Omentin serum concentration and hepatic expression in chronic hepatitis C patients - together or apart?

Omentin serum concentration and hepatic expression in chronic hepatitis C patients - together or apart?

Chronic hepatitis C (CHC) is accompanied by numerous metabolic disorders, partially associated with altered adipokine system regulation. Omentin (intelectin-1) is a novel adipokine known to play a pivotal role in metabolic regulation in CHC. In a group of 63 CHC patients (29 men/34 women) infected w...

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Published in:Polish journal of pathology Vol. 66; no. 3; pp. 231 - 238
Main Authors: Kukla, Michał, Waluga, Marek, Adamek, Brygida, Zalewska-Ziob, Marzena, Kasperczyk, Janusz, Gabriel, Aandrzej, Bułdak, Rafał J, Sobala-Szczygieł, Barbara, Kępa, Lucjan, Ziora, Katarzyna, Żwirska-Korczala, Krystyna, Surma, Edward, Sawczyn, Tomasz, Hartleb, Marek
Format: Journal Article
Language:English
Published: Poland Termedia Publishing House 2015
Subjects:
Adipocytes
Adult
Aged
Biopsy
Body mass index
Cytokines - analysis
Cytokines - biosynthesis
Diabetes
Disease
Female
Gene expression
Glucose
GPI-Linked Proteins - analysis
GPI-Linked Proteins - biosynthesis
Hepatitis C
Hepatitis C, Chronic - metabolism
Hepatitis C, Chronic - pathology
Histology
Homeostasis
Humans
Insulin resistance
Kinases
Lectins - analysis
Lectins - biosynthesis
Liver
Liver - metabolism
Male
Metabolism
Middle Aged
Pathogenesis
Proteins
Real-Time Polymerase Chain Reaction
Thermal cycling
Tumor necrosis factor-TNF
Womens health
Young Adult
United States > US
Germany
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Summary:Chronic hepatitis C (CHC) is accompanied by numerous metabolic disorders, partially associated with altered adipokine system regulation. Omentin (intelectin-1) is a novel adipokine known to play a pivotal role in metabolic regulation in CHC. In a group of 63 CHC patients (29 men/34 women) infected with genotype 1b, aged 6.6 ± 14.6 years, serum omentin levels and its gene expression in liver tissue were examined and their association with metabolic and histopathological features was assessed. Serum omentin levels were significantly higher in CHC patients compared to controls (p < 0.001), regardless of sex, body mass index (BMI), insulin sensitivity and lipid concentrations. There was no correlation between serum omentin and omentin hepatic expression. Neither parameter was associated with any histological features. Serum omentin in non-obese CHC patients seems not to be related to metabolic disorders or liver pathology. Omentin hepatic expression shows no relationship with either serum omentin levels or histopathological features. This suggests different mechanisms regulating circulating omentin concentration and omentin hepatic expression in CHC.
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SourceType-Scholarly Journals-1
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ISSN:1233-9687
2084-9869
DOI:10.5114/pjp.2015.54956