Search Results - "Gabriela Davey"

Ligand substitutions between ruthenium–cymene compounds can control protein versus DNA targeting and anticancer activity by Adhireksan, Zenita, Davey, Gabriela E., Campomanes, Pablo, Groessl, Michael, Clavel, Catherine M., Yu, Haojie, Nazarov, Alexey A., Yeo, Charmian Hui Fang, Ang, Wee Han, Dröge, Peter, Rothlisberger, Ursula, Dyson, Paul J., Davey, Curt A.

“…Ruthenium compounds have become promising alternatives to platinum drugs by displaying specific activities against different cancers and favourable toxicity…”
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Engineering nucleosomes for generating diverse chromatin assemblies by Adhireksan, Zenita, Sharma, Deepti, Lee, Phoi Leng, Bao, Qiuye, Padavattan, Sivaraman, Shum, Wayne K, Davey, Gabriela E, Davey, Curt A

“…Abstract Structural characterization of chromatin is challenging due to conformational and compositional heterogeneity in vivo and dynamic properties that…”
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The mechanics behind DNA sequence-dependent properties of the nucleosome by Chua, Eugene Y D, Vasudevan, Dileep, Davey, Gabriela E, Wu, Bin, Davey, Curt A

“…Chromatin organization and composition impart sophisticated regulatory features critical to eukaryotic genomic function. Although DNA sequence-dependent…”
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Nucleosome acidic patch-targeting binuclear ruthenium compounds induce aberrant chromatin condensation by Davey, Gabriela E., Adhireksan, Zenita, Ma, Zhujun, Riedel, Tina, Sharma, Deepti, Padavattan, Sivaraman, Rhodes, Daniela, Ludwig, Alexander, Sandin, Sara, Murray, Benjamin S., Dyson, Paul J., Davey, Curt A.

“…The ‘acidic patch’ is a highly electronegative cleft on the histone H2A–H2B dimer in the nucleosome. It is a fundamental motif for protein binding and…”
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Stereochemical control of nucleosome targeting by platinum-intercalator antitumor agents by Chua, Eugene Y D, Davey, Gabriela E, Chin, Chee Fei, Dröge, Peter, Ang, Wee Han, Davey, Curt A

“…Platinum-based anticancer drugs act therapeutically by forming DNA adducts, but suffer from severe toxicity and resistance problems, which have not been…”
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Specific DNA structural attributes modulate platinum anticancer drug site selection and cross-link generation by Wu, Bin, Davey, Gabriela E., Nazarov, Alexey A., Dyson, Paul J., Davey, Curt A.

“…Heavy metal compounds have toxic and medicinal potential through capacity to form strong specific bonds with macromolecules, and the interaction of platinum…”
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DNA stretching in the nucleosome facilitates alkylation by an intercalating antitumour agent by Davey, Gabriela E, Wu, Bin, Dong, Yuancai, Surana, Uttam, Davey, Curt A

“…DNA stretching in the nucleosome core can cause dramatic structural distortions, which may influence compaction and factor recognition in chromatin. We find…”
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α5β1 Integrin Controls Cyclin D1 Expression by Sustaining Mitogen-activated Protein Kinase Activity in Growth Factor-treated Cells by Roovers, Kristin, Davey, Gabriela, Zhu, Xiaoyun, Bottazzi, Maria Elena, Assoian, Richard K.

“…Cyclin D1 expression is jointly regulated by growth factors and cell adhesion to the extracellular matrix in many cell types. Growth factors are thought to…”
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Chromatin - a New, Old Drug Target by Davey, Gabriela E, Davey, Curt A

“…Chromatin is the therapeutic target for DNA-binding medicinal agents, yet we know substantially more about the interaction of drugs with naked DNA. Current…”
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Reduced expression of α5β1 integrin prevents spreading-dependent cell proliferation by Davey, Gabriela, Buzzai, Monica, Assoian, Richard K.

“…ABSTRACT Cell adhesion to substratum results in the initiation of integrin signaling and an integrin-dependent organization of the cytoskeleton (cell…”
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Intracellular Ca2+ and Zn2+ Levels Regulate the Alternative Cell Density-dependent Secretion of S100B in Human Glioblastoma Cells by Davey, G E, Murmann, P, Heizmann, C W

“…In recent years, protein translocation has been implicated as the mechanism that controls assembly of signaling complexes and induction of signaling cascades…”
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Correction to article ‘The mechanics behind DNA sequence-dependent properties of the nucleosome’ by Chua, Eugene Y D, Vasudevan, Dileep, Davey, Gabriela E, Wu, Bin, Davey, Curt A

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Human S100A11 Exhibits Differential Steady-State RNA Levels in Various Tissues and a Distinct Subcellular Localization by Inada, Hiroyasu, Naka, Michiko, Tanaka, Toshio, Davey, Gabriela E., Heizmann, Claus W.

“…In order to analyze the steady-state RNA levels of S100A11 in different tissues, a cDNA fragment of human S100A11 was isolated from a cDNA library. The…”
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Generation of antibodies specific for β-amyloid by vaccination of patients with Alzheimer disease by Nitsch, Roger M, Hock, Christoph, Konietzko, Uwe, Papassotiropoulos, Andreas, Wollmer, Axel, Streffer, Johannes, von Rotz, Ruth C, Davey, Gabriela, Moritz, Eva

“…To characterize antibodies produced in humans in response to Abeta42 vaccination, we carried out immunohistochemical examinations of the brains of both…”
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Targeting epigenetic vulnerabilities of cancer cells by exploiting chromatin structure and chemistry by Adhireksan, Zenita, Davey, Gabriela E., Ma, Zhujun, Palermo, Giulia, Riedel, Tina, Murray, Benjamin S., Nazarov, Alexey A., Hartinger, Christian G., Röthlisberger, Ursula, Dyson, Paul J., Davey, Curt A.

“…Abstract only…”
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Calcium-dependent translocation of S100A11 requires tubulin filaments by Davey, Gabriela E., Murmann, Petra, Hoechli, Mathias, Tanaka, Toshio, Heizmann, Claus W.

“…Protein translocation between different subcellular compartments might play a significant role in various signal transduction pathways. The S100 family is…”
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Transforming Growth Factor-β Overrides the Adhesion Requirement for Surface Expression of α5β1 Integrin in Normal Rat Kidney Fibroblasts by Dalton, Stephen L., Scharf, Eric, Davey, Gabriela, Assoian, Richard K.

“…We have previously shown that the expression of α5β1 integrin on the cell surface is dependent upon cell adhesion to the extracellular matrix, and we report…”
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Transforming Growth Factor-β Overrides the Adhesion Requirement for Surface Expression of α5β1 Integrin in Normal Rat Kidney Fibroblasts by Stephen L. Dalton, Eric Scharf, Gabriela Davey, Richard K. Assoian

“…We have previously shown that the expression of α 5 β 1 integrin on the cell surface is dependent upon cell adhesion to the extracellular matrix, and we…”
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Generation of antibodies specific for [beta]-amyloid by vaccination of patients with Alzheimer disease by Hock, Christoph, Konietzko, Uwe, Papassotiropoulos, Andreas, Wollmer, Axel, Streffer, Johannes, von Rotz, Ruth C, Davey, Gabriela, Moritz, Eva, Nitsch, Roger M

“…To characterize antibodies produced in humans in response to Abeta42 vaccination, we carried out immunohistochemical examinations of the brains of both…”
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Role of alpha5beta1 integrin in anchorage-dependent growth and TGFbeta-induced anchorage-independent growth by Davey, Gabriela Elizabeth

“…Increasing evidence indicates the importance of adhesion in cell growth. In particular, alpha5beta1 integrin is implicated in regulating proliferation in…”
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