Search Results - "Gabr, Gamal A"

PI3K-AKT Pathway Modulation by Thymoquinone Limits Tumor Growth and Glycolytic Metabolism in Colorectal Cancer by Karim, Shahid, Burzangi, Abdulhadi S, Ahmad, Aftab, Siddiqui, Nasir Ali, Ibrahim, Ibrahim M, Sharma, Priyanka, Abualsunun, Walaa A, Gabr, Gamal A

“…Colorectal cancer (CRC) is the third leading cause of death in men and the fourth in women worldwide and is characterized by deranged cellular energetics…”
Get full text

Integrated network pharmacology and experimental analysis unveil multi-targeted effect of 18α- glycyrrhetinic acid against non-small cell lung cancer by Irshad, Rasha, Raj, Nafis, Gabr, Gamal A., Manzoor, Nikhat, Husain, Mohammad

“…Non-small cell lung cancer (NSCLC) is one of the most malignant types of cancer with soaring incidence rates worldwide, attributed to its heterogeneity and…”
Get full text

Interactions of Apigenin and Safranal with the 5HT1A and 5HT2A Receptors and Behavioral Effects in Depression and Anxiety: A Molecular Docking, Lipid-Mediated Molecular Dynamics, and In Vivo Analysis by Amin, Faiq, Ibrahim, Mahmoud A A, Rizwan-Ul-Hasan, Syed, Khaliq, Saima, Gabr, Gamal A, Muhammad, Khan, Asra, Sidhom, Peter A, Tikmani, Prashant, Shawky, Ahmed M, Ahmad, Saara, Abidi, Syed Hani

“…The current study utilizes in silico molecular docking/molecular dynamics to evaluate the binding affinity of apigenin and safranal with 5HT1AR/5HT2AR,…”
Get full text

In silico drug discovery of SIRT2 inhibitors from natural source as anticancer agents by Ibrahim, Mahmoud A. A., Abdeljawaad, Khlood A. A., Roshdy, Eslam, Mohamed, Dina E. M., Ali, Taha F. S., Gabr, Gamal A., Jaragh-Alhadad, Laila A., Mekhemer, Gamal A. H., Shawky, Ahmed M., Sidhom, Peter A., Abdelrahman, Alaa H. M.

“…Sirtuin 2 (SIRT2) is a member of the sirtuin protein family, which includes lysine deacylases that are NAD + -dependent and organize several biological…”
Get full text

Exploring Natural Product Activity and Species Source Candidates for Hunting ABCB1 Transporter Inhibitors: An In Silico Drug Discovery Study by Ibrahim, Mahmoud A A, Abdeljawaad, Khlood A A, Abdelrahman, Alaa H M, Jaragh-Alhadad, Laila A, Oraby, Hesham Farouk, Elkaeed, Eslam B, Mekhemer, Gamal A H, Gabr, Gamal A, Shawky, Ahmed M, Sidhom, Peter A, Soliman, Mahmoud E S, Moustafa, Mahmoud F, Paré, Paul W, Hegazy, Mohamed-Elamir F

“…The P-glycoprotein (P-gp/ABCB1) is responsible for a xenobiotic efflux pump that shackles intracellular drug accumulation. Additionally, it is included in the…”
Get full text

Synthesis and Evaluation of Novel S -alkyl Phthalimide- and S -benzyl-oxadiazole-quinoline Hybrids as Inhibitors of Monoamine Oxidase and Acetylcholinesterase by Khan, Bilal Ahmad, Hamdani, Syeda Shamila, Jalil, Saquib, Ejaz, Syeda Abida, Iqbal, Jamshed, Shawky, Ahmed M, Alqahtani, Alaa M, Gabr, Gamal A, Ibrahim, Mahmoud A A, Sidhom, Peter A

“…New -alkyl phthalimide - and -benzyl - analogs of 5-(2-phenylquinolin-4-yl)-1,3,4-oxadiazole-2-thiol ( ) were prepared by reacting with -bromoalkylphthalimide…”
Get full text

Metabolic reprogramming by miRNAs in the tumor microenvironment: Focused on immunometabolism by Alshahrani, Shadia Hamoud, Ibrahim, Yousif Saleh, Jalil, Abduladheem Turki, Altoum, Abdelgadir Alamin, Achmad, Harun, Zabibah, Rahman S, Gabr, Gamal A, Ramírez-Coronel, Andrés Alexis, Alameri, Ameer A, Qasim, Qutaiba A, Karampoor, Sajad, Mirzaei, Rasoul

“…MicroRNAs (miRNAs) are emerging as a significant modulator of immunity, and their abnormal expression/activity has been linked to numerous human disorders,…”
Get full text

Dietary Thymol Improved Growth, Body Composition, Digestive Enzyme Activities, Hematology, Immunity, Antioxidant Defense, and Resistance to Streptococcus iniae in the Rainbow Trout (Oncorhynchus mykiss) by Hafsan, Hafsan, Saleh, Marwan Mahmood, Zabibah, Rahman S., Obaid, Rasha Fadhel, Jabbar, Hijran Sanaan, Mustafa, Yasser Fakri, Sultan, Mohammed Q., Gabr, Gamal A., Ramírez-Coronel, Andrés Alexis, Khodadadi, Mohammad, Dadras, Mahnaz

“…In this study, thymol (TYM) at dietary levels of 0, 1, 1.5, 2, and 2.5 g/kg diet was used to evaluate its effects on growth, digestive performance, immunity,…”
Get full text

Exploring Probenecid Derived 1,3,4-Oxadiazole-Phthalimide Hybrid as α-Amylase Inhibitor: Synthesis, Structural Investigation, and Molecular Modeling by Khan, Bilal Ahmad, Hamdani, Syeda Shamila, Khalid, Muhammad, Ashfaq, Muhammad, Munawar, Khurram Shahzad, Tahir, Muhammad Nawaz, Braga, Ataualpa A C, Shawky, Ahmed M, Alqahtani, Alaa M, Abourehab, Mohammed A S, Gabr, Gamal A, Ibrahim, Mahmoud A A, Sidhom, Peter A

“…1,3,4-Oxadiazole moiety is a crucial pharmacophore in many biologically active compounds. In a typical synthesis, probenecid was subjected to a sequence of…”
Get full text

Ambroxol Hydrochloride Loaded Gastro-Retentive Nanosuspension Gels Potentiate Anticancer Activity in Lung Cancer (A549) Cells by Md, Shadab, Abdullah, Samaa T, Alhakamy, Nabil A, Bani-Jaber, Ahmad, Radhakrishnan, Ammu Kutty, Karim, Shahid, Shahzad, Naiyer, Gabr, Gamal A, Alamoudi, Abdulmohsin J, Rizg, Waleed Y

“…This study aimed to develop gastro-retentive sustained-release ambroxol (ABX) nanosuspensions utilizing ambroxol-kappa-carrageenan (ABX-CRG ) complexation…”
Get full text

Chetomin, a SARS-CoV-2 3C-like Protease (3CL pro ) Inhibitor: In Silico Screening, Enzyme Docking, Molecular Dynamics and Pharmacokinetics Analysis by Ibrahim, Mahmoud A A, Abdelrahman, Alaa H M, Mohamed, Dina E M, Abdeljawaad, Khlood A A, Naeem, Mohamed Ahmed, Gabr, Gamal A, Shawky, Ahmed M, Soliman, Mahmoud E S, Sidhom, Peter A, Paré, Paul W, Hegazy, Mohamed-Elamir F

“…The emergence of the Coronavirus Disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has led to over 6…”
Get full text

Signaling Pathway Inhibitors, miRNA, and Nanocarrier-Based Pharmacotherapeutics for the Treatment of Lung Cancer: A Review by Md, Shadab, Alhakamy, Nabil A, Karim, Shahid, Gabr, Gamal A, Iqubal, Mohammad Kashif, Murshid, Samar S A

“…Lung cancer is one of the most commonly diagnosed cancers and is responsible for a large number of deaths worldwide. The pathogenic mechanism of lung cancer is…”
Get full text

Potential bioactivity of Phoenix dactylifera fruits, leaves, and seeds against prostate and pancreatic cancer cells by Ghazzawy, Hesham S, Gouda, Mostafa M, Awad, Nabil S, Al-Harbi, Nadi Awad, Alqahtani, Mesfer M, Abdel-Salam, Maha M, Abdein, Mohamed A, Al-Sobeai, Sanad M, Hamad, Asmaa A, Alsberi, Hassan M, Gabr, Gamal A, Hikal, Dalia M

“…The use of functional foods' phytochemicals in the chemoprevention of different cancer diseases has become one of the hot scientific areas in the clinical…”
Get full text

In-silico natural product database mining for novel neuropilin-1 inhibitors: molecular docking, molecular dynamics and binding energy computations by Ibrahim, Mahmoud A. A., Ali, Sara S. M., Abdeljawaad, Khlood A. A., Abdelrahman, Alaa H. M., Gabr, Gamal A., Shawky, Ahmed M., Mekhemer, Gamal A. H., Sidhom, Peter A., Paré, Paul W., Hegazy, Mohamed-Elamir F.

“…In the search for new metabolite inhibitors, a natural product activity and species source (NPASS) database was virtually screened using AutoDock software to…”
Get full text

Recent update of toxicity aspects of nanoparticulate systems for drug delivery by Patnaik, Soma, Gorain, Bapi, Padhi, Santwana, Choudhury, Hira, Gabr, Gamal A., Md, Shadab, Kumar Mishra, Dinesh, Kesharwani, Prashant

“…[Display omitted] Potential research outcomes on nanotechnology-based novel drug delivery systems since the past few decades attracted the attention of the…”
Get full text

Deteriorating insulin resistance due to WL15 peptide from cysteine and glycine‐rich protein 2 in high glucose‐induced rat skeletal muscle L6 cells by Guru, Ajay, Issac, Praveen Kumar, Saraswathi, N. T., Seshadri, Vidya Devanathadesikan, Gabr, Gamal A, Arockiaraj, Jesu

“…This study investigates the antioxidant and antidiabetic activity of the WL15 peptide derived from Channa striatus on regulating the antioxidant property in…”
Get full text

The association of in-utero exposure to polycyclic aromatic hydrocarbons and umbilical liver enzymes by Wanying, Li, Okromelidze, Mariami T., Ramírez-Coronel, Andrés Alexis, Zekiy, Angelina O., Obaid, Rasha Fadhel, Jawhar, Zanko Hassan, Gabr, Gamal A., Al-Hamdani, Mais Mazin, Kadhim, Sokaina Issa, Mustafa, Yasser Fakri, Najafi, Moslem Lari, Miri, Mohammad

“…The adverse health influences of polycyclic aromatic hydrocarbons (PAHs) exposures have been examined in several previous research. However, the evidence on…”
Get full text

Formulation development and characterization of lumefantrine nanosuspension for enhanced antimalarial activity by Shah, Ripalkumar, Soni, Tejal, Shah, Unnati, Suhagia, B. N., Patel, M. N., Patel, Tejas, Gabr, Gamal A., Gorain, Bapi, Kesharwani, Prashant

“…Variable and low oral bioavailability (4-11%) of lumefantrine (LUF), an anti-malarial agent, is characterized by very low solubility in aqueous vehicle. Thus,…”
Get full text

Nanovaccines in cancer immunotherapy: Focusing on dendritic cell targeting by Achmad, Harun, Saleh Ibrahim, Yousif, Mohammed Al-Taee, Muataz, Gabr, Gamal A., Waheed Riaz, Muhammad, Hamoud Alshahrani, Shadia, Alexis Ramírez-Coronel, Andrés, Turki Jalil, Abduladheem, Setia Budi, Hendrik, Sawitri, Windi, Elena Stanislavovna, Malyutina, Gupta, Jitendra

“…•Cancer immunotherapy, has revolutionized the treatment of many malignancies.•Nanovaccines could solve diverse problems that arose during cancer…”
Get full text

Unraveling the role of natural killer cells in leishmaniasis by Alizadeh, Zahra, Omidnia, Pooya, Altalbawy, Farag M.A., Gabr, Gamal A., Obaid, Rasha Fadhel, Rostami, Narges, Aslani, Saeed, Heidari, Aliehsan, Mohammadi, Hamed

“…•Activation of NK cells occurs through interaction between TLR-2 expressed on NK cells and LPG of Leishmania parasites.•NK cells are able to increase the…”
Get full text