Search Results - "Gacsalyi, I."

Glycine transporter type-1 and its inhibitors by Harsing, Jr, L G, Juranyi, Z, Gacsalyi, I, Tapolcsanyi, P, Czompa, A, Matyus, P

“…The ionotropic glutamate receptor NMDA is allosterically modulated by glycine, a coagonist, its presence is an absolute requirement for receptor activation…”
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Neuroprotective and anticonvulsant effects of EGIS‐8332, a non‐competitive AMPA receptor antagonist, in a range of animal models by Gigler, G, Móricz, K, ágoston, M, Simó, A, Albert, M, Benedek, A, Kapus, G, Kertész, S, Vegh, M, Barkóczy, J, Markó, B, Szabó, G, Matucz, É, Gacsályi, I, Lévay, G, Hársing, L G, Szénási, G

“…Background and purpose: Blockade of AMPA (α‐amino‐3‐hydroxy‐5‐methyl‐4‐isoxazolepropionic acid) receptors is a good treatment option for a variety of central…”
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S.03.03 Brain connectivity modulation by novel antipsychotics: an electrophysiological approach by Spedding, M, Sebban, C, Jay, T, Schenker, E, Gacsalyi, I

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P.3.d.021 EGIS-11148: pharmacological characterization of a new atypical antipsychotic compound by Levay, G, Moricz, K, Kompagne, H, Kertesz, S, Barkoczy, J, Harsing, L, Gacsalyi, I

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Chronic mild stress generates clear depressive but ambiguous anxiety-like behaviour in rats by Kompagne, Hajnalka, Bárdos, György, Szénási, Gábor, Gacsályi, István, Hársing, László G., Lévay, György

“…A 3-week chronic mild stress (CMS) protocol decreased sucrose preference of rats and increased immobility in the forced swim test. It also induced social…”
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P.1.d.003 Advantageous effect of deramciclane in the NaN3 model of Alzheimer's disease in rats by Megyeri, K, Móricz, K, Nagyné-Gyönös, I, Albert, M, Gacsályi, I

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P.1.d.019 Circadian pattern of wheel running activity of four laboratory mouse strains by Ágoston, M, Wellmann, J, Delagrange, P, Spedding, M, Gacsályi, I, Szénási, G

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P.2.d.003 Excitatory effect of the atypical antidepressant tianeptine in the rat hippocampus: in vitro study by Kapus, G, Vegh, M, Gacsályi, I, Spedding, M, Harsing, L.G

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Duration of action of GYKI 52466 and its analogues in antiepileptic, anti-ischaemic and muscle relaxant tests by Szabados, T, Gigler, G, Gyertyán, I, Gacsályi, I, Lévay, G

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The elevated plus maze test in mice-difficulties and solutions by Sziray, N., Gigler, G., Levay, G., Harsing, L.G., Gacsalyi, I.

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Behavioural studies with a highly emotional mouse strain newly bred in EGIS Pharmaceuticals Ltd by Bilkei-Gorzó, A, Müller, G, Gyertyán, I, Gacsályi, I, Szabados, T

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The glycine transporter-1 inhibitors NFPS and Org 24461: a pharmacological study by Harsing, Laszlo G, Gacsalyi, Istvan, Szabo, Geza, Schmidt, Eva, Sziray, Nora, Sebban, Claude, Tesolin-Decros, Brigitte, Matyus, Peter, Egyed, Andras, Spedding, Michael, Levay, Gyorgy

“…The in vitro and in vivo pharmacology of two glycine transporter-1 (GlyT1) inhibitors, N[3-(4′-fluorophenyl)-3-(4′-phenylphenoxy)-propyl]sarcosine (NFPS) and…”
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Effect of two noncompetitive AMPA receptor antagonists GYKI 52466 and GYKI 53405 on vigilance, behavior and spike–wave discharges in a genetic rat model of absence epilepsy by Jakus, Rita, Graf, Marton, Ando, Romeo D, Balogh, Brigitta, Gacsalyi, Istvan, Levay, Gyorgy, Kantor, Sandor, Bagdy, Gyorgy

“…The present study was conducted to investigate the effects of two noncompetitive alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor…”
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Effects of 2,3-benzodiazepine AMPA receptor antagonists on dopamine turnover in the striatum of rats with experimental parkinsonism by Megyeri, Katalin, Marko, Bernadett, Sziray, Nora, Gacsalyi, Istvan, Juranyi, Zsolt, Levay, Gyorgy, Harsing, Laszlo G

“…Abstract Although levodopa is the current “gold standard” for treatment of Parkinson's disease, there has been disputation on whether AMPA receptor antagonists…”
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P.3.039 Anxiolytic-like behavior after depletion of theserotonergic and noradrenergic systems in the rat by Levay, G., Sziray, N., Mark, B., Kapus, G., Gacsalyi, I.

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Differential EEG effects of the anxiolytic drugs, deramciclane (EGIS-3886), ritanserin and chlordiazepoxide in rats by DETARI, L, SZENTGYÖRGYI, V, HAJNIK, T, SZENASI, G, GACSALYI, I, KUKORELLI, T

“…The influence of serotonergic and benzodiazepine type anxiolytic drugs on the cortical activation and sleep-wakefulness cycle were compared by evaluating the…”
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Effect of deramciclane, a new 5-HT receptor antagonist, on cholecystokinin-induced changes in rat gastrointestinal function by Varga, Gábor, Kordás, Krisztina, Burghardt, Beáta, Gacsályi, István, Szénási, Gábor

“…Recent studies suggested that serotonin receptors may be involved in modulating the actions of cholecystokinin (CCK) in the gastrointestinal tract. The present…”
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EGYT-2509 a novel neuroleptic agent without extrapyramidal and endocrine side effects by Gacsályi, I, Petöcz, L, Fekete, M I, Bükkfálvi, B, Görgenyi, F, Arató, M

“…The dibenzodioxazocine derivative EGYT-2509 was effective in neuropsychopharmacological tests characteristic for neuroleptics and antiparkinsonian drugs. It…”
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Comparative clinical examination of Loderix (setastinum) and astemizole in pollenosis by Herjavecz, I, Karácsonyi, E, Mülbacher, S, Radics, K, Szilágyi, R, Gacsályi, I

“…The action and side-effects of Loderix (EGIS) were examined in comparison with Hismanal (Janssen) containing the non-sedative H1-receptor antagonist…”
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Possible involvement of the dopaminergic system in the mode of action of the potential antidepressant trazium esilate by Gyertyán, I, Petöcz, L, Bajnógel, J, Szücs, Z, Hegedüs, M, Gyüre, K, Gacsályi, I, Krizsán, D, Fekete, M I

“…Trazium esilate (EGYT-3615) is structurally an as-triazino isoquinolinium salt which showed considerable activity in pharmacological tests characteristic for…”
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