Search Results - "Gabriella Sozzi"

Paradoxical effects of chemotherapy on tumor relapse and metastasis promotion by D’Alterio, Crescenzo, Scala, Stefania, Sozzi, Gabriella, Roz, Luca, Bertolini, Giulia

“…Several lines of compelling pre-clinical evidence identify chemotherapy as a potentially double-edged sword: therapeutic efficacy on the primary tumor may in…”
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Biomarkers in Lung Cancer Screening: Achievements, Promises, and Challenges by Seijo, Luis M, Peled, Nir, Ajona, Daniel, Boeri, Mattia, Field, John K, Sozzi, Gabriella, Pio, Ruben, Zulueta, Javier J, Spira, Avrum, Massion, Pierre P, Mazzone, Peter J, Montuenga, Luis M

“…The present review is an update of the research and development efforts regarding the use of molecular biomarkers in the lung cancer screening setting. The two…”
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Antibody-Fc/FcR Interaction on Macrophages as a Mechanism for Hyperprogressive Disease in Non-small Cell Lung Cancer Subsequent to PD-1/PD-L1 Blockade by Lo Russo, Giuseppe, Moro, Massimo, Sommariva, Michele, Cancila, Valeria, Boeri, Mattia, Centonze, Giovanni, Ferro, Simona, Ganzinelli, Monica, Gasparini, Patrizia, Huber, Veronica, Milione, Massimo, Porcu, Luca, Proto, Claudia, Pruneri, Giancarlo, Signorelli, Diego, Sangaletti, Sabina, Sfondrini, Lucia, Storti, Chiara, Tassi, Elena, Bardelli, Alberto, Marsoni, Silvia, Torri, Valter, Tripodo, Claudio, Colombo, Mario Paolo, Anichini, Andrea, Rivoltini, Licia, Balsari, Andrea, Sozzi, Gabriella, Garassino, Marina Chiara

“…Hyperprogression (HP), a paradoxical boost in tumor growth, was described in a subset of patients treated with immune checkpoint inhibitors (ICI). Neither…”
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Clinical Utility of a Plasma-Based miRNA Signature Classifier Within Computed Tomography Lung Cancer Screening: A Correlative MILD Trial Study by SOZZI, Gabriella, BOERI, Mattia, MARCHIANO, Alfonso, NEGRI, Eva, LA VECCHIA, Carlo, PASTORINO, Ugo, ROSSI, Marta, VERRI, Carla, SUATONI, Paola, BRAVI, Francesca, ROZ, Luca, CONTE, Davide, GRASSI, Michela, SVERZELLATI, Nicola

“…Recent screening trial results indicate that low-dose computed tomography (LDCT) reduces lung cancer mortality in high-risk patients. However, high…”
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MicroRNA signatures in tissues and plasma predict development and prognosis of computed tomography detected lung cancer by Boeri, Mattia, Verri, Carla, Conte, Davide, Roz, Luca, Modena, Piergiorgio, Facchinetti, Federica, Calabrò, Elisa, Croce, Carlo M, Pastorino, Ugo, Sozzi, Gabriella

“…The efficacy of computed tomography (CT) screening for early lung cancer detection in heavy smokers is currently being tested by a number of randomized trials…”
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Tumor Extracellular Matrix Remodeling: New Perspectives as a Circulating Tool in the Diagnosis and Prognosis of Solid Tumors by Giussani, Marta, Triulzi, Tiziana, Sozzi, Gabriella, Tagliabue, Elda

“…In recent years, it has become increasingly evident that cancer cells and the local microenvironment are crucial in the development and progression of tumors…”
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Differential glycosylation of collagen modulates lung cancer stem cell subsets through β1 integrin‐mediated interactions by Gardelli, Cecilia, Russo, Laura, Cipolla, Laura, Moro, Massimo, Andriani, Francesca, Rondinone, Ornella, Nicotra, Francesco, Sozzi, Gabriella, Bertolini, Giulia, Roz, Luca

“…In lung cancer, CD133+ cells represent the subset of cancer stem cells (CSC) able to sustain tumor growth and metastatic dissemination. CSC function is tightly…”
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Highly tumorigenic lung cancer CD133⁺ cells display stem-like features and are spared by cisplatin treatment by Bertolini, Giulia, Roz, Luca, Perego, Paola, Tortoreto, Monica, Fontanella, Enrico, Gatti, Laura, Pratesi, Graziella, Fabbri, Alessandra, Andriani, Francesca, Tinelli, Stella, Roz, Elena, Caserini, Roberto, Lo Vullo, Salvatore, Camerini, Tiziana, Mariani, Luigi, Delia, Domenico, Calabrò, Elisa, Pastorino, Ugo, Sozzi, Gabriella

“…The identification of lung tumor-initiating cells and associated markers may be useful for optimization of therapeutic approaches and for predictive and…”
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Tumor-Initiating Cells of HER2-Positive Carcinoma Cell Lines Express the Highest Oncoprotein Levels and Are Sensitive to Trastuzumab by Magnifico, Alessandra, Albano, Luisa, Campaner, Stefano, Delia, Domenico, Castiglioni, Fabio, Gasparini, Patrizia, Sozzi, Gabriella, Fontanella, Enrico, Menard, Sylvie, Tagliabue, Elda

“…Purpose: The existence of tumor-initiating cells in breast cancer has profound implications for cancer therapy. In this study, we investigated the sensitivity…”
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Genomic Profiling of Patient-Derived Xenografts for Lung Cancer Identifies B2M Inactivation Impairing Immunorecognition by Pereira, Carolina, Gimenez-Xavier, Pol, Pros, Eva, Pajares, Maria J, Moro, Massimo, Gomez, Antonio, Navarro, Alejandro, Condom, Enric, Moran, Sebastian, Gomez-Lopez, Gonzalo, Graña, Osvaldo, Rubio-Camarillo, Miriam, Martinez-Martí, Alex, Yokota, Jun, Carretero, Julian, Galbis, Jose M, Nadal, Ernest, Pisano, David, Sozzi, Gabriella, Felip, Enriqueta, Montuenga, Luis M, Roz, Luca, Villanueva, Alberto, Sanchez-Cespedes, Montse

“…We aimed to maximize the performance of detecting genetic alterations in lung cancer using high-throughput sequencing for patient-derived xenografts (PDXs). We…”
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Novel method to detect microRNAs using chip-based QuantStudio 3D digital PCR by Conte, Davide, Verri, Carla, Borzi, Cristina, Suatoni, Paola, Pastorino, Ugo, Sozzi, Gabriella, Fortunato, Orazio

“…Research efforts for the management of cancer, in particular for lung cancer, are directed to identify new strategies for its early detection. MicroRNAs…”
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Establishment of patient derived xenografts as functional testing of lung cancer aggressiveness by Moro, Massimo, Bertolini, Giulia, Caserini, Roberto, Borzi, Cristina, Boeri, Mattia, Fabbri, Alessandra, Leone, Giorgia, Gasparini, Patrizia, Galeone, Carlotta, Pelosi, Giuseppe, Roz, Luca, Sozzi, Gabriella, Pastorino, Ugo

“…Despite many years of research efforts, lung cancer still remains the leading cause of cancer deaths worldwide. Objective of this study was to set up a…”
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Early Effector T Lymphocytes Coexpress Multiple Inhibitory Receptors in Primary Non-Small Cell Lung Cancer by Tassi, Elena, Grazia, Giulia, Vegetti, Claudia, Bersani, Ilaria, Bertolini, Giulia, Molla, Alessandra, Baldassari, Paola, Andriani, Francesca, Roz, Luca, Sozzi, Gabriella, Pastorino, Ugo, Mortarini, Roberta, Anichini, Andrea

“…Clinical efficacy of PD-1/PD-L1 targeting relies upon the reactivation of tumor-specific but functionally impaired PD-1 T cells present before therapy. Thus,…”
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The Landscape of Actionable Gene Fusions in Colorectal Cancer by Pagani, Filippo, Randon, Giovanni, Guarini, Vincenzo, Raimondi, Alessandra, Prisciandaro, Michele, Lobefaro, Riccardo, Di Bartolomeo, Maria, Sozzi, Gabriella, de Braud, Filippo, Gasparini, Patrizia, Pietrantonio, Filippo

“…The treatment scenario of metastatic colorectal cancer (mCRC) has been rapidly enriched with new chemotherapy combinations and biological agents that lead to a…”
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Diagnostic role of circulating extracellular matrix-related proteins in non-small cell lung cancer by Andriani, Francesca, Landoni, Elena, Mensah, Mavis, Facchinetti, Federica, Miceli, Rosalba, Tagliabue, Elda, Giussani, Marta, Callari, Maurizio, De Cecco, Loris, Colombo, Mario Paolo, Roz, Luca, Pastorino, Ugo, Sozzi, Gabriella

“…Interactions between cancer cells and the surrounding microenvironment are crucial determinants of cancer progression. During this process, bi-directional…”
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mir-660-p53-mir-486 Network: A New Key Regulatory Pathway in Lung Tumorigenesis by Borzi, Cristina, Calzolari, Linda, Centonze, Giovanni, Milione, Massimo, Sozzi, Gabriella, Fortunato, Orazio

“…Lung cancer is the most frequent cause of cancer-related death worldwide, with limited therapeutic options and rapid development of drug resistance. MicroRNAs,…”
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Plasma miRNA‐based signatures in CRC screening programs by Zanutto, Susanna, Ciniselli, Chiara Maura, Belfiore, Antonino, Lecchi, Mara, Masci, Enzo, Delconte, Gabriele, Primignani, Massimo, Tosetti, Giulia, Dal Fante, Marco, Fazzini, Linda, Airoldi, Aldo, Vangeli, Marcello, Turpini, Francesca, Rubis Passoni, Giovanni Giuseppe, Viaggi, Paolo, Arena, Monica, Motta, Roberta Ilaria Olimpia, Cantù, Anna Maria, Crosta, Cristiano, De Roberto, Giuseppe, Iannuzzi, Francesca, Cassinotti, Andrea, Dall'Olio, Valentina, Tizzoni, Laura, Sozzi, Gabriella, Meroni, Emanuele, Bisanti, Luigi, Pierotti, Marco Alessandro, Verderio, Paolo, Gariboldi, Manuela

“…Colorectal cancer (CRC) screening programs help diagnose cancer precursors and early cancers and help reduce CRC mortality. However, currently recommended…”
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Baseline and postoperative C-reactive protein levels predict mortality in operable lung cancer by Pastorino, Ugo, Morelli, Daniele, Leuzzi, Giovanni, Gisabella, Mara, Suatoni, Paola, Taverna, Francesca, Bertocchi, Elena, Boeri, Mattia, Sozzi, Gabriella, Cantarutti, Anna, Corrao, Giovanni

“…Abstract Background Higher blood levels of C-reactive protein (CRP) have been associated with shorter survival in patients with cardiovascular, chronic…”
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MiR-223 Exclusively Impairs In Vitro Tumor Growth through IGF1R Modulation in Rhabdomyosarcoma of Adolescents and Young Adults by Casanova, Michela, Pontis, Francesca, Ghidotti, Patrizia, Petraroia, Ilaria, Venturini, Lara Veronica, Bergamaschi, Luca, Chiaravalli, Stefano, De Cecco, Loris, Massimino, Maura, Sozzi, Gabriella, Ferrari, Andrea, Fortunato, Orazio, Gasparini, Patrizia

“…Adolescents and young adults (AYA) with rhabdomyosarcoma (RMS) form a subgroup of patients whose optimal clinical management and best possible access to care…”
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CXCR4 Inhibition Counteracts Immunosuppressive Properties of Metastatic NSCLC Stem Cells by Fortunato, Orazio, Belisario, Dimas Carolina, Compagno, Mara, Giovinazzo, Francesca, Bracci, Cristiano, Pastorino, Ugo, Horenstein, Alberto, Malavasi, Fabio, Ferracini, Riccardo, Scala, Stefania, Sozzi, Gabriella, Roz, Luca, Roato, Ilaria, Bertolini, Giulia

“…Cancer stem cells (CSCs) are functionally defined as the cell subset with greater potential to initiate and propagate tumors. Within the heterogeneous…”
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