Search Results - "Gad, Annica K B"

Hyaluronan nanoscale clustering and Hyaluronan synthase 2 expression are linked to the invasion of child fibroblasts and infantile fibrosarcoma in vitro and in vivo by Tonge, Joseph J., Notley, Scott V., Dunning, Mark J., López-Guajardo, Ana, Medcalf, Jessica D., Heldin, Paraskevi, Panoutsos, George, Gad, Annica K. B.

“…Infantile fibrosarcoma is a rare childhood tumour that originates in the fibrous connective tissue of the long bones for which there is an urgent need to…”
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Multicolor Fluorescence Nanoscopy by Photobleaching: Concept, Verification, and Its Application To Resolve Selective Storage of Proteins in Platelets by Rönnlund, Daniel, Xu, Lei, Perols, Anna, Gad, Annica K. B, Eriksson Karlström, Amelie, Auer, Gert, Widengren, Jerker

“…Fluorescence nanoscopy provides means to discern the finer details of protein localization and interaction in cells by offering an order of magnitude higher…”
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Majority of differentially expressed genes are down-regulated during malignant transformation in a four-stage model by Danielsson, Frida, Skogs, Marie, Huss, Mikael, Rexhepaj, Elton, O'Hurley, Gillian, Klevebring, Daniel, Pontén, Fredrik, Gad, Annica K. B., Uhlén, Mathias, Lundberg, Emma

“…The transformation of normal cells to malignant, metastatic tumor cells is a multistep process caused by the sequential acquirement of genetic changes. To…”
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Oncogenes induce a vimentin filament collapse mediated by HDAC6 that is linked to cell stiffness by Rathje, Li-Sophie Z., Nordgren, Niklas, Pettersson, Torbjörn, Rönnlund, Daniel, Widengren, Jerker, Aspenström, Pontus, Gad, Annica K. B.

“…Oncogenes deregulate fundamental cellular functions, which can lead to development of tumors, tumor-cell invasion, and metastasis. As the mechanical properties…”
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Metastasising Fibroblasts Show an HDAC6-Dependent Increase in Migration Speed and Loss of Directionality Linked to Major Changes in the Vimentin Interactome by Evans, Caroline A, Kim, Hyejeong Rosemary, Macfarlane, Sarah C, Nowicki, Poppy I A, Baltes, Carsten, Xu, Lei, Widengren, Jerker, Lautenschläger, Franziska, Corfe, Bernard M, Gad, Annica K B

“…Metastasising cells express the intermediate filament protein vimentin, which is used to diagnose invasive tumours in the clinic. We aimed to clarify how…”
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RhoA knockout fibroblasts lose tumor-inhibitory capacity in vitro and promote tumor growth in vivo by Alkasalias, Twana, Alexeyenko, Andrey, Hennig, Katharina, Danielsson, Frida, Lebbink, Robert Jan, Fielden, Matthew, Turunen, S. Pauliina, Lehti, Kaisa, Kashuba, Vladimir, Madapura, Harsha S., Bozoky, Benedek, Lundberg, Emma, Balland, Martial, Guvén, Hayrettin, Klein, George, Gad, Annica K. B., Pavlova, Tatiana

“…Fibroblasts are a main player in the tumor-inhibitory microenvironment. Upon tumor initiation and progression, fibroblasts can lose their tumor-inhibitory…”
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Transient state microscopy probes patterns of altered oxygen consumption in cancer cells by Spielmann, Thiemo, Xu, Lei, Gad, Annica K. B., Johansson, Sofia, Widengren, Jerker

“…Altered cellular metabolism plays an important role in many diseases, not least in many forms of cancer, where cellular metabolic pathways requiring lower…”
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ALD-R491 regulates vimentin filament stability and solubility, cell contractile force, cell migration speed and directionality by Kim, Hyejeong Rosemary, Warrington, Samantha J, López-Guajardo, Ana, Al Hennawi, Khairat, Cook, Sarah L, Griffith, Zak D J, Symmes, Deebie, Zhang, Tao, Qu, Zhipeng, Xu, Ying, Chen, Ruihuan, Gad, Annica K B

“…Metastasizing cells express the intermediate filament protein vimentin, which is used to diagnose invasive tumors in the clinic. However, the role of vimentin…”
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Vimentin Levels and Serine 71 Phosphorylation in the Control of Cell-Matrix Adhesions, Migration Speed, and Shape of Transformed Human Fibroblasts by Terriac, Emmanuel, Coceano, Giovanna, Mavajian, Zahra, Hageman, Tijmen A G, Christ, Andreas F, Testa, Ilaria, Lautenschläger, Franziska, Gad, Annica K B

“…Metastasizing tumor cells show increased expression of the intermediate filament (IF) protein vimentin, which has been used to diagnose invasive tumors for…”
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Regulation of cellular contractile force, shape and migration of fibroblasts by oncogenes and Histone deacetylase 6 by López-Guajardo, Ana, Zafar, Azeer, Al Hennawi, Khairat, Rossi, Valentina, Alrwaili, Abdulaziz, Medcalf, Jessica D, Dunning, Mark, Nordgren, Niklas, Pettersson, Torbjörn, Estabrook, Ian D, Hawkins, Rhoda J, Gad, Annica K B

“…The capacity of cells to adhere to, exert forces upon and migrate through their surrounding environment governs tissue regeneration and cancer metastasis. The…”
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Spatial organization of proteins in metastasizing cells by Rönnlund, Daniel, Gad, Annica K. B., Blom, Hans, Aspenström, Pontus, Widengren, Jerker

“…The ability of tumor cells to invade into the surrounding tissue is linked to defective adhesive and mechanical properties of the cells, which are regulated by…”
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A novel universal algorithm for filament network tracing and cytoskeleton analysis by Flormann, Daniel A. D., Schu, Moritz, Terriac, Emmanuel, Thalla, Divyendu, Kainka, Lucina, Koch, Marcus, Gad, Annica K. B., Lautenschläger, Franziska

“…The rapid development of advanced microscopy techniques over recent decades has significantly increased the quality of imaging and our understanding of…”
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Effects of vimentin on the migration, search efficiency, and mechanical resilience of dendritic cells by Shaebani, M. Reza, Stankevicins, Luiza, Vesperini, Doriane, Urbanska, Marta, Flormann, Daniel A.D., Terriac, Emmanuel, Gad, Annica K.B., Cheng, Fang, Eriksson, John E., Lautenschläger, Franziska

“…Dendritic cells use amoeboid migration to pass through narrow passages in the extracellular matrix and confined tissue in search for pathogens and to reach the…”
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A novel pipeline employing deep multi-attention channels network for the autonomous detection of metastasizing cells through fluorescence microscopy by Mamalakis, Michail, Macfarlane, Sarah C., Notley, Scott V., Gad, Annica K.B., Panoutsos, George

“…Metastasis driven by cancer cell migration is the leading cause of cancer-related deaths. It involves significant changes in the organization of the…”
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RhoD regulates cytoskeletal dynamics via the actin nucleation-promoting factor WASp homologue associated with actin Golgi membranes and microtubules by Gad, Annica K B, Nehru, Vishal, Ruusala, Aino, Aspenström, Pontus

“…The Rho GTPases have mainly been studied in association with their roles in the regulation of actin filament organization. These studies have shown that the…”
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Nanoscale localization of proteins within focal adhesions indicates discrete functional assemblies with selective force‐dependence by Xu, Lei, Braun, Laura J., Rönnlund, Daniel, Widengren, Jerker, Aspenström, Pontus, Gad, Annica K. B.

“…Focal adhesions (FAs) are subcellular regions at the micrometer scale that link the cell to the surrounding microenvironment and control vital cell functions…”
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Resolution, target density and labeling effects in colocalization studies – suppression of false positives by nanoscopy and modified algorithms by Xu, Lei, Rönnlund, Daniel, Aspenström, Pontus, Braun, Laura J., Gad, Annica K. B., Widengren, Jerker

“…Colocalization analyses of fluorescence images are extensively used to quantify molecular interactions in cells. In recent years, fluorescence nanoscopy has…”
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RhoD is a Golgi component with a role in anterograde protein transport from the ER to the plasma membrane by Blom, Magdalena, Reis, Katarina, Nehru, Vishal, Blom, Hans, Gad, Annica K.B., Aspenström, Pontus

“…RhoD is a member of the Rho GTPase family and it coordinates actin dynamics and membrane trafficking. Activation of RhoD results in formation of filopodia,…”
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Experimental and computational assessment of F-actin influence in regulating cellular stiffness and relaxation behaviour of fibroblasts by Fallqvist, Björn, Fielden, Matthew L., Pettersson, Torbjörn, Nordgren, Niklas, Kroon, Martin, Gad, Annica K.B.

“…In biomechanics, a complete understanding of the structures and mechanisms that regulate cellular stiffness at a molecular level remain elusive. In this paper,…”
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Rif proteins take to the RhoD: Rho GTPases at the crossroads of actin dynamics and membrane trafficking by Gad, Annica K.B., Aspenström, Pontus

“…The Rif and RhoD proteins belong to the Rho subfamily of small GTPases. Rif and RhoD have for too long remained in the shadows of the better known Rho GTPases…”
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