic acid hydrazide analogs, some derived oxadiazoles and azines have…”
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Design, synthesis and computational approach to study novel pyrrole scaffolds as active inhibitors of enoyl ACP reductase (InhA) and Mycobacterium tuberculosis antagonists by Prem Kumar, S.R., Shaikh, Ibrahim Ahmed, Mahnashi, Mater H., Alshahrani, Mohammed Abdulrahman, Dixit, Sheshagiri R., Kulkarni, Venkatarao H., Lherbet, Christian, Gadad, Andanappa K., Aminabhavi, Tejraj M., Joshi, Shrinivas D.

“…Novel 54 pyrrolyl acetohydrazide analogues were designed, synthesized and screened for antitubercular activity against InhA. Enoyl-ACP reductase/InhA one of…”
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Synthesis and antibacterial activity of some 5-guanylhydrazone/thiocyanato-6-arylimidazo[2,1-b]-1,3,4-thiadiazole-2-sulfonamide derivatives by Gadad, Andanappa K, Mahajanshetti, Chanabasappa S, Nimbalkar, Sudarshan, Raichurkar, Anandkumar

“…6-Arylimidazo[2,1-b]-1,3,4-thiadiazole-2-sulfonamides 3 on Vilsmeier-Haak reaction produced…”
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Design and investigation of metformin hydrochloride-Indion-254 complex for dispersible tablets by Villarroel, Arlene, Gupta, Madan, Pereira, Lexley, Gadad, Andanappa

“…Objective: Metformin is a first-line agent for the treatment of Type 2 diabetes. The taste of metformin hydrochloride drug powder is bitter and its formulation…”
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Stability studies of some glycolamide ester prodrugs of niflumic acid in aqueous buffers and human plasma by HPLC with UV detection by TALATH, Sirajunisa, SHIROTE, Pramod J, LOUGH, W. John, GADAD, Andanappa K

“…Glycolamide esters (compounds 1-17) of 2-(3-trifluoromethyl-phenylamino)nicotinic acid (niflumic acid, CAS 4394-00-7) have been synthesized and evaluated as…”
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