Search Results - "Gabrilovich, DI"

Abstract BS1-2: Myeloid-derived suppressor cells: many facets of regulation of tumor progression by Gabrilovich, DI

“…Tumor associated macrophages (TAM), myeloid derived suppressor cells (MDSC), represented by PMN-MDSC and M-MDSC, and dendritic cells (DC) are major components…”
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An effective immunization and cancer treatment with activated dendritic cells transduced with full-length wild-type p53 by NIKITINA, E. Y, CHADA, S, MURO-CACHO, C, FANG, B, ZHANG, R, ROTH, J. A, GABRILOVICH, D. I

“…P53-based immunization is an attractive approach to cancer immunotherapy due to the accumulation of p53 protein in tumor, but not in normal cells. However, it…”
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STAT1 Signaling Regulates Tumor-Associated Macrophage-Mediated T Cell Deletion by Kusmartsev, Sergei, Gabrilovich, Dmitry I

“…It is well established that tumor progression is associated with the accumulation of myeloid suppressive cells, which in mice include Gr-1+ immature myeloid…”
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Chemotherapy enhances tumor cell susceptibility to CTL-mediated killing during cancer immunotherapy in mice by Ramakrishnan, Rupal, Assudani, Deepak, Nagaraj, Srinivas, Hunter, Terri, Cho, Hyun-Il, Antonia, Scott, Altiok, Soner, Celis, Esteban, Gabrilovich, Dmitry I

“…Cancer immunotherapy faces a serious challenge because of low clinical efficacy. Recently, a number of clinical studies have reported the serendipitous finding…”
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Antigen-Specific Inhibition of CD8+ T Cell Response by Immature Myeloid Cells in Cancer Is Mediated by Reactive Oxygen Species by Kusmartsev, Sergei, Nefedova, Yulia, Yoder, Daniel, Gabrilovich, Dmitry I

“…Tumor growth is associated with the accumulation of immature myeloid cells (ImC), which in mice are characterized by the expression of Gr-1 and CD11b markers…”
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Tumor-Associated CD8+ T Cell Tolerance Induced by Bone Marrow-Derived Immature Myeloid Cells by Kusmartsev, Sergei, Nagaraj, Srinivas, Gabrilovich, Dmitry I

“…T cell tolerance is a critical element of tumor escape. However, the mechanism of tumor-associated T cell tolerance remains unresolved. Using an experimental…”
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Role of immature myeloid cells in mechanisms of immune evasion in cancer by KUSMARTSEV, Sergei, GABRILOVICH, Dmitry I

“…Tumor affects myelopoiesis by inhibiting the process of differentiation/maturation of antigen-presenting cells from their myeloid precursors and by stimulating…”
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Classification of current anticancer immunotherapies by Galluzzi, Lorenzo, Vacchelli, Erika, Bravo-San Pedro, José-Manuel, Buqué, Aitziber, Senovilla, Laura, Baracco, Elisa Elena, Bloy, Norma, Castoldi, Francesca, Abastado, Jean-Pierre, Agostinis, Patrizia, Apte, Ron N., Aranda, Fernando, Ayyoub, Maha, Beckhove, Philipp, Blay, Jean-Yves, Bracci, Laura, Caignard, Anne, Castelli, Chiara, Cavallo, Federica, Celis, Estaban, Cerundolo, Vincenzo, Clayton, Aled, Colombo, Mario P., Coussens, Lisa, Dhodapkar, Madhav V., Eggermont, Alexander M., Fearon, Douglas T., Fridman, Wolf H., Fučíková, Jitka, Gabrilovich, Dmitry I., Galon, Jérôme, Garg, Abhishek, Ghiringhelli, François, Giaccone, Giuseppe, Gilboa, Eli, Gnjatic, Sacha, Hoos, Axel, Hosmalin, Anne, Jäger, Dirk, Kalinski, Pawel, Kärre, Klas, Kepp, Oliver, Kiessling, Rolf, Kirkwood, John M., Klein, Eva, Knuth, Alexander, Lewis, Claire E., Liblau, Roland, Lotze, Michael T., Lugli, Enrico, Mach, Jean-Pierre, Mattei, Fabrizio, Mavilio, Domenico, Melero, Ignacio, Melief, Cornelis J., Mittendorf, Elizabeth A., Moretta, Lorenzo, Odunsi, Adekunke, Okada, Hideho, Palucka, Anna Karolina, Peter, Marcus E., Pienta, Kenneth J., Porgador, Angel, Prendergast, George C., Rabinovich, Gabriel A., Restifo, Nicholas P., Rizvi, Naiyer, Sautès-Fridman, Catherine, Schreiber, Hans, Seliger, Barbara, Shiku, Hiroshi, Silva-Santos, Bruno, Smyth, Mark J., Speiser, Daniel E., Spisek, Radek, Srivastava, Pramod K., Talmadge, James E., Tartour, Eric, Van Der Burg, Sjoerd H., Van Den Eynde, Benoît J., Vile, Richard, Wagner, Hermann, Weber, Jeffrey S, Whiteside, Theresa L., Wolchok, Jedd D., Zitvogel, Laurence, Zou, Weiping, Kroemer, Guido

“…© 2014. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution,…”
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International consensus guidelines for the definition, detection, and interpretation of autophagy-dependent ferroptosis by Chen, Xin, Tsvetkov, Andrey S., Shen, Han-Ming, Isidoro, Ciro, Ktistakis, Nicholas T., Linkermann, Andreas, Koopman, Werner J.H., Simon, Hans-Uwe, Galluzzi, Lorenzo, Luo, Shouqing, Xu, Daqian, Gu, Wei, Peulen, Olivier, Cai, Qian, Rubinsztein, David C., Chi, Jen-Tsan, Zhang, Donna D., Li, Changfeng, Toyokuni, Shinya, Liu, Jinbao, Roh, Jong-Lyel, Dai, Enyong, Juhasz, Gabor, Liu, Wei, Zhang, Jianhua, Yang, Minghua, Liu, Jiao, Zhu, Ling-Qiang, Zou, Weiping, Piacentini, Mauro, Ding, Wen-Xing, Yue, Zhenyu, Xie, Yangchun, Petersen, Morten, Gewirtz, David A., Mandell, Michael A., Chu, Charleen T., Sinha, Debasish, Eftekharpour, Eftekhar, Zhivotovsky, Boris, Besteiro, Sébastien, Gabrilovich, Dmitry I., Kim, Do-Hyung, Kagan, Valerian E., Bayir, Hülya, Chen, Guang-Chao, Ayton, Scott, Lünemann, Jan D., Komatsu, Masaaki, Krautwald, Stefan, Loos, Ben, Baehrecke, Eric H., Wang, Jiayi, Lane, Jon D., Sadoshima, Junichi, Yang, Wan Seok, Gao, Minghui, Münz, Christian, Thumm, Michael, Kampmann, Martin, Yu, Di, Lipinski, Marta M., Jones, Jace W., Jiang, Xuejun, Zeh, Herbert J., Kang, Rui, Klionsky, Daniel J., Kroemer, Guido, Tang, Daolin

“…Macroautophagy/autophagy is a complex degradation process with a dual role in cell death that is influenced by the cell types that are involved and the…”
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Immature myeloid cells and cancer-associated immune suppression by KUSMARTSEV, Sergei, GABRILOVICH, Dmitry I

“…Impaired balance between mature and immature myeloid cells is one of the hallmarks of cancer. In cancer patients as well as in mouse models there is increasing…”
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Regulation of dendritic cell differentiation and antitumor immune response in cancer by pharmacologic-selective inhibition of the janus-activated kinase 2/signal transducers and activators of transcription 3 pathway by NEFEDOVA, Yulia, NAGARAJ, Srinivas, ROSENBAUER, Amsler, MURO-CACHO, Carlos, SEBTI, Said M, GABRILOVICH, Dmitry I

“…Abnormal dendritic cell differentiation and accumulation of immunosuppressive myeloid cells in cancer is one of the major factors of tumor nonresponsiveness…”
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Combination of p53 Cancer Vaccine with Chemotherapy in Patients with Extensive Stage Small Cell Lung Cancer by ANTONIA, Scott J, MIRZA, Noweeda, MENANDER, Kerstin, CHADA, Sunil, GABRILOVICH, Dmitry I, FRICKE, Ingo, CHIAPPORI, Alberto, THOMPSON, Patricia, WILLIAMS, Nicholas, BEPLER, Gerold, SIMON, George, JANSSEN, William, LEE, Ji-Hyun

“…Purpose: The initial goal of this study was to test the immunologic and clinical effects of a new cancer vaccine consisting of dendritic cells (DC) transduced…”
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Inhibition of myeloid cell differentiation in cancer: the role of reactive oxygen species by Kusmartsev, Sergei, Gabrilovich, Dmitry I.

“…It is well established that tumor growth is associated with accumulation of immature myeloid cells (ImC). They play an important role in tumor‐associated…”
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VEGF inhibits T-cell development and may contribute to tumor-induced immune suppression by Ohm, Joyce E., Gabrilovich, Dmitry I., Sempowski, Gregory D., Kisseleva, Ekaterina, Parman, Kelly S., Nadaf, Sorena, Carbone, David P.

“…T-cell defects and premature thymic atrophy occur in cancer patients and tumor-bearing animals. We demonstrate that exposure of mice to recombinant vascular…”
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Rational design of shepherdin, a novel anticancer agent by Plescia, Janet, Salz, Whitney, Xia, Fang, Pennati, Marzia, Zaffaroni, Nadia, Daidone, Maria Grazia, Meli, Massimiliano, Dohi, Takehiko, Fortugno, Paola, Nefedova, Yulia, Gabrilovich, Dmitry I., Colombo, Giorgio, Altieri, Dario C.

“…Anticancer agents that selectively kill tumor cells and spare normal tissues are urgently needed. Here, we engineered a cell-permeable peptidomimetic,…”
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Consensus nomenclature for CD8+ T cell phenotypes in cancer by Apetoh, Lionel, Smyth, Mark J., Drake, Charles G., Abastado, Jean-Pierre, Apte, Ron N., Ayyoub, Maha, Blay, Jean-Yves, Bonneville, Marc, Butterfield, Lisa H., Caignard, Anne, Castelli, Chiara, Cavallo, Federica, Celis, Esteban, Chen, Lieping, Colombo, Mario P., Comin-Anduix, Begoña, Coukos, Georges, Dhodapkar, Madhav V., Dranoff, Glenn, Frazer, Ian H., Fridman, Wolf-Hervé, Gabrilovich, Dmitry I., Gilboa, Eli, Gnjatic, Sacha, Jäger, Dirk, Kalinski, Pawel, Kaufman, Howard L., Kiessling, Rolf, Kirkwood, John, Knuth, Alexander, Liblau, Roland, Lotze, Michael T., Lugli, Enrico, Marincola, Francesco, Melero, Ignacio, Melief, Cornelis J., Mempel, Thorsten R., Mittendorf, Elizabeth A., Odun, Kunle, Overwijk, Willem W., Palucka, Anna Karolina, Parmiani, Giorgio, Ribas, Antoni, Romero, Pedro, Schreiber, Robert D., Schuler, Gerold, Srivastava, Pramod K., Tartour, Eric, Valmori, Danila, van der Burg, Sjoerd H., van der Bruggen, Pierre, van den Eynde, Benoît J., Wang, Ena, Zou, Weiping, Whiteside, Theresa L., Speiser, Daniel E., Pardoll, Drew M., Restifo, Nicholas P., Anderson, Ana C.

“…Whereas preclinical investigations and clinical studies have established that CD8 + T cells can profoundly affect cancer progression, the underlying mechanisms…”
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Dendritic Cells and Tumor Microenvironment: A Dangerous Liaison by Fricke, Ingo, Gabrilovich, Dmitry I.

“…The fact that the immune response to cancer is compromised has been convincingly demonstrated in murine tumor models as well as in cancer patients. The…”
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Activation of Dendritic Cells via Inhibition of Jak2/STAT3 Signaling by Nefedova, Yulia, Cheng, Pingyan, Gilkes, Daniele, Blaskovich, Michelle, Beg, Amer A, Sebti, Said M, Gabrilovich, Dmitry I

“…Signaling via Jak2/STAT3 is critically important for normal dendritic cell (DC) differentiation. In addition, we have previously demonstrated that…”
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Involvement of Notch-1 signaling in bone marrow stroma-mediated de novo drug resistance of myeloma and other malignant lymphoid cell lines by Nefedova, Yulia, Cheng, Pingyan, Alsina, Melissa, Dalton, William S., Gabrilovich, Dmitry I.

“…The bone marrow (BM) microenvironment plays a critical role in malignant cell growth, patient survival, and response to chemotherapy in hematologic…”
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Increased Production of Immature Myeloid Cells in Cancer Patients: A Mechanism of Immunosuppression in Cancer by Almand, Bond, Clark, Joseph I, Nikitina, Ekaterina, van Beynen, James, English, Nicholas R, Knight, Stella C, Carbone, David P, Gabrilovich, Dmitry I

“…Defective dendritic cell (DC) function caused by abnormal differentiation of these cells is an important mechanism of tumor escape from immune system control…”
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